Sepsis & Pneumonia Reversal HMI Protocol

There are different types and causes for sepsis and pneumonia. In this piece, I will first look at holistic treatments for sepsis (Section A) and conclude with pneumonia reversals (Section B).

Section A

Sepsis

Sepsis is systemic infection that triggers shock and death. Its mortality rate is up to 40 to 50 percent, especially for the elderly. One out of every three patients who die in a hospital bed has sepsis. That’s around 300k victims a year in the USA. The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. (Source) Most mainstream doctors are clueless on how to reverse this condition. Sometimes antibiotics can work, but most times they dont.

Vitamin C treatment caused mortality rates to plummet

While many traditional naturopaths and holistic healers have been practicing sepsis holistic protocols for decades, it’s has been shunned by the mainstream medical community. These protocols are still rejected by allopathic official physicians, notwithstanding recent published evidence that holistic sepsis protocols are clinically superior to antibiotic therapy. Case in point below.

Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock…” (Source) (1)

To conduct the retrospective clinical study that led to this above mentioned conclusion, the researchers compared outcomes of 47 sepsis patients treated with a combination of intravenous vitamin C, hydrocortisone and thiamine vis a vis  47 sepsis patients treated with conventional medications. The holistic vitamin C treatment reduced mortality among the sepsis patients by 87 percent (when compared to patients who had been treated with standard therapy.) Only four of the 47 patients treated holistically died versus 19 of the 47 conventionally-treated patients. Furthermore,  no one in the holistic group developed organ failure. They were all weaned off vasopressors (used to offset drops in blood pressure) more quickly than the conventionally-treated group. This study,  published in the journal Chest, involved patients at Sentara Norfolk General Hospital in Norfolk, VA.

The Protocol and variants thereof

While there are other holistic protocols that include essential oils and other modalities, including without the use of hydrocortisone, the one that has been proven via this recent clinical trial is based on 1.5 grams of intravenous vitamin C every six hours for four days in associatin with 200 mg of thiamine  (Vit B 1) every twelve hours for four days, and 50 mg of hydrocortisone every six hours for seven days, followed by a three-day taper. Over 700 patients in the United States have been treated with Dr. Marik’s protocol to date (cost = $60 per patient). It can take one to  a few days to see a  turn around. Yet, it’s still very difficult to convince hospitals to use this protocol, if only because standard protocol can cost over 100,000 dollars to treat a sepsis patient.

Mechanisms

Systemic sepsis is normally triggered by a bacterial infection that triggers an extreme over-reaction by the immune system, what is called a cytokine storm, a biochemical phenomena that was pervasive durig the Spanish flu deaths after World War One. These concomitant inflammatory responses cause intense oxidative damage, widespread and abnormal blood clotting, mitochondrial dysfunction, loss of circulation in major organs, blood pressure drop and kidney failure and other organs and symptoms that eventually lead to death. One of the reasons this medical condition is so costlyt is because its  debilitating effects can persist for months, with over 40 percent of sepsis patients returning to the hospital within 3 months of being discharged. Even after recovery from sepsis using conventional treatments, the risk of dying remains high because mainstream medicine does not treat the causes, nor uses cost friendly techniques that can be done by the patient.

One of the reasons vitamin C works is because it’s an antioxidant that can turn into a proxidant at high dosages.  Vitamin C also suppresses inflammation, combats oxidative damage, improves circulation to organs, and boosts the immune system. The best way to boost Vitamin C is with a holistic nutritional diet. While drugs are not mandatory for the patients who are proactive, the drug hydrocortisone can be used, it has been shown to work with Vitamin C to protect against the capillary leakage that can occur during the course of this condition.

Part B

Pneumonia Prevention and Reversals

The eighth leading cause of death, in the United States, is pneumonia and influenza, killing over 50,000 people per year. Conventional medicine’s standard of care prevention wise recommends the flu shot. However, the evidence shows that these vaccines are deleterious to the  immune system, which contain way too many toxic ingredients like, mercury, aluminum and formaldehyde. Adding insult to injury, the most deadly cases of ‘viral pneumonia’ are treated with antibiotics which further weakens the immune system and the intestinal flora, if only because they are only effective with regard to bacteria.

To reverse pneumonia, one must first identify its cause, if it is driven by bacteria or viruses. Thereafter, we can put in place a holistic  protocol that is supported via anecdotal evidence. Right now, to my knowledge, there are no clinical trials that show that pneumonia can be reversed holistically without antibiotics. But cases studies do show this. To learn more, sign up for the HM Institute’s workshops or schedule a consultation.

Conclusion

Despite the evidence, (2) as seen via this above mentioned study,  most of the mainstream medical community continues to allege that sepsis and pneumonia holistic therapies are “unproven and ineffective” and that more trials are needed. Big Tobacco, the asbestos, diesel, arsenic, benene and now the telecommunition cell phone companies have all financed fraudulent studies to create “doubt” in the court room where “expertise” legal battles can take decades to get resolved. Meanwhile, the billions of dollars poor in.

Ch. J. (HM Institute director)

 

Text still under construction

Exhibit A

 

 

 

References

(1).

(2) In a 2018 review published in the well-regarded, peer-reviewed Journal of Critical Care, the authors acknowledged that vitamin C could mediate inflammation through its antioxidant activities. The team reported that emerging evidence supports the administration of vitamin C, in addition to standard therapy, to ease the effects of inflammation and improve blood flow to organs in patients with sepsis and septic shock. No less than eight new clinical trials – some using the same three constituents utilized by Dr. Marik – are scheduled to take place in 2018

Exhibits

Pharmacol Ther. 2018 Sep;189:63-70. doi: 10.1016/j.pharmthera.2018.04.007. Epub 2018 Apr 21.

Vitamin C for the treatment of sepsis: The scientific rationale.

Marik PE1.

Author information

Abstract

Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions. Sepsis results in the overwhelming production of reactive oxygen species with widespread endothelial, cellular and mitochondrial injury leading to progressive organ failure. Sepsis is associated with an acute deficiency of vitamin C. In experimental sepsis models, intravenous vitamin C reduces organ injury and improves survival. In addition, emerging evidence suggests that the combination of vitamin C, corticosteroids and thiamine may act synergistically to reverse sepsis induced organ dysfunction. These findings are supported by a recent observational study. Randomized controlled trials are underway to investigate this novel approach to the treatment of sepsis.

KEYWORDS:

Anti-oxidant; Ascorbic acid; Hydrocortisone; Sepsis; Septic shock; Thiamine; Vitamin C

PMID: 29684467 DOI: 10.1016/j.pharmthera.2018.04.007

J Crit Care. 2018 Feb;43:230-234. doi: 10.1016/j.jcrc.2017.09.031. Epub 2017 Sep 18.

Vitamin C: The next step in sepsis management?

Teng J1, Pourmand A2, Mazer-Amirshahi M3.

Author information

Abstract

Sepsis is a life-threatening medical condition, affecting approximately 26 million people worldwide every year. The disease is a continuum, marked by dysregulated inflammation and hemodynamic instability leading to shock, multi-system organ dysfunction, and death. Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed therapy. Despite these advances, morbidity and mortality has remained high, prompting investigation into novel therapies. Vitamin C is a water-soluble vitamin that plays a role in mediating inflammation through antioxidant activities and is also important in the synthesis of cortisol, catecholamines, and vasopressin, which are key mediators in the disease process. Emerging evidence provides cursory data in support of the administration of vitamin C in addition to standard therapy to ameliorate the effects of inflammation and improve hemodynamic stability in patients with sepsis and septic shock; however, further evidence is needed to support this practice. This review discusses the physiologic role of vitamin C as well as the recent literature and evidence for the use of vitamin C in patients presenting with sepsis.

KEYWORDS:

Ascorbate; Ascorbic acid; Sepsis; Septic shock; Vitamin C

PMID: 28934705 DOI: 10.1016/j.jcrc.2017.09.031

Chest. 2017 Jun;151(6):1229-1238. doi: 10.1016/j.chest.2016.11.036. Epub 2016 Dec 6.

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.

Marik PE1, Khangoora V2, Rivera R3, Hooper MH2, Catravas J4.

Author information

Abstract

BACKGROUND:

The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries.

METHODS:

In this retrospective before-after clinical study, we compared the outcome and clinical course of consecutive septic patients treated with intravenous vitamin C, hydrocortisone, and thiamine during a 7-month period (treatment group) with a control group treated in our ICU during the preceding 7 months. The primary outcome was hospital survival. A propensity score was generated to adjust the primary outcome.

RESULTS:

There were 47 patients in both treatment and control groups, with no significant differences in baseline characteristics between the two groups. The hospital mortality was 8.5% (4 of 47) in the treatment group compared with 40.4% (19 of 47) in the control group (P < .001). The propensity adjusted odds of mortality in the patients treated with the vitamin C protocol was 0.13 (95% CI, 0.04-0.48; P = .002). The Sepsis-Related Organ Failure Assessment score decreased in all patients in the treatment group, with none developing progressive organ failure. All patients in the treatment group were weaned off vasopressors, a mean of 18.3 ± 9.8 h after starting treatment with the vitamin C protocol. The mean duration of vasopressor use was 54.9 ± 28.4 h in the control group (P < .001).

CONCLUSIONS:

Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock. Additional studies are required to confirm these preliminary findings.

Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

corticosteroid; hydrocortisone; septic shock; thiamine; vitamin C

Comment in

How to Give Vitamin C a Cautious but Fair Chance in Severe Sepsis. [Chest. 2017]

PMID: 27940189 DOI: 10.1016/j.chest.2016.11.036

 

https://www.ncbi.nlm.nih.gov/pubmed/27940189

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

A Retrospective Before-After Study

Paul E. Marik, MD, FCCP

Correspondence information about the author MD, FCCP Paul E. Marik

 

Email the author MD, FCCP Paul E. Marik

, Vikramjit Khangoora, MD, Racquel Rivera, PharmD, Michael H. Hooper, MD, John Catravas, PhD, FCCP

PlumX Metrics

DOI: https://doi.org/10.1016/j.chest.2016.11.036 |

 

 

Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.

<div style=”float:right;margin-right:4em”>ClinicalTrials.gov Identifier: NCT03509350</div>

ClinicalTrials.gov Identifier: NCT03509350

Recruitment Status : Recruiting

First Posted : April 26, 2018

Last Update Posted : September 27, 2018

See Contacts and Locations

Sponsor:

Emory University

Collaborator:

The Marcus Foundation

Information provided by (Responsible Party):

Jonathan Sevransky, Emory University

 

Study Description

Brief Summary:

The VItamin C, Thiamine And Steroids in Sepsis (VICTAS) Study is a double-blind, placebo-controlled, adaptive randomized clinical trial designed to investigate the efficacy of the combined use of vitamin C, thiamine and corticosteroids versus indistinguishable placebos for patients with sepsis. The objective of this study is to demonstrate the efficacy of combination therapy using vitamin C, thiamine and corticosteroids in reducing mortality and improving organ function in critically ill patients with sepsis.

https://clinicaltrials.gov/ct2/show/NCT03509350

SUMMARY AND COMMENT | GENERAL MEDICINE INFECTIOUS DISEASES HOSPITAL MEDICINE

ON THE HORIZON

July 18, 2017

Vitamin C, Thiamine, and Hydrocortisone for Sepsis Patients

Patricia Kritek, MD reviewing Marik PE et al. Chest 2017 Jun

A single-center study showed remarkable mortality reduction with this cocktail.

A myriad of interventions for sepsis have been studied; the vast majority have been disappointing. Despite such setbacks, the search persists for the right combination of agents to stop inflammatory dysregulation.

During 6 months, all patients admitted to the medical intensive care unit (MICU) in a Norfolk, VA, hospital with severe sepsis or septic shock and elevated procalcitonin levels (≥2 ng/mL), received intravenous high-dose vitamin C (6 g daily), hydrocortisone (50 mg every 6 hours), and thiamine. In a before–after study design, 47 intervention patients were compared with 47 patients who had been admitted to the MICU in the 6 months prior to implementation. Patients in the two groups had remarkably similar baseline characteristics.

Mortality was markedly lower in the patients treated with vitamin C, hydrocortisone, and thiamine (9% vs. 41% in the earlier group). Intervention patients also had faster resolution of shock with shorter mean duration of vasopressor use and less need for renal replacement therapy.

COMMENT

With such a striking mortality difference, this study received considerable coverage in the lay press and a lot of discussion in ICUs. The authors discuss theoretical reasons for their choice of agents; for example, vitamin C has antioxidant properties, and thiamine deficiency is reportedly common in septic patients. They suggest that, although the study is small, single-center, and not randomized, this intervention is ready for implementation, because the potential benefits outweigh the risks. I don’t agree. We have learned the harms of early adoption in critical care (e.g., tight glucose control, activated protein C); although vitamin C and thiamine probably have fewer downsides, they are not without risk or cost. Researchers are evaluating vitamin C in sepsis patients in an ongoing randomized controlled trial, and adoption should await confirmatory results.

HMIemblemSmall
Disclaimer. Nothing in this post should be construed as medical or legal advise.
2017-8 (c). Happiness Medicine Institute. All Rights Reserved.

Happiness Medicine & Holistic Medicine Posts

Categories

Translate:

Follow me on Twitter

Translate »
error: Content is protected !!