Stem cells boosting

Numerous studies performed by various scientific teams throughout the world, including the National Institute of Health have clearly established that the higher the levels of circulating stem cells the better the ability of the body to maintain optimal health.

A recent publication in the New England Journal of Medicine reported that the level of stem cells in the blood was one of the best indicators of cardiovascular health. Elevating the number of stem cells in the blood has been shown to improve health in many ways

Circulating stem cells can reach various organs and become cells of that organ, helping such organ regain and maintain optimal health. Recent scientific discoveries have suggested that the number of circulating stem cells is a key factor; the higher the number of circulating stem cells the greater is the ability of the body at rebuilding itself

Recent scientific findings indicate that aging is closely associated with a loss of the number and function of adult stem cells throughout the body.1-5

Researchers have concluded that protecting those essential stem cells could play an important role in slowing and partially reversing aging.

Three studies published last year demonstrate that several nutraceutical compounds are capable of boosting stem cell function.

These studies revealed that extracts from berries and green tea, the dipeptide carnosine, and vitamin D—have the ability to favorably alter gene expression, and are capable of exerting powerful regulatory effects on stem cells and their environment.

These findings should help to crystalize the importance of utilizing natural molecules as a means of slowing aging.

1 Liang R, Ghaffari S. Stem cells, redox signaling, and stem cell aging. Antioxid Redox Signal. 2014;20(12):1902-16.

2Beerman I, Rossi DJ. Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. Cell Stem Cell. 2015;16(6):613-25.

3Blau HM, Cosgrove BD, Ho AT. The central role of muscle stem cells in regenerative failure with aging. Nat Med. 2015;21(8):854-62.

4Goodell MA, Rando TA. Stem cells and healthy aging. Science. 2015;350(6265):1199-204.

5Schultz MB, Sinclair DA. When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development. 2016;143(1):3-14.

Nutrients Promote Stem Cell Vigor

One large group of researchers has published extensively on their studies with a nutrient combination containing polyphenols from blueberry and green tea, as well as carnosine and vitamin D. Their work has shown that these nutrients promote the proliferation of healthy human adult stem cells, protect those cells from the destructive effects of oxidative stress, and produce improved cognitive and memory function in animals as a result of enhanced brain stem cell proliferation.9,11,12

Numerous other studies show that other common, readily-available nutritional supplements can also boost stem cell function in a meaningful way, to further slow stem cell-related aging. Let’s take a look at the highlights:

•In one study, a supplement containing green tea, astragalus, goji berry extracts, ellagic acid, and vitamin D fermented with a probiotic Lactobacillus species, was given to human volunteers twice daily for 2 weeks. Within a day, and continuing for the rest of the study, researchers detected significant increases in circulating bone marrow stem cells. They believe this was caused by stimulation of the body’s natural repair mechanisms (stem cells) by the nutraceutical combination.13

• Blueberry extracts are rich in polyphenols, which are highly protective molecules associated with a host of health benefits. A study in rats showed that supplementing animals in early life with a blueberry-enriched diet prevented bone loss (osteoporosis) at menopause.14 Closer examination of the protective effect revealed that the blueberry supplement stimulated bone-forming stem cells to mature into active bone-mineralizing cells. This action reduced the high post-menopausal rate of bone turnover that, in humans, results in easy fractures.14,15

• Spirulina is a blue-green algae that is known for its anti-inflammatory properties. A recent study showed that spirulina could prevent inflammation-induced decreases in brain stem cell proliferation that accumulates with aging.16 This resulted in improved functioning of stem cell mitochondria, which improved energy utilization and reduced oxidative stress.

9Acosta S, Jernberg J, Sanberg CD, et al. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation Res. 2010;13(5):581-8.

10Hoglinger GU, Rizk P, Muriel MP, et al. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat Neurosci. 2004;7(7):726-35.

11Bickford PC, Tan J, Shytle RD, et al. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006;15(1):118-23.

12Shytle RD, Ehrhart J, Tan J, et al. Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds. Rejuvenation Res. 2007;10(2):173-8.

13Mikirova NA, Jackson JA, Hunninghake R, et al. Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. J Transl Med. 2010;8:34.

14Zhang J, Lazarenko OP, Blackburn ML, et al. Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats. PLoS One. 2011;6(9):e24486.

15Chen JR, Lazarenko OP, Zhang J, et al. Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. J Bone Miner Res. 2014;29(5):1043-53.

16Bachstetter AD, Jernberg J, Schlunk A, et al. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PLoS One. 2010;5(5):e10496.

Stem cell boosts and longevity

1. Exercise
The human body seems designed to increase stem cell numbers when we are more active. This makes great sense if you consider that the more active that we are the more new cells that we’ll need as we are likely to lose more of our older cells by exercising. Here are two papers backing up the idea of exercise boosting our stem cell numbers.
▪ Macaluso, FKH Myburgh (2012) Current evidence that exercise can increase the number of adult stem cells. Journal of muscle research and cell motility. 33:3-4:187-98.

https://link.springer.com/article/10.1007/s10974-012-9302-0

▪ Blackmore, DG, et al. (2009) Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice. Stem Cells. 27:8:2044-52.

https://www.ncbi.nlm.nih.gov/pubmed/19544415

2. Caloric restriction and fasting
An article recently came out saying that fasting boosts stem cell numbers. The team from USC found that even just a few days of fasting increased the number of stem cells in our blood system. This potential connection between fasting and stem cell numbers also makes sense as our body probably needs to be more efficient at times of low food availability and boost resistance to infection.

www.techtimes.com/articles/8123/20140607/fasting-good-immune-system-triggers-stem-cell-regeneration.htm

3. Tai chi

Researchers in China have reported that people who practice the martial art Tai Chi saw a several-fold boost in their stem cell populations (by which they meant a specific type of cell called a “Progenitor CD34+Cells” cell. This seems a little too good to be true in terms of magnitude, but could fit in with the exercise boost discussed above.

focustaiwan.tw/news/asoc/201406070027.aspx

4. Sleep
Although I wrote earlier about how activity could boost stem cell levels, it also kind of makes sense that stem cells may do their thing while we are asleep. Stem cell science also supports this idea as well.

www.eurostemcell.org/fr/image/stem-cells-need-beauty-sleep-too

5. Protect yourself and your stem cells from radiation
When you read this you probably are thinking of dental or chest x-rays or CT scans, but I think a far more important source of radiation for most of us is UV light from the sun.
It is smart to protect your skin stem cells. Become an educated user of sunscreens and about sun exposure. Their use is complex and in fact may be harmful if misused as most of us do.
www.ipscell.com/2012/03/more-cancer-myths-including-some-biggies/

In any case, the best protection from skin cancer is shade or if you have to be out in the sun, clothing. Do not let sunscreen increase your sun exposure dramatically or its use will backfire.
Finally, something that is not recommended. Stem cell supplements are not of any use based on today’s clearest evidence. They are at best a huge waste of money and at worst a risk to your health.

We often get asked how patients can get more or better stem cells, or improve the quality of their stem cells before a procedure. The research is finally at a point where there are a few pointers we can give, along with our 7 years of experience. Here’s our top 10 list. Realize that age cures many sins, so if you’re under 30 years-old, only pay attention to the medications on the list:

1-Cut the sugar – We Americans consume way too much sugar. What do I mean by sugar? The white granular stuff plus bread, pasta, juice, super sweet fruits, etc. All of this produces too much insulin production, which combined with far too little activity, causes a metabolic syndrome. Consider going on a strict Atkins, Zone, or South Beach diet. These are all low glycemic diets-meaning that they can help control blood sugar and excessive insulin release. You’ll want to do this for a few months before your procedure-checking your Hemoglobin A1C (HBA1C) before and after (it may take 6 months for this to fall). The HBA1C you’re aiming for is 5.1. Another quicker test to see if you’ve beaten sugar addiction is what I call the chocolate bar test. Get a 70%, 80%, and 90% bar and taste them. If you try the 70% bar and feel it’s not sweet enough, go back to square 1, you’re a major sugar addict. If the 70% was sweet and the 80% was not sweet enough and very bitter, then you’re on your way, but not there yet-strict up the diet and cut more sugar. If you try the 80% and it’s a little sweet and the 90% tastes bitter, you’re about on track.
2-Reduce your calories – Even short-term calorie restriction can improve stem cell function. Try reducing your food intake by 20% for two weeks before you get your stem cells taken (making sure that you don’t substitute sugar as above).

3-Reduce your triglycerides – Triglycerides (TRG) are the storage system in the blood for carbohydrates that go unused. This one goes hand in hand with the first two recommendations and is also related to excess weight. This is one of our observations that comes from years of culturing cells. Stem cells grow poorly in patients with high TRG or who are obese. Get your triglycerides measured and reduce your carbs and food intake to bring them down to normal before you have your stem cells drawn.
4-Lift heavy weights and stay aerobically active – Research shows that more active older animals have better stem cells that create more bone,

www.ncbi.nlm.nih.gov/pubmed/22168399

exercise increases muscle stem cells,

https://www.regenexx.com/2012/01/exercise-increases-the-stem-cells-in-your-muscles/

and weight lifters have better stem cells.

https://www.regenexx.com/2011/04/do-weight-lifters-have-better-muscle-stem-cells/

In our clinic we have different activity level monikers-“Boulder active”, “American Active” and “Coach Potato”. Boulder active refers to Boulder, Colorado, the most physically fit city in America and just at the door of our clinic. This means 8-12 hours a week of exercise hard enough that carrying on a normal conversation during the activity would be tough. For example, this is bike riding in 50-100 mile clips (with mountains and at altitude), running a mountain trail for 2 hours with 1000 foot elevation gain, or scaling a 200 foot rock wall. American active is the usual health club scene. A bit of sauntering on the eliptical or using machines to lift weights, but a high reps and until a set number is reached. Couch potato means you don’t do either of these. We want our patients (if feasible) to be somewhere between Boulder and American active. This means that if you go to a gym, get a personal trainer to push you. If you lift weights with machines, do 5-8 reps at a weight that will cause the muscle to fail (means you can’t physically continue). If you run or bike, push it an extra 20-30% faster or longer. If you’re able, consider one of the popular cross fit routines like Insanity or PX90. What if your injuries preclude these workouts? Then try getting in the pool or focus on things you can do. What if you’re in poor shape with no hope of getting in better shape? Then just up your activity levels as best you can and focus on other areas discussed in this list. Our goal is not to create elite athletes, but to take the best stem cells we can.

5-Take your Supplements – Consider vitamin D3 or get some outdoor time-Several studies show that D vitamins and D3 in particular can help reduce stem cell aging, maintain their ability to turn into other needed cells, and make them healthier.

www.ncbi.nlm.nih.gov/pubmed?term=mesenchymal stem cell proliferation vitamin D

There are actually a number of common nutritional supplements that may benefit stem cells or cartilage. Curcumin, Quercetin, Glucosamine, and Chondroitin. Vitamin C has also been shown to promote stem cells toward cartilage.

6-Take your resveratrol (or drink some red wine in moderation).  Several studies have shown that the SIRT-1 enzyme pathway helps MSCs differentiate and proliferate.

www.ncbi.nlm.nih.gov/pubmed?term=mesenchymal stem cell proliferation resveratrol

In addition, this supplements helps control blood sugar, which fits in with the metabolic syndrome discussion above.
7-Low oxygen is better…sometimes – Even though you might not live at altitude, low oxygen levels help keep stem cells stay viable and grow. However, they differentiate better at normal oxygen.

www.ncbi.nlm.nih.gov/pubmed/22155244

GROW stem altitude

Differentiate …lower, more oxy

 

 

You may consider a vacation to a high altitude spot before your stem cell harvest. This may be why many elite athletes get benefit from sleeping in low oxygen conditioning tents. How about hyperbaric oxygen (HBO)? There is a study showing that HBO can help the stem cells of older patients only (animal study)-again, more on the side of helping stem cells to turn into other tissues.

www.ncbi.nlm.nih.gov/pubmed?term=22270336

8-Avoid Quinalone antibiotics – These toxic drugs hurt tendon cells as well as stem cells. They are commonly given for urinary tract infections and some orthopedic infections.

9-Avoid prescription medications – Again, based on our almost decade long experience with growing stem cells, many prescription drugs hurt stem cells. We have seen time and time again an inability to grow a patient’s stem cells that is reversible when we take the patient off the medication. Talk to a clinic physician to see if you’re on a bad stem cell drug. In the meantime, getting off everything you can 1-2 weeks before the stem cell harvest is a good idea (this needs to be cleared with your family or prescribing doctor).

 

10-Once the stem cells go back in, stay active – Pressure on MSCs improves their ability to turn into bone

www.ncbi.nlm.nih.gov/pubmed/22607391

and cartilage.

www.ncbi.nlm.nih.gov/pubmed/21783134

Stem Cell Breakthroughs
New stem cell breakthroughs are happening all the time. Just in the last year or so, researchers:
grew full-sized, beating hearts from adult skin stem cells; 1
• found a way to regrow craniofacial bones from stem cells to help people with facial and skull deformities; 2
• slowed the progression of ALS (Lou Gehrig’s disease) in patients by injecting stem cells from their bone marrow into their spinal fluid or muscles. 3
Recent research also shows stem could help diabetics and stroke victims. Stem cell treatments effectively treat arthritis and joint pain. And the list goes on…
2 easy ways to boost stem cells

1. Get eight hours of sleep each night. In 2013, Swiss researchers discovered that a disruption of normal sleep rhythms disrupted stem cell functioning.4

 

And last year, German researchers found that a good night’s sleep protects stem cells from DNA damage, which keeps them “young.”

2. Get the forgotten B vitamin. A recent study from the University of Georgia and Tufts University found that vitamin B9 — or folate — can stimulate stem cell proliferation. In fact, researchers are currently testing how a combination of stem cells and B9 can regenerate the spinal cords of injured animals.5

I recommend getting 800 mcg of folate each day.

If you choose to supplement, avoid the synthetic “folic acid” form of B9. Look for products that say “5-MTHF.” That’s the active form of B9.

1. Guyette, Jacques P., et al. Bioengineering Human Myocardium on Native Extracellular Matrix. Circulation Research. 2016;118:56-72.
2. Maruyama, Takamitsu, et al. Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration. Nature Communications. 10526 (2016) doi:10.1038/ncomms10526
3. Panayiota Petrou, MD1; Yael Gothelf, PhD2; Zohar Argov, MD1; et al. Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral SclerosisResults of Phase 1/2 and 2a Clinical Trials. JAMA Neurol. 2016;73(3):337-344. doi:10.1001/jamaneurol.2015.4321.
4. Janich, P., Toufighi, K., Solanas, G., Luis, N. M., Minkwitz, S., Serrano, L., Lehner, B. and Benitah, S. A. (2013) ‘Human epidermal stem cell function is regulated by circadian oscillations’, Cell Stem Cell 13(6): 745-53.doi: 10.1016/j.stem.2013.09.004
5. Zhang C, Shen L. Folic acid in combination with adult neural stem cells for the treatment of spinal cord injury in rats. Int J Clin Exp Med. 2015; 8(7): 10471-80.

 

 

 

 

 

 

 

 

://www.youtube.com/watch?v=QnrPAY9tyoY

Recent scientific findings indicate that aging is closely associated with a loss of the number and function of adult stem cells throughout the body.1-5

Researchers have concluded that protecting those essential stem cells could play an important role in slowing and partially reversing aging.

Three studies published last year demonstrate that several nutraceutical compounds are capable of boosting stem cell function.

These studies revealed that extracts from berries and green tea, the dipeptide carnosine, and vitamin D—have the ability to favorably alter gene expression, and are capable of exerting powerful regulatory effects on stem cells and their environment.

These findings should help to crystalize the importance of utilizing natural molecules as a means of slowing aging.

Nutraceuticals Rescue Aging Stem Cells

Aging is associated with the loss of adult stem cell function (see sidebar). This has prompted interest in ways of improving stem cell functionality in maturing individuals.6-8

It has been shown that connecting the circulation of an older animal with that of a younger one reduces the function of the younger animal’s muscle and brain stem cells and appears to accelerate aging.4,7 Components in the blood of the older animal interact with stem cells in the younger one, impairing their function.

Scientists at the James A. Haly Veterans Affair Hospital in Tampa tried to reverse that effect by treating older rats with a specific nutrient formulation, then observing the effects of the rats’ nutrient-rich blood on stem cells from other animals, both young and old.7

They fed young and aged rats either a standard diet or a nutrient-rich diet composed of a mixture of blueberry, green tea, vitamin D, and carnosine—all nutrients with known cell-protective effects—for 28 days. At the end of that period, the researchers collected blood serum from the older, supplemented rats and applied it to cultures of adult rat stem cells. One group of stem cells came from the memory-intensive brain area called the hippocampus, and the other from bone marrow, where blood cells and platelets are formed.

Serum from aged rats that were on the control diet had the expected effect on the cultured stem cells: their division rates slowed dramatically, producing fewer new stem cells. But serum from the supplemented aged rats did notcause those changes, and in fact produced results not different from those of serum obtained from young rats. This study demonstrated that targeted nutrient supplementation alone could rescue aging stem cells involved in both brain and blood system functions.

STEM CELLS AND AGING

Stem cells, unlike any other cells in the body, can self-renew and differentiate into many different kinds of cells.5

Early embryonic stem cells can differentiate into virtually any kind of cell, in any kind of tissue. Adults retain stem cells in all of their organs and tissues. Adult stem cells can still regenerate and differentiate, but usually only into mature cells in their particular tissue type.4,5

When tissue is damaged, tissue-specific stem cells leap into action, quickly forming into functional replacements for the damaged cells.4,5 In short, adult stem cells account for the healthy adult body’s ability to self-heal, and to retain its youthful vigor.

Recent studies now show that stem cell function declines with advancing age—falling victim to such threats as oxidative stress, inflammation, and DNA damage—and results in impaired ability of tissues and organs to repair themselves.1 In this way, aging itself is closely related to the accumulation of dysfunctional stem cells.1-5

Fortunately, one of the very causes of stem cell dysfunction can now be leveraged to prevent or reverse such dysfunction. Regulation through favorable alterations in gene expression is considered a major means of establishing and maintaining normal stem cell activities.2,4 We can now provide to living stem cells substances that exert favorable changes.

A growing number of studies demonstrate that application of a number of molecules that support metabolic function, protect against oxidative stress, prevent inflammation, and protect DNA repair can enhance the numbers – and function – of aging stem cells.9,11,12

The studies discussed in this article demonstrate that many commonly-used nutraceuticals may in fact produce their age-decelerating, organ-protecting, and life-extending effects at least in part by protecting adult stem cells.

Hope for Multiple Sclerosis

The second important study recently published demonstrated the impact of vitamin D on brain stem cells in a mouse model of multiple sclerosis (MS). MS is an autoimmune disease that damages nerve cells by impairing their ability to conduct signals. While treatments can slow the disease, it is considered incurable.8

Researchers used a mouse model of MS to determine whether vitamin D treatment could improve nerve function by protecting neuronal stem cells and by promoting their functions. Amazingly, they found that vitamin D supplementation reversed the nerve cell damage created by MS.8 Furthermore, they found that the supplement promoted the proliferation of neuronal stem cells, which contributed directly to improved brain function, and to their apparent recovery from MS. This study offered additional insights into how vitamin D could directly contribute to alleviating a condition in which adult stem cell function is compromised.

Beneficial Epigenetic Changes

The third important study also focused on stem cells in the brain and the impact of specific nutrients on brain function. Here, the researchers based their work on the observation that the decline in aging brain stem cells appears to be closely associated with increased levels of inflammatory signaling molecules, or cytokines.6

They supplemented rats with carnosine, blueberry, green tea, and vitamin D, the same group of nutrients previously proven to rescue aging stem cells. They found that supplemented animals had a large number of changes in the expression of genes concerned with a range of cellular functions.6 More specifically, they helped reduce proinflammatory cytokines, while increasing anti-inflammatory cytokines. The reduction in inflammation would explain the beneficial effects of the nutrients on stem cell function demonstrated in previous experiments.9

But the researchers dug deeper and made a remarkable discovery—the nutrient combination increased the production of genes that prompt progenitor cells (stem-like cells living in brain tissue) into becoming functioning adult neurons. In other words, it helped create healthy new brain cells.

This study powerfully demonstrates how targeted nutrients can favorably alter the environment faced by tissue stem cells in the brain, reducing the risk that they will develop into impaired, aged stem cells, and promoting their development instead into functioning adult brain cells. This is especially important for those at risk for neurodegenerative diseases like Alzheimer’s and Parkinson’s. These diseases are known to be associated with declining rates of brain cell renewal, which we now recognize requires healthy stem cells.6,10

Together, these three recent studies strongly indicate that specific nutrients can produce tremendous effects on adult tissue stem cells, helping protect them against the destructive impact of environmental factors, and preserving their ability to naturally heal tissues and restore their youthful function.

Let’s now turn to a brief review of the stem cell-protecting properties of some other familiar nutrients.

Nutrients Promote Stem Cell Vigor

One large group of researchers has published extensively on their studies with a nutrient combination containing polyphenols from blueberry and green tea, as well as carnosine and vitamin D. Their work has shown that these nutrients promote the proliferation of healthy human adult stem cells, protect those cells from the destructive effects of oxidative stress, and produce improved cognitive and memory function in animals as a result of enhanced brain stem cell proliferation.9,11,12

Numerous other studies show that other common, readily-available nutritional supplements can also boost stem cell function in a meaningful way, to further slow stem cell-related aging. Let’s take a look at the highlights:

  • In one study, a supplement containing green tea, astragalus, goji berry extracts, ellagic acid, and vitamin Dfermented with a probiotic Lactobacillus species, was given to human volunteers twice daily for 2 weeks. Within a day, and continuing for the rest of the study, researchers detected significant increases in circulating bone marrow stem cells. They believe this was caused by stimulation of the body’s natural repair mechanisms (stem cells) by the nutraceutical combination.13
  • Blueberry extracts are rich in polyphenols, which are highly protective molecules associated with a host of health benefits. A study in rats showed that supplementing animals in early life with a blueberry-enriched diet prevented bone loss (osteoporosis) at menopause.14 Closer examination of the protective effect revealed that the blueberry supplement stimulated bone-forming stem cells to mature into active bone-mineralizing cells. This action reduced the high post-menopausal rate of bone turnover that, in humans, results in easy fractures.14,15
  • Spirulina is a blue-green algae that is known for its anti-inflammatory properties. A recent study showed that spirulina could prevent inflammation-induced decreases in brain stem cell proliferation that accumulates with aging.16 This resulted in improved functioning of stem cell mitochondria, which improved energy utilization and reduced oxidative stress.

Summary

Recent research has revealed the crucial role of adult stem cells in promoting healing and regeneration following damage. Over time, their loss of function deprives our tissues of their youthful ability to recover from damage and regenerate themselves. This contributes to the loss of function that we see as aging.

The good news is that rejuvenating those adult stem cells can lead to a partial reversal of aging in our tissues. Even better, three landmark studies have shown us that rejuvenation of adult tissue stem cells is within our reach.

Supplementation with a variety of nutrients has been shown to restore the healing and regenerative capacities of aging adult stem cells, and results in the restoration of youthful function to the tissues where those stem cells reside.

The pace of scientific discovery in the nutrients realm continues to accelerate, opening the real possibility that many other nutraceuticals will be found to exert their health-promoting effects at least in part by stimulating stem cell recovery.

If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.

References

  1. Liang R, Ghaffari S. Stem cells, redox signaling, and stem cell aging.  Antioxid Redox Signal. 2014;20(12):1902-16.
  2. Beerman I, Rossi DJ. Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. Cell Stem Cell. 2015;16(6):613-25.
  3. Blau HM, Cosgrove BD, Ho AT. The central role of muscle stem cells in regenerative failure with aging. Nat Med.2015;21(8):854-62.
  4. Goodell MA, Rando TA. Stem cells and healthy aging. Science. 2015;350(6265):1199-204.
  5. Schultz MB, Sinclair DA. When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development.2016;143(1):3-14.
  6. Flowers A, Lee JY, Acosta S, et al. NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats. J Neuroinflammation. 2015;12:174.
  7. Bickford PC, Kaneko Y, Grimmig B, et al. Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells. Age (Dordr). 2015;37(5):103.
  8. Gu SG, Wang CJ, Zhao G, et al. Role of vitamin D in regulating the neural stem cells of mouse model with multiple sclerosis. Eur Rev Med Pharmacol Sci. 2015;19(21):4004-11.
  9. Acosta S, Jernberg J, Sanberg CD, et al. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation Res. 2010;13(5):581-8.
  10. Hoglinger GU, Rizk P, Muriel MP, et al. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat Neurosci. 2004;7(7):726-35.
  11. Bickford PC, Tan J, Shytle RD, et al. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006;15(1):118-23.
  12. Shytle RD, Ehrhart J, Tan J, et al. Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds. Rejuvenation Res. 2007;10(2):173-8.
  13. Mikirova NA, Jackson JA, Hunninghake R, et al. Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. J Transl Med. 2010;8:34.
  14. Zhang J, Lazarenko OP, Blackburn ML, et al. Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats. PLoS One. 2011;6(9):e24486.
  15. Chen JR, Lazarenko OP, Zhang J, et al. Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. J Bone Miner Res. 2014;29(5):1043-53.
  16. Bachstetter AD, Jernberg J, Schlunk A, et al. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PLoS One. 2010;5(5):e10496.

 

 

 

Stem cells are vital to the future of anti-aging medicine.

Every day I’m getting a little bit closer to harnessing their immortal power.

What are stem cells?

Stem cells are your reserve of “replacement cells.” Your body can use them to replace any kind of cell that is damaged, old or dying. They can morph into any kind of cell you need, including those for your eyes, kidneys, muscles, skin, heart or blood.

They also allow your body to regenerate damaged tissue in any organ — from your brain to your heart to your liver. 

What can affect your stem cells production?

As you age, your stem cells don’t repair and regenerate as well as they once did. Fatigue sets in. That can lead to poor regeneration or even degeneration of certain organs and tissues.

How the mitochondria correlates with stem cell production?

It’s as though your stem cells are running out of energy. You see, just like every other cell in your body, your stem cells contain tiny organelles called mitochondria. They provide the energy your cells need to function.

When mitochondria in stem cells are sluggish, your body’s stem cells can’t regenerate fast enough. The disease process starts to take over. That’s when you start to look, feel and act old.

What vitamin can power the mitochondria and boost stem cells?

There’s a simple vitamin that holds the key to restoring your stem cells and mitochondria to a biologically younger state.

Vitamin B to the rescue

In a study published in the journal Science, researchers revitalized stem cells in elderly mice by targeting a special molecule that helps mitochondria function properly.

They gave old mice a form of vitamin B3. B3 is also known as niacin, niacinamide or nicotinamide. And the mice taking the vitamin had dramatic anti-aging results!

Their muscles significantly regenerated through stem cell activity. The same thing happened with their brain and skin stem cells. And they also lived longer than mice that did not get the vitamin.1

In another study, half the mice were given a form of vitamin B3 for three or four months. The mice taking the vitamin had more energy, less weight gain, and improved insulin sensitivity. On a treadmill test, they could run 33% further than the control mice.2

How does vitamin B3 work?

In your body, B3 breaks down into a molecule called nicotinamide adenine dinucleotide (NAD+). NAD+ is found in every cell in the body. It helps transfer the energy from the foods we eat to the mitochondria where it gets converted to cellular energy.

As NAD+ levels decline, mitochondrial function is impaired. And you start to see many of the physical signs of aging. Studies link decreases in NAD+ levels to:

  • Brain degeneration
  • Inflammation of blood vessels
  • Fatty liver
  • Increased belly fat
  • Insulin resistance
  • Fatigue and loss of muscle strength

The benefits of increasing your NAD+ levels

Increasing your levels of NAD+ can help increase energy in the mitochondria. And that can boost the regeneration abilities of your stem cells.

How to boost your NAD+ levels?

One way to boost NAD+ is severely restricting the number of calories you eat. That has been proven to raise NAD+ levels in cells.3 But no one wants to starve themselves.

The easier way to increase NAD+ is with vitamin B3. Boosting NAD+ with vitamin B3 can help prevent the decline in cellular energy as you age. It also helps preserve the anti-aging action of your stem cells. But B3 does even more.

Vitamin B3 is active in more than 50 metabolic functions in your body. It aids digestion and helps eliminate toxins. It acts as a powerful antioxidant. It assists in producing sex hormones. And it is vital to energizing and maintaining healthy cells of all kinds.

Build Better Mitochondria For Yourself

You can boost your niacin levels with food. The best sources are grass-fed beef and organ meats, pastured eggs, chicken and turkey, and wild-caught salmon and tuna. Good vegetarian sources include peanuts, beets, leafy greens, nuts, peas and beans.

But for the anti-aging benefits to your mitochondria and stem cells, you’ll have to supplement. Look for a supplement containing niacin, niacinamide or nicotinamide. I recommend getting 750 to 1,000 mg a day. Just don’t rush in too fast.

When you start taking B3 supplements you may get a reaction known as “niacin flush.” It feels like a burning and prickly sensation over the face, neck and chest. It’s harmless and usually lasts less than 20 minutes.

The reaction wears off as you continue to use B3, so be patient. It may take a few weeks, but eventually you’ll build up a tolerance.

I recommend starting at a small dose of 250 mg per day. At first, take it every other day and slowly work up. Increase the amount gradually every month until you get up to your target. You can also split your dose into twice a day to help reduce the flush.

Here at the Sears Institute for Anti-Aging Medicine, I usually have patients gradually increase to up to 2 grams per day.

 


1. Hongbo Zhang, Dongryeol Ryu, Yibo Wu, et al. “NAD repletion improves mitochondrial and stem cell function and enhances lifespan in mice.” Science, 2016 Vol. 352, Issue 6292, pp. 1436-1443.
2. Canto C, Houtkooper RH, Pirinen E, et al. “The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.” Cell Metab. 2012;15(6):838-47.
3. Mouchiroud L, Houtkooper, RH, Moullan N, et al. “The NAD(+)/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling.” Cell. 2013;154(2):430-41.

“All of the bioactive components in our diet play a role in how cells can battle this tendency to become inflamed,” says Steindler. In particular, he is experimenting with three antioxidants, which he suspects may need to be consumed in higher doses as we age in order to ensure healthy stem cell function—ECGC, found in green tea; curcumin, found in turmeric; and sulforaphane, found in broccoli, Brussels sprouts and other vegetables.

http://now.tufts.edu/articles/feed-your-stem-cells

 https://www.youtube.com/watch?v=QnrPAY9tyoY

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