Contrarily to much of mainstream thinking and today’s gerontology and allopathic medicine’s belief system, the aging process can be extended to over 120 years with few if any serious chronic diseases. (1) The knowledge of extending life span with a healthy quality of life will start interesting more and more people, in particular the American baby-boomers. Over 90 million of them will soon be involved or are already struggling with serious debilitating diseases. Many will lose bodily parts, be blind, forget their names, get cancer and die miserably and prematurely while often going into bankrupcy to pay for medical approaches that expensively “band-aid”, displace and worsen symptoms.
While this workshop will invoke a few pharmaceutical endeavors to activate longevity pathways, including the most recent one on Metformin, the workshop presenter will present compelling in vitro and in vivo evidenced based science to show that we have been designed with feel good and longevity genes that can be activated with an appropriate holistic longevity “code” that is free from patented drug interventions. Longevity or “anti-aging” medicine is therefore no longer a field reserved for the wealthy who can afford these expensive pharmaceutical products and medical procedures, from bio-identical hormonal and stem cell treatments to protheses-based regenerative medicine and medical nanotechnology.
Weaved from a holistic lifestyle and specific natural molecules and health techniques, this holistic longevity code (heretofore HLC) can be partially activated via the person’s environment before birth and can continue throughout one’s lifetime, even during the adolescence’s growing and elderly phases. In this perspective, a new study partially proved the Optimal Longevity Institute’s (OLI) research by examining the aging process over 12 years of adults, aged from 26 to 38 years. (2) Thanks to this study, 18 biological measures were distinguished, all of which can help to determine, at any Life phase, whether people are aging faster or slower than their peers. Just this study proves that we, more than our genes, are in charge.
As the OLI’s research data shows, the process of aging shows in different human organs at different times and under different conditions, from the immune system, the eyes, joints, hair, kidneys, liver, lungs and brain. There are multiple pathways that determine both global and organ aging. General caloric restriction and resveratrol for example target the entire organism’s aging process affecting many longevity genes like sirtuins while sun exposure affects testosterone levels and exercises impact stem cell rejuvenation. (3)
What is remarkable with optimal longevity science is that we now have non invasive techniques that can significantly help us to address both the multiple and specific pathways of longevity, thanks to which today’s major chronic diseases can be obsolete, like the bucolic plague and tuberculosis of yesterday. Happiness and holistic longevity medicine is therefore the most logical, cost-effective, safe and efficient health-care system ever.
In this workshop, you will learn how to activate both longevity and “joie de vivre” (enjoyment of life) genes, micro-Rna’s, hormones and neurotransmitters thanks to the most recent cutting edge gerontology and life sciences combined to advanced European medical practice and French holistic savoir-faire.
“Scientists have focused their attention on centenarians as optimal model to address the biological mechanisms of “successful and unsuccessful ageing”. They are equipped to reach the extreme limits of human life span and, most importantly, to show relatively good health, being able to perform their routine daily life and to escape fatal age-related diseases, such as cardiovascular diseases and cancer…”. Immun Ageing. 2012 Apr 23;9(1):8.
Top: longevity hotspots in the world: Over a dozen
“In humans and other animals, cellular senescence has been observed to be connected to the shortening of telomeres with each cell cycle; when telomeres become too short, the cells die. The length of telomeres is therefore the “molecular clock”, Harvard Professor Hayflick.
Top: chromosomes capped with protective telomeres. Image licensed under cc.
WORKSHOP’S CONTENT FOR THE FIRST SESSION
1. Longevity and senescence defined
2. Centenarians versus Supercentenarians and longevity zones.
3. 18 longevity biomarkers
4. Life span versus health span: amyloidosis: under holistic conditions, the older we get, the fewer chronic diseases we activate.
5. Competing theories that can explain the molecular basis of aging: from genetics to epigenetics and more.
6. The latest data on longevity science: Engineered negligible senescence. The different variants of the Mediterranean lifestyle reputed to enhance chronic-diseased free longevity: (France, Spain, Italy, Greece, Maghreb, (North Africa) Machrek (in particular Lebanon and Syria), Israel, Turkey among other Nations).
Compelling evidence that humans have been designed via DNA (Life’ blueprint) and biological evolution to live over 120 years with a good health-span.
2. Animal and plant evidence: longevity mechanisms.
3. Human Individual Case studies, from Jack Lalanne, (who died early at 96 years a little after a heart valve replacement) and Jimmy Carter (who recently claimed to have reversed his advanced cancer at 91 years old), to Jean Calment (died at 122 years) and many others, in particular, the following official supercentenarians.
122 years, 164 days : Jeanne Calment (France) Feb. 21, 1875 – Aug. 04, 1997
119 years, 097 days : Sarah Knauss (U.S. (PA)) Sept. 24, 1880 – Dec. 30, 1999
117 years, 248 days : Lucy Hannah (U.S. (AL)) July 16, 1875 – Mar. 21, 1993
117 years, 230 days : Marie-Louise Meilleur (Canada (QUE)) Aug. 29, 1880 – Apr. 16, 1998
117 years, 27 days : Misao Okawa (Japan) Mar. 05, 1898 – Apr. 1, 2015
116 years, 347 days : Maria Esther Capovilla (Ecuador) Sept. 14, 1889 – Aug. 27, 2006
116 years, 276 days : Gertrude Weaver (U.S. (ARK.)) Jul. 04, 1898 – Apr. 6
116 years, 175 days : Tane Ikai (Japan) Jan. 18, 1879 – Jul. 12, 1995
116 years, 118 days : Elizabeth Bolden (U.S. (TN.)) Aug. 15, 1890 – Dec. 11, 2006
116 years, 100 days : Besse Cooper (U.S. (GA)) Aug. 26, 1896 – Dec. 4, 2012
Can a pattern or “code” be inferred from the centenarian and supercentenarian lifestyles. Why are most supercentenarians women ?
Focus on Hendrikje van Andel-Schipper, a 115 years supercentanarian Dutch woman who gave her body to science before she died, the genomic sequencing analysis of which has helped us to better understand the ultimate mechanisms by which humans die of “old age” as mother Nature designed.
4. Group case studies and hot longevity spots (Hunza, Nicoya, Mediterranean, Okinawa Abkhazkistan, Loma Linda etc).
Identifying a few conditions and mechanisms of action that help to explain how these centenarians and supercentenarians have achieved advanced age without crippling chronic diseases.
Top: red hot peppers, a great way to boost endorphins, immune function and metabolic pathways. Image licensed under cc.
MOST CENTENARIANS AND SUPERCENTENARIANS DIE FROM AMYLOIDOSIS DISEASES.
Supercentenarians (above 110 years) like Jeanne Calment and hundreds of others have escaped acquiring Society’s common chronic diseases that un-necessarily kill millions of Americans each year, such as heart disease, cancer, stroke and diabetes. However, centenarians and supercentenarians eventually succumb to Senile Systemic Amyloidosis or a related amyloidosis that alters proteins, (4) which start to stick to the inside of blood vessels thereby restricting blood flow and creating inner havoc. (Source) Conventional medicine has been unable to reverse this disease. On the other hand, the Happiness Medicine Institute’s expertise team has accumulated compelling evidence that shows that this disease can also be better controlled if not reversed with innovative science and advanced holistic medicine, which includes, among many other techniques, wine therapy. This section will thus look into amyloidosis causation and invoke a few anti-amyloidosis techniques.
MEDITERRANEAN LONGEVITY DINER WILL START AFTER THIS LAST SESSION
Top: Mushrooms (fungi) can supplement mammals with key polysaccharids, beta-glucans, vitamins D and B 12, among other nutrients, making them longevity foods.
HOLISTIC & ADVANCED LONGEVITY PROTOCOLS
1. Caloric Restrictions and CR mimetics: For over one hundred years, a large body of medical evidence shows that restricting calories at least 30-50% below average efficiently inhibits aging processes in all species tested. Different molecules like resveratrol and metformin can act as mimitics. Other techniques exist in holistic, integrative and functional medicine that need not deprive the body of nutritional contentment.
2. Telomere and telomerase interventions: Since the 2009 Physiology Nobel winner Elizabeth’s Blackburn (et al) discovery of telomerase regulation, many telomerase promoting techniques have been identified and used with success, from TERT gene therapy, to holistic techniques, all supported by published studies.
3. Stem cells regulation and production: At birth, we are endowed with around 20,000 stem cells. As age accumulates, the body tends to deplete these Master molecules, that which hinders tissue repair. From prolotherapy to tissue regeneration, stem cell differentiation and activation, innovative and holistic medicine has significantly impacted optimal longevity.
4. Activation and enhancement of DNA repair: Thanks to innovative and holistic DNA repair activation and to innate correction systems via, inter alia, DNA repair enzymes, the discovery of which was recognized by a 2015 Nobel in Chemistry, the body is able to repair defective DNA and altered signaling pathways. The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. With time, a cell accumulates a large amount of DNA damage, and can no longer effectively repair damage incurred to its DNA. As a consequence, it can enter one of three possible states: (a) an irreversible state of dormancy, known as senescence (b) cell suicide, also known as apoptosis or programmed cell death (c) unregulated cell division, which can lead to the formation of a tumor that is cancerous. The DNA repair ability of a cell is vital to the integrity of its genome and thus to the normal functionality of that organism. In this section, we will see via power point slides that many genes that were initially shown to influence life span have turned out to be involved in DNA damage repair and protection. (2) We will also examine innovative and holistic techniques that can enhance DNA repair mechanisms while reducing oxidative stress.
5. Chelation and metabolic detoxification: Optimal longevity has been shown to prosper via different detoxification procedures.
6. Clinical Nutrition, the microbiome and hydration: Major markers, from lipids, to blood sugar, polyphenols, antioxydants and other molecules. Different types of hydration approaches in conjunction with optimal nutrition and their superfoods nutrients can help to activate homeostasis and key longevity genes and hormones while ensuring a better functioning of neuro-transmitters and brain chemistry. Certain Longevity and superfoods or what has been called functional foods will be analyzed from goji and other berries and fruits, nuts to mushrooms, codyceps, plants, herbs (spices like turmeric, red peppers, garlic, ginger and many others) barks, cacao, roots, seaweeds, kimchi and other fermented and non fermented foods and beverages such as small amounts of “sulfite-free” red wine and polyphenol-rich teas. The importance of the microbiome and Vitamin B 12 and the relevance of the Mediterranean diet.
7. Mitochondrial, hormonal and neurotransmitter restoration and balancing in conjunction with trauma and stress reduction. New discoveries in cellular respiration, endocrinology, nutrition and neuro-science help us to understand not only how to prevent chronic diseases, but also how to successfully treat them, including, but not limited to Alzheimer’s Disease, Hashimoto, cancer and diabetes. Concomitantly, emotional strain and chronic stress are also significant aging factors that need to be addressed.
8. The contributions of Epigenetic science, Lifestyle therapy, Bio-physics, Integrative and functional medicine, psycho-neuro-immunology, psycho-neuro-endocrinology, sleep technology, hyperthermia, hydrotherapy, heliotherapy, balneotherapy, fasting, metabolic medicine and holistic savoir-faire in the realm of optimal longevity.
9. Other innovative but more conventional experimentations in molecular, regenerative and anti-aging medicine.
10. A few health and longevity tips to fine-tune one’s endocrine glands, lengthen one’s telomeres and help maintain the body’s stem cells and proteins in a properly folded state thereby avoiding amyloidosis and other diseases thanks to which the frontier of a healthy life span may extend to beyond 140 years old. In this section, we will also show you how to monitor and rebalance one’s blood sugar levels and keep one’s insulin receptors as sharp as one’s automobile’s spark plugs, how to optimize one’s mitochondria, lipid profile, thyroid function and revitalize one’s vitality and sexual hormones, from Dhea, estrogens and progestrone to testosterone, oxytocin, dopamine and many other longevity and feel good molecules. (5)
From supplementation, epigenetics and lifestyle medicine to innovative research, hard evidence supports the claim that 120 years old cancer-free supercentenarian life spans are both achievable and not predetermined by gene. Even if a good set of genes can favor longevity, they are not the decisive longevity factor.
Recap of the presentation’s key points…..Summary of the new 2015 findings in anti-aging medicine and longevity science, including the key conferences of the 2015 anti-aging medicine congress (A4M)….Questions and Answers discussion on Part One of the workshop.
PRECISION AND REFERENCE NOTES
(1). Today, there are 93 million “baby-boomers” Currently, there are more than 80,000 Americans 100 years of age or older, according to the U.S. Census Bureau. That number is expected to rise to more than 580,000 centenarians by 2040.
(2). “Quantification of biological aging in young adults,” Daniel Belsky, Avshalom Caspi, et al. PNAS, July 7, 2015. This research was funded by the New Zealand Health Research Council, U.S. National Institute on Aging, UK Medical Research Council, Jacobs Foundation and the Yad Hanadiv Rothschild Foundation.
(3). One’s metabolic rate and stress level are also general biomarkers while diet, certain superfoods, antifungals and micro-biome work on more specific pathways.
(4). L. Stephen Coles, Robert D. Young, Supercentenarians and transthyretin amyloidosis: The next frontier of human life extension, Preventive Medicine, 2012. The mechanism by which amyloidosis progresses involves a slow process in which a native protein called Transthyretin, which transports thyroid hormones to the body, becomes increasingly unstable. As humans age and-or cease to maintain themselves holistically, the carrier protein begins to unravel and misfold, sticking to the inside of blood vessels and restricting blood flow in different organs. This degenerative process can be compared to the metastatic malignancy process.
(5). Browner, WS; Kahn, AJ; Ziv, E; Reiner, AP; Oshima, J; Cawthon, RM; Hsueh, WC; Cummings, SR. (2004). “The genetics of human longevity”. Am J Med 117 (11): 851–60
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