- 1 The Happiness Medicine and Optimal Longevity Master Class Workshop
- 1.1 Location & Schedule (June 16th, Saturday: 8:30 to 5 Pm)
- 1.2 The Happiness Medicine Institute’s Three Days Master Class Training “Coach” Program
- 1.3 For Days Two and Three of the Workshop, click here
- 1.4 Coach Certification
- 1.5 Day One: Introduction to Holistic Rejuvenation Medicine
- 1.6 The workshop’s Presentations are supported with Strong Science
- 1.7 The following Workshop program comes from the Happiness Medicine Institute’s Book on Optimal Longevity
- 2 Preliminary Longevity & Mind Enhancement Meditation Exercise
- 3 Session A: Introduction to Holistic Rejuvenation Medicine
- 4 The Basics of Biogerontology
- 5 Session B. The Biology of Aging: Understanding the Mechanisms that Spur Accelerated & Delayed Aging
- 5.1 What is Biological Aging & Senescence ?
- 5.2 Cellular and Organismal Senescence is not shared by all Living Beings
- 5.3 Different Theories of Biological Aging
- 5.4 Cancer cells & Supercentenarians: Common threads
- 5.5 Case study A: Ultra rapid metabolic accelerating-aging
- 5.6 Case Study B: Ultra-slow Growth: Children who do not Age, genetically “frozen” in Time
- 5.7 Roundworms Experimentations confirm: aging and lifespan is regulated in part through the insulin/IGF-1 pathway.
- 5.8 Diet’s interaction with the IGF-1 pathway
- 5.9 Tentative Interpretation of the facts above
- 5.10 In Search for a Working Hypothesis of the Key mechanism(s) of Aging
- 5.11 The Major Molecular Mechanisms that best Explain the Aging Process
- 5.12 The Nine Central Hallmarks of Aging
- 5.13 1. Genomic instability.
- 5.14 2. Mitochondrial DNA Break-down & Dysfunction
- 5.15 3. Telomere Shortening and Telomerase Depletion
- 5.16 4. Epigenetic Alterations
- 5.17 5. Loss of Proteostasis
- 5.18 6. Deregulated Nutrient-sensing
- 5.19 7. Cellular Senescence
- 5.20 8. Stem Cell Exhaustion
- 5.21 9. Altered Intercellular Communication
- 5.22 Summary on the First Nine Hallmarks
- 5.23 Complementary Hallmarks
- 5.24 Longevity Mechanisms in supercentenarian & long-lived animals
- 5.25 Negligible senescence in the longest living rodents, the naked mole-rats & their DNA repair system
- 5.26 Gompertz Aging law and Biological “Immortality”
- 5.27 Tentative Concluding Remarks on Senescence and Aging mechanisms
- 5.28 In Search of one unified theory of aging
- 6 Session G: Research, Methodology & Legal Perspectives
- 7 Clinical Practice
- 8 Session C: Holistic Cardiology in a Nutshell. Extended Lifespans need Strong Hearts & Smooth Vasculature
- 8.1 Erectile Dysfunction (E.D.) is a “CVD canary in the Coal Mine” symptom that justifies an immediate rendez-vous with Cardiology Monitoring
- 8.2 Debunking myths & misleading claims regarding Fats
- 8.3 To Salt or Not to Salt ? The Evidence on Salt and CVD Diseases
- 8.4 Case Studies: Reversing Cardio-vascular diseases (CVDs) with Holistic Cardiology
- 9 Session D: Detoxification & Cleansing for Optimal Longevity
- 9.1 The Body’s has Six Key Metabolic Detoxification Pathways that need to be activated and fined-tuned
- 9.2 Sauna, Hydrotherapy & Hot tub Therapies
- 9.3 Removing Glyphosate ASAP
- 9.4 Home Detox from the Sick Building Syndrome
- 9.5 Occupants of water-damaged buildings (WDBs)
- 9.6 Fasting Techniques for Detoxification
- 9.7 On the New “fasting mimicking diet” trend being adopted by the Anti-Aging Community
- 9.8 Juicing Cleanses
- 9.9 What is the best “detox” water to Drink ? (Hydration, Structured Water & Toxicants)
- 9.10 The Myth of Drinking Lots of Water
- 9.11 Some “Toxicant & Cellular garbage disposal” help from our Microbiota Gluthatione-producing Friends
- 9.12 Case Study: Titanium Dioxide Nanoparticles
- 9.13 Case Study: Lead, Candles and More
- 10 Session E: Quality, Traditional & Moderate Wine intake extends Healthy Lifespans
- 11 Session F: Is the Body’s Endocannabinoid System essential insofar as general homeostasis, wellbeing & Longevity are concerned ?
- 12 Session H: The French & Holistic Approach to Health & Optimal Longevity
- 12.1 Joie de Vivre, French Cuisine & Tradition
- 12.2 French Homeopathy: Science, Wishful Thinking or Witchcraft ?
- 12.3 The Holistic Therapeutic Effect Principle
- 12.4 Auriculotherapy (Ear Acupuncture): French Quakery, Chinese pseudoscience or evidence-based Medicine ?
- 12.5 Case in Point: Acupuncture and Longevity Optimization
- 13 Lunch Break: Session I: Culinary Remedies, Longevity Smoothies, Essential Oils & Wine Demonstration
- 14 After-Lunch Meditation Exercise
- 15 Session J: Bio-Physics, Photons, Electro-acupuncture, Helio-therapy & inter-cellular Communication
- 16 Session K: Dental Holistic Care & how the Conventional Toxic Dentistry System impedes Americans fr reaching healthy Lifespans
- 17 Session L: The Reversal of Alzheimer’s Disease & Depression with Holistic Savoir-Faire
- 17.1 Detecting Alzheimer’s disease many years before symptomatology by looking at the Eye
- 17.2 Having APOE4 gene significantly ups Alzheimer’s Risk. Holistic Techniques can remove these Risks
- 17.3 Movement attenuates the deleterious effects of APOE4 & all other chronic diseases while boosting Telomeres, HGH & DHEA
- 17.4 Case Study: Reversing Alzheimer’s Disease with Holistic Medicine
- 17.5 Depression and Holistic Medicine
- 17.6 Case in point: Depression and Gut Disorders
- 18 Session M: The Microbiota Revolution in Medicine & how Microbiome Medicine Optimizes Longevity
- 18.1 Microbiota Dysbiosis
- 18.2 Case study: The Microbiota, Genes and Colon Cancer: Do Human eukaryotic genes cross-talk with Bacterial Genes ?
- 18.3 Case in Point: Are the Gut’s Bacteria capable of Detoxify human chemicals while favorably modulating ROS ?
- 18.4 Case Studies: The Gut microbiata via fecal transplants and the reversal of multiple diseases
- 18.5 Should Stool testing be part of all Diagnosis Work-ups ?
- 19 Session N: Holistic Nutrition, Gastroenterology, Weight Management & Diabetes
- 19.1 The Paleo-Keto-Mediterranean-Vegan-Caloric Restriction-Diet Variation” Debate
- 19.2 Limitations and Strengths of the Ketogenic Diet
- 19.3 Keto-strengths
- 19.4 Keto-Flaws and Serious Pitfalls
- 19.5 The Strengths and Limitations of the Paleo Diet
- 19.6 An effective recipe to die crippled with an onslaught of chronic diseases
- 19.7 Case Study: Reversing Diabetes Holistically
- 19.8 Happiness Medicine Institute’s Holistic Mediterranean Diet & Executive Recommendations
- 19.9 The Joie de Vivre French Approach to Food & the Art of Slow Eating
- 19.10 The Doctrine of Signatures (Teleological Nutritional Targeting)
- 19.11 The “Truth” (Debate) on Soy
- 19.12 Can Quality A2 Traditional-made Cheese be a Longevity and Medical Food ?
- 19.13 The French Paradox on the High Cholesterol & Low CVDs
- 19.14 Holistic Solutions to Low Stomach Acid and Slow Bowel Movement
- 20 Session O: Dietary Supplementation & Optimal Longevity
- 20.1 Safe and Efficient Supplementation for Healthy & Optimal Lifespans
- 20.2 Unsafe and-or inefficient Supplementation
- 20.3 Case study A: One of many examples of Dietary Supplements ending up as expensive urine
- 20.4 Case study B: A Published Study Claims a 20 percent increase of Liver Damage coming from Dietary Supplements
- 20.5 H.M. Institute Appraisal
- 20.6 Case Study 3: Resveratrol in a capsule, food or bottle ? Depends if one is a mouse, a patient, holistically inclined or a marketing agent
- 20.7 H.M. Institute’s Critical Appraisal
- 20.8 Session O: Chronic Stress & The Inner Saboteur
- 20.9 Consciousness Disorders
- 20.10 Subconscious’ programing or willful self-sabotage ?
- 20.11 Holistic Solutions
- 20.12 Proof that JDV Medicine is even better than General Wellbeing medicine
- 20.13 How to Sabotage one’s Health-care Self Interests and go into Extinction
- 21 Session P: Hands-on Techniques to enhance Longevity and de-activate the Inner Saboteur
- 22 Session Q: Advanced Cancer Protocols
- 23 Session R: Thermal Medicine: A French Speciality that would be of Benefit for the US Health-Care system
- 24 Session S: Regulating Cytokines, Optimizing balanced Hormones & Neuro-transmitters & Tweaking Longevity Genes
- 24.1 The Bliss Hormone Chemistry Network
- 24.2 DHEA
- 24.3 Human Growth Hormone (HGH)
- 24.4 The Vasopressin & Oxytocin
- 24.5 The Oxytocin-Vasopressin Pathway in the Context of Love and Fear
- 24.6 The Klotho Hormone
- 24.7 Neuropeptides, Neuro-transmitters & Healthy Longevity
- 24.8 Excitatory and inhibitory processes
- 24.9 Illustrations
- 24.10 Neurotransmitters’ Imbalance
- 24.11 Cytokines Signaling Molecules, Cytokines-Storms, Inflammaging & the Body’s integrity
- 24.12 The Role of endogenous cytokines in premature death, disease, health and longevity
- 24.13 Homeostatic Imbalance and Cytokine-storms
- 24.14 Holistic Interventions
- 24.15 Case in Point: Sepsis
- 24.16 Influenza Pandemics
- 24.17 Activating Key Longevity Genes
- 24.18 FOXO3 Activators and Rejuvenation
- 24.19 The Continuum of Ancestral Genes
- 25 Session T: Mitochondrial Bio-Genesis’ Restoration
- 26 Session U: Stem Cells: Repair, Replacement & Regeneration
- 27 Session V: Telomerase Therapy
- 28 Session W: Cellular Senescence & Autophagy Regulation
- 29 Session X: Circadian Rythms Activation & DNA Repair
- 29.1 Nicotinamide Adenine Dinucleotide, NMN & DNA Repair
- 29.2 The metabolite NAD+ has a key role as a regulator in protein-to-protein interactions that modulate DNA repair & NMN can help
- 29.3 Discussion
- 29.4 Nicotinamide Riboside & Longevity ?
- 29.5 Discussion
- 29.6 A Powerful Entourage Synergy effect between between Pterostilbene and Resveratrol ?
- 30 Session Y: Key Check-up and Monitoring Tests: From Self-testing to Genetic Evaluation and more
- 31 Session Z: Update on Today’s Bio-Engineering of anti-aging pharmaceuticals & Hi-Tech procedures
- 32 Session : Summary
- 33 Conclusion
- 33.1 The expected Benefits from attending these three one-day long Seminars
- 33.2 Workshop Presenter
- 33.3 The Difference between a Conventional Check-up versus a Holistic Tune-up.
- 33.4 Workshop details
- 33.5 Exhibit A
- 33.6 Video Excerpt on a 2016 Optimal Longevity Medicine Lecture from Professor Joubert (Optimal Longevity Institute)
- 33.7 Exhibits B
- 33.8 Video Excerpts by Professor Longo on Diet and Fasting’s on Longevity and Mark Mattson on Brain Rejuvenation via Caloric Restriction & Fasting (Source).
- 33.9 Exhibits C
- 33.10 Video excerpts on the Telomerase Enzyme’s ability to slow down and reverse the Aging Clock
- 33.11 Exhibits D
- 33.12 Video extract on Longevity Genes by Professor Sinclair (Harvard University)
- 33.13 For those interested in Holistic Retreat Updates & Continuing Education & Workshops from H.M. Institute
The Happiness Medicine and Optimal Longevity Master Class Workshop
“It is already possible to live to be well over 120 years (…) In my own laboratory at UCLA Medical Center, we have extended the maximum life span of fish by 300 percent.” Maximum Life Span”, NY: W. W. Norton, 1983 by Roy L. Walford, M.D..
Aging Research and the Preliminaries to Optimal Longevity Medicine
“And the LORD said, My spirit shall not always strive with man, for that he also is flesh: yet his days shall be one hundred and twenty years.” (Genesis 6:3: King James Version)
A spring workshop-seminar with a French biogerontologist Professor Joubert
“The idea is to die young as late as possible.” (Ashley Montagu)
Location & Schedule (June 16th, Saturday: 8:30 to 5 Pm)
The Workshop’s first day Seminar is scheduled for June 16th Saturday, from 8:30 AM to 5 PM at the following address: San Pedro Methodist Church Conference Room, 580 West, 6th Street, San Pedro CA. 90731. Contingent to the Conference room is a kitchen where we will prepare a longevity recipe during the lunch break. For all info and in order to register, please email at firstname.lastname@example.org.
The Happiness Medicine Institute’s Three Days Master Class Training “Coach” Program
This Section is under construction
For Days Two and Three of the Workshop, click here
To get certified as a Happiness Medicine and Optimal Longevity coach, the workshopee needs to attend the three days of training and pass a certification test at the end of the Program, after which he or she will get the Institute’s Certificate. This section is pending.
Day One: Introduction to Holistic Rejuvenation Medicine
From Theory to Practical Tools to Reach 120 years in good shape
Day One is a general introduction to this Master Class where we cover Theory and Praxis. Once we have the tools to better understand the fundamental mechanisms of holistic living and aging, we can then delve into some clinical experience, starting with the first holistic priority which is Holistic Cardiology. Thereafter, we analyse the Gut-Brain axis, (with a special focus on Alzheimer’s Disease and Depression) as well as the gastro-intestinal system, holistic dentistry and the body’s six detoxification pathways in association with brain health enhancement, the endocannabinoid system’s regulation, bio-physics and a few other longevity techniques. Diet being essential, we will examine different nutritional approaches as well as aromatherapy, wine medicine, thermal therapies, microbiota diversity, holistic cancer protocols, circadian biology, restorative sleep and more. To become an effective coach, the workshopee will need to understand Methodology, Medical Law and the inner Saboteur paradox (psycho-neuro-immunology). We will conclude this Day One Seminar with an overview on supplementation and different Longevity enhancement techniques that target the mitochondria, senescent cells, autophagy, hormonal imbalance, telomerase activation, genes, stem cells regeneration and Lab monitoring and more.
We will also give an update on the latest bio-tech and innovative research, some of which are in clinical trials.
The workshop’s Presentations are supported with Strong Science
The Workshop’s three Seminars’ content will be supported with strong published peer-reviewed evidence that will be visible either via internet posts, power point and-or video. For an introduction to the subject presented by Professor Joubert, see video A below. For a general overview on where we are today in terms of innovative Bio-Tech Research and longevity genes, see video D from Professor Sinclair.
The following Workshop program comes from the Happiness Medicine Institute’s Book on Optimal Longevity
(Working Tool for the Three Days Master Class)
This Section is under construction
To help the workshopees with the assimilation of the Workshop’s content, we are producing scientific data that supports some of the Workshop’s Recommendations. Most of this information comes from a Longevity Medicine book we are still working on.
Preliminary Longevity & Mind Enhancement Meditation Exercise
As we will see via supporting published evidence from the Workshop’s power point presentation, the mere practice of Meditation can spur multiple mechanisms of Longevity, including, but not limited to the the activation of the enzyme telomerase and the upregulating of anti- inflammatory pathways. Furthermore, intellectual assimilation of the content of this Workshop will be enhanced with a guided Meditation practice of 20 minutes or so.
The Magic of Meditation: From Genomic Expression to JDV Consciousness Activation
In 2011, researchers at Harvard were among the first to demonstrate that just eight weeks of mindfulness meditation training caused significant increase in the thickness of the hippocampus, one of the key brain organs. (Source) In this perspective, the same team of Harvard researchers also found that mindfulness meditation decreases brain cell volume in the amygdala, the part of our brain responsible for fear, anxiety and stress. (Source) These changes matched with the participants’ self-reports of their stress levels, demonstrating how changes in the brain correlate with subjective perception and feelings as well. Since focusing our attention on an object (ex: breath or mantra) is one of the central practices of meditation, it’s no surprise that meditation should help improve our ability to focus and be less susceptible to distractions. (Source) Improved concentration and attention is one of the most well-studied benefits of meditation. This is why it makes sense to start off this Workshop with some mind-blowing meditation which we will teach you.
Session A: Introduction to Holistic Rejuvenation Medicine
“The field of ageing research has been completely transformed in the past decade. . . . When single genes are changed, animals that should be old stay young. In humans, these mutants would be analogous to a ninety year old who looks and feels forty-five. On this basis we begin to think of ageing as a disease that can be cured, or at least postponed. . . . The field of ageing is beginning to explode, because so many are so excited about the prospect of searching for – and finding – the causes of ageing, and maybe even the fountain of youth itself”. (Guarente and Kenyon, Nature, 2000)
For centuries if not millennia, the aging process has been considered to be uncontrollable, even when the average lifespan did not surpass 40 years, which was just a little over 100 years ago. That changed in the early nineties when research on C. elegans, (a tiny nematode worm) confirmed that a single gene mutation extended its life, and that another mutation blocked that extension. The idea that age could be tweaked by twiddling a few control genetic switches ignited a research boom, including via Silicon Valley Billionaires. With hundreds of million dollars of research dollars, geroscientists got motivated to attempt to break and hack the Longevity Code.
In this perspective, various clinical interventions did increase the worm’s lifespan by a factor of ten and those of lab mice by a factor of two. Thereafter, telomeres of skin cells were tweaked to lengthen considerably, thanks to a new Lab procedure fine-tuned by Stanford university School of Medicine scientists, these cells were able to divide up to 40 more times more than untreated cells, which means that human somatic cells have been shown to surpass the Hayflick limit and potentially extend their lifespan 40 times more than before. “Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells”. (Source)
The scientific consensus thus transformed. Aging went from being a God given blessing or Satan’s curse, to an inevitable final stage (Cf Time cover from 1958: “Growing Old Usefully”), followed by a social issue (Time, 1970: “Growing Old in America: The Unwanted Generation”) to this avoidable “je ne sais quoi” phenomenon (1996: “Forever Young”) that could defer death to 142 years for starts (Cf 2015: Time “This Baby Could Live to Be 142 Years Old”).
However, because in Life and Biology, there are many howevers, the excitement was not long lasting, if only because it was discovered not too long ago that telomerase was not the central longevity engine. The Longevity Code cook-book is far more complex for mammals and even more so for humans than for a C. Elegans worm, fly, mouse or even the bat (who has an exceptionally long lifespan). Hence, the presentor’s scientific attitude is to prefer the known fundamentals that work to at least 122 years of age while being open to and expecting the best of speculative bio-tech longevity engineering stratagems, many of which are still in the early phases of clinical trials.
While some of these innovative technologies appear interesting, (e.g. telomerase enhancement, senescent cell removal, (senolytics), caloric restriction mimickers, blood donor plasma transfer, nano-robots, gene editing, stem cell cyro-preservation, Sirtuin-activating molecules and the like), not only it takes years for many of these anti-aging human trials to be completed, but thereafter, more waiting for accessibility of services which tend to have expensive price tags (eg, for telomerase enhancers via injection, experts are speaking about one million dollars for one rejuvenation shot). Furthermore, from what we know of the side effects of older “off label” “anti-aging” drugs like the diabetes drug metformin and the organ transplant drug rapamycin, (both of which were found to have longevity properties), risks may outweigh benefits, especially for people who are relatively healthy. Thus, waiting a few years (especially for baby-boomers) before some of these bio-tech longevity hacks may be accessible and proven safe and effective beyond any reasonable doubt is not cellularly responsible, if only because today we have the knowledge that key holistic tools can repair most metabolically impaired tissues thereby setting the stage for chronic diseases reversal, thanks to which the beneficiary can meaningfully slow down the aging process while extending a healthy Lifespan to at least 122 years lifespan, as demonstrated the World’s Guiness Record breaker champion, Ms Jeanne Calment, the Mediterranean swinger from South France who loved to fence (which she took up at 85), bike, dance and enjoy to the last bite over 2 pounds of dark chocolate each week of her happy long life.
The Basics of Biogerontology
After a brief introduction, the workshopees will be introduced to the evidence that corroborates the reality of healthy long human lifespans (in between 110 and 122 years of age). In this context, we will examine supercentenarian individuals like Jeanne Calment (who reached 122 years), the longevity valleys and blue zones as well as the scientific debates regarding maximum human lifespans. These analyses will help us to identify the key longevity factors that characterize some of these geographical areas where healthy centenarians are abundant. Thereafter, we will examine the aging and longevity biomarkers as well as the major hallmarks of aging.
Biomarkers (Aging and Longevity)
During the last few years, multiple efforts have been made to better quantify biological aging. One of the first institutes to work on this project are the National Aging Institute (cf. the Baltimore Longitudinal Study of Aging (BLSA)) and the N.I.H’s Nhanes survey. (Source). The European MARK-AGE brought together over 20 European countries to also contribure in this endeavor, while a group of scientists in New Zealand recently looked at 18 aging biomarkers in a cohort of young adults that were followed for 12 years. This New Zealand study, called the “Dunedin Study”, suggests that rates of aging can be measured even in relatively young adults. (Cf. Daniel W. Belsky et al., Quantification of biological aging in young adults, PNAS, Jul 2015, 112 (30) E4104-E4110).
Once we have reviewed most of the significant physical, biological and genetical (DNA) biomarkers that have been worked on, we will select the most relelvant biomarkers that appear to be the best suited to assess at any given moment a person’s biological age as well as his or her healthy lifespans predictors. These evaluations can also help to better address age-related diseases and one’s optimal longevity potential. One of the greatest challenges for future clinicians will be to integrate these aging and longevity biomarkers with the physiological and biochemical markers that are already in use in medicine.
The DNA Methylation Epigenetic Clock
Of all of the biological clocks that can be biomarkers of aging, the DNA methylation Epigenetic Clock is one of the more reliable ones, recently considered to be even more reliable than Telomerase Shortening. In this Persentation, we will show the evidence supporting this claim. Aging biomarkers are relevant because to know if such and such a longevity measure is working, we would normally need many years to see and feel the difference. However, with dependable biomarkers, we can monitor progress at a quicker pace, a bit like with cancer biomarkers.
Case studies of a few Humans and Animals who have significantly outlived their peers
Top: The French Mediterranean dancer, who is the Happiness Medicine Institute’s Hero, Madame Jeanne Calment, a Piscean born on February 21, 1875, is still the Optimal Longevity Champion. Having reached 122.5 years, according to her claims, she “allowed” herself to die. In other words, she could have continued to live. Her age was confirmed via birth certificate and the Guiness Record scientist-investigators confirmed this fact. In this picture, she was 120.
In this Presentation, we will study the Life and thoughts of the Mediterranean Extreme Longevity Champion Jeanne Calment whose longevity record has never been broken. (Source) We will also look at her lifestyle, her diet and her medical records that span from 111 years to 118. Thereafter, we will make an evidence-based determination as to what kept her going for over 122 years. A few other super centenarians as well as animals will be compared to this all time longevity record breaker. And yes, she drank red wine with her Med-diet meals, (with, on occasion A2 quality cheese & wild fish), had a great sense of humor and enjoyed lots of dark chocolate, up to one kilo a week (2.2. pounds). (Source) But according to Jeanne herself, French scientists and her doctor, her healthy lifespan secret was something else.
Are there genetic variants or determinants that account for extreme longevity in humans ?
“Centenarians are the best example of extreme human longevity, and they represent a selected population in which the appearance of major age-related diseases, such as cancer, and cardiovascular diseases among others, has been consistently delayed or escaped. The study of the long-lived individual genetic profile has the purpose to possibly identify the genes and the allelic variations influencing extended life expectancy, hence considering them as biomarkers of age-related diseases onset and development. The present study shows no significant differences between allelic variations of ABO blood groups among a group of centenarians from Western Sicily”. (Source)
Longevity scientists have been researching “protective longevity genes” for a long time. Some of these “life extension” genes function via cellular defense compensatory mechanisms, in particular with regard to oxidative stress, autophagy and inflammation. In this field, we will look at three of the more important families of genes that modulate age-related pathways. These are the SIRTUINS, APOEs and FOXOs (FOXO1 and FOXO3) (Cf. Willcox et al., 2006 and Soerensen et al., 2010, 2015 and Brooks‐Wilson, 2013). The variant FOXO3A for example, is found in many German centenarians as well as in a few other ethnic groups around the world, (Source). On the other hand, FOXO4 has a role in maintaining the harmful state of cellular senescence by sabotaging that specific mechanism that has been shown to selectively push senescent cells into self destruction. So not all FOXO variants have been created equal. On the other hand, the sirtuin genes modulate noly only anti-aging pathways, but also helps with chronic diseases. (Source) And wine’s resveratrol is a sirtuin 1 activator. While APOE4 is problematic, its variant (allele) APOE2 is anti-aging. (Source)
In this Presentation, we will briefly assess what is the relevance of longevity genes in relation to stochastic, environmental and epigentic factors upon which humans have control. Later on in the workshop, we will give a list of foods and supplements that can help to activate these and other longevity genes whose ribosomes produce proteins that have beneficial effects on multiple longevity pathways. (See ultra). What is important to underline at this juncture is that genes are downstream to what is quintessential: lifestyle, metabolic processes and holistic tweaking. Just like with cancer. To resolve the cancer challenge, we must focus upstream from genes. Same approach with longevity. We need to focus upstream from longevity and anti-longevity genes. Hence, the importance of rejuvenation and restorative therapies that address the root causes of aging. And by ricochet, this holistic approach helps to express (activate) the good genes and down regulate (de-activate) the harmful genes. But before we examine these techniques, we need to better undersand the major hallmarks of biological aging.
Session B. The Biology of Aging: Understanding the Mechanisms that Spur Accelerated & Delayed Aging
“Medicine is not only a science; it is also an art. It does not consist of compounding pills and plasters; it deals with the very processes of life, which must be understood before they may be guided.” Paracelsus
To be motivated to adopt a Holistic Restorative and Rejuvenation Lifestyle, it is first necessary to understand the mechanisms that govern normal aging in relation to accelerated aging and slow holistic “delayed” aging. When we see that Lifestyle and holistic savoir-faire impact all of the major hallmarks of aging, including gene expression, it is then easier to pay attention to what is important in Life, provided one desires a healthy supercentenarian existence. But one must genuinely and vividly desire to achieve this Life potential. The supercentenarian life is not for the faint of heart. To achieve this high vibrational level of Life, resistance against toxicity and activation of holistic techniques, including in the fields of relaxation, detox, exercises, meditation, up-beat attitude, quality nutrition, sleep and vibrant water intake, among other elements, are more important than the genetic or zip codes.
What is Biological Aging & Senescence ?
“ ..aging can be modulated by genetic pathways and biochemical processes which are evolutionarily conserved” (Lopez‐Otin et al., 2013))
Mainstream conventional non-holistic biological aging (or senescence) is characterized by a progressive loss of physiological integrity, leading to impaired function, rampant frailty, complete infertility and death in an expensive hospital bed, usually after a hefty morphine drip hook-up, but a little before the morgue industry arrives. I’ve also heard some gerontolists say that aging is the declining ability to respond to stress characterized by increased homeostatic imbalances and functional degradation occurring in a stochastic (random) fashion that leads to the accumulation of cellular damage, tissue decline and death (i.e., cerebral hypoxia, i.e., lack of oxygen to the brain, is the immediate cause of all human deaths).
On the other hand, there’s the holistic way to age, where the death candidate generally thrives until the last weeks and thereafter, leaves his or her body in his or her sleep and-or with full consciousness on the terrain with little if any painful experience.
Because the structural bio-chemical and genetic causes of aging and chronic diseases share similar mechanisms and since we can control and reverse most chronic diseases with holistic and innovative medicine, it necessarily follows that aging can be less a business than a ritual celebrating the ending or crowning of a human life.
Senescence is not the inevitable fate of all living organisms. The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats and the existence of species that have negligible senescence and even no biological aging have been documented for a long time.
A careful examination of the data shows that Life, of which humans are part, exudes multiple forms that experience very slow or no biological aging. Indeed, different living organisms who share the same genes as humans experience chronological decrease in mortality, for all or part of their life cycle (Cf. Ainsworth, C; Lepage, M (2007). “Evolution’s greatest mistakes”. New Scientist. 195 (2616): 36–39 Source). Species like the Hydra are quasi immortal while other species become more fertile with chronological age, like large turtles. The rock fish, like his lobster cousin can live for hundreds of years if it were not for predators and human toxic dumps. Some even exhibit negligible and even negative senescence, in which mortality falls with age, in disagreement with the Gompertz–Makeham “law” which provides that mortality rates accelerate exponentially with age.
Let us consider the Hydra. Today, the best natural scientists have not refuted that Hydra stem cells have a capacity for indefinite self-renewal. The transcription factor, “forkhead box O” (FoxO) has been identified as a critical driver of the continuous self-renewal of Hydra. (Boehm, Khalturin, Anton-Erxleben, Hemmrich, Klostermeier, Lopez-Quintero, Oberg, Puchert, Rosenstiel, Wittlieb, Bosch; Khalturin; Anton-Erxleben; Hemmrich; Klostermeier; Lopez-Quintero; Oberg; Puchert; Rosenstiel; Wittlieb; Bosch (2012). “FoxO is a critical regulator of stem cell maintenance in immortal Hydra“. Proceedings of the National Academy of Sciences. 109 (48): 19697. (Source)
Other living organisms like planarian flatworms, and certain sponges, corals, and jellyfish do not die of old age and exhibit potential immortality. (Petralia, Ronald S.; Mattson, Mark P.; Yao, Pamela J. (2014). “Aging and longevity in the simplest animals and the quest for immortality”. Ageing Res Rev. 16: 66–82. (Source).
Jellyfish are also known to defy time. The jellyfish known as Turritopsis doohmii, or more commonly, the immortal jellyfish bypasses death by actually reversing its aging process. If the jellyfish is injured or sick, it returns to its polyp stage over a three-day period, transforming its cells into a younger state that will eventually grow into adulthood all over again. (Source) Flatworms are also known for the biological “immortality”. Also called planarian worms, they are famous for their regeneration abilities. Even with a severed body, they will grow it back pronto.(Source) Then we have the Deinococcus radiodurans, a poly-extremophilic bacterium who is radiation-resistant. These immortal animals can also die and come back to life thanks to their DNA repair mechanism. According to Ira S. Pastor, “[They] can survive cold, dehydration, vacuum, and acid, and [have] been listed as the world’s toughest bacterium.” The Guinness Book of Records states that they “can resist 1.5 million rads of gamma radiation, about 3,000 times the amount that would kill a human”. As for the tardigrade, these creatures are capable of sticking around for thousands of years or even indefinitely “by entering a state of cryptobiosis, whereby their metabolism comes to a halt.” (Source).
Different Theories of Biological Aging
There are multiple theories as to why senescence occurs. Some groups of scientists posit it is programmed by gene expression changes, others that it is the cumulative damage caused by biological processes liked to mitochondrial dysfunction, ROS accumulation, cellular senescence and the P53 while still others believe that cellular senescence is the result of the body’s exhaustion of stem and repair cells in association with telomere attrition etcetera.
While there are many incertitudes in this field, what appears to be irrefutable is that the “terrain”, the “field”, the “milieu” tends to prevail over the “unit”, Life forms. For example, the same stem cells placed in three different petri dishes with a different milieu (terrain) will differentiate differently. Likewise, identical cells (like human twins) that are genetically identical, but have substantially different outside stimuli (bioterrains) will respond differently and hence have different lifespans. These facts indicate that the “terrain”, the “milieu”, the epigenetic factors play a key role in gene expression. (Ryley J; Pereira-Smith OM (2006). “Microfluidics device for single cell gene expression analysis in Saccharomyces cerevisiae”. Yeast. 23 (14–15): 1065–73. (Source)).
Cancer cells & Supercentenarians: Common threads
The current status of aging research exhibits many parallels with that of cancer research. The cancer field gained major momentum in 2000 with the publication of a landmark paper that enumerated six hallmarks of cancer (Hanahan and Weinberg, 2000), and that has been recently expanded to ten hallmarks (Hanahan and Weinberg, 2011). This categorization has helped to conceptualize the essence of cancer and its underlying mechanisms upon which good medicine can intervene.
In this perspective, the condition of cancer and aging may seem opposite processes, but in reality, they share common origins and pathways. What unites both these phenomena is the time-dependent accumulation of cellular DNA damage, which is a major hallmark of both aging and cancer. Therefore, cancer and aging can be regarded as two different manifestations of the same underlying process, namely, the accumulation of cellular damage and genomic instability. In addition, several of the pathologies associated with aging, such as atherosclerosis and inflammation, involve uncontrolled cellular overgrowth (Blagosklonny, 2008).
Furthermore, cancer and supercentenarians share a common “ally”, the telomerase enzyme. By activating its telomerase enzyme to keep telomeres long, cancer cells are quasi-immortal. As long as they have fuel, cancer cells continuously divide thanks to the self-replicating telomerase enzyme, hence they are not subject to the Hayflick limit (50 to 70 cell divisions) or the laws of senescence death. (Source). As a result, they don’t age. Similarly, those supercentenarians who reach long lifespans also have more active telomerase and longer telomeres, while children who age very quickly (like this proragia girl in the picture below) have very short telomeres.
Top: A young infant girl who suffers from Proregia syndrome. She is only around 2 years old, but appears much more. Also known as Hutchinson-Gilford syndrome, this disease is genetic. It is characterized by accelerated aging that is accompanied with the age-related diseases. The mean age at death of these patients is 12.5 years. These children die “old” before 15 or 20, at which point they look like 80 years old.
Case study A: Ultra rapid metabolic accelerating-aging
To better understand a few of the mechanisms behind normal an delayed aging, it’s useful to study cases where aging proceeds very fast and very slow. In humans, there’s a genetic disease called Proregia syndrome, also known as Cockayne syndrome (CS), Hutchinson-Gilford syndrome , Werner’s syndrome (WS), Bloom’s syndrome and trichothiodystrophy. All of these diseases are autosomal recessive disorders with progeroid symptoms. These disorders are rare genetic characterized with extreme premature aging and a shortened life expectancy. All of the hallmarks of aging are manifested, including cessation of growth, liver, kidney and bone abnormalities, retinopathy, hearing loss, sarcopenia, neurodegeneration, sensitivity to UV light, and a premature aged appearance due to kyphosis, baldness, loss of subcutaneous fat, and, inter alia, dry wrinkled skin. (Source)
Children with progeria have a mutation on the gene that encodes for lamin A, a protein that holds the nucleus of the cell together. This protein is also known as progerin. The defective protein makes the nucleus unstable and short-lived. (Source) The mean age at death of these patients is 12.5 years. (ibid) There is currently no treatment for these syndromes and the clinical management of patients is essentially palliative. Although some differences exist in the pathology of these conditions, the central causal factor of all these syndromes lies in impaired genome maintenance due to DNA repair deficiencies and genome instability. (Source). Two other hallmarks of aging, the depletion of stem cells as well as telomeres attrition, have also been identified to correlate with this disease.
Top: A 16 years old little girl who stopped growing at 11 months.
Case Study B: Ultra-slow Growth: Children who do not Age, genetically “frozen” in Time
In contradistinction to children who senesce fast, there are other children who don’t senesce at all or extremely slowly. They also eventually die young, from complications. The understanding of this medical phenomenon is recent, it started only in 2009 with the report about 16-year-old girl who seemed to be “frozen in time.” She was the size of an infant, with the mental capacity of a toddler rather than a teenager. (Source) See also Brown, Bob (23 June 2006). “Doctors Baffled, Intrigued by Girl Who Doesn’t Age”. Health. ABC News.
This genetic disease used to be called Syndrome X, but now it is labeled as “neotenic complex syndrome” (NCS). After having sequenced the genome of a few of these diseased children, the researchers found key de novo mutations (DNMs) in two development genes ((DDX3X and HDAC8), located on the X chromosome and affecting transcription regulation and chromatin modification, inter alia. (Source). See also Walker, R.; Pakula, L.; Sutcliffe, M.; Kruk, P.; Graakjaer, J.; Shay, J. (2009). “A case study of “disorganized development” and its possible relevance to genetic determinants of aging”. Mechanisms of ageing and development. 130 (5): 350–356. (Source))
Roundworms Experimentations confirm: aging and lifespan is regulated in part through the insulin/IGF-1 pathway.
Top: the transparent nematodeC. elegans.This roundworm is one of the most studied for neurodegeneration and longevity. Scientists have been able to significantly extend its lifespans by tweaking its genes.
In order to study key age-related genes, gerontology specialists examine many different types of genes that come from different animals. According to the GenAge database of aging-related genes, there are over 1800 genes altering lifespan in model organisms: 838 in the soil roundworm (Caenorhabditis elegans), 883 in the bakers’ yeast (Saccharomyces cerevisiae), 170 in the fruit fly (Drosophila melanogaster) and 126 in the mouse (Mus musculus). (Source).
The first mutation found to increase longevity in an animal was the age-1 gene in Caenorhabditis elegans. (Top Picture) Michael Klass discovered that lifespan of C. elegans could be altered by genetic tweaking (mutations), but Klass believed that the effect was due above all to the reduced food consumption (calorie restriction) regime the Elegans worm was put under. He published his results in 1983. (Source). Thomas Johnson later showed that life extension of up to 65% was due to the mutation in gene age-1 itself rather than due to calorie restriction. The age-1 gene encodes the catalytic subunit of class-I phosphatidylinositol 3-kinase (PI3K). (Source)
A decade after Johnson’s discovery, one of the two genes that are essential for dauer larva formation, the “daf-2”, once mutated, was shown by Cynthia Kenyon to double C. elegans lifespan. Nature. 366 (6454): 461–464 (Cf, Dorman, Jennie B.; Albinder, Bella; Shroyer, Terry; Kenyon, Cynthia (1995). See also “The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans”. Genetics. 141 (4): 1399–1406). See (Source).
The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. (Source). DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. (Source). Subsequent genetic modification (PI3K-null mutation) to C. elegans was shown to extend maximum life span tenfold. (Source) See also Shmookler Reis RJ, Bharill P, Tazearslan C, Ayyadevara S (2009). “Extreme-longevity mutations orchestrate silencing of multiple signaling pathways”. Biochimica et Biophysica Acta. 1790 (10): 1075–1083. (Source)
Diet’s interaction with the IGF-1 pathway
Research into the interaction between diet and the insulin/IGF-1 pathway has shown sugar intake to be negatively correlated with DAF-16 activity and longevity. In this perspective, Wild type C. elegans was fed a diet that included 2% glucose. It was subsequently shown that Daf-16 activity was reduced and lifespan was shortened by 20% compared to worms fed on glucose-free media. These findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms. (Lee, S. J.; Murphy, C. T.; Keyon, C. (2009). “Glucose shortens the life span of c. elegans by downregulating daf-16/foxo activity and aquaporin gene expression”. Cell Metabolism. 10 (5): 379–391. (Source)).
Tentative Interpretation of the facts above
The 20 percent shortening of the C Elegans’ lifespan with 2 percent glucose in the diet observation only suggests that sugar may be a problem with regard to longevity optimization. The worm was not fed human complex carbs, let alone organic fresh complex carbs, furthermore, healthy carbs for humans may fuel longevity pathways instead of a shortening lifespan because sugar is different from healthy carbs and mammals like humans are different from worms, even if we share common genes, biochemical pathways and wiggly manners. At this juncture, what the facts appear to be telling us is that in higher organisms, aging is likely to be regulated in part through the insulin/IGF-1 pathway.
In Search for a Working Hypothesis of the Key mechanism(s) of Aging
Since the discoveries invoked above, the interest in the molecular pathways that control aging has exploded, and many more mutations in metabolic pathways have been shown to affect lifespan in different model systems, ranging from yeast to mice. Studies suggest that new pathways are even more relevant for human lifespan. Among others, maintenance of mitochondrial function has been suggested to be a key mechanism of extending lifespan, as decreased mitochondrial function, impaired ATP generation and increased reactive oxygen species (ROS) levels have all been shown to be implicated in driving the aging process (Guarente L. Mitochondria: a nexus for aging, calorie restriction, and sirtuins? Cell. 2008;132:171–176. Full Article) (Source)
To further complexify the issue, it has been shown that an increase in ROS can actually be a good thing for longevity. This idea has now gathered a large body of supportive evidence showing that repetitive mild stress exposure has anti-aging effects. (Rattan, Suresh I.S. (2008). “Hormesis in aging”. Ageing Research Reviews. 7 (1): 63–78. (Source) See also: Gems, David; Partridge, Linda (2008). “Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger””. Cell Metabolism. 7 (3): 200–3. (Source)
On the other hand, other scientists have shown that mitochondrial dysfunction is less the driver of aging than telomere shortening.
“The new findings demonstrate that the telomere dysfunction and activation of p53 also trigger a wave of cellular and tissue degeneration that links telomeres to well-known mechanisms of aging that are not simply related to rapid growth and division. In other words, telomere dysfunction is not just one culprit in the declining health of advanced age. It’s the kingpin, according to DePinho and his colleagues. In addition, the process weakens the body’s antioxidant defenses against the damaging molecules known as reactive oxygen species, or “free radicals,” that accumulate with age and exposure to stress. Until now, some researchers had labeled the decline in mitochondria or the buildup of free radicals as the primary causes of age-related ills. The new work integrates these seemingly disparate mechanisms into one unified theory of aging. Telomere dysfunction causes this wave of metabolic and organ failure, the scientists found, because when the p53 gene is activated, it represses the functions of two master regulators of metabolism, PGC1-alpha and PGC1-beta. (…) “This is the first study that directly links telomere dysfunction to regulators of the mitochondria and antioxidant defense via p53,” DePinho said. “The discovery of this new pathway of aging integrates a lot of different ideas people have had and gives us a better understanding of the aging process.” (Source)
And since these above-mentioned findings, still new disvoeries have been made, many of which continue to either contradict and-or fine-tune the current model of aging. Now it would appear that telomere shortening is not the core mechanism since we can find animals that are long-lived with short telomeres and vice versa, short lived animals with long telomeres, including with the nematodes.
“Despite the close correlation of telomere length and clonal cellular senescence in mammalian cells, nematodes with long telomeres were neither long lived, nor did worm populations with comparably short telomeres exhibit a shorter life span. Conversely, long-lived daf-2 and short-lived daf-16 mutant animals can have either long or short telomeres. Telomere length of post-mitotic cells did not change during the aging process, and the response of animals to stress was found independent of telomere length. Collectively, our data indicate that telomere length and life span can be uncoupled in a post-mitotic setting, suggesting separate pathways for replication-dependent and -independent aging. (Source)
Even though mitochondrial homeostasis impairment is clearly associated with aging, the high complexity of aging phenotypes, and their underlying molecular mechanisms, make the deciphering of the real causing elements difficult. Moreover, the discovery of mitohormesis in stress response and ROS signaling pathways nuanced the idea of active and healthy mitochondria, and of ROS production and oxidative stress. Indeed, as described above, increased ROS and less active mitochondria can promote healthy aging and long lifespan. Likewise with telomerase enhancement and other pathways. In order to hone in on a core mechanism hypothesis then, we should first better examine what the major molecular mechanisms that are responsible for the aging process are.
The Major Molecular Mechanisms that best Explain the Aging Process
In this Presentation, we will identify and categorize the recognized cellular and molecular hallmarks (ie, the major mechanisms of action) that govern the process of aging.
There are nine major hallmarks: genomic instability, mitochondrial dysfunction, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication. There is a general consensus in the biogerontoloty community that these hallmarks are the most significant ones insofar as the process of aging is concerned. To these hallmarks, the Happiness Medicine Institute will add a few others.
Ideally, each hallmark should fulfill the following five criteria: (a) it should manifest during normal aging; (b) its experimental worsening should accelerate the aging process and (c) its experimental improvement should delay the normal aging process in a meaningful way, (d) any or all illnesses and chronic diseases that accompany those who are experimenting favorably with the targeted hallmark should attenuate if not reverse.(5) Given the holistic principle of inter-connectedness, activating the Life-enhancing elements of one Hallmark should also activate other Hallmarks in a way that restores homeostasis via identifiable compensatory mechanisms.
This Presentation will thus look at the major macro-mechanisms or hallmarks that characterize the evolutionary-sculpted aging cascade and whose control promotes healthy lifespans to at least 120 years.
The Nine Central Hallmarks of Aging
The scientific community on biogerontology and geroscience is more or less in unison with the following hallmarks of aging that are briefly described below and which will be better developed during the power point presentation. They were summed up and developed in an article written by Carlos Lopez-Otin et al and published in the peer reviwed Journal “Cell” in 2013 (The hallmarks of aging, Cell, June 2013, 153 (6); 1194-1217). However, not all scientists agree on all of the causes that explain these nine hallmarks of aging, and in particular, the hierarchy of causation (which causes are the most important)..
1. Genomic instability.
Genome instability is defined as higher than normal rates of DNA mutation. Mutation is not necessarily bad, but under the circumstances of today, it is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution. But as we see today, genomic instability has catastrophic consequences for age-related diseases such as cancer and other chronic diseases as well as accelerated aging.
In terms of causation, mutations arise either from the molecular inactivation of DNA repair pathways or as a result of an overload of genotoxic stress from cellular processes such as transcription and replication that overwhelm high-fidelity DNA repair. As we will see in the power point presentation, exposure to external genotoxic agents (pollution) is a huge driver to genomic instability. (Annu Rev Genet. 2013;47:1-32. Source)
2. Mitochondrial DNA Break-down & Dysfunction
Mitochondrial function has a profound impact on the aging process. As cells and organisms age under non holistic conditions, the efficacy of the respiratory chain tends to greatly diminish, thus increasing electron leakage and reducing ATP generation. This mitochondrial decline is especially noticeable in tissues with high energy demand such as the heart and the brain. In this context, mutations and deletions in aged mtDNA contributes all the more to aging that the oxidative microenvironment of the mitochondria lacks protective histones in the mtDNA. (Human mitochondrial DNA (mtDNA) is a double-stranded, circular molecule of 16,569 bp and contains 3 genes encoding 13 proteins, 22 tRNAs, and 2 rRNAs. Recent mitochondrial transcriptome analyses revealed the existence of small RNAs derived from mtDNA). Likewise with the gradual erosion of the mtDNA repair mechanisms.
In eukaryotic (human) cells, most of the genetic material is nuclear, stored in the nucleus of the cell, where it is strongly protected. On the other hand, the genetic material within these bacteria-derived mitochondria is less protected. Hence, their significant contribution to both chronic diseases and accelerated aging. The loss of AMPK expression as well as Telomere Length and TERT (telomerase) loss have also been associated with mitochondrial biogenesis dysfunction. (Source)
3. Telomere Shortening and Telomerase Depletion
Normal aging is accompanied by telomere attrition in mammals. Which means, the more somatic cells divide, the less long are telomeres. Once this cellular division reaches what is called the Hayflick peak or limit, they go into Sencescence. Molecularly, telomeres are short sequences of nucleotide repeats found at both ends of each chromosomes. Telomere length shortens with each cell division, which contributes to the normal process of cellular aging and sets an upper limit on cell lifetimes.
Telomeres provide genomic stability to normal cells and act as a tumor suppression mechanism. (Source). Telomere shortening takes place faster in animals that age faster than those that age slowly. Likewise with Proregia children where pathological telomere dysfunction dramatically accelerates their aging. On the other hand, the experimental stimulation of telomerase delays aging in both mice as well as in human cells in vitro. In Longevity medicine, the more one’s telomeres are maintained in good shape, in general, the longer he or she can extend lifespan. As we will teach in this workshop, there are a few holistic techniques we can activate that help humans to maintain cells’ TL (telomere length). But because of the interconnectedness principle, for meaningful life extension, telomere therapy by itself is not sufficient.
4. Epigenetic Alterations
The epigenome appears to be the master program which controls the expression of the genetic code by switching off and on genes and their proteins. There are multiple lines of evidence suggesting that aging is accompanied by epigenetic switches and that epigenetic perturbations can provoke, among other examples, progeroid syndromes in model organisms.
Furthermore, SIRT6 exemplifies an epigenetically relevant enzyme whose loss-of-function reduces longevity and whose gain-of-function extends longevity in mice (Kanfi et al., 2012; Mostoslavsky et al., 2006). Collectively, these works suggest that understanding and manipulating the epigenome holds promise for improving age-related pathologies and extending healthy lifespan. (Talens et al., 2012). In this Power Point Presentation, we will see more in detail how epigenetic changes involve alterations in (a) DNA methylation patterns, (b) post-translational modification of histones, and (c) chromatin remodeling.
5. Loss of Proteostasis
The decline in the protein quality of our cells, called the loss of protein homeostatis or proteostasis, is a fundamental mechanism of aging. (Powers et al., 2009). Even though our bodies have defenses against cellular stress, after decades of repeated assaults by stressors such as free radicals, waste material and toxins, the proteins in our cells become damaged. As a result, they misfold. Amyloidosis from which many supercentenarian die is a misfoldment of protein problem All cells take advantage of an array of quality control mechanisms to preserve the stability and functionality of their proteomes.
Proteostasis involves mechanisms for the stabilization of correctly folded proteins, most prominently the heat-shock family of proteins, and mechanisms for the degradation of proteins by the proteasome or the lysosome (Hartl et al., 2011; Koga et al., 2011; Mizushima et al., 2008). The activities of the two principal proteolytic systems implicated in protein quality control, namely, the autophagy-lysosomal system and the ubiquitin-proteasome system, decline with aging (Rubinsztein et al., 2011; Tomaru et al., 2012), supporting the idea that collapsing proteostasis constitutes a common feature of old age. However, there are holistic and genetic ways to to improve proteostasis.
6. Deregulated Nutrient-sensing
The “deregulated nutrient sensing” was the first hallmarks to be described to influence aging in animals, through the insulin and IGF‐1 signaling pathway (IIS) (Kenyon, 2005). IGF‐1 is produced by several cells types (mainly hepatocytes) in response to GH release from the anterior pituitary. IGF‐1 has been shown to trigger the same intracellular signaling pathways stimulated by insulin. The IIS pathway is the most evolutionarily conserved pathway of aging, shown to modulate lifespan in model organisms across a great evolutionary distance from Caenorhabditis elegans to mice (Kimura et al., 1997; Tatar et al., 2001; Fontana et al., 2010; Kenyon, 2010b; Mercken et al., 2013). Accordingly, genetic polymorphisms/mutations that cause loss of function of GH, IGF‐1 receptor, insulin receptor or its downstream factors, have been implicated in human longevity as in model organisms (Fontana et al., 2010; Kenyon, 2010b; Tazearslan et al., 2011; Barzilai et al., 2012; Milman et al., 2014). Dietary restriction is a well‐known environmental signal shown to expand lifespan in eukaryote species, from yeast to primates (Colman et al., 2009; Fontana et al., 2010; Mattison et al., 2012).
The “longevity response” to dietary restriction is regulated by several nutrient‐sensing pathways: the kinase TOR, AMP kinase, sirtuins, and the IIS (Kenyon, 2005). Current available evidence supports the idea that anabolic signaling accelerates aging, and decreased nutrient signaling extends longevity (Fontana et al., 2010). Even more, a pharmacological manipulation that mimics a state of limited nutrient availability, such as rapamycin, can extend longevity in mice (Harrison et al., 2009). In other words, less is more when it comes to this signaling pathway, as shown with worms, flies and mice (Fontana, op cit.) In addition to the IIS pathway that participates in glucose-sensing, there are three other pathways to the nutrient-sensing systems: mTOR, for the sensing of high amino acid concentrations; AMPK, which senses low energy states by detecting high AMP levels; and sirtuins. In Holistic medicine, we have techniques to help modulate these pathways.
7. Cellular Senescence
When telomeres shorten, cells can’t divide anymore, at which point they become senescent. When we are vibrant, senescent cells are thought to be cleared by the immune system, but when we are older, they stick around secreting harmful inflammation molecules and sticking to healthy cells. Canakinumab was manufactured to dampen this senescence inflammation called infammaging. But this drug has its limits. On the other hand, with holistic medicine, we have tools to assist in the removal of these inflammatory pro-aging senescent cells. (Source)
Technically, cellular senescence can be defined as a stable arrest of the cell cycle coupled to phenotypic changes (Campisi and d’Adda di Fagagna, 2007; Collado et al., 2007; Kuilman et al., 2010) This phenomenon was originally described by Hayflick in human fibroblasts serially passaged in culture (Hayflick and Moorhead, 1961). Today, we know that the senescence observed by Hayflick is caused by telomere shortening (Bodnar et al., 1998), but there are other aging-associated stimuli that trigger senescence independently of this telomeric process. Most notably, non-telomeric DNA damage and de-repression of the INK4/ARF locus, both of which progressively occur with chronological aging, are also capable of inducing senescence (Collado et al., 2007).
In addition to DNA damage, excessive mitogenic signaling is the other stress most robustly associated to senescence. A recent account listed more than 50 oncogenic or mitogenic alterations that are able to induce senescence (Gorgoulis and Halazonetis, 2010). All in all, cellular senescence appears to be a beneficial compensatory response to damage that becomes deleterious and accelerates aging when tissues exhaust their regenerative capacity. It’s been shown that a moderate enhancement of the senescence-inducing tumor suppressor pathways appears to be able to extend longevity (Matheu et al., 2009; Matheu et al., 2007), and, at the same time, elimination of senescent cells in an experimental progeria model has delayed age-related pathologies (Baker et al., 2011). Therefore, two interventions that are conceptually opposite are able to extend healthspan.
8. Stem Cell Exhaustion
Stem cell exhaustion unfolds as the integrative consequence of multiple types of aging-associated damages and likely constitutes one of the ultimate culprits of tissue and organismal aging. The decline in the regenerative potential of tissues is one of the most obvious characteristics of aging. For example, hematopoiesis declines with age, resulting in a diminished production of adaptive immune cells, a process termed immunosenescence, and in an increased incidence of anemia and myeloid malignancies (Shaw et al., 2010). A similar functional attrition of stem cells has been found in essentially all adult stem cell compartments, including the mouse forebrain (Molofsky et al., 2006), the bone (Gruber et al., 2006), or the muscle fibers (Conboy and Rando, 2012). Studies on aged mice have revealed an overall decrease in cell cycle activity of hematopoietic stem cells (HSCs), with old HSCs undergoing fewer cell divisions than young HSCs (Rossi et al., 2007). This correlates with the accumulation of DNA damage (Rossi et al., 2007), and with the overexpression of cell cycle-inhibitory proteins such as p16INK4a (Janzen et al., 2006).
As we oxidize (ie, age by losing electrons) our stem cells eventually lose their ability to divide and thus go into decline, at which point our bodies are unable to replace the stem cells that have migrated, differentiated, or died. Hence, the increase of age-related disorders, if only because the main function of stem cells is to replace damaged tissues. Because stem cell exhaustion is an important hallmark of aging, geroscientists are working on attempts to rejuvenate stem cells. Promising studies suggest that stem cell rejuvenation may reverse the aging phenotype at the organismal level (Rando and Chang, 2012). Integrative and regenerative medicine focuses on the early “banking” (storage) of stem cells that can be inoculated to worn out tissues when needed. Holistic medicine’s focus is on preserving and boosting one’s own stem cells. (Source)
9. Altered Intercellular Communication
Beyond cell-autonomous alterations, aging also involves changes at the level of intercellular communication, be it endocrine, neuroendocrine or neuronal (Laplante and Sabatini, 2012; Rando and Chang, 2012; Russell and Kahn, 2007; Zhang et al., 2013). As a consequence, neurohormonal signaling (eg, renin-angiotensin, adrenergic, insulin-IGF1 signaling) tends to be deregulated in aging as inflammatory reactions increase, immuno-surveillance against pathogens and premalignant cells declines, and the composition of the extracellular environment changes, thereby affecting the mechanical and functional properties of all tissues.
A prominent aging-associated alteration in intercellular communication is ‘inflammaging’, i.e. a smoldering pro-inflammatory phenotype that accompanies aging in mammals (Salminen et al., 2012). Inflammaging may result from multiple causes such as the accumulation of pro-inflammatory tissue damage, the failure of an ever more dysfunctional immune system to effectively clear pathogens and dysfunctional host cells, the propensity of senescent cells to secrete pro-inflammatory cytokines (see section on Cellular Senescence), the enhanced activation of the NF-κB transcription factor, or the occurrence of a defective autophagy response and SIRT6 may also down-regulate the inflammatory response through deacetylation of NF-kB subunits and transcriptional repression of their target genes (Kawahara et al., 2009; Rothgiesser et al., 2010).
Beyond inflammation, accumulating evidence indicates that aging-related changes in one tissue can lead to aging-specific deterioration of other tissues, explaining the inter-organ coordination of the aging phenotype. In addition to inflammatory cytokines, there are other examples of ‘contagious aging’ or bystander effects in which senescent cells induce senescence in neighboring cells via gap junction-mediated cell-cell contacts and processes involving ROS (Nelson et al., 2012). The microenvironment contributes to the age-related functional defects of CD4 T cells, as assessed by using an adoptive transfer model in mice (Lefebvre et al., 2012). Likewise, impaired kidney function can increase the risk of heart disease in humans (Sarnak et al., 2003).
Summary on the First Nine Hallmarks
The common characteristic of the first four hallmarks is the fact that they are all pretty much delerious to the body’s ability self-repair and thrive. This is the case of DNA damage, (including chromosomal aneuploidies), mitochondrial DNA mutations, telomere loss, epigenetic drift, and defective proteostasis. These hallmarks are often initiating and their damaging events progressively accumulate with time.
The next hallmarks appear to generate compensatory mechanisms that can mitigate the nefarious effects of the first hallmarks. However, while at low levels, they mediate beneficial effects, at high levels, they can become deleterious. This is the case for senescence, which protects the organism from cancer, but in excess promotes protein misfoldment and aging. Similarly, reactive oxygen species (ROS) mediate cell signaling and survival, but at chronic high levels produce cellular damage. And while optimal nutrient-sensing and anabolism mechanisms are key for survival, in excess then become counter-productive. These hallmarks can be viewed as designed for protecting the organism from damage or from nutrient scarcity, but when exacerbated or chronic, they generate further damage.
As for the last two hallmarks, stem cell exhaustion and altered intercellular communication, these can further messed up the body’s integrity by impacting its entire tissue homeostasis system. Notwithstanding the interconnectedness between all of these hallmarks and their evolutionary “conspiracy” to bury the host, happiness and holistic medicine can attenuate some of these mechanisms while reversing others.
The Happiness Medicine Institute’s excutive committee has identified additional hallmarks that both account for aging and offer possibilities for rejuvenation. First off, we have the Autophagy system whose mechanism of action is key insofar as removing metabolic wastes. Likewise with the Lysosome Degradation system. As for the Tissue and DNA repair system, new findings show that humans have some control over its reinforcment. Then we have Circadian Rythms mechanism. This hallmark relative to the circadian pathway is relatively new. The 2017 Nobel Prize in Physiology (Medicine) went to scientists who dug deep to unravel some of the mysteries of circadian biology. When humans don’t respect Nature’s rhythms like the sleep-wake (melatonin-cortisol) cycle, aging is accelerated big time.
Another new player is the Circular RNAs (circRNAs) system. CircRNAs are a newly appreciated class of RNAs found across phyla that are generated most commonly from back-splicing of protein-coding exons. Recent profiling of circRNAs genome-wide has shown that hundreds of circRNAs dramatically increase in expression during aging in the brains of multiple organisms. No other class of transcripts has been found to show such a strong correlation with aging as circRNAs. They could play a key role aging process. (Source)
Then we have the Endocannabinoid engine. The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system. (Source) The endocannabinoid system is also involved in regulating a variety of physiological and cognitive processes including but not limited to general homeostasis and fertility, pregnancy, postnatal development, appetite, pain-sensation, mood, memory, neurogenesis, inflammation, the immune system and, among other biological systems, the longevity pathways, including, but not limited to brain rejuvenation (neurogenesis), significant Lou Gehrig’s Disease life extension and general longevity via the dietary restriction signaling pathway. This biological ECS system is at the heart of evolutionary biology, ontological experience and optimal longevity. It is so important that scientists have created a new deficiency disease called “Clinical Cannabinoid Deficiency” disorder. (Source)
While the body is able to activate the ECS’s endocannibinoid receptors on its own, given mainstream’s toxicity, stress and conventional synthetic drug and trauma based medicine, much of the human and mamalian endocannabinoid system is under-activated or inhibited. Hence, the lack of wellbeing and joie de vivre.. A holisti lifestyle with certain cannabinoid plants can partially remedy this deficiency, thanks to which a healthy lifespan can be better expressed Helichrysum, Echinacea, (containing cannabinoids called N-alkylamides), liverwort, black pepper and a few others plants that contain cannabinoids can help, but cannabis is by far the most abundant and rich in healthy and longevity producing cannabinoids, over 80 of them, all integrated within the “whole” in the right proportions. (Source)
With the recent “revolution” in medicine concerning the microbiome, (which in reality is over one hundred years old), we feel that we must characterize this field as a major hallmark of aging, if only because these little critters within, 700 trillion of them, have close to 8 million genes that cross-talk with our 23,000 eukaryotic genes. (ie, most medical journals speak about 2.4 million genes, but official sources point to 8 million, Source). Indeed, the Microbiota’s and the Microbiome’s networking are key not only in health and diseases, but also in longevity. As we will see, the very same bacteria who have been so essential in the complexification of Life over the last 65 millions of years are living in our guts churning away to make us either sick and short lived or healthy and long lived. For example, supercentenarians have a diversed amount of youthful bacteria whereas sick people who die young have lots of dysbiosis. Microbiome science has been one of the most recent scientific revolutions in Medicine, disproving a big chunk of mainstream medical dogmas. Today, to the bacteria-laden microbiome, micro-biologists have identified inter-related networks of viruses, archeae, fungi, yeast and parasites that all contribute one way or another to the process of human biology, chronic diseases and aging. There are few other mechanisms that we see as Hallmarks, but for now, the ones we have mentioned should be enough to better understand and act upon Evolution’s “genetic curse” or mistakes: short human lifespans characterized by narcissistic predation, diseases, suffering and the deficiency of JDV.
Longevity Mechanisms in supercentenarian & long-lived animals
In this Presentation, we will examine a few survival and longevity mechanisms that allow certain animals to both avoid cancer and optimize longevity way better than most humans. First, we will look at a few large animals. According mainstream science theory, the larger the animal, the more the animals risk for cancer should go up. This correlation has often been confirmed in humans , i.e., the larger and taller humans have way more cancers than smaller humans (Source). The explanation is straightforward. In a multicellular organism, cells must go through a cell cycle that includes growth and division. Every time a human cell divides, it must copy its six billion base pairs of DNA, and it inevitably makes some mistakes. These mistakes are called somatic mutations and carry with them high risks for carcinogenesis. Therefore, in theory, large bodied and long-lived organisms should face a higher lifetime risk of cancer simply due to the fact that their bodies contain more cells and will undergo more cell divisions over the course of their lifespan. At least way more than a smaller human. The evidence proves the contrary .(Source)
However, a close look at data confirms that this above-mentioned correlation does not apply to animals, including mammals, as long as they are in the wild. In effect, as long as they are in the wild and kept away for human corporate garbage food and pollution, large animals like whales (who have 2000 times more cells, so they should have 2000 times more random cancer risks (Source)), sharks and elephants not only have very little (if any) cancer, but they surpass Hayflicks “biological clock” limit way better than humans by living hundreds of years.
By sequencing the genes of some of these animals, scientists were able to determine that these animals have perfected some of the same biological mechanisms humans have. For the bowhead whale (Balaena mysticetus) mammal, its innate intelligence has developed, inter alia, strong tumor suppressor genes (Source), hence, it’s ability to multiply trillion and trillions of cells without getting cancer and living over 200 years, as long as they avoid fishermen’s nets. (Source)
“The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance”. (Source)
Let’s look at lobsters. There is a debate among the scientific community whether these red ocean dwellers are biologically immortal animals or not because they continuously grow and reproduce, unless killed by predators. One lobster captured off the coast of Newfoundland was estimated to be 140 years old. (Source) These lobsters are like those big female turtles (tortoises) who also get to reach the supercentenarian status, the more they age, the more eggs and fertility they have. The New York Times reports that turtles might even be able to live indefinitely if they are able to avoid predators and disease.
Then we have a special A islandica clam called “Ming the Mollusk”,who was able to have reached over 500 years. (Source) Scientists believe that the ocean quahog’s longevity is related to its resistance to oxidative stressors.
. “Our findings demonstrate an association between longevity and resistance to oxidative stress–induced cell death in A islandica, consistent with the oxidative stress hypothesis of aging and provide justification for detailed evaluation of pathways involving repair of free radical–mediated macromolecular damage and regulation of apoptosis in the world’s longest-living non-colonial animal.” (Source)
Greenland sharks are also interesting super supercentenarians since they can surpass 400 years old and the don’t seem to reach sexual maturity until they are 150 years old, which is quite an anti-Darwinian behavior. The deep sea Rockfish also live for hundreds of years. What are their secrets ? Brandt’s bats, small mammals found throughout Eastern Europe and parts of Asia also live long lifespans, over 40 years, as long as they stay in the wild and are not killed. (Source) Maybe their secret is enjoying “siesta”., because this species loves to hibernate. They also have interesting hormone receptors. As for the Proteus fish, these can live for over 100 years. Proteus has a high tolerance to low oxygen levels, something that’s also true of naked mole rats and ocean quahogs.
Top: The naked mole rat who also broke the world record for longevity in its category
Negligible senescence in the longest living rodents, the naked mole-rats & their DNA repair system
Another animal, in this case a mammal, that is studied a lot in longevity medicine is the naked mole rat. This rodent is smaller than the common rat, but lives up to 32, as opposed to 3 years for the common rodent and like Jeanne Calment, holds the record for the longest living sentient being in its category, in this case the rodent genus. (Buffenstein R, Jarvis JU (May 2002). “The naked mole rat–a new record for the oldest living rodent”. Science of Aging Knowledge Environment. 2002 (21): pe7. (Source) And this naked rat lives long by staying healthy nearly to the end of their lives just like Jeanne Calment. What is his or her secret ? One possible secret may be hyaluronic acid. Just like one of Calment’s “secrets” to her smooth skin was Mediterranean oil olive she loved to pour on her skin, the naked rat also produces a vast amount of hylaluronic acid juice for an extra glowing naked body, which may be in part due to the overexpression of the gene that controls this natural beauty molecule. Indeed, the Naked mole rat produces an unusual form of hyaluronic acid, and in very high quantities, so that very large and de-bonded acid molecules saturate the tissues, providing antioxidant properties and possibly blocking cancer growth. There are other theories why the naked rat is resistant to cancer. (Source) This mammal also benefits from a clean and healthy vascularture, much more robust that the shorter-living rats. (Source) The reason for their longevity is still not settled, but at this point, it’s believed to be related to their ability to substantially reduce their metabolism during hard times, and so prevent aging-induced damage from oxidative stress. (Source) Their longevity has also been attributed to “protein stability.” (Pérez VI, Buffenstein R, Masamsetti V, Leonard S, Salmon AB, Mele J, Andziak B, Yang T, Edrey Y, Friguet B, Ward W, Richardson A, Chaudhuri A (March 2009). “Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat”. Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3059–64. Thanks to their extraordinary longevity, an international effort was put into place to sequence their genome. Further transcriptome sequencing (ie, transcriptome is the set of all RNA molecules in one cell or a population of cells) revealed genes related to mitochondria and oxidation reduction processes to have high expression levels in the naked mole-rat when compared to mice. (Source) In this perspective, the DNA repair transcriptomes of the liver of humans, naked mole rats and mice were compared. (Source) And low and behold, it was proven beyond any reasonable dought that these naked rats expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher level than did the other rodents. mouse. Furthermore, several DNA repair pathways in both humans and naked mole rats appeared to be well activated (expressed or up-regulated) in relation to the other rodents. (Source) These findings suggest that DNA repair is Key in longevity.
Gompertz Aging law and Biological “Immortality”
Biological immortality (sometimes referred to bio-indefinite mortality) is a state in which the rate of mortality from senescence is stable or decreasing, thus decoupling it from chronological age. Negligentable senescence can be included in this realm. Various unicellular and multicellular species, including some vertebrates, achieve this state either throughout their existence or after living a very long lifespan, cruising without diseases in a phase called “late-life mortality plateau” which some supercentenarian humans like Ms Calment have experienced. A biologically immortal living being can still die from means other than senescence, such as through injury or disease. Or they can slowly die at a very old age from a lack of ATP energy, like some lobsters, when they don’t have enough energy to build a new big shell to protect themselves from predators. According to mainstream Darwinian thinking, senescence or aging is necessary among humans because first, aged beings can’t reproduce well past their “prime” and make strong & healthy offsprings and second, there are not enough resources for everyone if people stayed around for too long.
In this Presentation, we will debunk both these propositions. Similary with Gompertz Aging law. This law provides (mathematically) that the increase in mortality with the passage of time (aging) tends to be logarithmic (exponential) (Source) In other words, the more we live, especially after 40 years old, the faster and faster our tissues get metabolically impaired. Concomitantly, the expression of deleterious genes accompany this maccabre dance to the graveyard. While it’s true that some people can oxidize and age faster and faster as death approaches, (Source), holistic lifestyle can significantly minimize this pace while optimizing the JDV space.
Tentative Concluding Remarks on Senescence and Aging mechanisms
One of the key lessons the ageless Hydra gives us is based on stem cells that don’t decline over time. (cf stem cell biology of the hydra). With an abundant and continuous supply strong stem cells and an ability to eliminate the cumulative buildup of misfolded proteins and aggregate waste products, the entire Hydra organism can be replaced over a short period of time provided it can find the metabolic resources to do so (ie, as it does with its symbiotic friendship with algae and corrol reefs).
Thomas Bosch from the Zoological Institute of Kiel University, who led an important Hydra study wrote that the longevity gene “… FoxO has been found to be particularly active in centenarians – people older than one hundred years – which is why we believe that FoxO plays a key role in ageing – not only in Hydra but also in humans”. (Source) And one of the reasons that this longevity gene FoxO is important is because it:
“ .. plays a decisive role in the maintenance of stem cells. It thus determines the life span of animals, from cnidarians to humans”.(Source)
As suspected then, The “Grand Master” called Evolution or God has designed foxy genes to better control and activate longevity via multiple mechanisms including but not limited via the production of an abundant supply of telomerase-rich stem cells.
“These findings contribute to a molecular understanding of Hydra’s immortality, indicate an evolutionarily conserved role of FoxO in controlling longevity from Hydra to humans, and have implications for understanding cellular aging (Source)
To optimize longevity then, what is therefore needed is a continuous supply of quality food and stem cells and a system or systems of removing aggregate debris and senescent cells. With a little help from our trillions and trillions of gut critters (archae, bacteria, fungi, and, inter alia viruses) and holistic savoir-faire, the immune and autophagy systems can satisfactorily accomplish this last task.
In Search of one unified theory of aging
While seemingly disparate, all of the aging mechanisms we have reviewed are inter-connected. Affecting one affects others. However, in all synergistic systems, there is usually a Core pathway, a Kingpin that prevails over the other pathways. Biogerontoligist spend much of their time trying to ascertain this Core. If and when such a Core will be established and replicated, with solid evidence that humans can optimize their lifespan to 120 years with few if any chronic diseases by significantly rejuvenating the key biomarkers of aging, then Biogerontology will have decoded the correct Unified Theory of Aging.
We are now ready to examine how holistic medicine can contribute to down-regulate the aging mechanisms and optimizing healthy lifespans. But first, we need to unmask conventional medicine’s research limitations (weaknesses) and delve into methodology.
Session G: Research, Methodology & Legal Perspectives
“The case against science is straightforward: much of the scientific literature, perhaps half, may simply be untrue. Afflicted by studies with small sample sizes, tiny effects, invalid exploratory analyses, and flagrant conflicts of interest, together with an obsession for pursuing fashionable trends of dubious importance, science has taken a turn towards darkness.” (Lancet Journal)
Medicine is a field of knowledge that is fraught with unreliability, contradictions, incompetence, careerism, conflicts of interests, fraud and change. Its published research findings are often refuted by subsequent evidence. Refutation and controversy is seen across the range of biomedical research designs, from clinical trials and traditional epidemiological studies to the most modern molecular research. Furthermore, much of biomedical research isn’t even reproducible. And there is increasing concern that in modern conventional biomedical research, false findings may be the norm. Integrative medicine is better, but also has it’s flaws.
“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of the New England Journal of Medicine” (“Dr. Marcia Angell, a physician and longtime Editor in Chief of the New England Medical Journal (NEMJ), which is considered to another one of the most prestigious peer-reviewed medical journals in the world). (Source)
In this Presentation, we will review the relevant facts with regard to methodological problems.
How to Find reliable scientific Data
Not always, but too often conventional medicine’s research experts use bias, reductionism and misleading statistical and rhetorical tricks to promote just about anything they get paid for. Integrative medicine’s experts are not immune from this human frailty either, occasionally using and abusing the People’s credibility and science virginity with biased studies on certain supplements, nutritional regimes, procedures and diagnosis tools. But the most pervasive harm that kills and maims the most patients (in the millions each year) comes from spined government-promoted studies that are ofen financed by conventional science’s food, agricultural, pharmaceuticaland medical industries, in particuar with regard to oncology, cardiology, neurology and metabolic diseases. A few illustrations will follow.Thereafter, we will give guidelines that can help to navigate the system so that accurate and relevant data can be established.
Are Animal Experimentation studies reliable ?
A careful look at the litterature shows that more often than not, animals will react differently than humans when they are being used as experimentation agents. Even if we share many common genes, they are still metabolically quite different. Which means that many times, they will produce physiological effects that are different from humans and the information collected from animals will be expensive and not be very useful for root cause based human medicine. Yet, animal research is at the core of American biomedical research..
“The resulting evidence suggests that the collective harms and costs to humans from animal experimentation outweigh potential benefits and that resources would be better invested in developing human-based testing methods. (Source)
For example, while over 100 human clinical trials testing anti-inflammatory drugs have failed, these have all been successful in mice trials. There have been a lot of similar results in the biomedical field with other experimentation.
“A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent. Here, we show that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another. Among genes changed significantly in humans, the murine orthologs are close to random in matching their human counterparts (e.g., R2 between 0.0 and 0.1). In addition to improvements in the current animal model systems, our study supports higher priority for translational medical research to focus on the more complex human conditions rather than relying on mouse models to study human inflammatory diseases” (Source)
On the other hand, if the goal is to better undersand biochemical pathways and metabolic cascades regarding physiological processes like aging, then the use of rodents, worms, yeast and flies can be useful because we do share a pool of similar gene groups with all of cellular “Life”, hundreds of gene groups that have been identified 3.5 billions years ago from what is called the “Last universal common ancestor” and 6,331 gene groups common to all living animals that have been identified from a single most recent “common universal ancestor” around 650 millions years ago in the Precambrian. (Cf. Borenstein, Seth (13 November 2013). “Oldest fossil found: Meet your microbial mom”. Associated Press)
So for the task of better understanding underlying physiological mechanisms, animals have helped us, and in actuality, the mouse has been instrumental in 51 Nobel prizes. But for root-cause holistic medicine, the sacrifices of animals on the altar of medical research is not necessary. On the other hand, for conventional medicine bent on treating symptoms with synthetic drugs, experimenting with animals is a sine qua non condition to research. But if root causes are the issue, then HM Institute posits that it would be more cost-effective, efficient and ethical to experiment directly with humans.
Medical Law: Liability, the Standard-of-Care & the Legal Protection of Alternative Medicine & Innovative Medical Research
“The medical profession is being bought by the pharmaceutical industry, not only in terms of the practice of medicine, but also in terms of teaching and research. The academic institutions of this country are allowing themselves to be the paid agents of the pharmaceutical industry. I think it’s disgraceful.” Arnold Seymour Relman (1923-2014), Harvard Professor of Medicine and Former Editor-in-Chief of the New England Medical Journal
We need to invoke the Law because most (not all, just most) of Mainstream medicine can not continue to be one of the top killers (and hence anti-longevity perpetrators) without the active complicity of the legal system. By “legal system” we include courts, law schools, law-makers, their donation lackeys and a few other players. In other words, it’s impossible to understand, let alone change the medical system and public health policies without examining the law and its limitations.
In this perspective, one of key notions this Workshop will often speak about is the “standard of care”. We think of the “standard-of-care” as the definition of proper scientifically based care that a patient receives from the medical establishment. However, this representation is misleading. Standards of care in the US are not based on Science. They are based on what the “Medical Community” thinks is Science. Ther a huge difference between what mainstream trained doctors think of what Science is and what Science is. We will therefore demonstrate with a decent preponderance of the evidence that the primary function of conventional medicne’s “standard of care” mantra is to quickly and impersonally deliver symptoms-only cash-maximizing medical treatment. If only to insure that the patient will come back for more.
In this presentation, we will also share power point information for the benefit of alternative health-care providers on liabilities as well as on legal protection techniques that can be implemented in order to avoid legal pitfalls and thrive as best as possible under the present circumstances. In addition, key arguments that can be invoked in a Court of law when arbitrary legal attacks hit (from Medical Boards, FDA, FTC, frivolous patients, et al) will follow as well as a brief discussion of Patients’ Fundamental Health Rights and Doctors’ Duties.
Case Study on Autologous Stem Cells, Cancer and the FDA
The Fact: Just recently, the FDA with the US Department of Justice filed suit against American stem cell clinics alleging that these clinics are using unproven and damaging stem cell therapies.
“The FDA will not allow deceitful actors to take advantage of vulnerable patients by purporting to have treatments or cures for serious diseases without any proof that they actually work,” said FDA Commissioner Dr. Scott Gottlieb (Source).
Prima facie (on the face), these alleged facts sound plausible. And mainstream media, the one who survives on pharmaceutical ads, often publish stories where alternative clinics mess up, including in stem cell therapy. (Source). But does that mean that the entire autologous stem cell industry is wrong and without supporting evidence that stem cell injections may be a better option over conventional medecine’s drugs and surgery ? What the above-mentioned FDA statement targeted was the following practice.
“The lawsuit seeks to stop U.S. Stem Cell Clinic and related parties from performing a surgical procedure using stem cells from autologous adipose tissue, even when a physician and patient agree that such a procedure is in the best interest of the patient. USRM believes that the patient and physician have the right to decide whether or not to use a patient’s own cells for a therapeutic purpose without federal government interference”. (Source)
Autologous stem cells means that these cells are one’s own. So that this Government interference mean that our own body is under the Government’s purview (jurisdiction), that our cells are analagous to a “drug” ? This question may become a writ of certiorari issue for the US Supreme Court. The facts suggests that this type of Government interference has gone on for many decades. But the more the Government interferes, the more stem cell clinics seem to be spreading, just like with medical cannabis clinics and other alternative therapies. So the central issue before the Court of Public Opinion is this. Could it be that these Government’s agents sole purpose in tightly regulating this market is to favor their re-election (or renomination) and Big Pharma’s corporate shareholders (wherein some of these public agents have financial assets), the industry that has been the number one in terms of election campaign donations ? Because in terms of safety and efficacy, the autologous stem cell industry is much less dangerous and more efficient than conventional medicine, even if there can on occasion be abuse (which in most cases can be addressed with tort law, it’s anticonstitutional and violative of international law for Government agents to hinder the progress of medical innovation and therapeutic freedoms, especially when the motives are based on self-aggrandizement and to self-enrichment via the big pharma bribery pathway).
Digging a little deeper, we find that concomitantly to suppressing medical freedoms and the free market, the FDA and it allies have been favoring huge Pharmaceutical Giants like Novartis in their own stem-cell projects. For these clients, the price tag is not 5,000 dollars (ie an average for an autologous (one own’s cells) stem cell “re-entry” injection), but more like 500,000 dollars an injection. One case in point is the cancer CAR-T treatment designed by Novartis and several other companies whose CEOs claim that each injection costs over 700,000 dollars, but out of humanity, they will go down to around $500,000 per injection. (Source) Novartis recently offered to reduce the price to 475,000 dollars per injection (Source) and the insurance companies are now considering paying for this.
CAR-T treatment is genetically manipulating infection-fighting T-cells that fight acute lymphoblastic leukemia, a form of blood cancer, in particular their T memory stem cells. (T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire spectrum of memory and effector T cell subsets). (Source)
Futhermore, because this drug also kills the patients B cells, these patients will need a 10,000 per month immunoglobulin IV. (ie, CAR-T CL leukemia treatment permanently puts in place a condition called B-cell aplasia). Immunoglobulin is already a big business generating about $8 billion in sales a year for drugmakers including Shire Plc, CSL Ltd., and Grifols SA. The antibodies are spun out of donated blood, and then sold at 10k an injection.
Since many of these patients are young, we are talking about over one million dollar of cancer and blood treatment, a proportion of which usually goes to pay politician-law-makers’ election campaigns, those where the US Supreme Court solemnly declared that official campaign candidates are both free to hide the source of finances and free to deceive via Ads the People in any election contest, Amendment One oblige. And nothing proves that these patients will thrive long term, let alone make it to 120 years. On the contrary, most of conventional oncology spurs the very underlying mechanisms that are responsible for accelerated aging.
In this Presentation, we will briefly examine whether the Government attorneys have met their burden of proving with a preponderance of the evidence two related claims: First that well performed stem cell therapy (for any diseases, especially for progressive joint disorders) is harmful and performing it would not constitute the “loss of chance” cause of action. (i.e., “the loss of chance” argument is a major one in medmal law). Second, that promoting only conventional cancer therapies that cost over one million dollars is not violative of informed consent and other aspects of the law in that both integrative and holistic oncology have consistently shown that these types of cancer (leukemia and other liquid and solid cancers) can be holistically treated in a cost-friendly way without the toxic and often debilitating life-long side effects of the Government-promoted conventional oncology industry. Etc and inter alia (inter alia is a legal term that means “among other things”). Tentative conclusion: RICO, the federal racketeering statute, was invoked in the Big Tobacco prosecution with some success. Does this statute apply to the Big Pharma consortium or cartel and those in the Government who willingly make this cartel richer and richer ? Just a question to ponder upon. This question is relevant in Longevity medicine, because without the respect of the fundamentals of basic Justice, public health and the conditions of wellbeing are greatly obstructed or compromised.
Top: coronary heart disease can be easily detected with a simple ear examination anyone can do
Session C: Holistic Cardiology in a Nutshell. Extended Lifespans need Strong Hearts & Smooth Vasculature
“Keep a quiet heart, Sit like a tortoise, Walk sprightly like a pigeon, Sleep like a dog” (Longevity advise from Li Ching-Yuen. Li was a mountain herbalist & a wine enthusiast who seemingly lived to 197 years.
Healthy extended lifespans need healthy epithelium. If the lining of the vessel walls are not healthy, all of the other tissues are affected. Blood flow is key and both holistic and nutritional medicine focus on this priority by prescribing daily servings of nitric oxide promoting dark green veggies, inter alia. (legal jargon for “among other elements”). (Source) When the epitehlium is damaged, Cardiovascular diseases (CVD) abound. CVDs in the US constitute both the First cause of premature death and the easiest epidemic to fixed holistically. If holistic and happiness medicine were the standards of care, conventional cardiology would go bankrupt within days, thanks to which millions of Americans would avoid CVDs and get closer to acheive their 120 years potential.
In this Presentation, we will examine the hard evidence that shows that most of conventional cardiology is both outdated and laden with deleterious consequences that hinder the People’s birthright to live a healthy lifespan to 120 years. Concomitantly, we will prove via published power point studies that integrative and holistic cardiology are clinically safer, more effective and cost-friendlier.
Erectile Dysfunction (E.D.) is a “CVD canary in the Coal Mine” symptom that justifies an immediate rendez-vous with Cardiology Monitoring
The evidence is crystal clear, libido health for both men and women declines when arteries get clogged up. ED is the highest CVD risk, fourty times more than other risks factors, including high blood pressure and low NO (nitric oxide). It is a red flag, what the experts call a “canary in the coal mine”. As a consequence, an immediate check-up at the cardiologist’s office as well as a blast of Omega 3 rich algae oil and a scoop of powedered flax seeds may be indicated pronto.
In this Presentation, we will talk about a few holistic tips to restore both the endothelium and glandular health. These tips are way safer and more efficient than viagra and any other drugs on the market. Without proper cardiovascular “self-care”, human lifespan is unlikely to reach 80 years old.
Debunking myths & misleading claims regarding Fats
There is no question that humans need cholesterol and lots of it. That’s why human liver cells as well as intestinal, reproductive and adrenal cells make it. Cholesterol is so vital for all of our cells’ membranes, hormones inter alia, that humans also have a HDL-based cholesterol recycling system. Recent well designed studies confirm that those who die the youngest have low cholesterol (Source) while those who live the longest and healthiest have more cholesterol.
“High LDL-C is inversely associated with mortality in most people over 60 years”. (BMJ, Source)
However, there’s controversy. When the body’s sensors register dietary cholesterol, (coming from animal sources), it signals our cells to stop producing endogenous cholesterol. So is this “replacement” deleterious ? While most serious food scientists agree that we need cholesterol, many disagree with regard to the source and amount of cholesterol. The Keto-paleo schools argue that good heath requires lots of dietary cholestrol from animals while other food scientists argue the opposite, that the body’s own cholesterol should be the only source of cholesterol.
In this perspective, Dr. William Clifford Roberts, Executive Director of Baylor Heart and Vascular Institute and long-time Editor in Chief of the American Journal of Cardiology, has argued that atherosclerosis has only one single cause, dietary cholesterol. (Source) In other words, neither being stressed out, overweight, smoking, diabetic, sedentary are sufficient factors by themselves to trigger CVDs. Roberts concluded that the sine qua non condition for a fatal or nonfatal atherosclerotic event like a heart attack is a high cholesterol levels. Source) Other cardiologists like Drs Esselstyn, Kahn and Ornish argue that high animal dietary cholesterol and saturated fats not only promote CVDs, but they also promote many other chronic diseases, from kidney failure to cancer and fertility dysfunctions. And still other published authors show that statin drugs un-necessarily reduce needed cholesterol while depleting Co-Q-10 enzyme.
On the other hand, a landmark systematic review and meta-analysis of observational studies showed no clear correlation between saturated fat consumption and all-cause mortality.
“Conclusions Saturated fats are not associated with all cause mortality, CVD, CHD, ischemic stroke, or type 2 diabetes, but the evidence is heterogeneous with methodological limitations. Trans fats are associated with all cause mortality, total CHD, and CHD mortality, probably because of higher levels of intake of industrial trans fats than ruminant trans fats. Dietary guidelines must carefully consider the health effects of recommendations for alternative macronutrients to replace trans fats and saturated fats”. (BMJ 2015, Source)
So does CVD pathogenesis and treatment require a paradigm shift ? Should we now all eat lots of animal cholesterol and saturated fat ? This Presentation we will attempt to clarify the cholesterol-fat debate and determine safe holistic protocols that safely promote endogenous cholesterol as well as all of the other types of good fatty acids the body and brain need for optimal functioning.
To Salt or Not to Salt ? The Evidence on Salt and CVD Diseases
In this Section, we will examine the salt question. Studies in Europe concluded that more salt is better for the health than less salt, including for CVD patients, provided the salt is not toxic and of the French celtic type, full of healthy minerals and trace minerals, over 60 of them. In the US, studies showed the opposite effects, the more salt was consumed, the more arterial stiffness, high blood pressure and CVD were seen. The Centers for Disease Control and Prevention (CDC) states that excess sodium can increase blood pressure and the risk for a heart disease and stroke in some individuals. (Source). Therefore, health authorities recommend limitations on dietary sodium. The United States Department of Health and Human Services recommends that individuals consume no more than 1500–2300 mg of sodium (3750–5750 mg of salt) per day (Source).
Japanese experts also found a link between higher sodium intake and an increased risk of hypertension (Takase et al, Journal of the American Heart Association, July 29, 2015; Murai et al, Journal of Hypertension, June, 2015, (Source). And a meta-analysis of 34 randomized trials found that modest salt reduction, to around 3 g/day, for at least a month lowered blood pressure significantly (He et al, BMJ, April 3, 2013). And still another study showed that everyone reacts differently, not everyone benefits from cutting salt, this study found no connection between sodium or potassium intake and elevated blood pressure (Sharma et al, Journal of Clinical Hypertension, April 11, 2014 (Source). And still other studies demonstreated that low salt (below 3 grams per day) was the worse of the worse in termso of promoting CVDs. (Source)
“Published in The Lancet, the study found that low salt, or sodium, intake may raise the risk of heart attack, stroke, and death, compared with an average salt intake. (Source)
In this Presentation, we will debunk myths, unmasks flawed studies and show the hard evidence with regard to the salt question. There is no question that Sodium is an essential nutrient, its ions are needed in small quantities by most living things, as are chloride ions. Salt is involved in regulating the water content (fluid balance) of the body. The sodium ion itself is used for electrical signaling in the nervous system and other bodily functions. (Source) One of the keys lies in the quality of the salt as well as its synergy with other food spices and food. Refining salt so that only sodium chloride is left is a miserable mistake like all refinement. Salt should be consumed unrefined and with quality food. It is thus likely that most American conventional and integrative cardiologists are misguided they recommend law-salt intake.
Case Studies: Reversing Cardio-vascular diseases (CVDs) with Holistic Cardiology
Section under construction
Session D: Detoxification & Cleansing for Optimal Longevity
“There were never so many able, active minds at work on the problems of disease as now, and all their discoveries are tending toward the simple truth that you can’t improve on nature.” (Thomas Edison, 1902)
In Conventional medicine, the Government’s N.I.H experts claim that “…there isn’t any convincing evidence that detox or cleansing programs actually remove toxins from your body or improve your health. Weight loss on a detox diet may be because these diets are often very low in calories” (Source) while independent but conventional scientists in peer-reviewed studies will outrightly debunk detoxification techniques as being useful for disease reversal and longevity. On the other hand, experts in the integrative-functional-holistic fields validate detoxification’s powerful impact on healing. After assessing the pros and cons of holistic and metabolic detoxification, the Happiness Medicine Institute has determined that detoxification in general is overwhelmingly supported by the evidence and constitutes a powerful rejuvenation technique, notwithstand a few isolated and unsupported cash-flow motivated claims in the alternative health field.
In this section, we will thus compare the arguments and facts with regard to the pros and the cons of different detox techniques and then make a reasonable determination as to where the preponderance of the evidence lies regarding some of the more popular detoxificataion claims that are invoked in the integrative and holistic fields: in particular: anemas, colonics, saunas, ionic foot baths, detox supplements (clays, ALA, Nac, milk thistle etc), diet, fasting, sweating, exercises and more.
The Body’s has Six Key Metabolic Detoxification Pathways that need to be activated and fined-tuned
There are 6 Phase II detoxification pathways in the body that need to be in good shape for Life to durably withstand the passage of time. Each conjugation pathway serves a specific purpose of detoxifying certain toxins and toxicants. These biochemical pathways require specific nutrients to function. These 6 detoxification pathways include: Glutathione conjugation, Methylation, Sulfation, Acylation/Glycation, Acetylation, and Glucuronidation. In this presentation, examine how to best activate these pathways.
Sauna, Hydrotherapy & Hot tub Therapies
While most health practitioners will agree with the importance of using a Sauna to better detox, most health practitioners will not recommend safe and efficient holistic protocols that should accompany sauna therapy as sweating is not enough to get rid of toxicants, if only because some of the released toxins and toxicants find their way back into the blood circulation where they can create havoc. In this Presentation, the H.M. Institute’s Holistic Approach to Sauna Detox and Hydrotherapy will be detailed.
Removing Glyphosate ASAP
Every generation and civilization has major toxicity challenges. In this Presentation, we will look at Glyphosate’s impact on over 15 common diseases and chronic conditions, delve into different protocols that can safely remove most of this ubiquitous poison. We will conclude with a word on testing.
Home Detox from the Sick Building Syndrome
We will also review the “home toxemia” challenge, the list of which is extensive. This Seminar’s section is important because holistic medicine’s first task is to identify the deep underlying causes to diseases and many of these causes are found in one’s living area and in the workshopee’s lifestyle. Just the air inside most homes have been determined to be up to five times worse than the air pollution outside, wrote the U.S. Environmental Protection Agency (ie, other sources say 10 times worse), while the W.H.O found that 4.3 million people die each year prematuraly from the air inside homes. (Source) To make matters worse, the non-profit Environmental Working Group tested over 2,000 cleaning products, and found that most of them contain chemicals that are linked to asthma, allergies, or even cancer. EWG found that, because American product manufacturers or distributors aren’t required to disclose all their ingredients, many of them don’t. Still worse, with electromagnetic and dirty electricity pollution, formaldehyde and arsenic in wood, lead in pipes, radon under the house, fire retardant outgasing from sofas and beds (toxic to the thyroid), mercury vapors in people’s mouths, deleterious bacteria and molds on the walls, and, among many other toxins, VOCs and phthalate esters all over (ie, these are plasticised polyvinyl chloride (PVC) materials used in floor (especially carpets) and wall covering materials, shower curtains, adhesives, synthetic etc), people develop respiratory, cancer, auto-immunity diseases, among other ailments.
Occupants of water-damaged buildings (WDBs)
Studies have demonstrated over and over that the indoor air of WDBs often contains a complex and deleterious mixture of fungi, mycotoxins, bacteria, endotoxins, antigens, lipopolysaccharides, and biologically produced volatile compounds. Occupants of water-damaged buildings (WDBs) can be victime to this SBS (sick building syndrome) involving multiple organ systems.
This Presentation will therefore look into this problem and also examine toxic garden, toxic cloth, toxic body & home care products that are injurious to health while not being effectively regulated by the Industry, let alone by the Government’s agencies.
Fasting Techniques for Detoxification
In this Presentation, we will briefly look at different types of Fasts, their benefits, limitations and risks. Some of the fasting techniques we will examine are the following: fruit fasts, mono-diet fasts, raw juicing fasts, caloric restriction, veggie-fruit rawfood diets, the Daniel fast, the “feast and famine” protocol, water fasts and, among others, the “warrior diet fast” (eating once a day), the intermittent and the alternate fast, all of which are new labels to simple millennia-old holistic techniques based on shutting down the gastric juices and exogenous food supply (and-or significantly reducing them) so that the body can better oxygenate, alkalinize, mineralize, detox, heal, retore homeostasis and rejuvenate. Water and juice fasting should be preceded with other types of detoxification so that released toxins and toxicants can be removed in a more gentle way. Without propre preparation, long juice and especially water fasts can lead to serious toxemia complications.
On the New “fasting mimicking diet” trend being adopted by the Anti-Aging Community
For the fasting mimicking diet (FMD), Professor Longo (presently director of the UCLA Longevity Institute) believes that his five days per month caloric restriction diet can mimic the effects of fasting with a meal program that is designed to inhibit the same metabolic pathways fasting would, thereby providing the body with nutrients that do not trigger the body’s growth responses. (See video below)
While Longo’ experimentations do show rejuvenation benefits from this “fasting mimicking diet”, we will argue that this mimicking diet can’t surpass a water-only fast, or even couple other types of light-food or herb-juice fasts.
Like herbal teas, juice cleanses have been popular in holistic centers for millennia. While juicing cleanses are potentiated by other holistic techniques, by themselves, as stand-alones, they can also be beneficial in terms of oxygenating, alkalinizing, detoxification and mineralizing the body’s tissues. Furthermore, the body’s conductivity also gets more intense. We may show this conductivity via an electrical experiment. (3 a). Water and juice fasting should be preceded with other types of detoxification so that released toxins and toxicants can be removed in a more gentle way.
What is the best “detox” water to Drink ? (Hydration, Structured Water & Toxicants)
Humans are made up of around 80 percent water. Given water’s essential role in cleaning out trillions and trillions of cells from metabolic waste, toxins and toxicants and in being the body’s lifeblood, it is important to avoid dead and toxic water. In this presentation, we will look at different hydration techniques, including vibrant mountain Vitamin B-12 rich spring water as well as structured water.
Toxins and toxicants are particularly relevant because many heavy metals and deleterious chemicals hinder the proper functioning of mammaliam metabolism, the repair genes, the mitochondria energy system, the immune system, the thyroid, the messaging molecules (cytokines, hormones, neuropeptides, neurotransmitters etc), genes’ co-factors, the microbiota, the metabolic detox pathways and the like. Two of many examples, when BPA and other obesogens latch on insulin receptors, insulin resistance is promoted, that which sets the stage for diabetes and early death (Source) and all the more so that animal saturated fat is abundant and exercises deficient. When heavy metals are present, Lyme’s bacteria become much stronger. There are hundreds of examples of this nature, a few of which will be discussed in this talk as well as house detox protocols via house plants, hepa filters, ionizers and essential oils, organic paint, healthy building material, water purifiers and more.
The Myth of Drinking Lots of Water
Just like eating three meals a day is myth, so is drinking eight 8 ounce glasses of water a day, an official report has confirmed this piece of allegation. (Source) More than maintream medicine’s dictats, thirst should govern by the hydration “instinct”, even among the elderly. When intense exercises, the steam room or a hot day come one’s way, the concerned person is usually thirsty and should drink to satiation quality water. As long as there’s a mostly plant based diet, it’s rare to be dehydrated. The best way to tell is by pinching the skin or looking at the urine. As long as one is not taking riboflavin (i.e., which fluoresces and turns your urine bright yellow), or ingesting beets, then the urine should be a light-colored yellow. The lighter, the cleaner the blood is. Moderately yellow urine can be OK too, especially after a heavy meal. (Source) Based on the results from different studies, a healthy person urinates on average about seven or eight times a day. Depending on one’s glucose or toxicity intake, urination can me more frequent. Drinking too much can put them people at risk of exercise-associated hyponatremia (EAH). In hyponatremia, the cells, including those in your brain, swell with too much water. (Source)
Some “Toxicant & Cellular garbage disposal” help from our Microbiota Gluthatione-producing Friends
There’s a relatively unknown probiotic strain that was discovered in Europe in 1995 and that naturally boosts glutathione levels. Glutathione is a powerful antioxidants that has wide-spread effects in that every cells of our body needs it to protect DNA from oxidative damage, among other functions. As a consequence, this ME-3 lactobacillus fermentum strain should be present in every living gut.
“There is much information about glutathione (GSH) in eukaryotic cells, but relatively little is known about GSH in prokaryotes. Without GSH and glutathione redox cycle lactic acid bacteria (LAB) cannot protect themselves against reactive oxygen species. Previously we have shown the presence of GSH in Lactobacillus fermentum ME-3 (DSM14241). Results of this study show that probiotic L. fermentum ME-3 contains both glutathione peroxidase and glutathione reductase. We also present that L. fermentum ME-3 can transport GSH from environment and synthesize GSH. This means that it is characterized by a complete glutathione system: synthesis, uptake and redox turnover ability that makes L. fermentum ME-3 a perfect protector against oxidative stress..…”. (Prikl Biokhim Mikrobiol. 2010 Sep-Oct;46(5):527-31.”Complete glutathione system in probiotic Lactobacillus fermentum ME-3” (Source))
As the Workshop presentation will show, Glutathione plays a crucial role in our antioxidant defenses and detoxification pathways. So making sure one’s gut has this L. fermentum ME-3 species is all the more important that human cells are often deficient in this molecule and supplements are not well absorbed. Glutathione is not an essential nutrient to consume because our body naturally makes it from cysteine, glutamine and glycine, but because most humans are hit with an continuous onslaught of toxicants, optimizing this molecule is essential if the goal is to live healthy for 120 years and beyond.
Case Study: Titanium Dioxide Nanoparticles
With millions of tons of titanium dioxide produced globally each year, this toxic chemical is present in suncreens, in paint pigment, cosmetics, toothpastes, pharmaceuticals, paper and food. It adds whiteness and brightness to products and also helps to resist discoloration, inter alia. With Hi-tech development, titanium dioxide nanoparticles (TiO2 NPs) have become widespread. (Nanoparticles are ultramicroscopic in size, making them able to readily penetrating skin and blood vessels. They can cross both the gut and blood brain barriers).
In this perpective, animal studies indicate significant accumulation of nanoparticles in the brain, while toxicity studies have shown the particles have negative effects on brain cell viability and function. (Source) These studies show that titanium dioxide nanoparticles induce a surge of reactive oxygen species as well as decrease in mitochondrial membrane potential. (Ie, the mitochondria has five delicate membraned compartiments, and toxicants mess their integrity). T.D. (titanium dioxide) nanoparticles were also found to harm astrocyte cells, which help regulate serotonin, dopamine and other neurotransmitters. (Ibid). Studies also demonstrated that astrocyte cells that weren’t killed were left damaged; they became unable to absorb glutamate, a neurotransmitter, such that it accumulated outside the cell, which may be implicated in Alzheimer’s and Parkinson’s diseases. (Source) Prenatal exposure to titanium dioxide nanoparticles also affects the cerebral cortex, olfactory bulb and brain regions intimately related to dopamine systems of mammals (Source) as well as wine appreciation. Exposure to titanium dioxide nanoparticles equally alters oxidative and inflammatory responses as well as the renin-angiotensin system in the brain (which plays a role in cardiovascular health, including hypertension, and aging), thereby modulating brain function. (Source) These toxicants also induce strong oxidative stress and mitochondrial damage in glial cells in your brain. (Source)
Yet, The U.S. Food and Drug Administration, the one whose Commissioners tend to conceal pharmaceuticals’ toxic effects and promote deleterious products like Trans-fats, GMO, mercury, antibiotics overuse and, inter alia, deadly pharmaceuticals in exchange of private gains (Source), continues to allow manufacturers to use up to 1 percent food-grade titanium dioxide without declaring it on labels. (Source) To make matters worse, the FDA commissioners (who usually get nominated to this position after they give hefty bribery donations to political recipients) and the Federal Agency for Acohol and Firearms have not only allowed over 70 additives and chemicals in wine, many of which are toxic, but have enacted rules to conceal these ingredients from the Public by not requiring their labeling. (Source) Since assuming office, the “make American Great” Administration has reversed a ban of a pesticide linked to brain damage, delayed clean air rules designed to reduce mercury emissions, and proposed to mothball a program designed to protect farmworkers from pesticides. He’s proposed to gut the Environmental Protection Agency’s budget, including cutting EPA funding for pesticide reviews by 20 percent, proposed a slashing of programs to protect children from lead, proposed deep cuts to Food and Drug Administration programs designed to review food chemicals and keep food safe and drafted new rules for industrial chemical reviews that will allow the EPA to rely on junk science. In particular, the new rules will allow the agency to ignore some of the ways in which American families are exposed to toxic chemicals, including “legacy” chemicals released into the environment decades ago, chemicals included in some household products like cosmetics, and chemical exposures and much more.
Case Study: Lead, Candles and More
Just one of many examples that affects consciousness disorders and accelerate aging and death. Lead, which, like arsenic, mercury, cadmium and thousands of other toxic chemicals, is still prevalent in Americans bodies, including babies. (Source). Lead is a divalent cation that mimics Ca2+ and potently activates PKC signalling. (Source). Administration of low levels of lead to rats produces deficits in PFC attentional regulation that mimic the symptoms of attention-deficit hyper-activity disorder (ADHD) (Source). In humans, lead poisoning is associated with reductions in PFC (Prefrontal Cortex) grey matter (Source) and with various behavioural changes that arise from PFC dysfunction, including ADHD-like attentional and impulse-control problems, and even sociopathic, (Source) irresponsible and criminal behaviours. (Source) In other words, lead poisoning highly correlates with crime rates and out-of-wedlock pregnancy in modern North America. (Source)
“Prenatal and postnatal blood lead concentrations are associated with higher rates of total arrests and/or arrests for offenses involving violence. This is the first prospective study to demonstrate an association between developmental exposure to lead and adult criminal behavior”. (Source)
All of this is nothing new. It’s been documented for millenia that lead poisoning had been constitutive of different epidemics and diseases, including what is called “painters’ madness” that Van Gogh suffered from, like with the mercury poisoned “Mad Hatters”of the Victorian epoque. One of the most famous and aggressive Empires to have fallen from lead poisoning was Rome. We can also see this in the stories that portray Emperor Nero’s imperial “wine-related”, but lead-driven anger. The Roman experts of those times would ferment wine in an abundance of lead in order to give it a sweet taste. Many authors have suggested that there was more than a correlation between lead and the fall of the Roman empire. Not only lead-sweeten wine, but wine cups, the piping system, foods preserved in lead syrup and lead utensils all contributed to lead toxicity in decadent Rome and its insane ruling class whose imperial members became so narcissistically predatory that they characterized their barbaric wars as “Pax Romana”, Roman Peace.
“At the peak of the power of the Roman Empire, lead production was about 80,000 tons per year, lead and its compounds were used with great inventiveness in numerous ways, and lead poisoning was pandemic, with the severity of poisoning proportional to the power and status of the class. Intake of lead by the aristocracy may have been as much as 1 mg/day. The resultant mental incompetence and especially the rapidly declining birth rate among the ruling class are now believed to have been major factors in the decline of the Roman Empire.(Source).
As a result, the poor decision making and impulsive behaviours of the Roman wealthy ruling class (consistent with PFC dysfunction) led to the downfall of Rome. Likewise with the American ruling class and the American Nation. To such a point that the toxicology experts can’t find lead-free Americans for cohort-based clinical trials.
“The estimated 3.5 million tons of lead produced annually during peak production in the 1970’s included about 0.4 million tons of organoleads. Such intense production has increased global contamination with lead enormously. Even under relatively ideal conditions the daily intake of lead is so much higher than in prehistoric times that investigators must pause to ask themselves what a proper control group really is”. (Source)
Candles, for example, often have a lead wick. The manufacturer’s reason is to slow down the candle’s combustion and to make the wicks more firm. Because most governments’ lawmakers appear to be either mentally impaired or don’t care about poisoning their People, children and animals, choosing bribery cash for their re-election campaigns over ethics, these candles, without labels, like with GMOs, glyphosate and thousands other toxic chemicals, continue to intoxicate with lead entire families thereby dysregulating stress signalling pathways and weakening PFC structure and function that promote conscioness disorders and accelerated aging.
“According to a recent study by the U.S. Consumer Product Safety Commission (CPSC), 40 percent of candles on the market contain lead wires inside their wicks. (…) A candle with a lead-core wick releases five times the amount of lead considered hazardous for children and exceeds EPA pollution standards for outdoor air, says the CPSC. Exposure to high amounts of lead has been linked to hormone disruption, behavioral problems, learning disabilities, and numerous health problems”. (source)
Per memory, the evidence conclusively shows that the “Sixth Life Extinction wave” (i.e., the fifth of which zapped the dinosaurs 65 millions years ago) is worsening everywhere where the Amerian fast-food, pink medicine, hi-tech and toxic GMO-Glyphosate agribusiness based economic model is taking root. In less than 40 years, over half of the World’s living species have been decimated and over two third of Americans have been diagnosed with some form of chronic disease and the World Health Organization’s and CDC’s prognoses indicate worse outcomes. And to this day, most American Democrats and Republicans leaders still appear to be oblivious to the most important duties and priorities Governments are constitutionally encoded with, protecting the “general welfare”, of which healthy food and water supplies as well as the Public’s health and future generations are paramount.
Session E: Quality, Traditional & Moderate Wine intake extends Healthy Lifespans
“Stop drinking only water, and use a little wine because of your stomach and your frequent illnesses.” 1 Timothy 5:23
The evidence the Presentation will share suggests that early death and multiple chronic diseases appear to be either partially or primarily the result of abstaining from this “essential nutrient” we call wine. But only if the dosage is “small to moderate”.
As Paracelsus said over two thousands years ago, “wine is a medicine, a food or a poison depending on the dosage”, to which we can add quality, pairing and timing. Too much wine will obviously harm the liver, the brain and other organs, but in the right proportion and context, wine can be a good medicine, just like essential oils, sunlight, exercises, heat, botanicals, caloric restriction, food, sound and the like. But for wine to be great medicine, it must be sipped holistically and its grapes and vinification should be prepared traditionally, (for that extra resveratrol boost) and without chemicals. Today, in the United States, the FDA allows Americans to drink wine that can have up to 76 additives, including but not limited to arsenic, lead and glyphosate. (Source) And because the US government does not require labeling, the wine consumer should ascertain that the wine is organic and traditionally made.
In this presentation, we will examine a few diseases that quality wine can help to both control and reverse as well as its impact on longevity.
“Wine is a traditional beverage that has been associated with both healthy and harmful effects. Conceptions like the so-called “French paradox” or the beneficial impact of the Mediterranean diet suggest benefit. (…) there is reasonable unanimity in beneficial effects of moderate wine consumption in cardiovascular disease, diabetes, osteoporosis, maybe neurological diseases, and longevity”. (Source)
On the issue of “Moderate” versus “biologically indicated” quality wine
While a new published study has suggested that even moderate wine could be deleterious to the health, another recently published study has corroborated that low dosage of alcohol consumption in comparison to no alcohol or high alcohol consumption was beneficial for glymphatic function, meaning that the mammalian brain was better able to clear itself of harmful debris, which is key if one wants to avoid neurological diseases and dementia.
This Presentation will look at the built-in flaws and biases conventional, alternative and vegan scientists use to unfairly and unscientifically condemn wine, even in moderate amounts. Wine in essence is dose-dependent medicine, so it’s a given that drinking too much is not healthy. But drinking cheap wine is also unhealthy, if only because American modern viticulture is one of the most soil-disturbing and chemically sprayed (i.e. lots of cancer among conventional viticulture farmers, including eye cancers). On the other hand, and most American physicians miss this piece of ancestral wisdom, quality wine in the right amount and at the right time and under the right holistic conditions is royal (great) medicine, the evidence of which remains overwhelming for dozens and dozens of health conditions. We will thus share a few elements of French holistic wine protocols to help control and reverse diseases, including liver diseases and alcoholism.
Does One glass of Red Wine a day contain enough Live Chemistry for Longevity Benefits ?
Differently from a resveratrol supplement, wine’s resveratrol is bathed in a milieu that contains hundreds of other inter-active live molecules, all of which helps resveratrol to be well assimilated and to perform its therapeutic “magic”. A typical glass of red wine can contain anything between 250 micrograms and 1.5 milligrams of resveratrol. Its precise amount depends on a number of variables, from the type of grape is used to make the wine, where the grape is grown, with what agricultural method (organic grapes have more resveratrol that non organic or poor grown grapes), with what vinification procedure (traditional long fermentation boosts resveratrol content), how ripe the grape is when it’s harvested, how long the wine is aged for before it’s drunk etc. Like with people, some wines age better than others.
In this Presentation, we will go into the details regarding the resveratrol question as well as with wine’s other polyphenols, flavonoids and hundreds of other beneficial substances, including live micro-organisms that fine-tune wine’s health and aging benefits, just like the human microbiota fine-tunes human healthy longevity.
Session F: Is the Body’s Endocannabinoid System essential insofar as general homeostasis, wellbeing & Longevity are concerned ?
“It’s not because we are old that we don’t play, it’s because we don’t play that we get old” (George Bernard Shaw)
The endocannabinoid system (ECS) is a newly discovered biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system. The endocannabinoid system is also involved in regulating a variety of physiological and cognitive processes including but not limited to general homeostasis and brain rejuvenation (neurogenesis). Likewise with cancer and over one hundred heath disorders.
“…cannabinoids may inhibit tumor growth by causing cell death, blocking cell growth, and blocking the development of blood vessels needed by tumors to grow. Laboratory and animal studies have shown that cannabinoids may be able to kill cancer cells while protecting normal cells”. (From the Federal Government’s National Cancer Institute) Source
In this Presentation, after a brief review of the endocannabinoid system (ECS) and one of its diseases officially called clinical cannabinoid deficiency disorder (CECD), we will look at a recent finding regarding cannabiniods’ role in optimal longevity. In this perspective researchers in 2017 confirmed that cannabinoids may be a forgotten essential nutrient, in particular for the elderly. Because levels of natural cannabinoids in the ECS decline with aging, these researchers focused on the correlation between cannabinoids and memory and provided convincing evidence that the lack of cannabinoids is a proximate cause of the loss of memory function in later life. Medical marijuana has also been shown to be beneficial for the elderly regarding pain management. (Source) We will also show that it is possible to stave off cognitive decline by using low doses of tetrahydrocannabinol to supplement endogenous cannabinoids. Likewise with Cannabis’ benefit effect with mitigating the United State’s hard alcohol and prescription opiate epidemics. Cannabinoids from different plants will also be reviewed in terms of their contribution to healthy lifespans, including, but not limited to different varieties of exotic peppers that also contain healing cannabinoids.
The Big Three C’s: Cannabinoids, Curcuminoids and Carotenoids
Given the entourage effect, synergy, homeostasis and other mechanisms that are inherent to the very engine of evolutionary biology, when we mix cannabinoids like CBDs, CBGs, CBNs, THCs, inter alia (among others) with other molecules coming from a living Rainbow-like diet full of luxuriant pigments and rich in polyphenols and phytochemicals like curcuminoids, carotenoids, terpenoids, peperine, myrcenes and other molecules, the synergistic combination of which potentiates multiple therapeutic effects. In this realm, combining organic black pepper to curcuminoids will also enhance their anti-inflammatory and antioxidants virtues, if only because curcuminoids’ bioavailability will increase by 2000 times.
“For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%.” (Source)
The fact that black pepper is rich in cannabinoids suggest that the curcumin-cannabis combo would be a medically efficient pairing. Now when we add carotenoids, the therapeutic bang may be even more interesting, as we will see via power point. In this presentation, we will thus demonstrate how to benefit from therapeutic formulas that can help upregulate both happiness and Longevity genes, as well as their neuropeptides and hormones.
Case study: Cannabinoids and Cancer
Section under construction
Session H: The French & Holistic Approach to Health & Optimal Longevity
“The fixity of the milieu supposes a perfection of the organism such that the external variations are at each instant compensated for and equilibrated. Therefore, far from being indifferent to the external world, the higher animal is on the contrary constrained in a close and responsive relation with it, of such fashion that its equilibrium results from a continuous and delicate compensation established as if by the most sensitive of balances.” (Professeur Claude Bernard)
In France, much of medicine reflects the culture of the “le juste milieu”, the Goldylock “right balance”. As a consequence, half of French medical doctors practice homeopathy while the vast majority of them will prescribe lifestyle “joie de vivre” medicine, whether it be via the famous three weeks (per year) Government paid health spa vacation in one of France’s sunny resorts and-or other modality, some of which include thermal therapy, wine medicine, leisure, homeopathy and multiple destressing techniques like sophrology, aromatherapy, phytotherapy, or, among other integrative and holistic techniques, healthy flavorful and uplifting food, spices and herbs, what is officially called clinical nutritional medicine, all in the “right balance” within a rich bio-diversity “entourage” and enjoyable milieu.
“Instead they offer a holistic approach to alleviating chronic conditions such as arthritis and multiple sclerosis. As well as bathing, curistes drink 10 tiny glasses a day of the mineral rich water. To me, the water tasted rather salty. One man I spoke to said it kept him awake at night. But most feel it helps, as do the massage, gymnastics and lessons in cooking healthy food that are also on offer. Between now and October, thousands of curistes – drawn mostly from France’s retired population – will spend up to three weeks floating and gossiping in the hot pools. The spas are set in beautiful gardens and staffed by doctors, physiotherapists and dieticians… all of which comes at a hefty price. Most can only afford it because the bill is footed by the State. (…) (Source)
In this presentation, we will define the hippocratic-based French approach to medicine, food and public health and briefly show a few of its strengths, some of which could benefit the American health-care system. (6 b)
Joie de Vivre, French Cuisine & Tradition
In the “crudités” part of French Mediterranean meals, flavor and esthetics are combined with rainbow colors. Each color, made from different plant pigments, is endowed with rich and complex phytonutrients and polyphenols that target specific metabolic pathways. Anthocyanins, pygnogenol and resveratrol for example all help activate the longevity sirtuin genes, inter alia.
In this presentation, we will review a few French Mediterranean “super-foods” and dishes, including, but not limited to fruit, flower, veggie, grains, roots and the herb Kingdom as well as fungi from the mushroom kingdom and friendly bacteria, all of which can help to avoid and even treat chronic diseases while activating longevity and “happiness” genes.
French Homeopathy: Science, Wishful Thinking or Witchcraft ?
In the United States, conventional medicine proponents consider homeopathy to be pseudoscience if not quakery. And for the Government officials, who have created a “National center for complementary and integrative Health” center to better control Science have also stated that the Status of Homeopathy is akin to a placebo. Different anglo-american politicians-lawmakers have also opined that all homeopathic products should contain the label: “product has no health claims, does not work”.
“Most rigorous clinical trials and systematic analyses of the research on homeopathy have concluded that there is little evidence to support homeopathy as an effective treatment for any specific condition”. (Source).
For these scientists, the first homeopathic law of similarities and the second law based on energy vibrations increasing with dilution (i.e., called potentiation or “less is more”) are figments of the imagination, especially when homeopaths dilute active molecules so many times that there is allegely no trace of any biological activity.
On the other hand, the for the French and millions of other non-French patients, homeopathy, like acupuncture, sophrology, wine, aromatherapy and other alternative non conventional medicine, is science-based, first clinically, positive results are recorded and secondarily, with experimentation. In this perspective, and contrarily to many alternative and holistic techniques which can’t be studied in a Double blind Randomized Clinical trial (ie, because patients who do for example hot tub therapy know they are in a hot tub), homeopathy can be subjected to this form of hypothesis experimentation testing. The review of the published literature shows that some studies dont validate homeopathy and others do. Just one example, from the European mushroom of death, the Amanita Phalloide, whose genome contains lethal frequency medicine that homeopathy can dilute so as to produce an anti-cancer holistic bang targeting an “ensemble” of signalling pathways that eventually tells cancer cells to gently switch off genes.
“With approximately 1–200 mL of A. phalloides D2 per year, the tumor growth of B-CLL can be arrested. Amanita therapy also shows good results in therapy or prophylaxis in a variety of other tumors such as colon carcinoma, mammary carcinoma, or tongue root tumor. This therapy does not affect the activity of somatic cells, especially the immune cells. Amanitin stops the activity of the tumor cells, and then they lyse and migrate. Thus, homeopathic dilutions from A. phalloides offer a strong tool for the therapy of cancer” (Source)
Amanita phalloides dilutions, that contain amanitin, have been applied for over 300 years, the classical homoeopathic indication being the fear of death. A conventional cancer diagnosis usually provokes a “fear of death” big time emotion. Which often leads to heart attacks and other serious complications. Nocebo effects kill. A biochemical reality that most conventional physicians don’t understand. Or don’t want to understand. In cancer biology, the evidence suggests that Amanita vibes help to switch tumor activity off. We even understand why, the mechanisms of action. The demonstration contained above is both convincing and compelling. But mainstream conventional medicine experts refuse to seriously examine this evidence. Especially in the U.S. So we have another Franco-american “conflict of perception”.
Homeopathy has been reimbursed by the French National health-care system since 1944-5. It is the leading alternative therapy for most diseases. The French, like the Germans also love the homeopathic version of mistletoe called in France viscum album, which is often prescribed to cancer patients. (Source) And reinbursed by the Government. In 2004, 62 percent of French mothers used homeopathic medicines in the previous 12 months and a survey of French pharmacists was conducted in 2004 and found that an astounding 94.5 percent reported advising pregnant women to use homeopathic medicines (Damase-Michel, C., Vie, C., Lacroix, I., Lapeyre-Mestre, M., Montastruc, J.L. Drug Counselling in Pregnancy: An Opinion Survey of French Community PharmacistsPharmacoepidemiol Drug Saf. 2004 March, 18;13(10):711”). Likewise with acupuncture and auriculotherapy, which is acupuncture via the ear. In this Presentation, we will briefly review some of the French People’s most used homeopathic products.
The Holistic Therapeutic Effect Principle
Homeopathic medicine is made from extremely small quantities of nanoparticles of substances extracted from plants, animals or minerals. The remedies are so diluted that, based on conventional chemistry, it is difficult to find any molecules of the original substance in the remedy. But as physicists know, it is not because we can’t quantify a given energy with today’s instruments that this presumed energy particle does not exist.
Two main axioms constitute the core principles of homeopathy. The “like cures like” principle holds that, if a substance causes a symptom (e.g. onion makes my nose run), then that substance can cure a disease that is characterised by a runny nose (e.g. hayfever or a common cold). The second principle assumes that the serial dilution process used for homeopathic remedies renders them not less but more potent (hence homeopaths call this process “potentiation”).
Both of these axioms fly in the face of maisntream conventional science. If they were true, much of what is learned in conventional physics and chemistry would be wrong. Homeopaths often say that we simply have not yet discovered how homeopathy works. In order to understand this apparent contradiction, we have to consider the complexities of the therapeutic response, which is by definition “holistic”. Whenever a patient or a group of patients receive a medical treatment and subsequently experience improvements, we automatically assume that the improvement was caused by the intervention. This logical fallacy can be misleading and has hindered progress in medicine for hundreds of years. Like the French Paradox study suggests, the reduction of CHD among the French could be due to wine, but it could also be the holistic result of other factors or frequencies, including those very vibes that emanate from French intestinal microbiota and sharing wine with friends and family over a sumptuous meal. For instance, regarding a disease treated by a homeopath, the condition could have improved on its own. Or the encounter between the therapist and the patient could have been therapeutic without any meaningful contribution from the treatment itself. Some homeopaths do emanate healing empathy and compassion. Or the patient could have had high expectations in the treatment that prompted a powerful placebo response. Or the patient self-administered some other treatments concomitantly or had a green smoothie as he or she was downing the homeopathic pellets. In other words, it is not the effect of the remedy per se, but the non-specific effect of the context in which it is given that oten benefits the patient.
From the point of view of Conventional science, the best way to resolve these complexities is to conduct clinical trials that differentiate between the specific and non-specific effects of a treatment. For most holistic treatment, this is not possible because of the principles of synergy and awareness. (Which i explained supra). But for some, like with homeopathy, it is possible to conduct double blind randomized clinical studies. In such studies, one group of patients receives the experimental treatment (e.g. a homeopathic therapy) and another group receives a placebo. If well designed, these studies expose the experimental group to the specific effect plus all the non-specific effects of an intervention, while the control group is exposed to precisely the same range and amount of non-specific effects but not to the specific effect of the treatment that is being tested. In this situation, any difference in outcome between the groups must be caused by the specific effects of the homeopathic remedy.
Over 200 clinical studies of homeopathic remedies are available to date. According to statistics, at least half of those may be flawed. It’s relatively easy to cherry pick and select those findings that one happens to like. To make a serious determination in terms of conventional science, we need to consider the totality of this evidence and weigh it according to its scientific rigour. This approach is called a systematic review. Over a dozen systematic reviews of homeopathy have been published. Almost uniformly, they come to the conclusion that homeopathic remedies are not different from placebo. (Source) In response, homeopaths will say either that the clinical trial was flawed, that mechanisms of action can’t be quantified and that their clinical experience is more important than the evidence from conventional clinical trials. And here we get at the core of the issue. If the World Health Organization and most medical doctors in France, Germany, India, Russia, inter alia use homeopathy, it’s because their patients get better as a result. Millions of them. Observational studies have shown this consistently (Source) Homeopaths insist that this amounts to evidence which is more relevant than that from clinical trials. In law, when someone gets better following some “intervention” and we can prove health improvements via biomarkers, we call this “evidence.” Just because we may today not be able to explain everything about homeopathy and holistic medicine, doest not mean this healing art should be ridiculed as most conventional doctors and Government officials do, using the law (coercion) instead of the free market and education to control and suppress this medicine. Furthermore, it’s easy to prove that allopathic medicine that these conventional State certified doctors use constitute one of the top causes if not the top cause to millions of innocent premature deaths and collective suffering. The way forward is open, transparent and holistic science, not opaque, biased analysis, cash-flow inspired ideology and rhetoric.
Auriculotherapy (Ear Acupuncture): French Quakery, Chinese pseudoscience or evidence-based Medicine ?
This “alternative medicine” is also controversial in the American mainstream, especially for Dr Barrett, chief of the American quackery brigade, who mocks this technique, as do many of his conventional and government colleagues who control the Government’s institutions. Easier to mock an innovative, but competing therapy than digging deep to ascertain it’s legitimacy and healing effects.
Auriculotherapy was invented in the 1950’s by Dr. Paul Nogier of Lyon, France, who expanded the original Chinese charts into a more comprehensive system. It has been recognized by the World Health Organization since 1987. Whereas the ancient texts showed only a few ear points for specific conditions, Dr. Nogier’s work demonstrated the ear is actually a micro-map (i.e., microcosm) of the entire body, with all body parts represented. Thus, all parts of the body can be evaluated and treated by means of the external ear. Much of Dr. Nogier’s original work has been verified in numerous research studies, and both Chinese and European systems are based on his work.
Auriculotherapy works by using points on the skin of the auricle (external ear) to diagnose and treat pain and medical conditions of the body. Also referred to as Auricular Medicine, practitioners all over the world use this therapy to treat pain, addictions and internal disorders. Whether used in conjunction with another treatment or by itself, auriculotherapy is often effective when other treatments have failed. Best of all, it is safe, non-invasive and has no known toxic effects. Auriculotherapy has its roots in Traditional Chinese Medicine. Just as this ancient healing art defines acupuncture points on the body for treatment of various conditions, similar points are defined on the ear. In France, ear acupuncture is often used as palliative care or for quality of life issues in oncology (Source).
Below, a few conditions ear acupuncture can treat: Breast hyperplasia (Source), pain reduction (Source), children myopia (Source), pain control after Caesarean section (Source), stimulation on vagal activity in healthy men: evidence from a three-armed randomized trial (Source) Transcutaneous auricular vagus nerve stimulation protects endotoxemic rat from lipopolysaccharide-induced inflammation (Source) Effects of electroacupuncture at auricular concha region on the depressive status of unpredictable chronic mild stress rat models. (Source) Transcutaneous auricular vagus nerve stimulation triggers melatonin secretion and is antidepressive in Zucker diabetic fatty rats. (Source) Transcutaneous Vagus Nerve Stimulation Modulates Default Mode Network in Major Depressive Disorder (Source) Chinese auriculotherapy to improve quality of life of nursing team. (Source) Auricular acupressure for pain relief in adolescents with dysmenorrhea: a placebo-controlled study. Auricular acupressure relieves menstrual pain and distress in high-school adolescents (Source)…The long-term effects of auricular therapy using magnetic pearls on elderly with insomnia. The results of this study indicate that auricular therapy could have a long-term effect on improving the quality as well as the quantity of sleep among the elderly (Source) A randomized controlled trial of auricular acupressure in heart rate variability and quality of life for hypertension. (Source) Study on the best solution of immediate analgesia of acupuncture for migraine. (Source) Efficacy of acupuncture combined with auricular point sticking on the content of serum prostaglandin F2α, and plasma arginine vasopressin in patients with menstrual headache (Source) The effects of auricular electroacupuncture on obesity in female patients – a prospective randomized placebo-controlled pilot study (Source) Acupuncture in treating sudden sensorineural hearing loss: a report of 2 cases. (Source) Clinical efficacy on vertebrobasilar insufficiency treated with auricular acupuncture. (Source) Auriculotherapy on menstrual irregularities in single girls with polycystic ovarian syndrome and aged 18-35 years in Isfahan in 2012. (Source) Ear acupuncture for co-occurring substance abuse and borderline personality disorder: an aid to encourage treatment retention and tobacco cessation. (Source)
Case in Point: Acupuncture and Longevity Optimization
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Lunch Break: Session I: Culinary Remedies, Longevity Smoothies, Essential Oils & Wine Demonstration
“Wine can be a poison, a food or a medicine depending on the dosage” Paracelsus
In this Kitchen Demonstration, we will demonstrate how to optimize certain foods (using plants, herbs, flowers, roots, essential oils, mushrooms and the like) via the making of a longevity dish (Smoothie, soup or the like) that comes from either the Mediterranean Diet, the Vegan Diet and-or the Rawfood Whole-Plant diet. Concomitantly, we will demonstrate how wine is used medicinally. As we work on our Demonstrations, the workshopees are free to munch on their own lunch.
After-Lunch Meditation Exercise
Session J: Bio-Physics, Photons, Electro-acupuncture, Helio-therapy & inter-cellular Communication
“We are still on the threshold of fully understanding the complex relationship between light and life, but we can now say emphatically, that the function of our entire metabolism is dependent on light.” Dr. Fritz Albert Popp
As the mitochondria’s integrity erodes with time and entropy, there tends to be a cellular upheavel in the production of ATP, ROS and over-all inter-cellular communication. One of the consequences of this process is sarcopenia, the loss of muscles and bone density, a condition that leads femoral and hip fractures among the elderly. Is this condition the result of a natural old age process or the result of impaired thinking ? Can Sun therapy (in Europe, this medicine is called “heliotherapy”, from the Greek “helio”, which means Sun), acupuncture, bio-photons, bio-electricity and a holistic lifestyle help to overcome sarcopenia, bone loss, brain atrophy and accelerated aging ?
“Biophotons may represent a complex cell-to-cell communication that relies upon speed of light transmission. The physics of light seems to fit the biological observations. Light is the most efficient and fastest mediator of information in the world. The coherent property of biophotons may have a profound effect on their ability to influence information transfer. Frequency coding gives light a capability of encoding information from DNA in biophotons. (Source)
While biophysics and longevity research is still nascent and unsettled, we already have emerging evidence that bio-electricity and photons may have an important role in health and longevity including on inter-cellular communication and the mitochondria, whose degradation is one of the aging hallmarks we have examined.
“In recent years, a growing body of evidence shows that photons play an important role in the basic functioning of cells. Most of this evidence comes from turning the lights off and counting the number of photons that cells produce. It turns out, much to many people’s surprise, that many cells, perhaps even most, emit light as they work. In fact, it looks very much as if many cells use light to communicate. There’s certainly evidence that bacteria, plants and even kidney cells communicate in this way”. (From M.I.T. Source)
In this presentation, we will show what the evidence suggests with regard to the role of photons on the mitochondria and inter-cellular communication. Bio-electricity and particle-wave medicine, from electro-acupunture to Pemf, low dose radiation, TENS, Sound frequencies and more all appear to favorably mitigate chronic diseases and modulate longevity pathways inc .
Cell Phone Radiation & EMFs Toxicity
In the same way that bioelectricity and photons can boost vitality and longevity, in a similar way, dirty electricity, cell phone radiation and harmful EMF (electro-magnetic frequencies) can be toxic and shorten lifespan. In this perspective, a look at the hard evidence shows that Emf toxicity and electro-smog are anti-Life frequencies and radiation coming from wifi, cell phones, cell phone towers, electrical appliances, smart meters, blue tooth technology, micro-wave oven, high voltage lines etc., all impact health and our polarity and battery-structured cells via different mechanisms including cell-membrane calcium channel flow. Just recently, in Poland, the number one issue in Krackow’s elections was based on removing electro-smog and cell phone towers. In France, Israel and a few other countries, cell phones and wifi technology have been banned from elementary schools as the evidence is irrefutable that wifi equipement and cell phones are even more damaging to young brains. But in the United States, Big Business has blocked responsible public regulation, notwithstanding the WHO’s International Agency for Research on Cancer (IARC) categorization of electromagnetic fields as ‘possible human carcinogens’ that might transform normal cells into cancer cells. (Source) In February, 2018, the findings of two government-funded animal studies were published thus confirming the association between cell phone radiation and cancer. (Source). The Ramazzini Institute in Italy replicaated the studies and corroborated a clear link between cellphone radiation and Schwann cell tumors (schwannomas). (Source A and Source B). In this perspective, Dr. Martin Pall published research22,23,24,25 (Source A and Source B) showing that low frequency microwave radiation activates voltage-gated calcium channels (VGCCs). (Source.) These channels are located on the outer membrane of human cells. Once activated, the VGCCs open up, allowing an abnormal influx of calcium ions into the cell, which activates nitric oxide (NO). NO is the only molecule in the body produced at high enough concentrations to outcompete other molecules for superoxide and is a precursor for peroxynitrite. (Source) These deleterious oxidant stressors coming from cell phones as well as cell towers are thought to be a root cause for many of today’s chronic diseases. (Source) Numerous other studies have confirmed that the electromagnetic field (EMF) radiation emitted by cell phones causes anomalous cell growth and cancer. (Source), Two areas of the body, the eyes, and the testes can be particularly susceptible to heating by EMFs because of the relative lack of available blood flow to get rid of the excessive heat load. Laboratory experiments have shown that short-term exposure to high levels of RF radiation (100-200 mW/cm²) can cause cataracts in rabbits and temporary sterility (lowered sperm count and motility) (Source) The Environmental Working Group (EWG) has a web page entitled “Cell Phone Radiation Damages Sperm, Studies Show” published August 2013.” (Source) For eyes, the mechanism is unclear but may include changes in heat sensitive enzymes that normally protect cell proteins in the lens. Another mechanism that has been advanced is direct damage to the lens from pressure waves induced in the aqueous humor (Source). DHA is concentrated in our brain, testes, and eyes, so there’s a possibility that EMF oxidizes DHA. Prof Leszczynski of Finland’s radiation and nuclear safety authority found that, at the maximum legal limit for mobile radiation, one protein, in particular, HSP 27, was affected. HSP 27 plays a critical role in the integrity of the blood-brain barrier (Source). In this presentation, we will discuss some the emerging evidence on EMFs and Cell phone radiation’s impact on health and longevity as well as ways to mitigate and avoid their deleterious effects.
Addressing Systemic Inflammation and inter-cellular Communication
As mammalian cells divide and transform into senescent cells, their communication with other cells becomes dysfunctional leading to an increase in chronic inflammatory distress signals and misfiring of hormonal and neurotransmitter messaging. As a consequence thereto, neuropeptides and hormonal signaling go haywire. For example, the aging hypothalamus changes neurohormone signals, which in turn affects food intake and metabolism. Since the hypothalamus also regulates sleep cycles, these changes can perturb sleep, inhibit DNA repair and, inter alia, accelerating aging even further.
All in all, there is more and more compelling evidence that aging is not an exclusively cell biological phenomenon and that it is coupled to a general alteration in intercellular communication as well as environmental factors including, but not limited to “fields”. Proof of principle already exists for rejuvenation through blood-borne systemic factors (Conboy et al., 2005; Loffredo et al., 2013; Villeda et al., 2011).
In this Presentation, we will look at what we can do as humans to both clean-up, cool-down and tune-up the inter-cellular communication network. It’s a bit like public international law. For the inter-state system to avoid war, diseases and function smoothly, norms need to unite more than they divide and erode. While the inflammation cascade is beneficial under precise conditions, inflammation that accompanies chronic diseases is not, even slow mild inflamation is deleterious and damaged the inter-cellular network. There are dozens of plants and molecules that are effective in downregulating inflammation, from turmeric, frankincense, mushrooms and many plants.
Modified Citrus Pectin and Inflammation.
Found in the pith of citrus fruit peels, modified citrus pectin (MCP) has been shown to inactivate galectin-3, blocking its ability to send destructive inflammatory molecular signals throughout the body. (Cf 4Kolatsi-Joannou M, Price KL, Winyard PJ, Long DA. Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury. PLoS One. 2011;6(4))
Because of its ability to block galectin-3, modified citrus pectin is emerging as a key natural compound for chronic diseases and longevity. This supplement is popular in the Integrative and Holistic Oncology world.
Case Studies: Addressing diseases with Frequency & Electro-medicine: Brain Cancer and more
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Session K: Dental Holistic Care & how the Conventional Toxic Dentistry System impedes Americans fr reaching healthy Lifespans
Because the present conventional dentistry standards of care are connected to chronic diseases and accelerated aging, this talk will review some of the key holistic measures that can avoid toxic dentistry, including but not limited to healing early-mid cavity decay with holistic savoir-faire techniques, detoxing via oil pulling, home-made essential oil mouthwash, safe mercury-amalgam removal protocols, biocompatible dental material, avoiding endocrine disrupting leaching chemicals like BPA from different dental components (e.g., including, but not limited to BPA sealants, if only because it has been shown that BPA can lead to autoimmune diseases), using ozone, lasers that can replace the “drill & fill” technique and more. Implants with one’s own dental stem cells is already operational, but the conventional dentistry system is hindering it’s full clinical availability while the Government’s NIH experts still refuse to finance studies on mercury’s devastating health effects, all of which are fully supported by hard evidence from hundreds of peer reviewed studies that can be found in the international scientific literature.
Given the US’s peridontal infection epidemic (over 65 percent of teeth loss is due to gum disease and over 90 percent of Americans have some form of gum disease) as well as the toxic heavy metal poisoning pandemic (including, but not limited to mercury and industrial fluoride), the root canal aberration (i.e. leaving a dead tooth in the body is medically insane), avoidable cavitations, galvo-currents and more, biological and holistic dentistry is a necessary tool to consider if the workshopee is serious about optimizing a healthy lifespans to 120 year and beyond. Likewise with new technologies like laser and 3 D cone beam scans that can detect serious infections and tooth abcesses that digital scans and x-rays miss. This Presentation will included case studies of cancer and cardiac cases being resolved once dental problems were holistically fixed.
On the Horizon: Dental stem cells
As mentioned above, natural implants that come from one’s own dental stem cells have already been successful with animals and humans via clinical trials, therefore in theory, this procedure is operational, but not yet accessible. In addition to the fine-tuning of scaffolds and growth factors, there is Bureaucracy. Meanwhile, stem cell research continues and now, the expert scientists are telling us that some time in the not too distant future, we will be able to use our own dental stem cells to regenerate non dental tissues, from heart tissue to hepatic, renal and more.
“.…Dental stem cells (DSCs) have a remarkable self-renewal capacity and multidifferentiation potential; DSCs are extremely accessible and prevail during all life; DSCs, as stem cells therapies, have shown amazing therapeutic abilities in oro-facial, neurologic, corneal, cardiovascular, hepatic, diabetic, renal, muscular dystrophy and autoimmune conditions; DSCs are becoming extremely relevant in tissue engineering and regenerative medicine” (Source).
There are already a different global services that will store fallen teeth for future regenerative use. For now, the focus is a child’s baby tooth, as they have the most potent stem cells, especially in wisdom teeth. See: Store-A-Tooth. From what i understant, these companies partner with one’s dentist to collect the tooth and have it shipped overnight to their facility in a temperature-controlled kit. Once the tooth is in their hands, they extract the stem cells and place them in a culture where they can grow. Then, the cells, along with the tooth, are cryopreserved. The price is hefty. And there is no guarantee that in 20 years, these stem cells will still be potent.
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Aromatherapy: for oral cavity and body health
Aromatherapy is one of many holistic dental techniques. French-invented, modern aromatherapy (founded by René-Maurice Gottefaussé & Vanet) has been taught in France for over a century, thanks to which we now know how to best use plant volatile essential oils and their blends for the optimization of the oral cavity, mood, detox, immune-boosting and many other conditions and diseases via their incorporation in water, food, air, land (as natural insecticides), massage, suppository and, among other modalities, intravenously and via mouthwash, in particular cloves essential oil whose eugenol compound helps to both numb tooth pain and remove deleterious bacteria. In this Presentation, we will review of few of the key essential oils that can be useful for healthy extended lifespans.
Session L: The Reversal of Alzheimer’s Disease & Depression with Holistic Savoir-Faire
“In investigating nature you will do well to bear ever in mind that in every question there is the truth, whatever our notions may be. This seems, perhaps, a very simple consideration, yet it is strange how often it seems to be disregarded. I remember at an early period of my own life showing to a man of high reputation as a teacher some matters which I happened to have observed. And I was very much struck and grieved to find that, while all the facts lay equally clear before him, those only which squared with his previous theories seemed to affect his organs of vision.” (Lister)
It remains impossible to achieve a healthy 120 years, let alone JDV when serious mental and neurological disorders like Azheimer’s Disease (AD), Parkinson, Depression or M.S. hit. In the U.S., Alzheimer’s Disease incidence will triple to what it is today. In England, where holistic lifestyle has not been well rooted, AD has replaced both cancer and CVD as the number one killer and the US is not far behind, at least for the elderly. For those with the APOE 4 gene, the risk factors are higher and strike earlier.
Conventional Medicine neurological experts, just like in the cancer, cardiovascular and most other chronic disease fields, have blindly postulated that the major culprit is a symptom or group of symptoms that drives the disease. In this case, the central hallmark of AD. has been conventionally determined to be the beta amyloid plaque, a form of misfolded proteins. After over 30 years and billions of dollars testing drugs in clinical trials, not one of these anti amyloidal drugs made a difference in terms of safely and efficiently treating this disease. (The amyloid plaque did shrink with some of these drugs but from the viewpoint of even delaying the Alzheimer’s process, these lab molecules failed. And they will continue to fail because their approach is symptomatic).
In this Presentation, we will show via documened power point that holistic scientists and neurologists have proven beyond any reasonable doubt, that amyloid plaque is a mere symptom, not the cause of Alzheimer’s Disease, just like high blood pressure is an adaptive and compensatory symptom of being in a very high altitude area. Furthermore, we can demonstreate that the amyloid plaque, just like the arterial and dental plaques, is a defense mechanism against other deeper causes that conventional medicine misses or refuses to investigate.
For over twenty years now, we have known that the so called “Alzheimer Disease hallmark”, the amyloidal plaques as the driver of the disease, is a dogma. Below, a 2004 piece from a group of scientists who are not fooled by conventional medicine’s approach.
“Ever since their initial description over a century ago, senile plaques and their major protein component, amyloid-beta, have been considered key contributors to the pathogenesis of Alzheimer disease. However, counter to the popular view that amyloid-beta represents an initiator of disease pathogenesis, we herein challenge dogma and propose that amyloid-beta occurs secondary to neuronal stress and, rather than causing cell death, functions as a protective adaptation to the disease….”. By analogy, individuals suffering from altitude sickness nearly always have elevated levels of hemoglobin. However, while hemoglobin is toxic to cells in culture and increased erythropoiesis at sea level can be deadly, it is clear that the increases in hemoglobin occurring at altitude are beneficial. Amyloid, like hemoglobin, may also be beneficial, in this case, following neuronal stress or disease. Although controversial, a protective function for amyloid-beta is supported by all of the available literature to date and also explains why many aged individuals, despite the presence of high numbers of senile plaques, show little or no cognitive decline. With this in mind, we suspect that current therapeutic efforts targeted toward lowering amyloid-beta production or removal of deposited amyloid-beta will only serve to exacerbate the disease process. (Ann N Y Acad Sci. 2004 Jun;1019:1-4). (Source)
Below, another piece of published evidence from 2002, wherein the authors show that both amyloid-beta and tau, the major components of senile plaques and neurofibrillary tangles, are less the central mediators of the pathogenesis of Alzheimer disease than protectors from upstream biochemical events, including, but not limited to oxidative stress.
“… in light of recent evidence, such “lesion-centric” approaches look to be inappropriate. In fact, rather than initiators of disease pathogenesis, the lesions occur consequent to oxidative stress and function as a primary line of antioxidant defense. (…) The notion that amyloid-beta and tau function as protective components brings into serious question the rationale of current therapeutic efforts targeted toward lesion removal”. Free Radic Biol Med. 2002 Nov 1;33(9):1194-9 (Source)
In clear, as we will see in this power point presentation, the brain’s innate intelligence puts in place defense mechanisms (in the form of amyloid-beta and tau proteins) in order to mitigate the assaults of toxins, allopathic drugs and heavy metals, including loads of mercury that are still systematically placed right under the brain, in the oral cavity’s teeth where mercury vapors are able to cross the blood brain barrier and accumulate therein
In this Presentation, we will thus show how to avoid Alzheimer’s as well as other neurological risks by over 90 percent. Reversal of most of these mental disorders has also been established, including for Alzheimer’s Disease via different holistic protocols, some of which we will examine.
Detecting Alzheimer’s disease many years before symptomatology by looking at the Eye
Alzheimer’s disease (AD) develops undetected for many years due to the lack of early diagnostic biomarkers. In advanced AD, visual deficits related to cortical neurodegeneration are have been recognized. Recent recent studies have moreover identified that the retina could be affected prior to the Alzheimer attack on vulnerable brain areas such as cortex and hippocampus.
“Translation of these findings to clinical diagnosis could lead to earlier therapeutic interventions and, consequently, better chances to delay or halt AD progression”. (Curr Alzheimer Res. 2017;14(1):6-17)
In this above-mentioned meta analysis, a total of 134 papers were included in the review, the majority dealing with the earliest dysfunction of synaptic and neuronal networks in vulnerable brain areas. The researchers found evidence in 11 papers indicating why putative retinal synaptic dysfunction holds the potential to become the earliest sign of AD, allowing for a non-invasive and easy detection using modern imaging and functional techniques. Iridology also claims to be able to detect Alzheimer’s disease just by looking in the iris. But these claims appear to be contorversial. We will look into this deeper.
Having APOE4 gene significantly ups Alzheimer’s Risk. Holistic Techniques can remove these Risks
The APOE protein carries cholesterol and other fats through the blood. If we eat a high-fat diet, our bodies make more APOE. APOE is also found in the brain. It’s important for brain development and repair of brain structures after injury or inflammation (Source) This protein is encoded thanks to the APOE gene.
There are three major variations (alleles) of the APOE gene called APOE2, APOE3 and APOE4. We are each born with two alleles at the APOE gene and can have any combination of the three different alleles. For example, we could have E2/E2; E2/E3; E3/E3, E and so on.
These APOE gene alleles produce different forms of the protein Apolipoprotein E. Studies indicate those with the APOE4 allele are significantly more likely to get late-onset Alzheimer’s disease than others. Those with two copies of the APOE4 allele are at even greater risk.(Source) Having the APOE4 allele does not mean a person will definitely develop Alzheimer’s, it just significantly increases the likelihood of acquiring not only AD, but also other forms of Dementia and CVDs.
On the other hand, the APOE2 is protective, especially in terms of longevity. In the general population in Europe / USA, roughly 75% of people are APOE3/3, and the APOE3/4 or 4/4 variants are present in 20 – 25 % of Westerners.
The most cost effective way to find what genes one has is through 23andMe company. (Source) See below in the Monitor tests for details. In this Presentation, we will show via power point how to significantly disarm APEO4 via holistic medicine.
Movement attenuates the deleterious effects of APOE4 & all other chronic diseases while boosting Telomeres, HGH & DHEA
Drawing from neuroscience, anthropology, and brain-imaging research, scientists have shown that the evolution of increased physical activity “…approximately 2 million years ago served to reduce the amyloid plaque and vascular burden of APOE ɛ4, relaxing genetic constraints on aging”. (Source) Furthermore, in 2009, after Biochemistry Professor Elizabeth Blackburn discovered that the enzyme telomerase has the ability to lengthen the telomere (and won a Nobel Prize for her efforts), the following year, scientists showed that exercise mitigates the effect of chronic stress on telomere length. (Source) Complementary studies also found a reduction of telomere shortening when the elderly practiced high-intensity-type exercises. (Source)
Numerous other studies have shown that maintaining a minimum quantity and quality of exercise decreases the risk of death, prevents the development of certain cancers, lowers the risk of osteoporosis and increases longevity. Even daily walks helps. (Source), as well as ritual-exercises like Chi Gong, Tai Chi, Tibetan stances and Yoga. One study showed that daily yoga practice is linked to an increase in two key substances linked to youth and longevity: Growth hormone (GH or somatotropin), a peptide hormone and dehydroepiandrosterone sulphate (DHEAS), a key longevity androgen hormone. (Source)
Thus, everyone can benefit from exercises, especially ALzheimer and Chronic disease patients as well as those who are making efforts to reach 120 years. In this Presentation, we will look a the supporting evidence as well as a few key longevity exercises, including the Tibetan ones.
Case Study: Reversing Alzheimer’s Disease with Holistic Medicine
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Similarly, depression is less the result of a deficiency of psychotropic drugs than an inflammatory condition associated with neuro-transmitter imbalances, toxemia, lack of quality sleep and and other related factors. Because inflammation is greatly modulated by the immune system and the gut, holistic healers and teachers first address gut dysbiosis, then look at the immune system and finally the bain’s neuro-plasticity (which includes the nerve growth factor) and even neuro-genesis.
Diet, exercises (important to stave off depression), heliotherapy, meditation, massage, acupuncture and a few supplements are some of the healing tools Holistic practitioners use. Often, cancer patients who are zonked with radiation and chemo have their protein reserves decimated. Hence, healthy plant-based and fiber-strong nutrition with an abundance of dark greens and quality fatty acids (most of the brain and cells membranes are made from fat) is key. And lots of vitamins, minerals, flavonoids and polyphenols are also helpful. For quick relief, acu-pressure, oxygenation via exercises and thermal detox are recommended as well as certain nutraceuticals (dietary supplements) like St John’s Wort, magnesium, curcumin, mitochondrial boosters, drug-free regime (ie, tylenol for example eventually harms both the mitochondria and kidneys), acytel-choline, mushrooms, cafeine, omega 3, BDNF nutrients, cannabinoids, L-theanine from green tea, lavander essential oil (the Germans have a powerful one in capsules) and a few others. L-theanine with or without CBD cannabinoids can help to foster spiritual alertness and mental clarity, analagous to having a zen meditative state. Meditating and having some green organic tea with L-theanine and-or light roasted (or green infused) organic coffee can also be beneficial as is yoga and most everything else that is holistically restorative, including sleep of course. This Presentation will thus review a few evidence-supporting slides.
Case in point: Depression and Gut Disorders
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Session M: The Microbiota Revolution in Medicine & how Microbiome Medicine Optimizes Longevity
Since 2012 when the Journal Nature published the Human Microbiome Project’s (HMP) results, the very face of medicine has changed. With 8 million Microbiota genes that cross talk with our 22,000 (or 23K) human eukaryotic genes, we better understand the Microbiota’s pivotal role with regard to physiology, diseases and longevity, all thanks to our inner Garden’s critters made from bacteria, virus, fungi, archaea and, inter alia, their genes.
“The human body contains trillions of microorganisms — outnumbering human cells by 10 to 1. Because of their small size, however, microorganisms make up only about 1 to 3 percent of the body’s mass (in a 200-pound adult, that’s 2 to 6 pounds of bacteria), but play a vital role in human health (…) Researchers now calculate that more than 10,000 microbial species occupy the human ecosystem. Moreover, researchers calculate that they have identified between 81 and 99 percent of all microorganismal genera in healthy adults (….) HMP researchers also reported that this plethora of microbes contribute more genes responsible for human survival than humans contribute. Where the human genome carries some 22,000 protein-coding genes, researchers estimate that the human microbiome contributes some 8 million unique protein-coding genes or 360 times more bacterial genes than human genes. This bacterial genomic contribution is critical for human survival. Genes carried by bacteria in the gastro-intestinal tract, for example, allow humans to digest foods and absorb nutrients that otherwise would be unavailable. (Source)
These discoveries on the microbiota have been shown to be useful for the control and reversal of not only Alzheimer’s disease, but for auto-immune diseases, diabetes, cardiovascular issues, cancer and more. The evidence confirms that both the microbiota and the microbiome impact the expression of our entire genetic Code in multiple ways. In addition, the microbiota makes many of our key nutrients and molecules, from the vitamins K and B6, to neuropeptides like serotonin and dopamine that affects our neurochemistry, to short chain fatty acids, to the protection of the gut lining, the promotion of signaling molecules, the downregulation of inflammation and more.
In this Presentation, we will look at a few of these discoveries and show how human Lifespan can be extended with the use of a holistic lifestype and diet that includes certain probiotics, probiotics and superfoods that favor certain key gut bacteria that inhabit healthy centenarians, most of whom harbor a microbiota as rich and diverse as those of thirty years old.
As we will see, the very same bacteria who have been so essential in the complexification of Life over the last 65 millions of years are living in our guts churning away to make us either sick and short lived or healthy and long lived. For example, supercentenarians have a diversed amount of youthful bacteria whereas sick people who die young have lots of dysbiosis and poor diversity. Microbiome science has been one of the most recent scientific revolutions in Medicine, disproving a big chunk of mainstream medical dogmas. In this Presentation, we will also look at binders what hinders the optimization of the microbiota’s robustness and diversity.
Case study: The Microbiota, Genes and Colon Cancer: Do Human eukaryotic genes cross-talk with Bacterial Genes ?
As we have seen and will see again one of the superhero Longevity Gene is the old (billion years old) Sirtiun 3 who has multiple roles in homeostasis and longevity. When it is well expressed, it talks with different species of human microbiota whose Sirtuin 2 genes resonate with human eukariotic Sirtuine 3 genes. In other words, they cross talk to figure out what is the best evolutionary strategy is regarding growing colon cells in the very gut that these genes reside. Crosstalking between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis and the subsequent anti-inflammatory and tumor-suppressing tactics that are put in place with the Bacterial allies is less delusionary than real, anchored in biology, but not in the FDA data-banks.
“The key microbes that prevent downregulation of Sirt3 expression during colorectal tumorigenesis are L. reuteri and L. taiwanensis, which may provide a precise therapeutic strategy for the prevention of Sirt3-deficient colon cancer by manipulation of the gut microbiome… Moreover, Sirt3 and commensal microbiota synergize to regulate the expression of CLCN4 in the development of colon cancer…Considering the gut probiotic effect of SIRT3KO mice, it is possible that probiotic bacteria, such as Lactobacillus, may provide bacterial Sir2 (a gene was homologous to eukaryotic Sirt3) for deacetylase activity. A previous in vitro experiment demonstrated that bacterial Sir2 activity is elevated with co-culture of Lactobacillus acidophilus and Caco-2 cells (Source) Thus, Sirt3 may be crucial for a probiotic effect in gut tumorigenesis. In conclusion, Sirt3 is a novel colonic tumor suppressor that inhibits colonic tumorigenesis via an interaction with the gut microbiome”. (Source)
In this Presentation, we will look a little deeper at how the microbiota’ s genes and our own genes collaborate to remove cancer cells. But there’s a caveat. Human genes can also be hijacked by Microbiota genes to spread cancer thereby shorten longevity. The macriobiota can even block conventional oncology’s weapons of mass cellular destruction. Which may be a good thing, but Big Pharma & the FDA do not agree. The Key issue then is under which holistic conditions can we coordinate human and bacterial genes to optimize cancer-free longevity ?
Case in Point: Are the Gut’s Bacteria capable of Detoxify human chemicals while favorably modulating ROS ?
One of the difference between Holistic Medicine and Conventional Medicine is that the Government’s medicine is based on ignorance, greed and war via weapons of cellular mass destruction, inter alia, while Holistic medicine is based on knowledge, (including the highest form, intuitive knowledge, the one Einstein used), generosity and peace, in particular via the harmonization of all of the constituent members of this thing called Life. So not only is the microbiota capable of removing the Government sponsored corporate chemicals that assail Life, including most, perhaps 99 percent of Conventional Oncology’s cytotoxic chemo (hence the epiphenomenon called chemo resistance), but it is also capable of producing its own Number One detoxifier molecule, the great Glutathione. Futhermore Glutathione helps with modulating ROS and since ROS is a factor in aging, we have a win win situation where certain species of bacteria will both reduce ROS and activate the detox pathways. At least if the Government’s medicine stops spreading it’s chemical poisons tous azimuths.
There is much information about glutathione (GSH) in eukaryotic cells, but relatively little is known about GSH in prokaryotes. Without GSH and glutathione redox cycle lactic acid bacteria (LAB) cannot protect themselves against reactive oxygen species. Previously we have shown the presence of GSH in Lactobacillus fermentum ME-3 (DSM14241). Results of this study show that probiotic L. fermentum ME-3 contains both glutathione peroxidase and glutathione reductase. We also present that L. fermentum ME-3 can transport GSH from environment and synthesize GSH. This means that it is characterized by a complete glutathione system: synthesis, uptake and redox turnover ability that makes L. fermentum ME-3 a perfect protector against oxidative stress. “ (Source)
Case Studies: The Gut microbiata via fecal transplants and the reversal of multiple diseases
If time allows, we will also examine fecal transplants and how they have been successful with autism, obesity, colitis, infections and other diseases than hinder the 120 years reach.
Should Stool testing be part of all Diagnosis Work-ups ?
Given the importance of the microbiota as both factors and indicators of diseases, ordering a stool test should be part of the standard of care. In this presentation, we will identify simple methods that everyone can put in place in order to determine some of what stools indicate, in particular, in terms of smell, looks, texture and micro-organisms composition and their endotoxins and metabolites.
The Internet, bookstores and libraries are replete with nutritional claims that are often contradictory and scientifically spinned or biased, including, but not limited to dash-paleo-keto high-fat, mid-animal proteins, low-carb, high-calorie schools diets which tend to be inflammatory and deleterious for long term health and longervity.
On the other hand, anti-inflammatory plant-based, high fiber, high bitters, mid vegan fats, low protein, low calorie and high low-glycemic carbs ancestral diets tend to avoid chronic diseases and optimize longevity, including the mostly plant-based Mediteranean diet, as long as this diet has a low amount of clean quality animal foods, including raw organic honey and wild small clean fish (ie, Smash). But diets that include more than 5 percent animal foods (depending on the person’s gene pool) and-or have loads of processed foods tend to be deleteriously inflammatory and, inter alia, toxic to human kidneys, the endothelium and overall health. (9) In other words, as Michael Polene put it, the available evidence suggests that Evolutionary Biology formed humans to be “mostly plant-based” eating fresh, whole and clean foods. In this Presentation, we will dive deep into the compelling evidence that proves beyond any reasonable doubt which diet is the best for which group of people..
The Paleo-Keto-Mediterranean-Vegan-Caloric Restriction-Diet Variation” Debate
What is the Best Diet for Energy Production, Memory Maintenance, Hormonal Optimization, Tissue & DNA repair, immune-enhancement and Cancer-Free Long Lifespans to 120 Years that is also good for the Planet ?
Because Food is an important human element in both healthy lifespan protocols and sensory gratifying pleasures called “table pleasures” in French, which, for many, has become a religion, we will delve into this question with an added layer of rigor. For now, having reviewed the available scientific litterature, the facts suggest that the ideal human longevity diet is not consistent with the most popular diets in the US. In other words, this “ideal nutritional regime” is neither vegan, nor vegetarian, nor keto nor paleo nor compatabile with the Standard American Diet, let alone the insectivore diet.
While both the modern Paleo and Keto diets appear to be improvements over the over the 40,000 years old Neanderthal diets and the government’s GMO-based SAD (ie SAD = Standard American Diet), the facts show that both keto and paleo low-carb diets are not long term sustainable even if they can be efficient for blood sugar control, weight management and a few other conditions (including epilepsy and brain cancer with regard to a low protein restricted ketogenic diet).
In this Presentation, we will show the compelling evidence that supports the best “across the board” nutrition plans that are consistent with the general principles of the Science of Optimal Longevity, the Engine of evolutionary biology and gastroenterology.
The Second part of this Discussion will go into specific and customized or personalized dietary recommendations according to different categories of adults, geographical differences and genetic variabilities. We will also look at some of the most popular American diets (e.g., the Zone Diet, Macrobiotic Diet, Dash & Sibo diets, the Low-Carb Diets (Keto or Ketogenic Diet, Atkins Diet, South Beach Diet, The Whole 30 Diet), pesca-vegetarian diet, veganism, Gerson and Hippocrates Institute diets etc) and identify both their strong and weak aspects.
Limitations and Strengths of the Ketogenic Diet
Because there is a lot of confusion mingled with misleading and risky allegations with regard to the popular Ketogenic diet, this Presentation will examine the hard evidence. In this perspective, i will therefore briefly introduce the subject so that workshopees will be broached on the subject. For starts, suffice to characterize the Ketogenic diet as a nutritional regime that reshuffles the ratio of the three basic macronutrients. It reduces carbs to less than 5 percent or around 30 grams a day. Fats are the highest of all macronutrients. But trans-fats are rejected and grass-fed animal fats are prioritized. Protein from most animals is either moderate or relatively high.
The Ketogenic diet has been used as medicine for close to one hundred years. In particular with regard to epilepsy. More recently, certain scientists like Professor Seigfriend (who we interviewed for two hours) have promoted its use for certain types of brain cancer. Depending on many variables, other cancers can also benefit from this diet, but usually not long term. And more recently, after a few sweeping internet marketing tsunamis, a growing number of the educated population, including within Drs Hyman, Perlmutter and Mercola’s keto-communities, has been using with some success this diet for diabetes, blood sugar, weight management. For many people, they are satisfied because they can quickly see and feel improvements, in particular, the Hemoglobin A1C is low, insulin is flat-lined and weight is shed. And for some people that’s enough to kickstart a healthy holistic lifestyle. Moreover, by adopting this diet, the Keto-people are opting out of the GMO processed food standard american diet rabbit hole. Just this by itself is beneficial. And secondarily, the keto-guerrilos are seeing short term success with regard to the stabilization of their blood sugar. So that’s good too. For some people, all they need is a little extra voltage to rewrite the Subconscious’ self-sabotage program and dare live more holistically.
Keto-Flaws and Serious Pitfalls
However, the deleterious effects of this diet eventually catches up to the patient. And the published evidence has corroborated that this keto-diet should not be used long term for many decades. But the Keto-scientists have used flawed studies, in particular small population sizes conducted over short time periods, often over weeks or months. Monsanto used this same deceptive investigatory trick too. GMO foods were given to rats for a few months, no cancer. And the French followed up with a two years study with the same GMO food and rats and cancer spread all over (cf Senelli). An illustration of this flaw is a keto study published in 2017 documenting the results of 10 weeks of a ketogenic diet on 262 patients following a diet containing less than 30 grams of carbohydrate per day, with high fat and an average of 175 grams of protein per day (McKenzie AL, Hallberg SJ, Creighton BC, Volk BM, Link TM, Abner MK, et al. A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes. JMIR Diabetes. 2017;2(1):e5). These researchers showed how 10 weeks of ketosis resulted in an average A1c decrease of 1.0%, an average weight loss of 7.2%, and how more than 56% of participants reduced their need for insulin drugs. However, in order to ascertain the true effectiveness of any diet, the cohorts should involved thousands if not tens of thousands of people. And for nutritional studies to be well designed, we need at least 2 to 5 and more years. And we already have these studies, all of which show that low carb diets and high animal diets are unhealthy.
Noto H, Goto A, Tsujimoto T, Noda M. Low-Carbohydrate Diets and All- Cause Mortality: A Systematic Review and Meta-Analysis of Observational Studies. PLoS ONE [Internet]. 2013 Jan 25 [cited 2014 May 9];8(1). Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC355597.
Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, et al. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med. 2016 Aug 1
Fung TT, van Dam RM, Hankinson SE, Stampfer M, Willett WC, Hu FB. Low-carbohydrate diets and all-cause and cause-specific mortality: Two cohort Studies. Ann Intern Med. 2010 Sep 7;153(5):289–98.
As these and other studies show, the keto diet long term tends to increase the risk for hemorrhagic stroke, hypertention, atherosclerosis (cf via the Tmao metabolite mechanism), diabetes mortality, risk for obesity risk for cancer (animal cholesterol is a factor) and, inter alia, an increased risk for all-cause mortality.
Furthermore, there’s evidence that even ketones can fuel cancer growth. (Source). Naturally induced ketones with restricted caloric intake or fasting is usually healthy, if only because other longevity mechanisms kick in, including autophagy. But taking exogenous ketones and eating in a way that gets the body to run on ketones most if not all of the time has been shown to be long term deleterious to health
On the other hand with organic plant-strong Mediterranean or Vegan diets, based on healthy carbs, mushrooms and little if any animal food and chemicals, insulin is not spiked and there are no issues with uncontrolled obesity, diabetes or other metabolic disorders. The scientific data shows that insulin resistance and blood sugar instability result from animal fats in association with refined toxic carbs and toxicants. (Source)
Another way to demonstrate this above-mentioned assertion would be to conduct an experiment to simply reduce free fatty acid (fat) in the bloodstream to see if insuline resistance got better, became more sensitive. This working hypthesis was put to the test in 1999 and since, it has not been refuted.
“We conclude that lowering of elevated plasma FFA levels can reduce insulin resistance/hyperinsulinemia and improve oral glucose tolerance in lean and obese nondiabetic subjects and in obese patients with type 2 diabetes” (Diabetes. 1999 Sep;48(9):1836-41. (Source))
The Strengths and Limitations of the Paleo Diet
In this Presentation, we will analyze the evidence that suggests that paleo diets are ok short term as long as the principle of nutritional synergy (the combo of nutrients) is respected. However, the evidence also suggests that mid to long-term, the paleo diets are inconsistent with human optimal healthy long lives, let alone evolutionary biology and human cellular homeostasis. These animal-strong and plant-weak (under 5 percent of total calories a day) diets tend to fuel endocrine, cancer, kidney and, among other ailments, cardiovascular complications. Cancer for example does not only use glucose, glutamine, acetate and animo acids to grow. Cancer cells are metabolically flexible, when glucose is insufficient, they will use fatty acids and in particular cholesterol as a fuel. Research has shown beyond any reasonable doubt that for key oncogenic events to materialize, an abundance of cholesterol is needed. Without enough cholesterol, cancer cells just can’t proliferate. (Source). Animal foods also promote CVDs, (Source), Kidney failure and a slew of other chronic diseases. Plants (carbs) don’t because they don’t have cholesterol and not much saturated fats (outside of coconut oil). And they are rich in fiber and key nutrients, including polyphenols, bioflavonoids, omega 3 and antioxidants.
An effective recipe to die crippled with an onslaught of chronic diseases
The worse scenario in terms of insulin resistance and the onset of diabetes and CVDs is to ingest refined carbs, toxicants like BPa and an abundance of fats, especially animal and saturated fats. When the nutrition is adpated to human needs, insulin, which is one of the most anabolic hormones humans have, is beneficial to get not only blood sugar into tissues, but also amino and fatty acides. And glycogen (stored glucose in the liver) is needed for quick energy release, including during exerices and “fight & flight” episodes. Futhermore, the brain functions better on glucose than ketones, even if ketones can be an emergency fuel. While Drs Hymans and Mercola’s allegation that ketones are cleaner “fuels” (in terms of ROS production) is not completely wrong, this claim is nonetheless misleading, if only because without enough healthy carbs and fibers, the body does not get to make enough of the good ROS the body needs, inter alia, the microbiota does not thrive as it should and multiple chronic diseases as well as accelerated aging creep in mid to long term.
This presentation will go into the details and show, with a preponderance of the evidence, that both the keto and paleo diets are not consistent with human optimal longevity. Maybe with dogs, as they can eat tons of animal cholesterol-laden meat and have impeccable endothelium, but humans can’t, with animal cholesterol and satruated fat rich foods, their arterial inner lining get clogged up as do their insulin receptors. A recent case in point is the ongoing President of the American Heart association who recently got hit with a heart attack at the age of 52. When we mix refined carbs with animal foods in the same meal, their saturated fats, in conjunction with deleterious chemicals, inter alia, compromise the entire insulin and blood stabilization machinery, as a result blood sugar spikes, insulin becomes resistant, it can’t activate the glucose transport pathway and the arteries get messed up to the point where thrombosis and heart attacks are likely. The evidence shows that even whole-food carbs like bananas can be a problem when high glycemic foods are synergiezed with animal fat in the same meal. To optimize healthy lifespans, workshopees should first learn about holitic cardiology, chronobiology and the Med-diet.
Case Study: Reversing Diabetes Holistically
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Happiness Medicine Institute’s Holistic Mediterranean Diet & Executive Recommendations
The Holistic Mediterranean Diet is an improvement over the classical Med-Diet in that it upregulates and improves the expression of thousands of genes while diversifying the microbiota like no drug or other diet can. For many decades, the prevailing evidence had determined that the classical South European Mediterranean Diet has been the best human longevity diet. Thousands of published papers in the best peer-reviewed journals corroborate this piece of allegation. Even the controversial Ancel Keys ended up adopting the Med Diet by moving to South Europe where he lived with his wife in decent shape until he reached 100 years. (Source) The French version of this classical Italo-Greek Diet is what super-longevity champion Jeanne Calment thrived on until 122 and a half years.
Out of over a dozen Mediterranean versions of the Med-Diet, the Hapiness Medicine Institute’s Holistic Medicterranean Diet has fine-tuned this nutritional regime by taken the best of all of these Med-diet versions, from the Med-diet of Kosher Israel, to the mint-humus Med-diet of Morocco, Lebanon, Spain, Turkey, Icaria, Italy, Corsica, Croatia, Slovenia and more while improving it in light of new scientific discoveries, daring medical hypotheses and intuitive guidance.
In this Presentation, we will thus prove beyond any reasonable doubt that the Happiness Medicine Institute’s Holistic Med-Diet is clinically and nutritionaly superior to all other diets, in particular with regard to chronic diseases and TMAO avoidance, energy production, diversity of the microbiota and longevity optimization. The popular keto-paleo and even vegan medical doctors and plant-based nutritionists who unscientifically equate wine with “alcohol” will instinctively and-or ideologically protest against Happiness Medicine Institute’s executive conclusions. But the data is irrefutable. Epidemiologically, the longest-lived people who have out-survived all others, including the Seven-Day-Adventists, the Amish and the Okinawans, have all adopted the so-called longevity or blue zones traditions based on ancestral fiber-rich & wine-strong Med-Diet, inter alia. With today’s scientific discoveries on the halmarks of aging and the tweaking of longevity genes, we should be able to do much better than even today’s longevity record-breaker champion, Jeanne Calment herself, if only because Jeanne smoked cigarettes and had lots of sweets (e.g.. pastries and chocolate) until 119 years when she willingly accepted her personal doctor’s strict recommendations to stop these two habits.
For now, and in general, the Happiness Medicine Institute recommends one of two nutritional modalities, depending on genetic variations (SNPs), health status, energy requirements, culture and tastebuds. The first is to thrive only on fungi (mushrooms) & organic wholesome, fiber-rich, anti-inflammatory plant-based foods at least half of which should be raw (fresh, sprouted or fermented). The second nutritional regime would be “mostly vegan”, which means that the general principles of the Holistic Mediterranean Diet mentioned above would apply, in particular, at least 95 percent wholesome mushrooms and plants (e.g., fruits, flowers, greens, seeds, nuts, beans, berries etc) and not more than 5 percent quality and sustainable animal foods who do not produce cortisol-laden fear when they die. However, because being 100 percent vegan under holistic conditions is difficult and quasi-impossible for most People, being vegan five days a week, fasting to activate autophagy, mitophagy & cellular repair, inter alia, on the sixth day and, on the seventh day, Sabbath, the day of therapeutic rest, having some small amounts of healthy ancestral wine and food from our animal cousins, all of which can be optimizing and is consistent with the Science that supports the Holistic Mediterranean Diet, a diet that is based on no less than 5 millions years of evolutionary biology. But there are two conditions. And these are hinged on common sense, forensic science and intuitive intelligence. First, the food-medicine that animals can share with humans should not be the result of violence and unsustainable practices, if only because the death-fear emotion in sentient animals produces an abundance of endogenous toxic chemicals (i.e. endotoxins), including lactic acid and cortisol, both of which acidify human tissues and if there’s a PH condition that most humans need to avoid, it’s acidification and uric acid of their tissues. While this feat is holistically accomplishable with dairy, eggs and sustainable raw organic honey, it is less with fish, especially these days when the powers that be are willy nilly continuing to destroy the Ocean’s homeostasis and Life on Earth. And secondarily, when animal foods are ingested, for proper and clean digestion, and in order to bypass their high cholesterol, choline, carnitine, bacterial load, putrefaction content and saturated fats, inter alia, holistic nutritional rules that help to mitigate if not reverse the damage should be applied (This Presentation will go over some of these nutritional and combination “synergy” rules).
The Joie de Vivre French Approach to Food & the Art of Slow Eating
Food is not only about ingesting calories. Nutrition is also more than a Science. It’s also an art. An art that creates scientific biochemical results. Hence the esthetics of Food. In France, one of the first concerns is “presentation”, how food is presented on the table. It has to look appetizing. Second, the gusto-olfactory senses that target the limbic zone need to be activated via pleasant aromas. If the food doesn’t smell good, including the camembert cheese, then French people tend to avoid it. Third, the eater should be mindfully present in his or her food experience and enjoy salivating and downing the tasty food, including with quality wine that will help to digestive juices to get better activated. All negative and-or stressful talk should be deferred. Fourth, this mindful enjoyment (ie, part of the joie de vivre experience) should be expressed in a serene and beautiful atmosphere (flowers on the table etc) and the eating should be slowly savoured. Fast eating in a stressful environment activates the sympathetic dominance system which reduces the flow of the gastric juices and favors intestinal permeability (leaky gut syndrome). This is called the sympathic physiologic strress reponse, which is an evolutionary mechanism. Among other disorders, fast and stressful food eating leads to metabolic havoc, including, but not limited to obesity and liver disease.
“In this study, we cross-sectionally examined the association of the self-reported rate of eating with current Body Mass Index (BMI), and BMI-change from 20 years of age to the current age….Conclusion: Our results among middle-aged men and women suggest that eating fast would lead to obesity” (Source)
Fifth, food should be enjoyed with family and friends as long as the vibes are pleasant non stressful and when possible, the meal should be wrapped up with a warm herbal tea, so that the stomach PH and gastric juices work better. The largest meal should be eating at lunch time. Thereafter, a small siesta to help optimize the vagus nerve and microbiota functions while enjoying digestive “peace” either in a restful backyard hammock or in another quiet area. Eating late in the evening is not healthy for reasons which this Workshop will explain.
“Subjects who habitually ate before bedtime, and those who ate fast and before bedtime, tended to have an increased risk of NAFLD. Earlier intervention to modify these poor eating behaviors could be useful to prevent NAFLD”. (Population Health Management 2016;19:279-283). (Source) (NAFLD is non alcohol fatty liver disease, which is now a new epidemic in the USA).
In other words, when eating is not holistically approached, the gastro-intestinal signaling pathways are messed up, which leads to mal nutrient assimilation, a inefficient calorie burning rate, and, inter alia, food cravings.
Thus, in this Presentation, we will learn all about these principles, from digestion preparation (including bitters) to culinary principes, food combination, spice medicine and more. The take-away in this lesson is to understand that if the body-mind does not fully experience culinary beauty, taste and smell, then the body’s innate intelligence will not be entirely sastified, at which point the eater will seek to eat more and not assimilate well. This is one reason why the French tend to have small rations of quality food and why American fast food companies have a difficult time rooting on French soil.
The Doctrine of Signatures (Teleological Nutritional Targeting)
The Holistic Mediterranean Diet also incorporates the best of the millenia-old “Doctrine of signatures”. Referred to in the classical period of Rome as the “Law of Similarities” and the “law of like cures like” among the Homeopathes, this ancient healing art is now called by scientists, “Teleological Nutritional Targeting”. Often associated with the work of herbalists and wise women, this TNT (Teleological Nutrional Targeting) drew upon the belief that natural objects that looked like a part of the body or act like a body process could cure diseases that would arise there. In this perspective, folk healers in the Christian world claimed that God deliberately made plants to resemble the parts of the body so as to give them a clue as to what could cure them. This doctrine of signatures has been used around the world in pre-modern cultures where the principle of thought-by-association or “analogy” thinking has been accepted as a valid means of obtaining knowledge of the world. The idea is that a plant that looks like the disease, organ, or person will be healing and natural beauty. Horsetail (Equisetum arvensis) for example, looks like horse hair, so it is good for the hair. It also grows on wet sands, so it is remedy for the kidneys. Thus, the shape, color, and habitat all can be used to determine the uses of a plant. In addition to the appearance, the taste, smell, touch or texture can also provide “signatures” or cues from Nature. Thus, the putrid smell and bad taste of figwort (Scrophularia spp.) indicate that it is a remedy for putrefaction. Since it has gland-like or hemorrhoids-like flowers, it is also called figwort or pilewort and marked as a lymphatic remedy and a hemorrhoid remedy. Even sound can provide a signature. Black cohosh (Cimicifuga racemosa) and wild indigo (Baptisia tinctoria) have been used as Snake Medicines by American Indians because the seeds in the seedpod produce a rattling sound. Take the eyebright plant, whose flower looks like bright blue eyes, this plant has been used to treat eye diseases for millennia and many French naturopaths continue to use this plant for this purpose. Likewise with ginseng, this rooot looks like a two legged human and is one of the best adaptogenes for humans abundantly used by Chinese healers. There are thousands of plants that have a pattern that resembles a body organ or physiological function and that this pattern acts as a signal or sign or cue regarding healing benefit. In Anthroposophic Medicine, Mistletoe is a good case in point. A parasitic plant that resembles cancer’s modus operandi, the mystic scientist Rudolf Steiner deduced that Mistletoe should be indicated for cancer. Today, mistletoe is one of the most popular cancer medicines in Europe, in both its homeopathic version (called viscum album in France and escador in German) and IV drip medicine. Consider also a sliced carrot, this slice looks like the human eye (pupil, iris and radiating lines) and Science has shown that carrots greatly enhance blood flow to eyes while beta-carotene (precursor of Vitamin A) bolsters vision. A tomato has four chambers and is red, just like the heart. All of the research shows tomatoes are indeed pure heart and blood food. Apples as well. Cut the apple in half and it looks like a throbbing heart. Grapes hang in a cluster that has the shape of the heart. Each grape looks like a blood cell and all of the research today shows that grapes are also profound heart and blood vitalizing food. Likewise with cancer. These clusters of cells could also be cancer cells and grapes’ resveratrol and polyphenols are great for the immune system’s anti-cancer brigade. Kidney Beans actually heal and help maintain kidney function and yes, they look exactly like the human kidneys. Celery, Bok Choy, Rhubarb and more look just like bones. These foods specifically target bone strength. Bones are 23% sodium and these foods are 23% sodium. If you don’t have enough sodium in your diet the body pulls it from the bones. A Walnut looks like a little brain, a left and right hemisphere, upper cerebrums and lower cerebelums. Even the wrinkles or folds that are on the nut looks like the neo-cortex. And we now know that walnuts help develop many neuro-transmitters for brain function. Likewise with the prostate. This male and female gland (yes, females also have one, but it’s smaller and not used for semen production) looks exactly like a prostate gland. By being covered in muscles, the prostate gland looks even more like walnuts and yes, there are published peer-reviewed studies that show that walnuts slow down the growth of prostate cancer.
“The significant decrease in the alpha-T: gamma-T ratio with an increase in serum gamma-T and a trend towards an increase in the ratio of free PSA:total PSA following the 8-week supplement study suggest that walnuts may improve biomarkers of prostate and vascular status”. Nutr J. 2008 May 2;7:13. (Source)
“Our results suggest that a diet rich in ET-containing foods, such as walnuts, could contribute to the prevention of prostate cancer”. Food Funct. 2014 Nov;5(11):2922-30 (Source)
While some of this healing art may be exagerated, it is amazing how many of these plants that are suggestive of human body parts and-or physiological process does start the healing process in the targeted organ and as far as the Happiness Medicine Institute’s executive Committee is concerned, this type of medical art should the new standard of care replacing the Pharmakia-drug Cartel that finances corruption and a significant number of law-makers. This initiative would avoid the hundreds of thousands of prescription deaths each year from the Government’s certified conventional medicine while igniting the healing process pronto. Indeed, with Nature’s cues, from morphology, to smell, physiological function etc, this healing art is truly holistic and is thus a necessary part of the Holistic Mediterranean Diet and Optimal Longevity protocols.
In this Presentation, we will look over the scientific basis of some of the wild plants in terms of their morphology and other bodily function. There are hundreds and hundreds of these plants that have been validated by nutritional science. Thousands more await validation. The Swiss genie (in medicine) Paracelsus based part of his medical system upon this type of similarity or signature and called it “magia naturale”, or natural magic. Bacon was also a proponent, but being left brain dominant, he was more rigorous in terms of a cause-and-effect empirical association. Darwin also reasoned from the morphological similarities in birds on the Galapagos to arrive at the Theory of Evolution while Goethe tried to establish a new scientific discipline based on analogical thought, imagination and intuition. He was the first to observe that the flower structures were modified leaves. This was his starting point to the principles of developmental morphology. He realized that each vertebra was a variation on the same structural theme and that the skull in itself was a modified vertebra. Rudolf Steiner attempted to continue Goethe’s holistic approach, a few French scientists as well and then came the nasty British industrial Revolution, the excesses of the American civil war, the horrors of scientific materialism expressed via Dr Goebbles extermination schemes and the inanities of American taylor-based neoliberalism, all of which suppressed intuitive, archetypal and holistic science, based on the criticism that it was the product of “enthusiasm” and “fantasy” and therefore not the result of randomized controled studies and Science. This healing art was therefore characterized as quakery and rendered illegal when practiced as medicine. Etcetera with some ad nauseum.
The “Truth” (Debate) on Soy
As explained in the methodology section, in medicine, nothing is definitive while in nutrition or any health science, “truth” has often been self-servingly biased or assumed based on false premises and spurious representation. In other words, when anyone states “the truth” (“the truth about cancer”, the “truth about dairy”, “the truth about carbs” etc), we can be sure that bias and ideology rule. Nonetheless, with the emergence and accumulation of hard and reproducible evidence, we can now assert with a strong sense of scientific confidence that the “Soy” debate is “closed”, at least insofar as non GMO organic soy is concerned. Meta-analyses after meta-analyses have shown that traditionally grown soy (without the GMO and pesticides) is one of the healthiest foods for most people once it’s correctly prepared. In this perspective, the more fermented and-or sprouted, the healthier. But The scientific confusion stems from conventional nutritionists and medical doctors (including many integrative physicians) not understanding clinical nutrition and holistic science, in particular the difference between plant phytoestrogens and mammalian estrogens in relation to the Alpha and Beta estrogen receptors. In this Presentation, we will explain why organic quality fermented soy is a superfood. A small percentage of consumers will be allergic even to organic soy. We will explain why.
Can Quality A2 Traditional-made Cheese be a Longevity and Medical Food ?
“He will not look upon the rivers, the streams flowing with honey and curds”. Job 20:17
Not all cheese have been created equal. In this presentation, we will review the benefits as well as the weaknesses of cheese. Much of the deleterious aspects of cheese in the U.S. come from the inflammatory A1 beta casein type of milk, (even organic), which is the only type of milk we can find in the American mainstream. A2 beta-casein milk comes from South Europe, in particular France. As we will see via power point, it is much healthier. Another weakness of American cheese is the mandatory pasteurization of all American milk, even organic. This process destroys the naturally present SIgA, which is an immunoglobulin that helps neutralize lectin-like compounds in cheese by binding to them. Furthermore, raw cheese has all of the necessary enzymes for proper digestion, it’s other molecules are in better shape and it tastes much better. The ideal cheese is thus organic raw goat or sheep cheese that comes from well treated ruminants who are integrated in traditional farms. As a consequence, by grazing pasture land, they help to avoid wild fires while fertilizing the soil with their poop and providing quality milk for both their baby ruminants and humans who may benefit from cheese medicine. Under these conditions, cheese can’t be mass produced like in toxic animal farms.
We will also show that most of the strong anti-cheese claims of vegan American scientists and medical doctors are delusional (not anchored in scientific reality). Consistent epidemiological evidence has proven for many decades that the A2 cheese-based Mediterranean Diet is still the golden standard diet for healthy longevity, much more than the vegan, keto or paleo diets. We have sound evidence that supports this medical claim for multiple health conditions, including, but not limited to cancer prevention and cancer treatment, (for certain cancers), gout treatment, teeth caries, (cavities), CVD risk reduction, for different neurological disorders and inter alia longevity optimization. (Cf. HM Institute is drafting a detailed Report on this topic).
“The final analyses included 15 prospective studies. (…) This meta-analysis of prospective studies suggests a nonlinear inverse association between cheese consumption and risk of CVD. (Source) (European Journal of Nutrition, December 2017, Volume 56, Issue 8, pp 2565–257
Given genetic variations and damaged bodies, not everyone can benefit from cheese medicine. Some people are better off with no dairy at all, especially those without lactase who are lactose intolerant and taxed with an immune-disease, allergies, advanced cancer (especially hormone-sensitive cancers like breast, ovarian and prostate malignancies), advanced CVD, advanced Arthritis and genetic SNPs. For those not certain, a 99 dollars Genomic test may be indicated.
Outside of these categories of humans, most People will generally profit from small amounts of quality dairy, in particular raw probiotic-rich yogurt and cheese from well-treated A2 ruminants when taken holistically and synergistically during a Mediterranean-type diet. Consistent epidemiological evidence has proven for many decades that the Med Diet is still the golden standard diet for healthy longevity, much more than the vegan, keto or paleo diets. Like with fermented soy (miso, natto etc) and fermented grapes (wine, porto etc), fermented raw milk has preserved nutrient-densed foods and interesting molecules like stem cells, quality dairy has fed and healed humans for many millennia, including during Jesus Christ’s time when dairy was both a food and medicine, including, but not limited to camel milk.
“…. specific diseases and medical conditions that have been treated by camel milk or urine, including cancer,3 chronic hepatitis,4 hepatitis C infection5,6 and peptic ulcers.7 Even more recently, it has been reported that camel milk has cured severe food allergies in children who were unresponsive to conventional treatments8 and diabetes mellitus.9 Furthermore, camel milk is endowed with anti-malignant,10 antiplatelet11 and anti-thrombotic properties12 in addition to a host of anti-bacterial and viral properties,13,14 suggesting, among other things, the existence of a very strong immune system, which was recently shown to be equipped with unique light-chain-only antibodies.15”. (Source)
Since the French Roquefort sheep cheese (which has been a traditionally made – for over five hundred years – from free-range raw sheep milk from the great Larzac plains and aged in penicillin-laden super-bacteria-rich caves) is sold for dirt cheap at Trader’s Joe, we will briefly examine it’s medical claims as well as its nutritional elements, including, but not limited to B-6, B-12 and K-2 from the Microtiota’s bacteria, Vitamin D from the Sun and DHA from ALA.. Besides Roquefort, I have not found any other A2 raw quality cheese in the United States. Dutch Meadow Farms and Target sell A2 cow milk, but i have found not found A2 organic raw cheese.
Top: In France, Cheese is prefered raw and organic, from grass fed animals, without antibiotics and artificial hormones and combined with wine. Although cow cheese is cheaper, most of the French prefer sheep and goats cheese, if only because these cheese have healthier casein protein and lipid profile than cow cheese, hence the gusto-olfactory contentment. As an accompaniment, polyphenol-rich wine and when available, organic fresh grapes, olives and nuts are also indicated. This custom helps with digestion, bio-availability and mineral balance. Organic catechin-rich Green tea can also help to burn cheese’s rich saturated and unsaturated fat content while flooding the bloodstream with complementary antioxidants, blood-thinning compounds and immuno-building molecules. A2 cheese is also rich in important fats, like DHA as well as its many fat-soluble vitamines, like Vitamin A, D and the prized K-2 and B-12 etc..
The French Paradox on the High Cholesterol & Low CVDs
Coined by Professoer Serge Renaud of Bordeaux, the French Paradox concept means that the wine-drinking French are the only People among 40 studied countries that defy the causative association between dietary cholesterol & saturated fat intake in relation to coronary heart disease. Most American scientists couldn’t understand why a Nation that deliberately ignores the American Federal food guidelines could enjoy four times more full fat creamy butter, way more cheese and have an incidence of coronary heart disease (CHD) that is much less. (cf. ”Serge Renaud: from French paradox to Cretan miracle”. The Lancet. 355 (9197): (Source) And to this day, this French paradox phenomenon continues to be ideologically spined, from Dr Gerger, to Drs Barnard, Fuhrman, Klaper and the others, all of whom appear to need to demonize wine as “evil alcohol” devoid of health benefits. Yet, the evidence shows that when used holistically, wine is medicine and can help heal dozens of diseases and health conditions. For example, wine’s oligomeric procyanidins have been proven to confer protection to human vascular cells (Oenology: Red wine procyanidins and vascular health”. Nature. 444 (7119): 566. (Source) and red wine polyphenols were shown to reduce the absorption of malondialdehyde which is implicated in elevating levels of low-density lipoprotein in the onset of arteriosclerosis. (Source). Quality wine taken holistically is also an aromatase inhibitor, helps with digestion, diabetes, cancer, Alzheimer’s Disease, boosts HDL, has vasodilatory and blood thinning properties (much less dangerous than aspirin or warfarin) as well as being favorable to the microbiota while being anti-bacterial, targeting especially deleterious bacteria, including those in the oral cavity and on wounds.
And even alcohol, in small to moderate quantities has consistently been proven to confer health benefits. Hundreds of published serious independent studies show that light to moderate alcohol consumption is cardioprotective. In this perspective, a 2006 study concluded, “Even in men already at low risk on the basis of body mass index, physical activity, smoking, and diet, moderate alcohol intake is associated with lower risk for myocardial infarction.” (“Alcohol Consumption and Risk for Coronary Heart Disease in Men With Healthy Lifestyles”. Arch Intern Med. 166 (19): 2145–50). (Source) Furthermore, besides ethanol, there are hundreds of other beneficial compounds and flavonoids in wine that all act synergistically and all the more so that wine is combined with food, especially a trans-fat free Med Diet type of nutrition regime which optimizes healthy lifespans, the evidence is also compelling on this point.
Furthermore, it has also been shown that cheese’s bioactive peptides (from cheese moulds) is a factor in the “French paradox”, if only because the vast majority of the French will pair cheese with wine. Inter alia, intestinal alkaline phosphatase (IAP), a potent endogenous anti-inflammatory enzyme, is stimulated by various components of milk, thanks to which this enzyme dephosphorylates and thus detoxifies pro-inflammatory microbial components like lipopolysaccharide, making them unable to trigger inflammatory responses, inter alia. (Source). And then, in addition to the dosage, there’s the quality of wine (most cheap wines are laden with glyphosate, heavy metals and other deleterious chemicals), the timing of wine drinking (ie chronobiology) and much more that explains this French Paradox, or why the CHD promoting animal fats are mitigated in their clogging and inflammatory effects. The fact that most vegetable oils, trans fats and animal fat contribute to CHD and CVD is not at issue. The point of the French paradox is that there are holsitical ways to bypass this problem, just like Jeanne Calment bypassed the nefarious effects of the cigarettes she smoked from 25 years old until 119 years with her Medterranean Lifestyle and attitude.
Holistic Solutions to Low Stomach Acid and Slow Bowel Movement
With improper eating and the passage of time (aging), gastric juice secretions malfunction.The Standard American Diet combined to American conventional medicine (including proton pump inhibitor and anti-acid prescriptions) constitutes a “perfect storm” combo for gastro-intestinal related and metabolic disorders. In this Presentation, we will learn about Self-help tests for both bowel movements and stomach acid and examine holistic solutions to better assimilate both nutrients and the “information” flow of food.
Session O: Dietary Supplementation & Optimal Longevity
Are non prescription pills, supplements and neutraceuticals useful or deleterious for durable health and optimal longevity ?
Many conventional and integrative medicine, biogerontology and anti-aging specialists claim that many dietary supplements like niagen (nicotinamide riboside), resveratrol, D-ribose, vitamin D3, antioxydants, Fish and MCT-Krill DHA-rich Oils, Algae, Vitamin B-12, metformin, ketones, Co-Q-10, PQQ, berberine, L-Carnitine, NAC, BDNF boosters, vitamins D & K-2 and many other supplements are safe and efficient insofar as risk prevention and longevity activators are concerned. This talk will show the data that either substantiates some of these claims or debunks them.
For example, on one of dozens of supplements we may review, fish oils, the viewer can confirm via mouse click below the data that confirms that fish oils are less and less reliable as healthy sources of long chain Omega 3s, worse, not only the evidence debunked the claim that fish oils are cardio-protective, even if they may reduce tryglicerides, but they were shown via multiple published peer-reviewed meta-analyses to significantly increase cancer risks, including, but not limited to aggressive prostate cancer (ie with a 71 percent risk).
Thus, for fish oil supplements and other pills and extracts (what is called neutraceuticals), we will weigh or evaluate the credibility and strength of the evidence and pinpoint where the preponderance of the evidence for a given product’s safety and efficiency may lie. In addition, we will teach workshopees how to employ a few of the forensic detective’s truth-digging tools, thanks to which the workshopee will be better able to distinguish flawed and biased publications from truthful ones supported by strong science and intuitive knowledge.
Safe and Efficient Supplementation for Healthy & Optimal Lifespans
A person’s genetic variations, (Apoe4, MTFR with methylation issues etc) allergies, the person’s gastrointestinal system, nutritional status, milieu status (where the person lives) inter alia are variables that determine what is safe and efficient insofar as supplements are concerned. If the person is living holistically 95 to 100 percent eating fresh organic food mostly from the garden and drinking healthy spring water and small amounts of wine, then there usually is no need for supplementation, even if he or she is vegan. But since most people don’t live holistically, we will review a few supplements that can help with both health and optimal longevity.
First off, if the person is 100 percent vegan, but imperfect holistically, then there are three key supplements that may be useful. He or she may want to consider algae based DHA, especially for motherhood. Fish oils tend to be full of toxic chemicals, metals and can putrefy. Furthermore, as we showed, there can be a link with cancer and fish oils. But DHA is too important to minimize. Unless a test can show that one’s ALA is properly absorbed and converted to DHA and EPA. Rare for most vegans, but holistic vegans can achieve this conversion. Also unless the person is drinking mountain water or eating organic dirt, there may be a deficiency with Vitamine B 12 that can lead to high homocystein and CVDs events. The deficiency of this vitamin triggers symptoms that are similar to Alzheimer’s Disease symptoms, so this supplement is also important for imperfect vegans. If there is a lack of sunshine on the skin, vitamin D 3 would also be recommended. Vitamin K 2 would be another one if the vegan lacks fermented foods.
For Mediterranean persons who actively enjoy the Sun and have on occastion wild clean small fish (cf the “smash” list) and-or A2 goat or sheep cheese (organic & raw preferably) with their wine, these last three supplements are not as needed. However, if the menu is not mostly holistic, then supplementation may be needed. A1 cows milk, or yogurt or cheese, even organic would be considered too inflammatory, but if A1 cow cheese is nonethless ingested, then lots of anti-inflammatory turmeric and protolytic supplementation may be a good idea. Because of the link between an excess amount of choline and Tmao molecules that can nurture CVDs, inter alia, and the association between rich cholesterol yolks and cancer, the evidence militates against eating eggs. The facts show that cancer cells thrive on dietary cholesterol, methionine, carnitine, inter alia, as much as on refined carbs (sugars), folic acid (not folate, but the supplement folic acid) and industrial vegetable oils, inter alia see ultra. If the concerned person is at least 95 percent holistic, has no major chronic diseases and has a source of holistic chicken who eat holistically, with lots of organic wiggly worms, bugs (for the zinc) and live plants (ie, with no inflammatory omega 6 rich grains) and who are happy laying eggs for humans, meaning no cortisol acidifying stress etc. then ingesting from time to time a few soft boiled eggs (not hard boiled as cooked yolks oxidizes its cholesterol which feeds arterial plaques and fried eggs produces lots of cancer-cancer acrylamides and other deleterious compounds) with some red HDL boosting and blood thinning bacteria-balancing wine can be compatible with healthy lifespans, as proves beyond any reasonable doubt just about all of the longevity and blue zone epidemiological published studies I’ve seen. Organic traditionally made wine is better because the resveratrol, pygnogenol, flavonoid, probiotics and hundreds of other keen molecules are potentialized with traditionally made, long-must macerated wine, inter alia. On the other hand, non traditionally made wines tend to be loaded with heavy metals, pesticides, glyphosate and other deleterious chemicals without a good phytonutrient or micro-organism profile and American red wines are often not fermented correctly. So good quality wine with eggs will help with the digestion of these foreign proteins and reptile lipids. One should not forget that chicken are birds and birds are one of the few reptiles animals that survived the Dinosaur Extinction 65 millions years ago, so they are biologically and evolutionary quite different from mammals including humans. In the same way we can make a case with gluten-laden wheat being a grass food evolutionarily designed for ruminants and not for humans, (this is a big argument of the keto-paleo proponents) we can also make a case arguing that reptile eggs should be left to real carnivores and even omnivores like cayotes and wild foxes.
In this Presentation then, we will look at some of the dietary supplements that may be indicated for those who do not eat perfectly holistic, some of which are magnesium, enzymes, probiotics, flavonoids, polyphenols, Vitamin D3 & K2, astaxantine, sirtuin boosters (we will go over the list), AMPK activators, Mitochondria promoters (PQQ, Co-Q-10 etc), mushrooms (lion’s mane etc), roots (turmeric, astralagus, beets, ginger powders etc), herbs & spices & detoxifiers (green tea, milk thistle, rhodiola, sulfurophane etc) and more.
Unsafe and-or inefficient Supplementation
Case study A: One of many examples of Dietary Supplements ending up as expensive urine
Recently published in the serious Journal of the American College of Cardiology, a systematic review of existing data and single randomized control trials published in English from January 2012 to October 2017 found that multivitamins, vitamin D, calcium and vitamin C (the most common supplements) showed no advantage or added risk in the prevention of cardiovascular disease, heart attack, stroke or premature death.
“The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force review. Their systematic reviews and meta-analyses showed generally moderate- or low-quality evidence for preventive benefits (folic acid for total cardiovascular disease, folic acid and B-vitamins for stroke), no effect (multivitamins, vitamins C, D, β-carotene, calcium, and selenium), or increased risk (antioxidant mixtures and niacin [with a statin] for all-cause mortality). Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufficiency) was not demonstrated; therefore, any benefits seen must be balanced against possible risks” (Source)
While this study claims that these supplements also showed no risk, I would question the calcium supplement. In Traditional Holistic medicine we are cautious with supplements and the data shows that some of the calcification we can see in age-related diseases like artherosclorosis, cancer and arthritis can be spurred by both the calcium in A1 cows as well as many calcium supplements. Best to take one’s calcium needs in vegetables, seeds and nuts. Calcium is better assimilable via organic plants, and all the more so that calcium interacts in synergy with its milieu.
Case study B: A Published Study Claims a 20 percent increase of Liver Damage coming from Dietary Supplements
A 2014 study published in the Journal of Hepatology found dietary and herbal supplements had a 20 percent increase in liver damage versus a 3 percent increase for Big Pharma medication.. In pertinent part, the Study states:
“ The Drug‐Induced Liver Injury Network (DILIN) studies hepatotoxicity caused by conventional medications as well as herbals and dietary supplements (HDS). To characterize hepatotoxicity and its outcomes from HDS versus medications, patients with hepatotoxicity attributed to medications or HDS were enrolled prospectively between 2004 and 2013. The study took place among eight U.S. referral centers that are part of the DILIN. Consecutive patients with liver injury referred to a DILIN center were eligible. The final sample comprised 130 (15.5%) of all subjects enrolled (839) who were judged to have experienced liver injury caused by HDS. Hepatotoxicity caused by HDS was evaluated by expert opinion. Demographic and clinical characteristics and outcome assessments, including death and liver transplantation (LT), were ascertained. Cases were stratified and compared according to the type of agent implicated in liver injury; 45 had injury caused by bodybuilding HDS, 85 by nonbodybuilding HDS, and 709 by medications. Liver injury caused by HDS increased from 7% to 20% (P < 0.001) during the study period. Bodybuilding HDS caused prolonged jaundice (median, 91 days) in young men, but did not result in any fatalities or LT. The remaining HDS cases presented as hepatocellular injury, predominantly in middle‐aged women, and, more frequently, led to death or transplantation, compared to injury from medications (13% vs. 3%; P < 0.05).” (Hepatology 2014;60:1399–1408)
From 2004 to 2013, Navarro and fellow researchers examined the hepatotoxicity levels in 839 patients suffering from liver injury, focusing specifically on whether levels were a result of taking supplements or medications. The results showed liver injuries from supplements increased by 20 percent over the almost 10-year study versus a 3 percent increase for Big Pharma drugs.
H.M. Institute Appraisal
Hepatotoxicity is essentially chemically-driven liver damage. Many dietary supplements are synthetic chemicals. As noted, HM Institute opined that anything synthetic is foreign to the liver, and hence has the potential to be toxic. While this study was a local and small one (under 1000 patients), it is not reflective on the entire Nation. There may also have been other variables, like sources of pollution or toxic additives in both the supplements and the food the patient ate. However, it must be noted that even if the Big Pharma Drugs’s injuries increasd by only 3 percent, that included 709 patients out of 839. So the thumbs down are still on the side of Big Pharma. It’s also possible that pharmaceutical drugs injuries maxed out. On the other hand, the supplements had started low and increased by 20 percent. To give a definite assessment, we would need to read the entire article. We only have read the abstract. Nonetheless, we need again to distinguish holistic from integrative medicine. Integrative medicine will have recourse to a lot of labs and supplementation, including bio-identical hormones to get quick results while holistic medicine will encourage the patient to produce his or her own chemicals (hormones, neurotransmitters, neuropeptides etc) via nutrition, detox, fasting, exercise, the microbiota and the like. For holistic medicine, including homeopathy, less is more, including with supplementation.
Case Study 3: Resveratrol in a capsule, food or bottle ? Depends if one is a mouse, a patient, holistically inclined or a marketing agent
Supplements are not always the preferred moleculary delivery system of important nutrients. In rodents for example, hundreds of studies have shown that resveratrol supplementation is healthy for mice: it decreased cardiovascular risk factors, improved cardiovascular function and physical capacity, and decreased inflammation, leading to improved vascular function, inter alia. But when this same supplement is given to humans, the opposite happens.
“Ageing is thought to be associated with decreased vascular function partly due to oxidative stress. Resveratrol is a polyphenol, which in animal studies has been shown to decrease atherosclerosis, and improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signalling and through an improved antioxidant capacity. We tested the hypothesis that resveratrol supplementation enhances training-induced improvements in cardiovascular health parameters in aged men. (…) Resveratrol did not alter the effect of exercise training on the atherosclerosis marker vascular cell adhesion molecule 1 (VCAM-1). Sirtuin 1 protein levels were not affected by resveratrol supplementation. These findings indicate that, whereas exercise training effectively improves several cardiovascular health parameters in aged men, concomitant resveratrol supplementation can blunt these effects. (J Physiol. 2013 Oct 15;591(20): (Source)
H.M. Institute’s Critical Appraisal
While resveratrol supplementation can have benefits in other areas of medicine than those mentioned in this study, including in longevity, the scientific data suggests that there are other better and more holistic ways to fix a cardiovascular problem than with supplements, unless the patient can’t get himself or herself to change lifestyle and nutrition. Furthermore, capsules not only can contain deleterious additives, but when molecules like resveratrol are isolated and increased, they are deprived of the synergistic “entourage” effect and thus, can generate side or toxic consequences. When mainstream scientists look at what Nature’s pharmacy can give them, they try to find the active ingredient and then isolate it, study it’s chemical configuration and then synthesize and patented it for cash-flow. Even if it’s not synthesized, these molecules will be increased like with tetrahydrocannabinol from cannabis, curcumin from turmeric or resveratrol from grapes. However, more and more Research is showing that for one molecule to work well, with little if any side or toxic effects, it needs it’s “entourage”, all of the other molecule-buddies it came with. This has been shown for tumeric and cannabinoids.
Same rationale for resveratrol. This molecule is a super-molecule. It is a stilbenoid found in the skin of red grapes and potentiated with traditional vinification. It was shown to extend the lifespan of yeast, worms, and flies. It has been shown to activate Sir2 and therefore mimics the effects of calorie restriction. But in holistic medicine, it acts better within the food and especially the wine because there, in its natural “habitat”, it is potentiated and synergized with all of resveratrol’s other buddy molecules it came with in the first place. The proof is in the sipping of moderate but quality wine.
“Wine intake may have a beneficial effect on all-cause mortality that is additive to that of alcohol. This effect may be attributable to a reduction in death from both coronary heart disease and cancer. (Source)
Furthermore, current evidence has shown that the mainstream scientists of yesterday were wrong on resveratrol dosage. If taken holistically, resveratrol-based food and especially red wine will have enough resveratrol strength to activate human longevity and wellbeing genes and pathways. Be that as it may, as a sirtuin activator, resveratrol can be helpful for some people.
Session O: Chronic Stress & The Inner Saboteur
“I regard consciousness as fundamental. I regard matter as derivative from consciousness” Max Planck (leading expert in quantic physics, Nobel laureate)
For reasons that are still mysterious, within human brains, the combined activity of billions of neurons generates a conscious experience as well as the awareness of conscious reality. In this perspective, the founder of quantic physics, Planck, summed up his Life’s work by stating that consciousness is so fundamental to the human experience, matter and the universe that nothing would exist without it. A paper published by Dean Radin, PhD, in the peer-reviewed journal Physics Essays, explains how the double slit experiment has been used multiple times to explore the role of consciousness in shaping the nature of physical reality. (source)
Thus, it follows that the psychology of aging and the “science” of Consciousness activation are important pieces of the holistic optimal longevity code. In these realms, most centenarians and supercentenarians who make it to over 100 years appear to have mastered the art of chronic stress and drama control. Chronic Stress seriously impacts the mind-body, as a consequence, it tends to alienate an equanimity-based Consciousness as well as the Gut microbiota’s “mood” and the brain’s lobe that is the most evolved, the prefrontal cortex.
“The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental effects of stress exposure. Even quite mild acute uncontrollable stress can cause a rapid and dramatic loss of prefrontal cognitive abilities, and more prolonged stress exposure causes architectural changes in prefrontal dendrites. Recent research has begun to reveal the intracellular signalling pathways that mediate the effects of stress on the PFC. This research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness”. (Nat Rev Neurosci. 2009 Jun; 10(6): 410–422. (Source)
Furthermore, the scientific litterature confirms that most of these super-longevity achievers have avoided all of the major chronic diseases of their peers. The HM Institute’s longevity hero, Jeanne Calment for example was the epitome of an unflappable archetype who avoided chronic degenerative diseases until she quite smoking cigarettes and eating sweets at 119 years old. Multiple studies also positively correlate optimism with longevity. On the other hand, chronic stress, emotional scars, what is called ACES (advanced childhood emotional stressors) or childhood traumas, durable maternal deprivation, as well as Professeur Laborit’s “inhibition of action” process can all negatively impact the epigenetic expression of human genomes and the development of degenerative diseases.
For example, rat pups exposed to extensive maternal deprivation have enduring dendritic retraction in the PFC and increased anxiety-like behaviours. (Source). By contrast, exposure to a mild stress, for example when a juvenile monkey learns that the mother will return after a short period of separation, seems to encourage resilient responses to stress in adulthood. (Source) and reduces glucocorticoid receptor expression in the dorsolateral PFC. (Source) Likewise with the microbiota. Its genome can impact human motivation, if only because its millions of genes cross-talk to our 23,000 eukaryotic human genes. For example, an abundance of serotonin and dopamine neuropeptides are made in the gut depending on signaling molecules, which themselves depend on Lifestyle choices. This is relevant because the microbiota is directly linked to the brain via the nerve-rich enteric system and vagus nerve. And recent studies have shown that the “extreme” elderly have a set of microbiota that corresponds to those who are in their thirties while those who age in an accelerated way carry a microbiota habita characterized by a lack of diversity and an abundance of deleterious bacterial species. Furthermore, there are “fear-laden insecurity” issues that can subvert one’s JDV and consistently, though subconsciously feed the “disability” identity.
“These findings suggest that 2 forms of volitional medical self-sabotage—preventing wounds from healing and making medical situations worse on purpose—may be associated with and contribute to numerous physical symptoms on a review of systems. They also broach the deeper question of whether, in some patients, medical self-sabotaging symptoms and multiple self-reported symptoms in the review of systems purposefully function to engage health care professionals, maintain an illness identity, and/or self-sabotage a healthy lifestyle by promoting a sense of disability” Medically Self-Sabotaging Behavior and Multiple Symptoms on the Review of Systems (Source)
Subconscious’ programing or willful self-sabotage ?
The idea of “the saboteur within” sabotages conscious self-improvement efforts that express the Joie de Vivre (JDV) consciousness that is embedded within our genome and soul (ie, soul = consciousness minus (-) the “mind” = mindless awareness). Within this context, and according to the lastest findings of the “positive psychology” and “consciousnes” experts, the task of the subconscious is to record & interpret each experience and thereafter, file the data in the memory storage area or the brain-consciousness network for future reference and guidance. This means that regardless of right or wrong and good or bad, the subconscious files quanta of relevant information and personal “truths” that determines one’s future course of action. These truths may not necessarily be true when seen from someone else’s perspective, but as the subconscious has interpreted them, they are part of the “karma” and “survival” program that makes up one’s core belief system. In this perspective, as one goes through life’s adventures, the subconscious is continually referring to these records and then prompting the brain to signal to the body to produce the appropriate messaging chemicals, (ie, hormones, neurotransmitters, cytokines etc). Thereafter, the mind applies Reason to give meaning to the body’s cues.
When humans try to improve their lives, in particular nurture a behavior that is consistent with a healthy lifespan, their conscious mind will generally attempt to make new choices that may appear, for the subconscious, risky. As long as there is no real threat of a major change in the core belief system, the subconscious should not react. However, as one begins to get closer to making conscious core changes affecting one’s subconcious belief system, the subconscious tends to do whatever it takes to maintain the status quo. In psychological terms, this is called the “comfort zone” and explains why most people prefer the status quo and have a hard time nurturing a holistic lifestyle that would be more favorable to their goals of living a healthy long life.
The evidence suggests that the unwillingness to embrace positive change by adopting a holistic lifestyle does not appear to be motivated out of intentional “sabotage”. The subconscious appears to be merely doing its job of keeping its host aligned with the dusty “files” in the brain-consciousness network. If the prevailing files are mostly trauma, indoctrination, fear of excommunication from one’s group, mistrust from bad experiences, repeated criticisms from sabotaging family members (“you will never be able to acheive that”, “eat thy lard-laden cookie and be quiet”, “honor my idols” etc), then these recorded “files” would impact healthy lifespan decision-making. Likewise with files that are centered on one’s trust-laden upbringing, deep dreams, hidden passions, especially when the person is from 0 to 7 years old. Furthermore, certain species in mammilian microbiota communicate directly with the brain for the maintenance of the status quo. It’s been proven that humans have different species of bacteria which will produce chemicals to tell the human brain to crave for the foods they need to thrive and survive. And there are inflammatory and addictive foods that can also affect healthy lifespan behavior. For example, studies have shown that cortisol-rich and acidifying meats as well an excess hypoglycemia from refined sugar and even omega 6s long fatty acids that cross the brain blood barrier have promoted violent-types of behavior and unhealthy outcomes that hinder the person’s self-love potential. And the casein-morphine molecules of A1 cheese tend to be all the more addictive that it’s full of artificial hormones, antibiotics and other deleterious molecules.
“The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.” Nikola Tesla
The inner sabotage then appears to be less sabotage than a computer program to maintain the status quo and-or one’s core belief system as well as the deleterious “addiction” signals that appear to come from the gut’s microbiota and inflammatory toxic diets. Therefore, when and if the conscious being decides to behave in a way that is consistent with fulfillment, JDV, optimal health and longevity, he or she proactively needs to change the “core belief” program as well as the composition of the microbiota and his-her diet and lifestyle. The process for changing the subconscious’ “file-records” can be long and tedious if only psychotherapy, too much thinking and Big Pharma’s drugs are used. Worse, it’s been well established that psychotropic drugs tend to shorten healthy lifespans. However, with different consciousness and microbiota holistic techniques, it’s possible to activate a state of Consciousness or mindless awareness (ie, awareness without the thinking) that can help to promote the restoration of this “formless eternal Presence” different Consciousness experts like Deepak Chopra, Ekhart, Tanzi, Wayne Dyer, Boudhist, Tao & Zen masters recommend. Once this “space” of non-duality has been reached, then it is easier to reprogram the subconscious to be more proactive and positive. Furthermore, when the mind is cleansed of past constructs, traumas and negativities, it would appear that harmonic resonance raises the Field’s frequency, at which point the different sections of the brain get reconnected or rewired via the activation of billions of synapses. (cf, Dispenza’s work). At this point, according to Dispenza, a stronger harmonic resonance and frequency coherence ensue and that this awareness state can be expressed via millions of milli-volts measured via functional MRI. (cf Dispenza et al and Lipton). While some of these claims sound speculative and-or mystical, others appear to be grounded in Science.
In summary, the data seems to suggest that when diet and the body’s microbiota are out of whack and out of synch (ie, as well as the body’s hippocampus-pineal-adrenal-gonad axes and heart rate variabilities) and when the Conscious and Subconscious are not aligned, behavior tends to be self-sabotaging, not conducive to healthy lifespans, at which point low frequency living (characterized by deleterious habit, fear, intolerance, negativity, auto-immune diseases and sabotage, both of others and of self) appears to prevail. As a consequence, the JDV (joie de vivre) Consciousness can’t be expressed. There is also some evidence that shows a correlation between intense emotional “feel-good” intentions and synchronistic events, many of which can spur personal evolution in a way that is more consistent with growth, JDV, healthy lifespans and self-replication, in conformity with both Darwinian “science” and Biblical tradition. So intense “prayer” and the activation of different meditation and breathing techniques may be of benefit. In this Presentation, we will look at a few studies that support some of these claims and assumptions.
Proof that JDV Medicine is even better than General Wellbeing medicine
JDV (Joie de vivre) = Purposeful joy, holistically expressed in a meaningful “now” existence
The clinical evidence that Joie de Vivre (JDV) is superior to general wellbeing (satisfaction-based happiness) has been overwhelming for those on the terrain for millennia and millennia. Even the great historian Arnold Toynbee talked about this in his keen analyses on neolithic villages. The French historian Michelet as well. As did the Hebrew Flavius. But it’s only been since 2013 that scientists have been able to test this hypothesis and prove beyond any reasonble doubt that JDV (Joie de vivre) is the way to go in terms of metabolic smoothness and healthy aging. As stated, JDV is more than contentement, well-being, happiness or downing a glass of organic beer on a hot sunday afternoon. It is a state characterized by purposeful joy, holistically expressed in a meaningful “now” existence. JDV is beyond Existentialism, but there are teleological elements of existentialism therein.
In this perspective then, researchers from UCLA and the University of North Carolina put to the test this hypothesis, by comparing two groups of people, one happy in the mainstream tradition and the other super happy in the holistic tradition. What they showed was that the individuals who had high levels of what they called “eudaimonic well-being” (which in French would be translated by joie de vivre) showed very favorable gene-expression profiles in their immune cells. They had low levels of inflammatory gene expression and strong expression of antiviral and antibody genes. However, people who had relatively high levels of hedonic well-being (the type of happiness that comes from today’s consumption society spurred by selfies and auto-gratification behavior) showed just the opposite. They had an adverse expression profile involving high inflammation and low antiviral and antibody gene expression.
“To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.” (Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13684-9.”A functional genomic perspective on human well-being”. (Source)
Now that the entire human genome has been mapped, we can ascertain with a strong sense of certitude to what degree this genetic bleuprint is fluid, dynamic and “open” to human consciousness, mindful awareness, hutzpah and creative imagination, the same one that assisted Professor Einstein in ascertaining his E = MC2. In this perspective, what this experimentation proved was that the genetic expression of the Life Code depends less on the evolutionary principle of adaption than on a person’s passion, belief system, convictions, deep thoughts, feelings, moods, expectations and the like, all of which contribute to create a vibrational and sometimes healing “field”. Which is one reason why both placebo and nocebo effects have strong biochemical consequences. Just believing in the conventional doctor’s “terminal verdict” nocebo will put in place the very biochemical phases of accelerated aging and painful death.
How to Sabotage one’s Health-care Self Interests and go into Extinction
“It is believed that as much as 80% of all disease and illness is initiated and aggravated by stress.” The National Safety Council
In this section, we will review the new medical discipline called “psycho-neuro-endocrine-immunology”. Research in this field indicates that our thoughts and emotions can markedly affect the activity of the physiological systems (e.g., immune, endocrine, cardiovascular) connected to the brain. In other respects, neuroimaging studies of emotional self-regulation, psychotherapy, and the placebo effect demonstrate that mental events significantly influence the activity of the brain. In this context, we will look at case studies where people allow themselves to be stressed out, take in the Government’s sanctioned fast foods, quick allopathic fix medicine, pollution, statutory inanities, inter alia, thereby sabotaging their health, their family’s welfare and the integrity of future generations.
In other words, there is a price to pay when a person chooses to be conformist and well adapted to a toxic Society. I think it was Krishnamurti who said that being adapted to a sick society was no measure of health. In the same way, accepting most of the EPA, FDA, CDC, NIH, DEA’s USDA, Big business influenced norms with regard to public health and conventional medicine tends to invite more chronic diseases and accelerates aging and even the Society’s ultimate demise, just like in Rome and other civilizations that have deviated from holistic lifestyles.
Session P: Hands-on Techniques to enhance Longevity and de-activate the Inner Saboteur
“It’s not because we are old that we don’t play, it’s because we don’t play that we get old” (George Bernard Shaw)
In this Presentation, we will teach hands-on exercises to optimally breath, move, meditate, see and activate key energy fields, including via acu-pressure, EFT, reflexology, aromatherapy, sophrology and more. If time allows, we will also delve into evaluation techniques like muscle testing (kinesiology), Chinese nail and tongue testing, stool & urine analysis, psycho-morphology and facial diagnosis, metabolic body types assessment, ear lobe examination (that can help to predict coronary crises), alternate nostril breathing, HRV support and other holistic tools like organoleptic testing that can assist us in pinpointing warning signs, some of which can be as useful as genetic and biochemical tests given their relevance, simplicity and immediacy.
Session Q: Advanced Cancer Protocols
Optimizing the Cancer Control, Repair & Reversal Code: a precondition to Optimal Longevity
Notwithstanding their nuisance, cancer cells have mastered the art of longevity since their “innate evolutionarily-based intelligence” has tweaked its genome to produce a continuous fresh supply of telomerase enzymes thanks to which they can divide endlessly and remain forever “strong” and “young”. In this Presentation, we will unmask cancer’s intrinsic weaknesses and explain a few of its underlying mechanisms. But between cancer as a biological reality and conventional oncology as a system of deleterious dogmas, the central problem lies with Conventional Oncology.We will thus discuss the limits of conventional oncology in relation to the strengths of holistic cancer protocols.
From 1991 to the 2018, published studies, including in the Lancet Journal, have proven beyond any reasonable doubt that systemic cytotoxic chemo-blasting more often than not doesn’t durably save lives of those who have “solid” cancers. The five year survival rates for liquid canccers (e.g. lymphomas and, inter alia, leukemias) are much better, but these malignancies often come back with a vengeance after the five-year period and-or have toxic effects that seriously affect the patient’s ability to reach a healthy 120 years of lifespan. Worse, the evidence shows that with conventional chemotherapy, cancer patients’ demise tends to be accelerated. While radiation and cytotoxic chemo do shrink tumors, there are no published studies the H.M. Institute is aware of that show a positive correlation between tumor shrinkage and significant long-term survivability. Thus, the emerging reality (for the last 40 to 50 years) is that most of these conventional medical interventions will weaken what can restore the patient’s “élan vital” (i.e., a notion from Prof. Henri Bergson which include the immune, digestive, microbiota, endocannabinoid and neurological systems) while fueling what metastasizes cancer, in particular, the microscopic circulating tumor and stem cells that most conventional oncologists still refuse to inform the patient about, in violation of medmal law and ethics. Even most of conventional oncology’s more recent targeted monoclonal antibodies, signaling inhibitors, genetic interventions and immunotherapeutics have toxic side effects that can be avoided with alternative and holistic oncology. Many of these targeted therapies including immunotherapeutics have been hyped misleadingly as new cancer “cure-alls”. While it is true that a small percentage of cancers go away with immunotherapeutics, these effects are usually not long lasting, the modalities are very expensive and the outcome of holistic oncology’s cases tend to be much better, provided the patient is compliant with a holistic lifestyle and restorative protocols..
Integrative Versus Conventional Oncology Clinics: Strengths and Limitations
« …si j’avais un cancer, je n’irai jamais dans un centre anticancéreux classique. Seules les victimes du cancer qui vivent loin de ces centres ont une chance. » “If i had a cancer, i would never to to a conventional anti cancer center. Only cancer victims who live far from these centers have a chance”. (Source) Pr Georges Mathé (famous contemporary French oncologist)
For H.M. Institute, there is no question that integrative oncology’s modalities and clinics are much better than conventional oncology clinics. The well known Professor Georges Mathé (oncologist) used to say: “Si j’avais une tumeur, je n’irais pas dans un centre anticancéreux » (Le Monde, 4 mai 1998) (“If i had a tumor, i would not go to an anticancer center”) (Source). Among a few other French oncologists who have questioned the very legitimacy of conventional oncology’s thinking and modalities, I’m invoking Georges Mathé because he was recognized in the US as a cancer, stem cell and bone transplant pioneer in that he proved as early as 1963 that cancer was curable via the immune system. He also demonstrated that stem cells could both heal radiation damage and fight cancer. Dr. Joseph H. Antin, chief of stem cell transplantation at the famous Dana-Farber Cancer Institute in Boston, summed up Mathé’s work: “It was quite a leap of scientific genius. He’s one of the original innovators. Much of what we have accomplished can be linked back in a fairly direct way to the work that he did in the 1950s and ’60s.” (“Dr. Georges Mathé, Transplant Pioneer, Dies at 88”. New York Times, Source).
However, because American integrative oncology clinics are required by law to not deviate from the standard of care, their experts are still necessarily tied to some toxic and-or invasive treatments, often by necessity in order not to loose their license. Moreover, integrative oncology clinics focus mostly on trying to mitigate and repair the collateral damages that is precipitated by the State’s conventional weapons of mass cellular death while continuing to follow the conventional standard of care, whether it be chemo, radiation, surgery or another hi-tech conventional modality. Furthermore, I have seen outdated and unsubstantiated “integrative oncology” practices and for the most part, this type of oncology remains intrinsically stressful, in that most of the integrative alternative treatments costs are not covered by Medicare, Medicaid or private insurances. In reality, as mentioned before, the “zip code” (social status) is key. Most cancer patients can’t pay 200 to 500 dollars an hour for integrative oncology consultation fees, let alone 1500 dollars for one IPT (insulin potentiated therapy) I.V.. And for those who are not wealthy who do make that sacrifice, the financial burden tends to become so stressful that they can’t even afford to eat organic, destress with wome quality beach time let alone sleep deep with equanimity, being worried about finance. Thus, the Happiness Medicine Institute prefers holistic and happiness medicine first. Bottom line: While some of these integrative oncology and even “anti-aging” clinics appear to be useful in comparison to conventional oncology clinics, the H.M. Institute recommends first informed self-care on the part of the patient with holistic guidance based on hard evidence and friendly alertness.
In this perspective, a holistic practitioner will teach the patient how to gently outsmart cancer by switching off the expression of cancer’s oncogenes as well as certain cancer pathways and enzymes, including, but not limited to nagalese. Holistic cancer patients also learn how to activate their own longevity and tumor suppressor genes and renew their red and white blood cells with holistic stem cell therapy, to the point where cancer patients will be able to put in place new defense and dendritic-based surveillance networks that will help with both the body’s autophagy-based clean-up system as well as with the immune system’s recognition of cancer cells. Just like in war, to fight cancer’s symptomatology with conventional weapons of mass cellular destruction tends to make both nefarious bacteria and cancer cells stronger, more inflammatory and more virulent in the vast majority of cases. And yes, there are deep connections between bacteria and cancer, some of which have only been recently identified. Medically speaking, in the field of systemic cytotoxic chemotherapy, this process is called “chemo-resistence”, a medical epiphenomenon that has proliferated within cash-flow based conventional oncology for the last sixty years, the evidence is compelling on this question as we will see via power point slides.
Furthermore, most of the State’s licensed conventional oncology experts not only never address the deep root causes of cancer, but they summarily reject alternative and holistic approaches that do. In integrative and holistic oncology, there are hundreds of proven integrative and holistic techniques that have been successful in controling and treating cancer without the use of conventional medicine’s toxic modalities, some of which are detoxification, hyperthermia, aromatherapy, oxidative therapies (eg, hbot, ozone, hydrogen peroxide, high dose pro-oxidant vitamin C and others), natural anti-fungal substances, phytotherapy (herbs and formulas like those of Drs Méssegué, Lévy, Lautier, Hoxey or from the Canadian Essiac nurse) enzymes, different supplements (artemisia – from which the med. artesunate comes from –, selenium, amygdaline, benzaldehyde, berberine, mistletoe, DCA, PMVA, MCP, ribose, Key vitamins and minerals, probiotics, botanical-based IPT, PH therapy, clinical nutrition, (ie, including protein restricted, raw-vegan, cultured Mediterranian and ketogenic diets, for certain malignancies), “glutamine, IGF-1 & mTOR” inhibition, restricted caloric nutrition, targeted juicing, stress management, exercises, wild seeds, cordyceps fungus, tree mushrooms, dentretic cell strategies and many other holistic interventions that target the so-called “hallmarks” of oncogenesis’ engines and their signaling, from angiogenesis to metastases and another dozen pathways. In this perspective, thermal therapy, inflammation inhibition and vibrancy (electromagnetic) enhancement strategies are three important statagems that most American conventional oncologists miss. Hyperthermia, a German and French speciality and electro-medicine (a French and Israeli speciality) have had great results with cancer control and reversal, especially when these are combined to clinical nutrition, inter alia.
“Cancer-related frequencies appear to be tumor-specific and treatment with tumor-specific frequencies is feasible, well tolerated and may have biological efficacy in patients with advanced cancer. (Source) (See also the acupuncture litterature, electro-magnetic technology and tumor treating fields for other electro-medicine examples)
One reason most conventional oncologists refuse to try, even “off-label” many of the integrative and holistic cancer therapies that are supported by Science is because of the way they were trained and not trained, in particular, most American MD physicians don’t understand or don’t want to understand that cancer is more of a lifestyle and metabolic disorder then a genetic one. Even though the genetic code matters with regard to carcinogenesis, the zip code and even more the holistic code are more important. Prefering to characterize cancer less as a DNA mitochondrial and cellular respiration dysfunction than as a nuclear genetic disorder should be at least recognized as a medical mistake. But, alas, good medicine continues to be sacrificed on the altar of greed, arrogance and the stubborn forces of ignorance. If anything, official cancer sites should at least inform people on a regular basis that two weeks of dietary change is enough to significantly reduce cancer biomarkers.
“They found that only two weeks of diet exchange was enough to change the makeup of the intestinal microbiota and affect a number of biomarkers associated with colon cancer risk. The rate of cell turnover in the intestinal lining, levels of fiber fermentation, bacterial metabolic activity, and inflammation all reflected the change in eating patterns”.(Source)
Same duty with regard to the evidence that within 30 to 90 days, most cancer patients who are compliant with proven holistic cancer protocols can have their malignancies safely and efficiently declared N.E.D. (no evidence of disease) with few if any recurrence risks. In this perspective, and among others scientists, Professor Ornish has proven with an overwhelming preponderance of the evidence that cancer genes and tumor suppress genes can be favorably modulated just with inexpensive holistic and happiness medicine, even without supplementation, let alone patented drugs, surgery, radiation, targeted therapies, genetic interventions, inter alia.
In this Presentation, we will give a few tips on how to holistically restore the body’s hijacked immune-surveillance mechanisms and revitalize the entire metabolism (the body’s “soil” or “bioterrain”) with holistic savoir-faire so that cancer can’t grow and in many cases, starts to shrink within 2 to 5 weeks. To help the workshopee understand that the human body has it’s own T-cell based “chemo” that selectively zaps cancer cells and creates a tag-based memory system to destroy these cells if they decide to reappear, we will show a short university-made video. Likewise with the proof that cancer is more of a mitochondrial disorder than a genetic one, (genes do matter, but they are downstream consequences, like tumors, part of symptomatology). If we have time, case studies and key cancer tests (including the genetic and supplement sensitivity Greek test as well as CTS, CSC, Phi, nagalese, oncoblot, French and European tests) and some of the latest holistic breakthrough protocols will be reviewed. To which we may include new findings with regard to focused sound therapy as well as other frequency and ultrasound modalities concerning tumor regression, angiogenesis, mestastatic control, the tumor micro-environment, epigenetics and the like. During Day three’s Seminar, we will finish and complete what was not finishied in this present Session. Meanwhile, the workshopee can check out H.M. Institute’s sister Cancer Research Institute via mouse click as well as its cancer documentary based on the interviews of over sixty cancer experts, from Gerson, Gonzalez, Bergson and Beljanski to Seigfried, Yu, Cousens, Weeks, Lucan, Simoncini and many others.
Case Study: Cancer Reversal with Holistic Oncology
Section under construction
Session R: Thermal Medicine: A French Speciality that would be of Benefit for the US Health-Care system
“Primum non nocere” (First do no Harm) Hippocrates, the Father of medicine
Hippocrates’ based Thermal Medicine or Thermalism includes, but is not limited to Spa, massage, traditional hydrotherapy, peat baths, balneotherapy treatments, sulphur-based spa drinking water, pleasures of water games, relaxation, saunas, fitness programs, beauty treatments (in particular with clays), detox, wine therapy and, inter alia, hyperthermia therapies, in particular hot baths and showers that come from the sulphur-rich volcanic waters in France’s southern Spa resorts (called “Thermes”, “station thermale” or “Cure thermale”).
This type of preventive and curative medicine is so safe, efficient and cost-friendly that the French National Heath-care system has offered this therapy free of charge since 1944 for all who reside in France (including American residents) and benefit from a doctor’s “thermes” prescription. It is one of the most popular healing systems in France. Many French People will take a three weeks health-vacation per year in one of France’s thermal centers where they can soak up hot sulphur-based thermal spring water, among other detox and rejuvenation holistic techniques. In this Presentation, we will examine the health and longevity benefits of this type of Medicine and wrap up with a word on how it could be of great benefit to the US Health-care system.
Heat Shock Proteins and Hormesis Mechanism
Heat and cold hydrotherapy and other holistic techniques will spur the cell’s production of heat shock proteins, whose effects can be both protective and beneficial to health. In this Presentation, we will explore this mechanism in light of healthy lifespans.
Session S: Regulating Cytokines, Optimizing balanced Hormones & Neuro-transmitters & Tweaking Longevity Genes
There are over fifty known hormones. Almost all affect personality and physiology. At least seven vary greatly with gender. With the gift of Life, we have been equipped with key messaging molecules, three are central: neurotransmitters, cytokines and hormones. With the passage of time, many of these molecules get roughed up and imbalanced. This is why these messaging molecules need regular holistic “tune-ups”, especially then someone is trapped in the vicious cycle of accelerated aging. By holistic tune-ups, we don’t necessarily mean hormone or even bio-identical hormone replacement therapies. We are first and foremost talking about epigenetical fine-tuning of molecules that help us to be in coherence with our purpose, thereby optimizing healthy longevity and JDV.
The Bliss Hormone Chemistry Network
The human body is equipped with dozens and dozens of key hormones and neuropeptides that need to be holistically tweaked, activated and balanced if humans are to live healthy lifespans with JDV to 120 and beyond in accordance to Genesis and human potential. The bonding and “love” chemical called oxytocin is key. This “double casquette” molecule is both a peptide hormone and a neuropeptide, as a result, its tasks are widespread and key, especially if humans are to shift from a morbid fear-based society to a more spiritual trust-based civilization. Not enough of it leads to distrust, fear and defeat, while just enough, the right balance will be conducive to bonding, trust and biological Life’s mission, self-replication.
Then we have the “mother” hormone, pregnenolone as well as the more common “trio soldiers”, estrogen, progesterone and testosterone, all of which are key for happy and healthy lifespans and offspring reproduction. Cortisol and thyroid hormones are also necessary as well as many other endogenous compounds that make up the human neuropeptide-hormonal communicatory network. When thyroid gland dysfunctions, the body’s entire metabolism is off. So this endocrine organ should be promptly fined-tuned. The adrenal glands often get exhausted and can’t produce enough of its stress-related hormones, as a result, energy exhaustion and mitochondrial dysfunction tend to follow. So it’s important to maintain healthy the thyroid and adrenal glands with the H.M Institute’s holistic restorative program. As for one of the “Kings” of the longevity hormones, DHEA, we need a separate section.
Exempted from classification as a controlled substance by Congress, thanks to powerful industry lobbying (DHEA’s chief protector was Senator Orrin Hatch of Utah, where supplement makers are heavily concentrated), DHEA can be acquired without a prescription while in Canada and many other countries, DHEA is available only by prescription. DHEA is the most abundant steroid hormone in the body. The supplements are made in labs from chemicals found in wild yams and soybeans. Endogenously, DHEA is made from cholesterol by multiple tissues, but essentially by the adrenal glands and is a precursor to 18 steroid hormones including the commonly known sex hormones estrogen and testosterone. That’s why it is known as one of the “Master Hormones” of our Body-Temple. Healthy DHEA production is critical for lean muscle development, fat burning, bone growth, cardiac-health, including nitric oxide production, bedroom gymnastics, skin health, immunity and more. (Source) . DHEA also provides protection against the effects of physical stress and inflammation.
However, just swallowing DHEA pills may not be the optimal way to boost one’s DHEA. The biochemistry is complex, and DHEA supplementation results are highly variable and regularly unpredictable. There may be better ways to up this hormone than via capsules. DHEA appears to also have biological effects independent of its conversion into other hormones. After age 25, DHEA production begins to decline, and by age 70 it typically has fallen by about 80 percent. People with certain major chronic diseases tend to have more rapid declines in DHEA. Many hormones and other compounds in the body also decline with age.
Human Growth Hormone (HGH)
Human growth hormone is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. Stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland, HGH is also a stress hormone in that it raises the concentration of glucose and free fatty acids while stimulating the production of IGF-1, which is also another powerful growth hormone. Many integrative medicine physicians have used HGH to help their older patients to have younger and sexier bodies. Especially since a 1990 NEJM published study showed that all of those who took this hormone got a younger body without significant side effects.
“The findings in this study are consistent with the hypothesis that the decrease in lean body mass, the increase in adipose-tissue mass, and the thinning of the skin that occur in older men are caused in part by reduced activity of the growth hormone—IGF-I axis, and can be restored in part by the administration of human growth hormone.1 , 2 The effects of six months of human growth hormone on lean body mass and adipose-tissue mass were equivalent in magnitude to the changes incurred during 10 to 20 years of aging” (Source)
Subcutaneous administration of recombinant biosynthetic human growth hormone was injected three time a week with no evidence of tachyphylaxis or hormone resistance or anything else of significance in terms of toxic side effects. The doses where not hefty, approximately 0.03 mg per kilogram which corresponds to a physiological dose.
However, in the U. S. of A, HGH prescribing medical doctors have often gotten their medical license suspended or revoked for having prescribed this peptide hormone. The only FDA-approved use of HGH is for replacement therapy in adults with GH deficiency of either childhood-onset (when a child does not grow) or adult-onset (usually as a result of an acquired pituitary tumor, that’s why Tony Robbins is so tall). While there are couple other “off label” uses, these are restrictive and for most anti-aging longevity uses, the prescribing doctor can get machine-gunned coerced into submission, his business shut down and jailed with hard-core criminals on felony charges. In 1990, the US Congress passed an omnibus crime bill, the Crime Control Act of 1990, that amended the Federal Food, Drug, and Cosmetic Act, that classified anabolic steroids as controlled substances and added a new section that stated that a person who “knowingly distributes, or possesses with intent to distribute, human growth hormone for any use in humans other than the treatment of a disease or other recognized medical condition, where such use has been authorized by the Secretary of Health and Human Services” has committed a felony” (Source).
On the other hand, for livestock use, bovine Growth Hormone (to increase the secretion of cow milk full time (360 days a year), inter alia), is fully legal, even if this type of modified milk spurs health problems, including cancers, in particular, breast, ovaries and prostate malignancies while significantly shortening the lives of these mother cow ruminants, inter alia. But for those anti-aging guerrilos who are not afraid of cancers and desire a younger sexy body, they can legally “cheat” by gulping down as much GH steroid-laden cow milk as their stomachs can handle. But the Happiness Medicine Institutes’ Executive Committee prefers to recommend more holistic ways to help the body produce this important hormone endogenously. In this Presentation, we will therefore examine holistic and natural ways to produce DHEA and HGH for the benefit of healthy longevity optimization, cow welfare and future generations.
The Vasopressin & Oxytocin
Vasopressin is made in the brain. Both men and women make it. However, just likek the female hormone estrogen synergiizes with oxytocin, the male hormone testosterone synergizes with vasopressin, the two greatly enhance each other. A woman and man might have equal levels of vasopressin but the man experiences stronger effects. Physically, vasopressin causes water retention and high blood pressure; high levels may increase forehead size. Personality wise, vasopressin influences male social and sexual behavior, public communication, and paternal behavior and more
The Oxytocin-Vasopressin Pathway in the Context of Love and Fear
“There is no fear in love: but perfect love casteth out fear”. (1 John 4: 18)
Oxytocin (OT) and vasopressin (VP) are ancient peptide molecules with many behavioral and physiological functions. These pleotropic peptides evolved from a single genetic source OT and VP, with their receptors, function as an integrated, adaptive system, allowing the mammalian body to survive, maintain homeostasis, and reproduce. For optimized results, need to be tweaked synergistically.
“..complex behavioral functions, including selective sexual behaviors, social bonds, and parenting require combined activities of OT and VP. The behavioral effects of OT and VP vary depending on perceived emotional context and the history of the individual.” Front Endocrinol (Lausanne). 2017; 8: 356. (Source)
Adding to the complexity of this pathway, the OT and VP receptors are quite variable and need to be epigenetically tuned. In this Presentation, we will look at a few techniques that optimizes this combo.
The Klotho Hormone
Klotho is a pleiotropic protein that circulates as a hormone following cleavage from its transmembrane form. It regulates insulin (Kurosu et al., 2005), Wnt (Liu et al., 2007), and fibroblast growth factor (FGF) (Urakawa et al., 2006) signaling. Overexpression of klotho extends life in organisms (Château et al., 2010, Kurosu et al., 2005), up to 31% in one study (Source), whereas lowering klotho shortens it (Kuro-o et al., 1997). Elevated klotho levels in humans, resulting from genetic variation (Arking et al., 2002, Dubal et al., 2014, Yokoyama et al., 2017), is also associated with longer lifespan (Arking et al., 2002, Invidia et al., 2010) in some populations. In model organisms and humans, levels of klotho decline with age (Duce et al., 2008, Semba et al., 2011), chronic stress (Prather et al., 2015), cognitive aging (Shardell et al., 2016), neurodegenerative disease (Semba et al., 2014), and models of neurodegenerative disease (Dubal et al., 2015, Massó et al., 2015). In addition, variations in the Klotho gene (SNP Rs9536314) are associated with both life extension and increased cognition in human populations. (Cf., Dena B. Dubal et al., Life Extension Factor Klotho Enhances Cognition, Cell Reports, 2014). In addition, several studies have shown promising results in the use of Klotho proteins as therapeutic agents to help in slowing down the progression of kidney diseases, diabetes, and cancer.
In this Presentation, we will show via power point different holistic techniques, nutrients and, among other elements supplements and that can significantly help to activate this protein-hormone. We will also learn what undermines this protein-hormone.
Neuropeptides, Neuro-transmitters & Healthy Longevity
Neuropeptides are small protein-like molecules (peptides) used by neurons to communicate with each other. They are neuronal signalling molecules that influence the activity of the brain and the body in specific ways. Different neuropeptides are involved in a wide range of brain functions, including analgesia, reward, food intake, metabolism, reproduction, social behaviors, learning and memory. Neuropeptides are related to peptide hormones, and in some cases peptides that function in the periphery as hormones also have neuronal functions as neuropeptides In this perspective, the human genome contains more than 70 genes that encode precursors of neuropeptides. At present about 100 different peptides are known to be released by different populations of neurons in the mammalian brain.
“…neuropeptides are the most diverse class of signaling molecules in the brain engaged in many physiological functions. According to this definition almost 70 genes can be distinguished in the mammalian genome, encoding neuropeptide precursors and a multitude of bioactive neuropeptides” (Methods Mol Biol. 2011;789:1-36)
Neurotransmitters are endogenous chemicals that enable neurotransmission. It is a type of chemical messenger which transmits signals across chemical synapses which are associated to neurons. Neurons form elaborate networks through which nerve impulses (action potentials) travel. Each neuron has as many as 15,000 connections with neighboring neurons. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available from the diet and only require a small number of biosynthetic steps for conversion. Neurotransmitters play a major role in shaping everyday life and functions. Their exact numbers are unknown, but more than 100 chemical messengers have been uniquely identified. (Source)
Excitatory and inhibitory processes
A neurotransmitter can influence the function of a neuron through a remarkable number of mechanisms. In its direct actions in influencing a neuron’s electrical excitability, however, a neurotransmitter acts in only one of two ways: excitatory or inhibitory. A neurotransmitter influences trans-membrane ion flow either to increase (excitatory) or to decrease (inhibitory) the probability that the cell with which it comes in contact will produce an action potential. Thus, despite the wide variety of synapses, they all convey messages of only these two types, and they are labeled as such. Type I synapses are excitatory in their actions, whereas type II synapses are inhibitory. Each type has a different appearance and is located on different parts of the neurons under its influence. Each neuron receives thousands of excitatory and inhibitory signals every second.
Biochemically derived from tryptophan, serotonin is a monoamine neurotransmitter that is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. It has a big job in helping animals experience feelings of well-being and happiness. It does have a drawback in that it can promote a feeling of obsession and addiction. But if the addiction is healthy wellbeing, then long live longevity addiction.
Dopamine is also an important neurotransmitter. The brain includes several distinct dopamine pathways, one of which plays a major role in the motivational component of reward-motivated behavior. The anticipation of most types of rewards increases the level of dopamine in the brain. The right quantity, a feel good “reward” type of feeling. As Jeanne Calment showed, it’s helpful to anticipate the daily “reward” of a big piece of dark non-GMO chocolate each day. According to her testimony, this holistic technique (of expecting each day something she considered to be a reward) helped to make her outlive her peers. Dopamine also modulates the sympathetic system. Disorders due to its deficiency include depression, sadness and parkinsonism. Dopamine affects movement, attention, learning, reinforcement and, inter alia, pleasure.
Acetylcholine: One of the major neurotransmitter in the brain, spinal cord and peripheral nerves. It also found in RBC’s and other cells in the body. It is synthesized in the neurons and released at nerve ending to pass on the nervous stimuli post synaptically. It is a part of parasympathetic system. It exerts actions opposite to that of sympathetic system. Acetyl choline is involved in almost all the body functions like heart beat, respiration, digestion, excretion, reproduction etc. Deficiency and rise in the levels of acteylcholine leads to many diseases and also toxic effects. Examples of diseases include parkinsonism, Alzheimer disease, glaucoma etc. Acetylcholine affects movement, learning, memory, REM Sleep and other processes.
Norepinpehrine: This also widely distributed like acteyl choline. It covers all of the sympathetic functions and has actions opposite to acetyl choline. Norepihephrine affects eating, alertness, wakefullness. Epinephrine is similar to nor-epinephrine in terms of actions and also chemistry. But it is present in more quantities in blood and peripheral body organs and to a small extent in brain. In periphery it is released by adrenal medulla. It is involved in stress regulation and is also called as flight or fight hormone. It acts through similar receptors as that of epinephrine. Its quantity levels rise is in the body is indicative of stress or struggle. Epinephrine also affects metabolism of glucose and energy release during exercise.
Serotonin: This is found in large quantities in intestine, platelets and also brain. It is an important transmitters in stress, mood and also coagulation. Its deficiency or change is seen in disorders like depression, schizophrenia etc. Gluatamate is a neurotransmitter found predominantly in brain. It is also an amino-acid. It is involved in memory and learning. When the brain undergoes oxygen deficient stress or physical injury its release in the extracellular space can be devastating leading to nervous tissue damage (excito-toxicity).
GABA (gamma amino benzoic acid) is another neurotransmitter present predominantly in brain. It acts to control nerve conduction and electric potential in the brain and also muscle tone. Its deficiency leads to epilepsy. It acts through GABA receptors. This neurotransmitter plays a key role in epilepsy or convulsion disorder. Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.
Because neurotransmitters are functionally integrated with the immune system and the endocrine system (including the adrenal glands), neurotransmitter imbalances can cause widespread health problems such as Brain fog: loss of mental focus, ADD, ADHD, impaired memory, poor decision making. Insomnia: difficulty falling asleep, staying asleep, or both; Pain: migraines, fibromyalgia, fatigue. Obesity: metabolic syndrome, insulin resistance, and diabetes; Mood disorders: depression, mood swings, irritabilit Anxiety: panic, obsessions, PTSD Behavioral disturbances addictions, binge eating, compulsions impulsivity, gambling, autism and more.
Cytokines Signaling Molecules, Cytokines-Storms, Inflammaging & the Body’s integrity
Cytokines are a broad group of signaling proteins that are produced transiently, after cellular activation, and act as humoral regulators which modulate the functions of individual cells, and regulate processes taking place under normal, developmental and pathological conditions (Dinarello et al. 1990; Meager 1998). Unlike hormones, cytokines are produced by cells which are not organized in special glands and which act systemically to affect biological phenomena such as inflammation, wound healing, organogenesis and oncogenesis. Cytokines include, but are not limited to chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors.
The Role of endogenous cytokines in premature death, disease, health and longevity
While cytokines are important for embryogenesis and fighting off infections and in other immune responses, they can get dysregulated, lose their balance, at which point conditions like inflammation, trauma, sepsis, schizophrenia, major depression, Alzheimer’s disease and, inter alia, cancer can ensue.
Homeostatic Imbalance and Cytokine-storms
Normal tissue integrity is preserved by feedback interactions between diverse cell types mediated by adhesion molecules and secreted cytokines, inter alia. Disruption of normal feedback mechanisms threatens tissue integrity. Over-secretion of cytokines can trigger a dangerous syndrome known as a cytokine storm which is seen in acute pancreatitis and other conditions. Cytokine storms are suspected to be the main cause of death in the 1918 “Spanish Flu” pandemic that killed over 50 million people within a short time. A cytokine storm is an overproduction of immune cells and their activating compounds (cytokines), which, in a flu-like infection for example, is often associated with a surge of activated immune cells into the lungs. The resulting lung inflammation and fluid buildup can lead to respiratory distress and can be contaminated by a secondary bacterial pneumonia, often enhancing the mortality in patients. (Source). Ironically, the stronger and healthier these victims were, the quicker they died. This is why so many young people with a strong immune system died during the Spanish flu. Recently, this 1918 flu virus was resussitated and injected to primate macaques. The results where as devastating as in 1918.
“Scientists said they were struck by how suddenly and overwhelmingly the 1918 flu struck seven macaques that were tested (…) The virus spread faster than a normal flu bug and triggered a “storm” response in the animal’s immune systems. Their bodies’ defenses went haywire, not knowing when to stop, researchers said. The lungs became inflamed and filled with blood and other fluids. (…) “There was some surprise that it was that nasty,” University of Washington virologist and study co-author Michael Katze said. “It was the robustness of the immune system that helped victimize them.” (Source)
With so many unhealthy conditions that pervade the American Nation, from over 80,000 unregulated toxic chemicals (toxicants), electrical pollution, chronic stress, massive autoimmunity, desertification, drought and bacterial resistance, it is likely that there will be in the not too distant future pubic health crises and cyto-storms that will lead hundreds of thousands if not millions of tax-paying Americans into the death throes of cyto-storms and other biological and chemical onslaughts. It will therefore be useful to teach a few holistic techniques which can turn off cytokines switches. Furthermore, as inflammation accumulates, even and especially slow-growing inflammation, aging accelerates. Biogerontologists call this condition “inflammaging”. In this Presentation, we will look at different holistic ways to turn “off” inflammatory switchs, thanks to which we can reduce premature senescence.
Case in Point: Sepsis
In order for the elderly and less elderly to achieve 120 years, they must be knowledgeable about what can quickly kill them. One of these quick-kill modalities is a trip to a conventional hospital where a patient can acquire some form of infection, and acquire sepsis. Sepsis is a common American cause of death in conventional hospitals. Each year, an estimated 1 million Americans get sepsis (Source) and up to half of them die from this condition and-or the conventional treatment. (Source) From a serious examination of the facts, it appears that Conventional hospital treatments for most chronic diseases, including sepsis are crafted more to maximize cash-flow than to optimize the People’s “blood-flow”, the public good, public health, good medicine, healthy longevity. According to the Agency for Healthcare Research and Quality, sepsis is the most expensive (i.e. lucrative) condition being treated in U.S. hospitals, costing more than $24 billion in 2014. (Source). A big proportion of the hospitalized elderly will die from this nosocomial disease. The condition becomes particularly deadly if the infection involves methicillin-resistant or vancomycin-resistant Staphylococcus aureus (MRSA or VRSA) bacteria, both of which, like cancer cells, have become resistant (stronger) to conventional medicine’s weapons of massive cellular destruction. These and other common hospital-acquired infections starts with symptoms of infection and can too often progress to septic shock, (Source) at which point the throes of death become a both a credible and creeping reality.
In effect, unless correctly (holistically) treated, sepsis can quickly result in extremely low blood pressure that is unresponsive to fluid replacement, that which weakens the heart and provokes multiple-organ failure and, inter alia, respiratory arrest. Other illnesses such as bronchitis, pneumonia, strep throat or kidney infection can lead to septic shock as well as certain localized infections caused by bacteria, fungi or viruses. As a result, vigilance and preventive proactiveness should always be one’s duty, especially if the infection is contracted in the hospital setting. There was a study I read years ago that showed a NYC hostical’s death curve going significantly down when its staff went on strike. This too is a relevant piece of evidence insofar as the limitations of conventional medicine is concerned.
In this Presentation, we will review what to do (and take) and not do (and not take) when one needs to be present in infected areas. As we saw in the case above on the Spanish Flu, “cytokine storms” usually hit the worse those who have a healthy immune system, so the holistic preventive and curative solutions are not always to have the strongest immune system, albeit robust immunity is needed for most conditions. Thereafter, we will hone in on different holistic treatments that can resolve infections in generals and sepsis in particular. While antiobiotics are not always counter-indicated, they should only be used at the last resort since holistic medicine can be much safer, cost-friendly and effective in resolving infections and septic shocks without damaging the human organism. Consultation with one’s competent holisticlly trained doctor is encouraged.
An estimated one third of the world’s population (or ≈500 million persons) were infected with the Spanish Flu (Source) during the 1918–1919 influenza pandemic. The disease was exceptionally severe. Case-fatality rates were >2.5%, compared to <0.1% in other influenza pandemics. Total deaths were estimated at more than 50 million and were arguably as high as 100 million. (Source)
The impact of this pandemic was not limited to 1918–1919. All influenza “A” pandemics since that time, and indeed almost all cases of influenza “A” worldwide (excepting human infections from avian viruses such as H5N1 and H7N7), have been caused by descendants of the 1918 virus, including “drifted” H1N1 viruses and reassorted H2N2 and H3N2 viruses. The latter are composed of key genes from the 1918 virus, updated by subsequently incorporated avian influenza genes that code for novel surface proteins, making the 1918 virus indeed the “mother” of all pandemics, including future pandemics.
In 1918, the cause of human influenza and its links to avian and swine influenza were unknown. That question did not begin to be resolved until the 1930s, when closely related influenza viruses (now known to be H1N1 viruses) were isolated, first from pigs and shortly thereafter from humans. Seroepidemiologic studies soon linked both of these viruses to the 1918 pandemic (Source) Subsequent research indicates that descendants of the 1918 virus still persists enzootically in pigs. They probably also circulated continuously in humans, undergoing gradual antigenic drift and causing annual epidemics, until the 1950s. With the appearance of a new H2N2 pandemic strain in 1957 (“Asian flu”), the direct H1N1 viral descendants of the 1918 pandemic strain disappeared from human circulation entirely, although the related lineage persisted enzootically in our swine cousins.
But in 1977, human H1N1 viruses suddenly “reemerged” from a laboratory freezer (Source). They continue to circulate endemically and epidemically. H1N1 viruses descended from the 1918 strain, as well as H3N2 viruses, have now been cocirculating worldwide for three decades and show little evidence of imminent extinction. Vigilance is therefore recommended. In this Presentation, we will examine options people have if ever a virulent viral pandemic were to spread again. Including homeopathic options that were used in France during the 1918-19 viral attack. Difficult to achieve healthy 120 years lifespans if our bacteria and virus co-evolution partners (including in human microbiota) decide to reflect the sad state of human affairs, as they did during the First (technically the Fifth) World War, where chemical warfare and other barbaric weapons of massive cellular destruction were legally distributed by the misguided Governmet officials of those times.
Activating Key Longevity Genes
In this Presentation, we will focus on activating three families of Longevity genes: the 7 members Sirtuin family, the APOE tribe and the wild FOXOs, a few members of whom can be helpful insofar as keeping human cellular repair and other longevity systems in decent shape. FOXO4 for example is elevated in senescent cells. (Source). Thus, to efficiently address senescent cells, we must also modulate this SNP (gene variation). Among other examples, let us consider one FOXO activator that is presently in the public debate.
FOXO3 Activators and Rejuvenation
Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity. FOXO proteins represent a subfamily of transcription factors conserved from Caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin and insulin-like growth factor signaling. In particuar FOXO3 appears to be especially interesting for optimal longevity.
“…Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample sizes, lack of precise phenotyping, and population stratification, among other challenges. Therefore, to more precisely assess potential genetic contributions to human longevity from genes linked to IIS signaling, we chose a large, homogeneous, long-lived population of men well-characterized for aging phenotypes, and we performed a nested-case control study of 5 candidate longevity genes. (….) Genetic variation within the FOXO3A gene was strongly associated with human longevity. The OR for homozygous minor vs. homozygous major alleles between the cases and controls was 2.75 (P = 0.00009; adjusted P = 0.00135). Long-lived men also presented several additional phenotypes linked to healthy aging, including lower prevalence of cancer and cardiovascular disease, better self-reported health, and high physical and cognitive function, despite significantly older ages than controls. Several of these aging phenotypes were associated with FOXO3A genotype. Long-lived men also exhibited several biological markers indicative of greater insulin sensitivity and this was associated with homozygosity for the FOXO3A GG genotype. Further exploration of the FOXO3A gene, human longevity and other aging phenotypes is warranted in other populations. (Source)
In this Discussion, we will discuss what the ongoing research is with FOXO genes as well as holistic and nutritional approaches to activate and optimize the best of this Gene group.
The Continuum of Ancestral Genes
The genetic code appears to be nearly identical for all known lifeforms, from bacteria and archaea to animals and even plants, who have their own energy “mitochondria” in the form of chlorophyll-rich chloroplats, an immune and communicatory system and much more. The universality of this code is generally regarded by biologists as definitive evidence in favor of universal common descent. (Cf. “The universal nature of biochemistry”. Proceedings of the National Academy of Sciences of the United States of America. 98 (3): 805–08) This “common universal ancester” construct has been debated for a long time. (cf. Steel, Mike; Penny, David (13 May 2010). “Origins of life: Common ancestry put to the test”. Nature. 465 (7295): 168–169. doi:10.1038/465168a. PMID (Source). Common ancestery describes how, in evolutionary biology, a group of organisms share a most recent common ancestor. There is an abundance of evidence of common descent of all life on Earth from the last universal common ancestor (LUCA). (Source), whose gene pool (determined to be 355 groups of genes) continues to be shared by the genomes of the three main domains of life: archaea, bacteria, and eukaryotes. (Wade, Nicholas (25 July 2016). “Meet Luca, the Ancestor of All Living Things”. New York Times). From what the experts can tell, at this juncture, LUCA could have been a deep sea anaerobic bacteria or archaea that started to evolve within extreme deep ocean vents. Other experts claim that this universal ancester came from the Cosmos. Biologists often point to the universality of many aspects of cellular life as supportive evidence of this common Genetic Life Code. These similarities include the energy carrier adenosine triphosphate (ATP), and the fact that all amino acids found in proteins are left-handed, (and sugars right handed), including those amino acids that come from outer space.
For example, the sirtuin gene group regulate important biological pathways in bacteria, archaea and eukaryotes. The name Sir2 comes from the yeast gene ‘silent mating-type information regulation 2’, which is the gene responsible for cellular regulation in yeast. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation[ and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis (Borenstein, Seth (13 November 2013). “Oldest fossil found: Meet your microbial mom”).
In 1859, Charles Darwin published On the Origin of Species in which he twice stated the hypothesis that there was only one progenitor for all life forms.
“Therefore I should infer from analogy that probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed.” (Darwin, Charles. On the Origin of Species. London: John Murray, Albermarle Street. 1859. pp. 484, 490)
The last sentence of his book begins with a restatement of his hypothesis: “There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one…” (Ibid). However, as Darwin’s intellectual challenger Lamarck suggested, decades before Darwin wrote his treatise, the awesome force of cultural and family inheritance (a form of epigenesis) is such that the evolutionary-inspired Life Code is based less on natural selection than on the Inheritance of Acquired Characteristics, an idea that was first presented in 1801. In other words, if an organism changes during life in order to adapt to its environment, those changes are passed on to its offspring.
Session T: Mitochondrial Bio-Genesis’ Restoration
The capacity for mitochondrial biogenesis has been shown to decrease with age, and such decreased mitochondrial function has been associated with diabetes and cardiovascular disease. (Source) Aging and disease can induce changes in the expression levels of proteins involved in the fission and fusion mechanisms of mitochondria, thus creating dysfunctional mitochondria. (Source). One hypothesis for the detrimental results of aging is associated with the loss of telomeres, the end segments of chromosomes that protect genetic information from degradation (Source). Telomere loss has also been associated with decreased mitochondrial function. Deficiency of telomerase reverse transcriptase (TERT), an enzyme that plays a role in preserving telomeres, has been correlated with activated p53, a protein that suppresses PGC-1α (Source).Therefore, the loss of telomeres and TERT that comes with aging has been associated with impaired mitochondrial biogenesis. AMPK expression has also been shown to diminish with age, which may also contribute to suppressing mitochondrial biogenesis. (Source)
Pyrroloquinoline quinone and Mitochondrial Biogenesis
Pyrroloquinoline quinone, also known as PQQ, is a compound found naturally in the soil and certain foods and wine that is believed to help aid in the formation of new mitochondria cells. It’s also produced naturally in the human body.
PQQ was first discovered as a cofactor for enzyme reactions in bacteria where it serves a similar function to that of B vitamins for humans. (Source) (A “cofactor” = it helps enzymes accomplish their tasks, including transferring electrons. PQQ can bring some serious benefits when it comes to ATP-based energy, as the mitochondria acts as the battery of the cell and is responsible for generating power, especially if it’s combined with CoQ10.
“Pyrroloquinoline quinone (PQQ) is linked to fundamental biological processes such as mitochondrial biogenesis and lipid metabolism. PQQ may also function as an essential micronutrient during animal development. Recent studies have shown the therapeutic potential of PQQ for several age-related diseases due to its antioxidant capacity. However, whether PQQ can promote longevity is unknown. Here, we investigate the effects of PQQ on oxidative stress resistance as well as lifespan modulation in Caenorhabditis elegans. We find that PQQ enhances resistance to oxidative stress and extends the lifespan of C. elegans at optimal doses. The underlying molecular mechanism involves the increased activities of the primary lifespan extension transcriptional factors DAF-16/FOXO, the conserved oxidative stress-responsive transcription factor SKN-1/Nrf2, and upregulation of daf-16, skn-1 downstream targets including sod-3, hsp16.2, gst-1 and gst-10. Our findings uncover a novel role of PQQ in longevity, supporting PQQ as a possible dietary supplement for overall health improvement. (Source).
In this Presentation, we will look into PQQ and a few other Mitochondrial activators.
Session U: Stem Cells: Repair, Replacement & Regeneration
As humans age and oxidize (lose electrons), inter alia, stem cells eventually lose their ability to divide and thus go into decline, at which point human bodies are unable to replace the stem cells that have migrated, differentiated, or died. Hence, the increase of age-related disorders, if only because the main function of stem cells is to repair and replace damaged tissues.
“In adults, stem cells are responsible for the repair of damaged tissues, and the replacement and regeneration of tissues that turn over rapidly, such as the skin, blood or the lining of the intestine. Recent evidence suggests that most, if not all tissues may contain stem cells with the potential to repair damaged tissue”. (Source)
Because stem cell exhaustion is an important hallmark of aging, geroscientists and biogerontologists are working on attempts to rejuvenate stem cells with synthetic chemicals and high tech technology. However, most times, this leads to both drug resistance and significant complications and toxic effects. On the other hand, integrative and regenerative medicine focuses on the early “banking” (storage) of stem cells that can be inoculated to worn out tissues when needed. These integrative clinics are also starting to use autologous stem-cells via injections on the same visit day. Holistic medicine’s focus is on preserving and holistically replenishing stem cells for quality living over 100 years. (Source) Before dieing, supercentenarians tend to have fewer and fewer stem cells, less than a handful, it’s been recorded that one supercentenarian lady was living just on two stem cells. In this Presentation, we will therefore examine holistic techniques to both preserve and produce quality stem cells that can repair and replace tissues until 120 years or so.
Natural Beauty, Hyaluronic Acid and Longevity
As the naked rat example (invoked above) suggested, hyaluronic acid may be a relevant longevity molecule and not only for the physical appearance.
“The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression.” (Source)
It so happens that when we repair the age-related damges to the extracellular matrix (ECM), by removing some of its stiffening, inter alia, hyaluronic acid flows better and as a bonus, we get longevity benefits like the old naked rat who outlives his mouse colleague by at least ten times. While the skin wrinkles are not constitutive of an aging hallmark (young people can have facial wrinkles form too much sun exposure and older people less depending on their genes), they do reflect metabolic impairment.
Case Study A: Stem cells in Clinical Medicine
Section under construction
Case Study B: How to activate one’s stem cells holistically
Section under construction
Session V: Telomerase Therapy
Telomere Shortening accelerates Aging
Located at the end of our chromosomes, these DNA repeats modulate the number of times cells divide. The longer the telomeres, the more cells divide, from 50 divisions or doublings to 70 for example, which corresponds to about 120 years, which has been called the Hayflick limit. The shorter telomeres get, the less they divide. When they can no longer divide, they then go into the senescence mode, and that not only clogs up the system, but accelerates aging.
Telomerase Activation prolongs both healthy lifespans and cancer cells
While all of our cells’ DNA code for telomerase gene, this gene is dormant in our somatic cells. Different labs have found this gene in just about all of our somatic cells, but they are not activated. However, for germ (gonads) cells and cancer cells, the DNA of these structures fully express the telomerase enzyme genes, which means that germ and cancer cells always divide and therefore don’t age, as long as they have a source of food. This is why babies are not born with the aged cells of their parents. The Telomerase clock is renewed at each birth. Stem cells have their telomerase partially expressed for minimum telomerase expression. The better the expression of these genes within stem cells, the better stem cells can get their cellular repair task done. But all of our other somatic cells are destined to die within the Hayflick limit, some quicker than others depending on epigenetic factors.
To significantly extend a healthy human lifespan, we therefore need to focus on the expression of telomerase genes in both somatic and stem cells. While conventional medicine and its mainstream scientists are searching for cash-flow drugs, genetic editing technology and other high-tech tools to activate telomerase genes without promoting cancer, Holistic Savoir-faire has been teaching for millennia years simple longevity techniques like sun bathing, meditation, certain caloric restricted diets and, among other approaches, “joie de vivre” lifestyle, all of which have been proven by a preponderance of the evidence to upregulage telomerase genes without feeding carcinogenesis. Of hundreds of telomerase activators conventional medicine has tested, just about all have a cancer risk (including other side effects) and don’t appear to be that efficient in terms of optimal longevity. Differently from the conventional approach, the more we can boost the telomerase genes holistically, the less cancer cells proliferate and the healthier and longer human cells live. (Source). This presentation will review some of these techniques. Among other examples, let us consider a popular Telomerase activator that is presently in the public debate and somewhat controversial.
There are a few telomerase activators that are being researched. One of the ones we will look at is called Ta-65. This supplement was discovered as a chemically defined small molecule activator of telomerase in the year 2000 from an empirical screen of natural product extracts from traditional Chinese medicines. Since that time, there have been research and observational studies on TA-65 in humans and animal models supporting improvements in biomarkers of aging, including immune, cardiovascular, metabolic, bone, and inflammatory markers, without significant signs of toxicity The formulation (TA-65MD) is manufactured under the regulations of current good manufacturing practice (cGMP); it is designated as GRAS (generally recognized as safe) for use in a medical food and is sold as a dietary supplement by the company TA Sciences.
“TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 117 relatively healthy cytomegalovirus-positive subjects aged 53–87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period (530 ± 180 bp; p = 0.005), whereas subjects in the placebo group significantly lost TL (290 ± 100 bp; p = 0.01). The high dose of TA-65 (1000 U) showed a trend of improvements in TL compared with that of the placebo group; however, the improvements did not reach statistical significance. TL changes in the low-dose group were similar for both median and 20th percentile TLs. The findings suggest that TA-65 can lengthen telomeres in a statistically and possibly clinically significant manner.” (A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study, 2017 (Source)
The Plant: Astralagus
“Owing to a dramatic increase in average life expectancy and the Family Planning program of the 1970s – 1990s, China is rapidly becoming an aging society. Therefore, the investigation of healthspan-extending drugs becomes more urgent. Astragalus membranaceus (Huangqi) is a major medicinal herb that has been commonly used in many herbal formulations in the practice of traditional Chinese medicine (TCM) to treat a wide variety of diseases and body disorders, or marketed as life-prolonging extracts for human use in China, for more than 2000 years. The major components of Astragalus membranaceus are polysaccharides, flavonoids, and saponins. Pharmacological research indicates that the extract component of Astragalus membranaceus can increase telomerase activity, and has antioxidant, anti-inflammatory, immunoregulatory, anticancer, hypolipidemic, antihyperglycemic, hepatoprotective, expectorant, and diuretic effects…..” (Source)
Astragalus membranaceus (Huangqi) is one of the most important Qi tonifying adaptogenic herbs in Trational Chinese Medicine, it has a long history of medicinal use. The Chinese claim that its inexpensive extracts alone are sufficient to boost longevity and wellbeing. On the other hand, the TA 65 scientists claim that only their proprietary blend of molecules can do the magic. By themselves within the root, they would be too weak, like with resveratrol and thousands of other compounds, goes to the allegation. Thus, it is claimed that specific astragalosides need to be isolated and purified and then super multiplied for a therapeutic bang. In this discussion, we will dig deeper to see what the biological reality is and then make a determination as to what is the most safe, cost-effective and especially effective way to go, the whole plant extract or the pill. If time allows, we may also study other telomerase activaators.
Session W: Cellular Senescence & Autophagy Regulation
When telomeres shorten, cells can’t divide anymore, at which point they become senescent. When we are vibrant, senescent cells are thought to be cleared by the immune and the autophagy systems, as a result, healthy lifespans tend to be much longer. On the other hand, when senescent cells stick around secreting harmful inflammation molecules and sticking to healthy cells, aging is accelerated. Canakinumab was manufactured to dampen this senescence inflammation called infammaging. But this drug has its limits. (Source).
Unresolved DNA damage can impair cellular function, promote disease development, and accelerate aging (López-Otín et al., 2013). To prevent such undesired consequences, cells are equipped with a range of DNA repair mechanisms (Hoeijmakers, 2009). However, these mechanisms are not flawless. When repair falls short, tissue integrity is still at least initially maintained by independent stress-response mechanisms as apoptosis and cellular senescence (de Keizer, 2017). Senescent cells are permanently withdrawn from the cell cycle and generally develop a persistent pro-inflammatory phenotype, called the senescence-associated secretory phenotype (SASP) (Coppé et al., 2008). The SASP influences the cellular microenvironment, which can be beneficial early in life or in an acute setting of wound healing (Demaria et al., 2014, Muñoz-Espín et al., 2013).
However, unlike apoptotic cells, which are permanently eliminated, senescent cells can prevail for prolonged periods of time and accumulate with age (Krishnamurthy et al., 2004). Because of their low but chronic SASP, persistent senescent cells are thought to accelerate aging and the onset of age-related diseases (de Keizer, 2017). Indeed, senescence has been associated with a plethora of (age-related) pathologies, and, conversely, genetic clearance of senescent cells can delay features of aging (Baker et al., 2016).
In this Presentation, we will examine a few holsitic techniques that can help to clear cellular senescent cells as well as activate autophagy.
Amyloidosis and the Art of Removing extracellular Deposition of Misfolding Proteins
Many centenarians and superccentenarians avoid chronic diseases and surf on a smooth plateau until the stem cells, inter alia, can’t keep up with the repair and-or replacement of tissues. Thereafter, cellular impairment can be massive, thanks to which the supercentenarian doesn’t have to wait too long before passing to the next round of spiritual adventures. And the most decisive element that accounts for the “extreme” elderly’s demise is less cancer, diabetes, lupus or heart attacks than the misfoldment of their own proteins, the TTR of which is a big one. ANd this misfoldment can clog up mutliple organs (the heart, kidneys and brain being three major ones) and be systemic.
“The systemic amyloidoses are a family of diseases induced by misfolded and/or misassembled proteins. Extracellular deposition of these proteins as soluble or insoluble cross β-sheets disrupts vital organ function.1 More than 27 different precursor proteins have the propensity to form amyloid fibrils.2 The particular precursor protein that misfolds to form amyloid fibrils defines the amyloid type and predicts the patient’s clinical course. Several types of amyloid can infiltrate the heart resulting in progressive diastolic and systolic dysfunction, congestive heart failure, and death. Treatment of cardiac amyloidosis is dictated by the amyloid type and degree of involvement. Consequently, early recognition and accurate classification are essential.3 (Source
The Transthyretin transport protein (TTR)
Transthyretin (TTR) is a transport protein in the serum and cerebrospinal fluid that carries the thyroid hormone thyroxine T4 as well as the retinol-binding protein. This is how transthyretin got its name: transports thyroxine and retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid. With time and unholistic living, this protein readily misfolds. In this Presentation, we will examine what the bio-tech Industry is working on to address this misfoldment challenge, and thereafter, we will look at Holistic medicine and its ability to both prevent and signficantly delay the onset of amydoilosis and to mitigate it’s cellular havoc when it’s already there.
Autophagy: A key longevity pathway honored with a 2016 Nobel
Autophagy is an evolutionally conserved cytoplasmic degradation system in which varieties of materials are sequestered by a double membrane structure, autophagosome, and delivered to the lysosomes for the degradation.
“Autophagy is an ancient pathway in which parts of eukaryotic cells are self-digested within the lysosome or vacuole. This process has been studied for the past seven decades; however, we are only beginning to gain a molecular understanding of the key steps required for autophagy. Originally characterized as a hormonal and starvation response, we now know that autophagy has a much broader role in biology, including organellar remodeling, protein and organelle quality control, prevention of genotoxic stress, tumor suppression, pathogen elimination, regulation of immunity and inflammation, maternal DNA inheritance, metabolism, and cellular survival. Although autophagy is usually a degradative pathway, it also participates in biosynthetic and secretory processes. Given that autophagy has a fundamental role in many essential cellular functions, it is not surprising that autophagic dysfunction is associated with a wide range of human diseases. Genetic studies in various fungi, particularly Saccharomyces cerevisiae, provided the key initial breakthrough that led to an explosion of research on the basic mechanisms and the physiological connections of autophagy to health and disease. The Nobel Committee has recognized this breakthrough by the awarding of the 2016 Nobel Prize in Physiology or Medicine for research in autophagy.” (Source)
“The increased neuronal autophagy is revealed by changes in autophagosome abundance and characteristics, and by diminished neuronal mTOR activity in vivo, demonstrated by a reduction in levels of phosphorylated S6 ribosomal protein in Purkinje cells. The increased abundance of autophagosomes in Purkinje cells was confirmed using transmission electron microscopy. Our data lead us to speculate that sporadic fasting might represent a simple, safe and inexpensive means to promote this potentially therapeutic neuronal response”.(Source)
Autophagy has equally been recognized as a crucial defense mechanism against malignancy, infection and neurodegenerative diseases. When things are running smoothly in a cell, autophagy occurs at a low level, helping to recycle worn-out cellular components. It’s a type of ‘maintenance’ mode. But when things become stressed in a cell (not enough nutrients or energy, dysfunctional components, or invasion by microbes), autophagy kicks in its stress response mode. Activation of autophagy counteracts the age-associated accumulation of damaged cellular components and enhances the metabolic efficiency of cells. (Source) In particular, autophagy can be activated to remove dysfunctional mitochondria (mitophagy) which produce a lot of harmful reactive oxygen species (ROS) that degrade the cell (Source) These processes are reported to extend the lifespan of several species. (Source)
In this Presentation, we will show different ways to promote autophagy within different tissues. Exercises Dietary Restriction and fasting are all autophagic. Taken certain supplements also, in particular nicotinamide Nicotinamide is a member of the vitamin B family and an ingredient for making the essential energy molecule nicotinamide adenine dinucleotide (NAD). It has been reported to forestall Alzheimer’s through increasing autophagy in neurons. (Source) It can also induce autophagic recycling of mitochondria, which is beneficial to cellular health and longevity. (Source)
Spermidine and Autophagy
Spermidine has been linked to hair growth, arterial health, longevity, epithelial stem cell modulation, and autophagy activation. In effect, spermidine is another one of those molecules that erodes with non holistic aging and thus, needs to be seriously boosted.
“… Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells. In addition, spermidine administration potently inhibited oxidative stress in ageing mice. In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis. Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan. The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells. Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity. (Source)
Session X: Circadian Rythms Activation & DNA Repair
The aging hallmark relative to the circadian pathway is relatively new. The 2017 Nobel Prize in Physiology (Medicine) went to scientists who dug deep to unravel some of the mysteries of circadian biology. When humans don’t respect Nature’s rhythms like the sleep-wake (melatonin-cortisol) cycle, aging is accelerated.
Deep restorative Sleep is one of Happiness Medicine’s twelve most important wellbeing tools, more powerful than pills, surgery and any high-tech procedure combined, because none of conventional medicine’s weapons and procedures can repair damaged DNA, spur rejuvenation hormones, charge up neurotransmitters, calm inflammation, calm the mind and detox beat-up tissues like deep restorative sleep.
In this Presentation, we will examine the best deep sleep protocols, including, but not limited to different ways to holistically resolve Apnea, snoring, frequent urination and other sleeping problems. As for holistic ways to promote DNA repair, this topic is so important that we will only briefly talk about it in this Seminar. Seminar B will focus more on this longevity mechanism.
Nicotinamide Adenine Dinucleotide, NMN & DNA Repair
NAD+ is a key co-enzyme and metabolite called Nicotinamide Adenine Dinucleotide (NAD+) that the mitochondria in every cell of our bodies depend on to fuel all basic functions. (Source) Over time, decreasing NAD+ promotes chronic diseases and aging. (Source). Different scientists claim that is one of the key factors that explains why we age (Source). In this NAD+ plays a key role in communicating between the nucleus of cells and the Mitochondria that power cell activity (Source). One of its key role is to ensure DNA repair, a longevity function which is essential.
“DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD+ (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD+ to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate–ribose) polymerase], a critical DNA repair protein. As mice age and NAD+ concentrations decline, DBC1 is increasingly bound to PARP1, causing DNA damage to accumulate, a process rapidly reversed by restoring the abundance of NAD+. Thus, NAD+ directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging.” Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A. Sinclair. A conserved NAD binding pocket that regulates protein-protein interactions during aging. Science, 24 Mar 2017: Vol. 355, Issue 6331, pp. 1312-1317 (Source) (Full article)
In this perspective, it would appear that the supplement called with Nicotinamide Mononucleotide (NMN), the immediate precursor used by the body to create NAD+, can replenish stores of NAD+ and help to reverse the aging process.
The metabolite NAD+ has a key role as a regulator in protein-to-protein interactions that modulate DNA repair & NMN can help
Proof of concept
A recent study showed that rreating mice with a NAD+ precursor, or “booster,” called NMN improved their cells’ ability to repair DNA damage caused by radiation exposure or old age. Most recently Professor Sinclair and his team demonstrated that supplying old mice with NMN in their drinking water for 2 months greatly increased the number and size of blood vessels throughout the body, such that they were indistinguishable from young mice. In fact, the old mice who received the supplement had nearly twice the endurance as those that did not, and were as fit and strong as young mice. (Source) A randomized control trial (considered the gold standard of scientific research) from a different group of researchers published November 2017 in the journal Nature found that people who took a daily supplement containing NAD+ precursors had a substantial, sustained increase in their NAD+ levels over a two-month period. Human trials of NMN therapy are still ongoing. (Source)
Professor Sinclair and his UNSW colleague Dr Lindsay Wu were winners in NASA’s iTech competition in December last year and both claim that this molecule can help to preserve astronauts health from cosmic radiation while also helping 96 per cent of childhood cancer survivors, all of whom suffer a chronic illness by age 45, including cardiovascular disease, Type 2 diabetes, Alzheimer’s disease, and cancers unrelated to the original cancer. Conditins which constitute accelerated ageing. “While resveratrol activates SIRT1 alone, NAD+ boosters activate all seven sirtuins, SIRT1-7, and should have an even greater impact on health and longevity,” claims Professor Sinclair. (Source)
The evidence does appear to support the claim that when there’s a deficiency of NAD+, there’s a loss of cellular function leading to disease and aging. As well as the claim that supplementation with Nicotinamide Mononucleotide (NMN), the immediate precursor used by the body to create NAD+, can replenish stores of NAD+ and help to reverse the aging process. The Key issue though lies elsewhere : Is there convinging proof that NMN is better than holistic techniques like exercises, herbology and dietary restriction ? Because if all NMN does is mimick some of holistic lifestyle’s rejuvenation, then this supplement may not be that needed, except maybe for those who refuse to go holistic.
The Anti-aging products from skin creams to chemical peels and sirtuin activators are part of a $250 billion industry, but to my knowledge, not many stand up to medical scrutiny. Sinclair plans to take his NAD+ research through the U.S. Food and Drug Administration (FDA) approval process and eventually create a pill that could be prescribed by a doctor or purchased over the counter. Another company he is linked with, called Elysium, is already selling a supplement called Basis that contains compounds known to boost NAD+ levels. (Basis is the supplement tested in the 2017 Nature study.) Supplements are not required to undergo years of clinical research and FDA approval processes Leonard Guarente, Elysium’s chief scientist and co-founder (who also directs the Glenn Center for Biology of Aging Research at MIT where Sinclair works) prudently (from the legal perspective) says Basis is not intended to extend people’s life spans, but only to help them stay healthier for longer. Eight Nobel laureates are on the company’s scientific advisory board. Since Sinclair has sold his resveratrol-based sirtuin (anti-aging enzyme SIRT1 activator) booster company for billions of dollars, just before resveratrol supplements were shown to be not that great of sirtuin-longevity boosters, this NAD team has the funds to pay for the most prestigious Nobel supporters and the most daring scientific and even marketing adventures.
Thus, given the history of this area of metabolism related to sirtuins, caloric restriction mimickers and their manipulation, one has to be prima facie skeptical. Initially promising (and overhyped) results in mice went essentially nowhere, or turned out to make the condition of obesity a little less harmful, while showing little evidence of utility for healthy individuals. If human data showing meaningful benefits from NMN that could not be achieved via exercise or calorie restriction, than ok, this supplement would be interesting. As of now, this supplement appears to be of benefit only to those who prefer to pay rather than exercise or eat less or live holistically. Furthermore, this supplement does not appear to target what is needed in rejuvenation medicine, techniques to promote the elimination of senescent cells, the repair of DNA and some of the inhibition of other aging pathways that we talked about.
Nicotinamide Riboside & Longevity ?
Another NAD+ precursor vitamin is Nicotinamide riboside (NR). NR is a supplement that affects energy generation in mitochondria and gene regulation through the same pathway as resveratrol and caloric restriction. It has been shown to host NAD+ by over 2 fold with a single dose. It is sold under the label Niagen. A Clinical trial appears to be ongoing. (Source). This one will be recruiting in 2019 (Source)
“Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD+ metabolism in humans. We report that human blood NAD+ can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD+ with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide. We further show that single doses of 100, 300 and 1,000 mg of NR produce dose-dependent increases in the blood NAD+ metabolome in the first clinical trial of NR pharmacokinetics in humans…” (Source)
NR has been promoted since 2014 including via Life Extension. (Source) At first, when i read about a new life extension supplement that is herald as a “Longevity breakthrough”, like with cancer breakthroughs, my the red lights in my frontal cerebral cortex lighgt up. For example, phrases like “dramatic longevity improvement with fruit flies” , “..we fed it to mice and they lived X% longer”, or better yet, “In preliminary human trials, mortality was found to be ….% lower.” However, as we explained in the Methodology section, all of these phrases must be carefully analyzed to see exactly what the story is and if the study is not flawed by design.
Looking at the facts in this NR case, it would appear that the articles about NR talk lots about biochemical pathways and chains of genes that promote other genes etc. Biochemistry is important for generating ideas, but we must be wary when the study goes too much into theory and biochemistry. The hard evidence in Longevity medicine remais life extension human trials and epidemiology. Lab experiments on live mice run hundreds of thousands of dollars to test a single compound. So its better to test on insects first. Worms and flies are much cheaper to breed than mice, and the experiments last weeks instead of years. Furthermore, genetics of these lower animals is well-understood, and easy to manipulate. Experiments with worms and flies provide an intermediate proving ground for ideas before the expensive life span trials with rodents. There are many interventions that work well to extend life in flies that don’t work in mammals. We can’t be testing everything, so we rely on biochemistry for plausible candidates. But jumping from biochemical theory to marketing of a supplement can be misleading. Going back to NR, it appears that the evidence for its life expectancy benefit is indirect. There have been few positive results for fruit flies, let alone mice. If it works in humans, benefits will likely be limited to people who are overweight. And there are reasons to expect only limited benefits from the pathways through which NR works. Furthermore, it may be that there have already been experiments feeding NR to mice or rats, but often, as we saw, negative results don’t get published.
Tentative conclusion: There’s no doubt that Niagen (NR) is capable of boosting NAD+. But the issue remains that Holistic Lifestyle is also able to accomplish this biochemical feat. Furthermore, all three variations of vitamin B3 are capable of accomplishing the same result, though at different degrees. Indeed, the evidence appears to indicate that the three variations of vitamin B3, NR, NAM (Nicotinamide), and NA (Nicotinic Acid) are all precursors of NAD+. All three produce NAD+ in the human body. (Cf. Preiss-Handler Pathway, NAD+ Salvage Pathway) Furthermore, exercise, fasting, caloric restriction or other techniques can also boost NAD+ at virtually zero monetary cost.We will go into additional details in the Discussion.
A Powerful Entourage Synergy effect between between Pterostilbene and Resveratrol ?
The evidence shows that Pterostilbene, one of Resveratrol’s key partners, also mimics many of the beneficial effects of resveratrol, to which it is molecularly related, including, but not limited to caloric restriction. Furthermore, this natural compound favorably regulates genes involved in the development of cancer, atherosclerosis, diabetes, and the system-wide inflammation that underlies a variety of age-related disorders.
“…(…) Multiple studies have demonstrated the antioxidant activity of pterostilbene in both in vitro and in vivo models illustrating both preventative and therapeutic benefits. The antioxidant activity of pterostilbene has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes”. (Source)
Pterostilbene (pronounced terro-STILL-bean), found in blueberries, grapes and especially grape leaves as well as in the bark of the Indian Kino Tree, has been used for centuries in Ayurvedic and European medicine (especially for the Greeks and the Mediterranean French who eat grape leaves). Pterostilbene and resveratrol are both stilbene compounds, closely related structurally, which gives them similar but not identical functions. Researchers have found that these two compounds work in a synergistic fashion to activate one’s “longevity genes.” Pterostilbene produces its beneficial effects on gene expression in ways that enhance those produced by resveratrol. That is why pterostilbene functions particularly well when combined with resveratrol. In this Presentation, we will delved in the details as well on the best holistic ways to ingest and assimilate both pterostilbene and resveratrol.
Session Y: Key Check-up and Monitoring Tests: From Self-testing to Genetic Evaluation and more
In this power-point talk, we will thus delved into some of the most important holistic, functional, integrative and allopathic tests that can be done to determine health and disease status, (diagnosis) to monitor disease progression (prognosis) and to evaluate the safety and efficiency of treatment plans and longevity protocols. We will also quickly look at dozens of biomarker lab tests that can detect underlying chronic conditions that are not yet symptomatic. Like with genetic tests.
Although proactive prevention is key in health, most people don’t get motivated to have a proactive & preventive holistic lifestyle until the “proof of the pudding” via lab tests and-or organ failure corroborate threatening signs. Integrative medicine experts have dozens and dozens of lab tests to sell to their clients. But these can be quite expensive and many are not reimbursed by insurance companies. This section will thus focus on the most important ones. We will also go over a few self-care tests that can be done by the patient (i.e., via en educated examination of the ears, the eyes, tongue, poop, urine, smell, pelvic gait, temperature and more).
Session Z: Update on Today’s Bio-Engineering of anti-aging pharmaceuticals & Hi-Tech procedures
In this last Section, we will look at some of the most interesting innovative technologies that are either freshly on the market or still being worked on, from biogerontology institutes in France, China, Japan, Germany, Israel to those in the US, including the Silicon Valley bio-tech giants and their prestigious scientists and billionaires. Some of these medical innovations target many of the aging mechanisms we have seen, from. telomerase insufficient, to senescent cell removal, (senolytics), caloric restriction mimickers, blood donor plasma transfer, nano-robots, gene editing, stem cell cyro-preservation, Sirtuin-activating molecules and the like). Pharmacological treatments have also been shown to extend lifespan through activation of autophagy, indicating autophagy could be equally a potential target to modulate animal and human lifespan. (Source)
Targeting Senescent Cells with Conventional Pharmaceuticals & Senolytics
Not too long ago, scientists have genetically modified mice to remove their senescent cells, allowing the rodents to live longer and reducing plaque buildup in their arteries. (Source). Such genetic alterations aren’t practical for people, but researchers have reported at least seven compounds, known as senolytics, tha can terminate senescent cells’s lifespan. A clinical trial is testing two of the drugs in patients with kidney disease, and other trials are in the works..
What are Senolytics ?
“ Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age‐related phenotypes, chronic diseases, geriatric syndromes, and loss of physiological resilience. Among the chronic conditions successfully treated by depleting senescent cells in preclinical studies are frailty, cardiac dysfunction, vascular hyporeactivity and calcification, diabetes mellitus, liver steatosis, osteoporosis, vertebral disk degeneration, pulmonary fibrosis, and radiation‐induced damage. Senolytic agents are being tested in proof‐of‐concept clinical trials. To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, because use of long‐term endpoints such as lifespan or healthspan is not feasible. These strategies include testing effects on multimorbidity, accelerated aging‐like conditions, diseases with localized accumulation of senescent cells, potentially fatal diseases associated with senescent cell accumulation, age‐related loss of physiological resilience, and frailty. If senolytics or other interventions that target fundamental aging processes prove to be effective and safe in clinical trials, they could transform geriatric medicine by enabling prevention or treatment of multiple diseases and functional deficits in parallel, instead of one at a time.” (Source)
A senolytic (from the words “senescence” and “lytic” – destroying) is among the class of small molecules under basic research to determine if they can selectively induce death of senescent cells (Source)s. In basic research, senescence is a potential tumor suppressive mechanism (Source) and possible factor that accelerates the aging process. (Source). The goal of those working to develop senolytic agents is to delay, prevent, alleviate, or reverse age-related diseases (Source).
Senescent cells carry the type of DNA damage that should spur a protective protein, called p53, to put them down. Instead, the researchers found that a different protein, FOXO4, latches onto p53 and prevents it from doing its duty. To counteract this effect, Dr Keizer and colleagues designed a molecule, known as a peptide, that carries a shortened version of the segment of FOXO4 that attaches to p53. In a petri dish, this peptide prevented FOXO4 and p53 from hooking up, prompting senescent cells to commit suicide. And it spared healthy cells.
The researchers then injected the molecule into mutant mice that age rapidly. These rodents live about half as long as normal mice, and when they are only a few months old, their fur starts to fall out, their kidneys begin to falter, and they become sluggish. However, the peptide boosted the density of their fur, reversed the kidney damage, and increased the amount of time they could scurry in a running wheel. (Source) Another example, in a study published in 2015 in the journal Aging Cell (Source) researchers irradiated mice legs to simulate the ravages of age. One application of a senolytic to the affected legs, and they showed a return to pre-radiation performance, a result that held up over the next seven months. The senolytics appeared to reverse the effects of aging.
Peptides are short chains of amino acid monomers linked by peptide (amide) bonds. Research has examined the role of peptides in both cancer and aging. Experimentation and different clinical trials are pending on the use of peptides and sy for the removal of senescent cells. There are a few… Some of these peptides appear to bestow upon the patient 20 to 40 percent lifespan increase.
“…It was shown that long-term treatment with some peptide preparations increased mean life span by 20-40%, slow down the age-related changes in the biomarkers of aging and suppressed development of spontaneous and induced by chemical or radiation carcinogens tumorigenesis in rodents.” (Biogerontology. 2010 Apr;11(2):139-49 Peptide bioregulation of aging: results and prospects. Source)
Brief Analysis on a few of the pending Longevity Human Clinical Trials
As we tried to show, we can have great longevity results with worms, mice or even the naked mole rat, but for the “rubber to meet to road”, we need convincing well-designed impartial human clinical trials to ascertain if a supplement, pharmaceutical or whatnot works and is safe. Because the key three issues for the common consumer are and have always been these: Does it work ? Is it Safe ? And cost-friendly ? Most clinical trials will cover the first two issues via rigorous experimenations. We will look at the types of trials that are the most compelling, including their built-in flaws. But the ultimate determination comes from the Court of public opinion, first from peer-reviewed journals, then from consumers and lastly via class action suits, or the like.
Session : Summary
Honing in on Key Rejuvenation and Life Extension Techniques
This Talk will hone in on what appears to be the quintessence and most promising of the present Research on significant and healthy lifespan extensions, most of which can be subsumed within three general categories: Telomerase cellular delivery via gene-tweaking; DNA repair mechanisms via molecular signaling and Metabolic Fine-tuning via holistic savoir-faire.
First Category relative to telomerase activation: Even though an abundance of telomerase enzymes and long telomeres can accompany conditions like cancer and accelerated aging, contemporary Research (including today’s 51 clinical trial on telomerase) is investing hundreds of million of dollars on a relatively new gene-therapy what was invented in 1999. Today, after 18 years of experimentation, longevity scientists are honing in on the telomerase enzyme as one of the central rejuvenation engines that could significantly reset the aging clock of somatic cells. (See Source)
The second category is focused on DNA repair mechanisms and sirtuin genes. Many Longevity experts and Biogerontologists claim that aging’s central hallmark is characterized by the failure of DNA repair mechanisms to correctly unfold and fix the cell’s accumulated damage.
As a consequence, genomic instability accumulates and with it, carcinogenesis, other degenerative diseases and accelearted aging, which would be one of Nature’s ways to invite death to end a person’s healthy lifespan for having excessively deviated from evolutionary biology. Professor Sinclair from Harvard is one of the main scientists who has invested a lot of time and effort in this realm. His Lab has been focused on this question for years, first on wine’s resveratrol molecule and more recently on NAD +, inter alia. (See Exhibit D for illustrations)
The Third Category is hinged more on metabolic and holistic medicine, in particular of how food, movement and fasting can turn on and off epigenetically switches that will activate survival, feel-good and longevity genes. While the proponents of this school are not as extravagant or ambitious as the first two other schools in terms of extreme longevity to over 150 years, it’s theoretical foundations are coherent while its evidentiary basis is supported by petri dish, animal, comparative studies, epidemiology and non-randomized human clinical trials. Professor Seigfried, Longo, Ornish and the Happiness Medicine Institute’s Team are a few of its proponents. (See Exhibit B for illustrations).
In addition to a scant review of the pending clinical trials on senolytics, C.R. mimetics, senescent cells, what the National Institute of Aging and other Longevity Research institutes are working on and a word on the inter-connectivity of all of aging’s hallmarks, this Section will therefore weigh the central arguments of each of these three schools and make a factual determination as to which avenue of Research may be the most promising in terms of the People (ie, and not just the wealthy one-percent who can afford a one million dollar longevity treatment “shot”) being able to benefit from an affordable and meaningful access to the best optimal longevity tools that will significantly extend healthy Lifespans for the majority in the here and the now while contributing in resolving both the Nation’s social security and the national debt crises.
The Optimal Longevity Tune-up Protocol in a Nutshell
To maximize a healthy lifespan, the first physiological tune-up procedure that is usually needed accross the board is to address the Brain-Gut Axis by optimizing the patient’s sleep patterns followed by stress management protocol, a plan to clear and clean up the excretion and detox pathways (which includes the oral cavity) and by making sure water & food intakes are personally optimized as well as the microbiota’s diversity and balance and the workshopee’s entourage field.
When the body is freed from nutritional imbalances, toxins, parasites, infections, auto-immunity, inflammation, oxidation, emotional scars, energy blocages, toxic fields and other co-morbidities, the workshopee will feel, digest and poop better, at which point the patient can better activate his-her body’s main bio-chemical signaling systems (ie, hormones, cytokines and neurotransmitters), thanks to which all of the body’s major physiological systems can get fine-tuned for optimal performance, including, but not limited to the body’s stem-cell based repair mechanisms, rejuvenation hormones and longevity genes.
In this Presentation, we will outline part of the Optimal Longevity Protocol (Strategy) to significantly reduce all risks of chronic diseases while meaningfully increasing one’s lifespan to over 100 years. For the compliant good candidates, over 120 years. Seminar 2 and 3 will complete this Protocol.
The Healing Milieu’s Entourage Effect
“La forme est l’Émanation du Fond” (Victor Hugo)
Etymologically, the words health and healing comes from the words “holy” and “whole” and can be construed to mean “to make whole again”. Same with the French word “santé” (health), which comes from sainteté (being saintly). Homeostasis, or the restoration of mileu’s balance and diversity has also characterized the essence of good medicine. In this realm, the milieu or bio-terrain (also called the micro-environment) as well as the entourage and macro-environment or “field” that surrounds the patient are also important to optimize. Dr. Claude Bernard, demonstrated beyond any reasonable doubt with myriad experimentations (so many that his wife got upset) that the conditions of the internal environment dictate Life. Today, this conclusion has been recently confirmed via the Government’s NIH’s microbiome project of 2008, close to two centuries after the French relevant discoveries. This talk will develop the relevance of these concepts,
“Ignorance kills my People” (Bible) Put Fr Re on Human rights
Aging is defined as a progressive decline in intrinsic physiological function, leading to an increase in age-specific mortality rate and a decrease in age-specific reproductive rate. Some of the major theories of aging that we have examined include telomere shortening theory, epigenetic and genetic regulation theory, stem cell theory, mitochondrial dysfunction, metabolic and immune deregulation, proteostasis loss and, among others, the gut microbiota regulating theory. We saw that some of these aging hallmarks could be favorably fixed. We also saw that fixing the roots of aging also benefits the resolution of most chronic diseases.
However, not all scientists agree on all of the causes that explain the hallmarks of aging we identified, and in particular, the hierarchy of causation (which causes are the most important). But for the Happiness Medicine Institute’s executive Committee, the central cause is this constant onslaught of low and not so low bombardment of chemicals, fake food and chronic stress the American government still refuses to properly regulate as well as the refusal of those who control the Government to promote a holistic culture based on sustainability, holistic medicine and, inter alia, an UBI policy. If these conditions were respected, then most people would avoid chronic diseases, at which point the red carpet of 120 healthy years would unfold.
Since life began on Earth roughly 3.5 billion years ago, five major mass extinctions and several minor ones as well, have led to large and sudden drops in biodiversity and genetic variation. (Source) The Phanerozoic eon (the last 540 million years) marked a rapid growth in biodiversity via the Cambrian explosion, a period during which the majority of multicellular phyla first appeared. The next 400 million years included repeated, massive biodiversity losses classified as mass extinction events. In the Carboniferous, rainforest collapse led to a great loss of plant and animal life. The Permian–Triassic extinction event, 251 million years ago, was the worst; vertebrate recovery took 30 million years. The most recent, the Cretaceous–Paleogene extinction event, (Named the Holocene or Anthropocene extinction) occurred 65 million years ago and has often attracted more attention than others because it resulted in the extinction of the dinosaurs, today’s birds of which are one of the few flying creatures we still can enjoy. And since the emergence of humans, an ongoing biodiversity reduction and an accompanying loss of genetic diversity had grown almost exponentially. In the last 40 years, over half of wild Life has gotten destroyed. (The number of wild animals on Earth has halved in the past 40 years, according to a new analysis. Creatures across land, rivers and the seas are being decimated as humans kill them for food in unsustainable numbers, while polluting or destroying their habitats, the research by scientists at WWF and the Zoological Society of London found” (Source)
Likewise with the destruction of our own bio-diverse microbiota, those little critters (archaea, fungi, viruses, bacteria etc) whose millions of prokaryotic genes continuously cross-talk with our own eukaryotic genes, who were on Earth before humans, who were instrumental for the key mechanisms of this thing called Life many billions of years ago and who continue to guide us to healthy longevity or an inflammatory death. Without holistic medicine and a robust gut, optimal longevity, like the Planet’s survival, will remain too difficult to achieve.
The expected Benefits from attending these three one-day long Seminars
“Man surprised me most about humanity. Because he sacrifices his health in order to make money. Then he sacrifices money to recuperate his health. And then he is so anxious about the future that he does not enjoy the present; the result being that he does not live in the present or the future; he lives as if he is never going to die, and then dies having never really lived.” The Dalai Lama
With this above-mentioned holistic knowledge, everyone who is motivated and compliant with holistic lifestyle and most of these longevity techniques and who has not gotten into serious debilitating accidents, including surgical, radiological and drug major incidents, should be able to reach the supercentenarian birth-right status without major chronic diseases, whatever the workshopee’s family history may be in terms of weak genetic links and SNPs (pronounced “snips”).
In particular, the knowledge imparted, if applied, can favorably impact up to 18 biomarkers, this means to say that the workshopee’s blood pressure, sugar stability, oxygen intake, neurogenesis, immune-regulation, hormonal signaling, insulin sensitivity, neurotransmitter firing, cholesterol-lipid profile, oral health, heart rate variability, hypothalamus-pituitary-adrenal axis homeostasis, mitochondrial function, microbiota diversity, bowel movement, deep sleep patterns, inflammation control (measured by CRP, interleukin 6, TNF alpha, inter alia) and many other health and longevity biomarkers should significantly improve within one to three months if not earlier.
As a double bonus, the workshopee, if holistically compliant, will strengthen his-her bio-terrain to such an extent that she-he will be quasi-immune from contracting some of the more common chronic “civilization” diseases, in particular, the Big Five, considered to be today’s “Black Plagues”: diabetes, cardiovascular events, cancer, auto-immunity and mental disorders like Azheimers, Depression and Parkinson. And as a last double bonus, the workshopee should appear biologically younger with visible radiance and save money by getting rid of most or all of his-her “symptom” based prescription drugs, in conformity with Dr. William Osler’s recommendation (see quote above) and the exigencies of Reason.
The supercentenarian birth-right status starts at 110 years, but our human biological potential, as of this writing, has been formally determined to be around 120 years (called the Hayflick limit), the epitome of which is represented by a French Mediterranean upbeat lady Jeanne Calment who died at 122 and a half after experiencing a Life of purpose, enjoyment and holistic savor-faire, including via 2.2 kilos of dark chocolate each week, lots of dancing, fencing, socializing, musicotherapy, red wine and relishing in the Mediterranean Lifestyle with her daily unflappability vibe.
However, more and more research indicates that some time in the not too distant future, we may be able to tweak our genetic material, longevity pathways and wellbeing genes to prolong a healthy lifespan to beyond 140 years. But we are not there yet. We will therefore focus on what we know is achievable, a Lifespan of 120 years in relatively good shape, with all of one’s conscious awareness and major bodily functions working enough to experience Life to its fullest, with what we call in France, “La Joie de Vivre”.
Ch. Joubert (H.M. Institute Director)
Director of the Happiness Medicine Institute, the Optimal Longevity Institute, the Advanced Cancer Research Institute, the Holistic Justice Institute and the Centre Mediterranéen Holistique de Vitalité et de Longévité Optimale in South Europe which organizes Optimal Vitality and Longevity mountain retreats during most Summers.
These workshops are fundraisers that will help us complete a book and a film-documentary on holistic oncology medicine.
Top: “To Life” (“L’ Chaim” in Hebrew). Professor Joubert, at the international integrative oncology convention (2016) in San Diego toasting and “dégusting” (sipping) a small amount of red resveratrol-rich pinot wine with the conference President, Annie Brandt and her two assistants. “Wine is an appropriate article for mankind, both for the healthy body and for the ailing man.” Hippocrates
“Medicine is a collection of uncertain prescriptions, the results of which taken collectively, are more fatal than useful to mankind. Water, air and cleanliness are the chief articles in my pharmacopeia”. Napoleon Bonaparte To which Ben Franklin, the Spiritual Father of the U.S. of A replied: “The best of all medicines is resting and fasting”. Thus, these two giants agree on therapeutic siestas….(napping). Today, one of the central public issues is to incorporate this piece of advise within the legally enforceable health Code. Which would mean that all employers, including the Govenment and its military, FDA and judicial branches, would need to install meditation and siesta equipment and allow a good two hours for lunch breaks.
The Difference between a Conventional Check-up versus a Holistic Tune-up.
“Conventional Doctors are trained less to understand the conditions of health than to diagnose the symptoms of diseases. That’s why a 5 to 10 minutes doctor’s visit is sufficient. The Check-up visit mainly consists in identifying symptoms and finding a corresponding drug and-or surgical procedure to supress the identified symptoms. On the other hand, a Holisically trained Health Professional is trained to identify the immediate and structural causes of diseases. Thereafter, the holistic healer will both guide and teach the patient to become “whole” again, to restore the body’s main homeostasis and repair mechanisms, at which point both the healer and the healee, as a team, can activate a customized (personalized) “tune-up” Protocol that will favorably modulate the mal-being and-or illness condition at hand.” (H.M. Institute)
Scheduling: First Day Seminar: Second Week-end in May, 2018: Second Day Seminar: Sometime in the Summer of Fall: Third Day Seminar: Sometime in the end of Summer, Fall or Winter
Location: San Pedro. L.A.To be determined, most likely in a Community Church
Duration: Each Session is 8 hours.
Break-time: One hour for Leisure in between the 8 hours long Seminar. (Please bring your own lunch and-or snacks)
Content: All supported with Power Point Presentation and sometimes Video presentations
Price: To be fixed.
These funds will help Christian to complete a documentary on holistic oncology.
For Info and Registration, please contact Annette
or Christian at: email@example.com
Video Excerpt on a 2016 Optimal Longevity Medicine Lecture from Professor Joubert (Optimal Longevity Institute)
Top. The Presentor, Professor Joubert, delivering a Longevity Medicine talk in South California in 2016. See also Longevity Video via this link
Video Excerpts by Professor Longo on Diet and Fasting’s on Longevity and Mark Mattson on Brain Rejuvenation via Caloric Restriction & Fasting (Source).
Video excerpts on the Telomerase Enzyme’s ability to slow down and reverse the Aging Clock
Video extract on Longevity Genes by Professor Sinclair (Harvard University)
Top: Tibetan Mountain Goji Berries, a favorite super fruit among supercentenarian Chinese Taoists and Tibetan Buddhists. Its polysaccharides have many benefits including by enhancing: “… neurogenesis in the hippocampus and subventricular zone, improving learning and memory abilities” (Source)
“Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.The enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being without distinction of race, religion, political belief, economic or social condition”. (World Health Organization’s Constitution)
Top: Ylang Ylang flower, from which is distilled one of the best aromatherapy essential oils
Top: Rosemary, one of the Mediterranean plants that is abundant in both the Mediterranean longevity valleys and in centenarians’ guts
Top: red hot peppers, a great way to boost endorphins, immune function and metabolic pathways.
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