The Entourage Effect

History’s Princes did not win battles and Peace in an isolated way. They knew how to activate “entourage” effect. Just like Optimal Longevity Protocols.

The term entourage effect refers to a concept and proposed mechanism by which compounds present in cannabis which are largely non-psychoactive by themselves modulate the overall psychoactive effects of the plant (these resulting principally from the action of the main psychoactive component of cannabis, tetrahydrocannabinol (THC)), in particular CBD binds to THC to calm it down.

Cannabidiol (CBD) is believed to be the major modulatory component of cannabis, mitigating some of the negative, psychosis-like effects of THC, and is included in some medicinal formulations alongside THC. (1,2) CBD co-administration also reduces the negative effects of THC on memory. (2)

Myrcene, which is recognized as a sedative component in hops, may be responsible for the sedative effects (“couch lock”) of certain cannabis strains (sedative effects are commonly ascribed to the indica cannabis type). Linalool may also contribute to the entourage effect, modulating the glutamate and GABA neurotransmitter systems to produce sedative and anxiolytic effects. (3)

Professor Mechoulam is behind the “Entourage effect”

The phrase entourage effect was introduced in 1998 by S. Ben-Shabat, (4) and by Raphael Mechoulam (5) to represent a novel endogenous cannabinoid molecular regulation route. The phrase refers to the compounds present in cannabis supposedly working in concert to create “the sum of all the parts that leads to the magic or power of cannabis”. (1) Other cannabinoids’, terpenoids’, and flavonoids’ contribution to clinical cannabis effects has been espoused as an “entourage effect”.

The entourage effect is considered a cannabinoid system modulator and is achieved in pain management through increasing receptors affinity to enhance endogenous anandamide activity and/or reducing enzymatic anandamide degradation. (6)

Pharmacology

Endogenous 2-acyl-glycerols can increase 2-arachidonoylglycerol biological activity, which alone shows no significant activity. This entourage effect may represent a novel endogenous cannabinoid activity molecular regulation route. (4) Cannabinoid system modulators like N-palmitoylethanolamine may be said to exhibit the entourage effect, increasing receptors affinity to enhance endogenous anandamide activity and/or reducing enzymatic anandamide degradation. (7)

Conclusion

Professor Mechoulam also discovered the very existence of the Cannabinoid receptors. He should have gotten a Nobel for his work. But Mainstreamers are afraid to promote even more cannabinoids.

 

Reference and Precision Notes

  1. Chen A (20 April 2017). “Some of the Parts: Is Marijuana’s “Entourage Effect” Scientifically Valid?”Scientific American. Retrieved 2017-12-31.
  2. Fine PG, Rosenfeld MJ (2013-10-29). “The endocannabinoid system, cannabinoids, and pain”Rambam Maimonides Medical Journal4 (4): e0022. doi:10.5041/RMMJ.10129PMC 3820295Freely accessiblePMID 24228165.
  3. Russo EB (August 2011). “Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects”British Journal of Pharmacology163 (7): 1344–64. doi:10.1111/j.1476-5381.2011.01238.xPMC 3165946Freely accessiblePMID 21749363.
  4. Ben-Shabat S, Fride E, Sheskin T, Tamiri T, Rhee MH, Vogel Z, Bisogno T, De Petrocellis L, Di Marzo V, Mechoulam R (1998). “An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity”. European Journal of Pharmacology353 (1): 23–31. doi:10.1016/S0014-2999(98)00392-6PMID 9721036.
  5.  Gupta S (11 March 2014). “Medical marijuana and ‘the entourage effect’ – CNN”CNN. Retrieved 31 December 2017.
  6. Jerome, Bouaziz (April 1, 2017). “The Clinical Significance of Endocannabinoids in Endometriosis Pain Management”Cannabis and Cannabinoid Research2 (1). doi:10.1089/can.2016.0035. Retrieved 8 May 2017.
  7. Bouaziz J, Bar On A, Seidman DS, Soriano D (April 1, 2017). “The Clinical Significance of Endocannabinoids in Endometriosis Pain Management”Cannabis and Cannabinoid Research2 (1): 72–80. doi:10.1089/can.2016.0035PMC 5436335Freely accessiblePMID 28861506

Should Dr. Raphael Mechoulam Be Awarded the Nobel Prize?

With decades of pioneering and critical work unlocking the potential medicinal benefits of cannabis – from discovering THC to the body’s cannabinoid system – should Israeli Dr. Raphael Mechoulam be awarded a Nobel Prize? Check out these videos and make your own decision.

 

 

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