Contents
- 1 Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
- 1.1 Search Results
- 1.1.1 Oxytocin controls differentiation of human mesenchymal stem cells …
- 1.1.2 Preconditioning of stem cells by oxytocin to improve their therapeutic …
- 1.1.3 Oxytocin improves proliferation and neural differentiation of … – NCBI
- 1.1.4 Oxytocin is an age-specific circulating hormone that is necessary for …
- 1.1.5 Oxytocin controls differentiation of human mesenchymal stem cells …
- 1.1.6 Preconditioning of Stem Cells by Oxytocin to Improve Their …
- 1.1.7 Oxytocin improves proliferation and neural … – ScienceDirect.com
- 1.1.8 [PDF]Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells …
- 1.1.9 Love, Death, and Oxytocin | Josh Mitteldorf
- 1.1.10 Restoration of angiogenic capacity of diabetes … – BMC Cell Biology
- 1.1.11 Neuromodulation by Oxytocin and Vasopressin: Neuron – Cell Press
- 2 Nutrients Boost Stem Cell Function
- 2.1 Nutraceuticals Rescue Aging Stem Cells
- 2.2 Hope for Multiple Sclerosis
- 2.3 Beneficial Epigenetic Changes
- 2.4 Nutrients Promote Stem Cell Vigor
- 2.5 Summary
- 2.6 References
- 2.7 Search Results
- 2.7.1 Nutrients Boost Stem Cell Function | Life Extension Magazine
- 2.7.2 5 Ways Stem Cell Anti Aging Treatment Works | NSI
- 2.7.3 Researchers study secrets of aging via stem cells | Harvard Gazette
- 2.7.4 Exercise is a Powerful Tool to Increase Your Stem Cells
- 2.7.5 Thumbs Down on Stem Cell Enhancers? – Dr. Weil
- 2.7.6 Saunas could heal your mood and your heart | New Scientist
- 2.7.7 New Method of Creating Stem Cells is a “Game Changer” – D-brief
- 2.7.8 Making Old Muscle Young – MIT Technology Review
- 2.7.9 Cell-Seeded Sutures to Repair the Heart – MIT Technology Review
- 2.7.10 Save Our Bones Bulletin: Just Discovered Stem Cells Grow Bone, Non …
- 2.8 Ads
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“The stability of the internal environment (the milieu intérieur) is the condition for the free and independent life”. Professeur Claude Bernard (Dr Claude Bernard is one of the recognized fathers of modern medicine)
Happiness is the physiological result of the body’s natural state of homeostasis, what Claude Bernard called the “milieu intérieur”. Most humans have lost their natural ability to reset their “milieu intérieur”. Once homeostasis is re-established, happiness follows. There are many physiological mechanisms that promote this the State of Happiness.
Holistically-based Happiness Medicine is the only Medical system that is consistent with a healthy long life. It Must therefore be the New Golden Standard of Care for all Chronic Disease Challenges
“The art of medicine consists of amusing the patient while nature cures the disease”. Voltaire
As a starting point, H.M Institute is in agreement with the centrality of Voltaire’s twin-pronged argument invoked above. First, medical doctors first and foremost need to bestow upon their patients an abundance of happiness vibes and humor, as their basic role is less to cure the patient than to amuse him or her, as the French 18th century Enlightenment philosophers like Voltaire recommended. (7)
Voltaire’s second postulate is based on the two millennia Hippcratic tradition of allowing Nature to carry out its healing mechanisms. Traditional Naturopathy and Holistic Medicine are the only medical systems that fully allow this mechanisms to flower. These practitioners teach the requisite holistic techniques that favor this healing process. (8)
For Happiness Medicine, prescriptions and recommendations are based on holistic techniques that promote not only self-healing, but also homeostasis and happiness. By definition, a happiness-based holistic technique is safe, efficient, cost-friendly and evolutionarily good for both the individual and the Community as a whole. (9) This signifies that with Holistic Medicine, populations become healther, live longer and become abundant, in conformity with the diktat of both Darwinism and Christianity. (10)
When chronic diseased patients fully embrace Holistic and Happiness medicine, there is usually no need for Pharmakia and conventional medicine. Drug prescription and surgery can be envisioned for those chronic diseased patients who dont believe in holistic and happiness medicine. On the other hand, in modern Societies, Pharmakia-based conventional medicine can be suited for emergency care. But only when other less invasive medical systems are unavailing. Biblical medicine’s prophets have harsh words against this type of medicine. (11)
(7). Thus, medical doctors need to go to comedy schools to get retrained, thanks to which their symptom alleviating tool boxes will have humor sketches, comedy stunts, new age technology, placebo inventions and the like to better captivate the patient’s spirit, thanks to which his or her symptoms will start subsiding. (7)Dr Seigel. Humor and happiness cures
(8). Dr means to teacher….
(9)By definition, a happiness-based holistic technique is safe, efficient, cost-friendly and evolutionarily good for both the individual and the Community as a whole. (9) When chronic
(10). 1). Diktat is defined as an order or decree imposed by a ruler or a Force. In this perspective, Darwin proved beyond any reasonable doubt that Life’s Natural Selection’s mechanism favors the conditions that lead to biological replicability. Whatever or whomever survives rugged competition does so in order to replicate, thus natural selection is engineered to favor sexual reproduction conditions. In this perspective, the Bible’s Genesis validates this “Diktat”, in its command to procreate and multiply. (Genesis 9:7: “As for you, be fruitful and increase in number, multiply on the Earth and increase upon it” (The new American Standard Bible calles this diktat “the Covenant of the Rainbow. This Diktat is also confirmed in Genesis 1:28). Darwin’s writings, like his Jewish collaborator Karl Marx’s writings are thus consistent with the reproductility principle, the essence of which is also in Genesis. Thus, with Darwinism, Marxism and Christianity, this diktat concerns most of Humanit
(10). Con med emergency care.
Bible on sorcellerie and Pharma.Even the Bible’s authors note that pharmakeia is synonemous with pseudo-science, “Satan” and sorcery. “… the light of a lamp will not shine in you (the great city Babylon) any longer; and the voice of the bridegroom and bride will not be heard in you any longer; for your merchants were the great men of the earth, because all the nations (ethnos) were deceived by your sorcery (pharmakeia)”. (Revelation 18:23) (See the Institute’s analysis on this issue, via mouse click here).
And biochemically, enthusiasm is where there’s the most oxytocin, and a few other neuropeptides ..etc
A while ago, the English-American “French” (1) revolutionary Tom Paine wrote that our country, our identify Nations should be “where there is no Liberty”. (2) Hence his passion and sacrifices in many enlightenment and political battles, in England, the US and even France, where he almost lost his head. (3)
Paine’s belief can be associated to the philosophical prinipe of the notion “permanent revolution”, where prosperity and peace on Earth will come only when all of Humanity will be united, as once predicted Sri Aurobindo.
Akin to macriobiome
Ever since taught… Paine’ Belief is a nobel one, and one that would solve many political and econcomic problems
But the problem is that most people stay stuck in their hard wired “comfort zoned” and do little if anything significant to enhance their local and national community, let alone the international one.
Today, one of the major breakthroughs of medicine, the miccrobiome, shows us the way to promote not only genuine health and wellbeing, but also community development and trans-national harmony
Bacteria France yogurt
If guests (bacteria, virus and even fungi) are not happy within, they will created havoc, neurotransmitters, hormones out of whack etc ( )
One they are all in harmony,
Happy Lifestyle, happy foods, happy how we were designed, genes…but over the last few millennia of struggle, misguidance, promoted unhappy genes…diseases, civilization mercantile…Toynbee.
Many of the Institutes blogs and contributions are permeated with this common thread of synergistic harmony. Hence the blog’s name, Happiness Medicine. Next level from integrative and even holstic medicine.
Home is where we feel the most Alive, the most Enthusiams (Thou) and Happiness. On Earth as it is in Heaven. So Im not talking about escapes directly to “Heaven” as most Christian. We can here Heaven, and then most diseases will disappear.
Meaningfully access our true Home, the Home of Happiness within, then without
H.M.Institute is also in unision with Claude Bernard’s “milieu intérieur” equilibrium and its corollary, homeostasis, regarding the avoidance and resolution of most diseases. However, since Hippocrates, Bernard and Flemmings, there have been a lot of medical discoveries and innovations that need to be considered when addressing illnesses, some of which include the Science of the Microbiome, the Biology of Telomeres and stem cells, the Medicine of Circadian rythms, the Therapy of quality and moderate wine and herbs, thermal, energy and physical therapies, psycho-neuro-endocrino-immunology, regarding which the feel good neuropeptides, hormones and neurotransmitters all collaborate as a united “family” or “tribe” and via precise signaling molecules to both preserve and optimize human metabolism, resilience and evolutionary-based adaptability that meet both Darwin’s and the Bible’s sexual reproduction diktat. (1)
What is Happiness Medicine ?
Happiness Medicine is the English translation of the best medical intervention ever, called “Joie de vivre” medicine (1). Joie de vivre is a Medical system that has excelled in France. After over 1600 years of experimenting with the best health-care systems, French scientists and philosophers unearthed one that the World health Organization characterized as the number One, out of 192 countries, of the international community.
” ” (2)
Joie de Vivre medicine is much more than the combined placebo and molecular effects of drugs or supplements. This type of medicine manifests as a “Joy of Living” that incorporates multiple dimensions, from the pleasure of food, to health vacation, existential awareness, romance, social progress, spiritual endeavor and common universal values, including Christianity. As France has been the seat of Christian values and Biblical medicine for over 1500 years. (3)
Given the results of Happiness Medicine, it is reasonable to call it the “next level” of safe, efficient and cost-friendly care. Happiness Medicine includes, but is not limited to the best of its closest allies, from Holistic medicine, to naturopathic care and more. When happiness medicine is practiced, the body can better process toxicity. This has been the case with many healthy supercentenarians, including Jeanne Calment who smoked cigareets until 119 years old and merely passed from “old age” at 122 and a half, a little before she decided to abandon her Earthly “Joie de Vivre”. (4)
Happiness is the physiological result of the body’s natural state of homeostasis, what Claude Bernard called the “milieu intérieur”. Most humans have lost their natural ability to reset their “milieu intérieur”. Once homeostasis is re-established, happiness follows. There are many physiological mechanisms that promote this the State of Happiness.
The Happiness Medicine Institutes’ scientists research these mechanisms and once actionable protocols are established, the Institute teaches them via coaching, writing, workshops or talks.
Home is Where Happiness & Enthusiasm are the most Alive
According to Hayflicks, 99 percent of human existence, the average longevity has been 18 years old. today, in developed countries, more than 80% of the population today will survive past the age of 70. About 150 years ago, only 20% did. The natural laws of physics may dictate that most things must die. But that does not mean we cannot use nature’s templates to extend healthy human lifespan beyond 120 years.
Future open to more 12-
https://www.ncbi.nlm.nih.gov/pubmed/25614443
Rapid results
In contrast to laboratory mice, the length of killifish telomeres, which average around 6,000-8,000 nucleotides, is similar to that of humans. As a result, Harel and his colleagues were able to quickly see the effect of a telomerase-disabling mutation in the fish. Interestingly, fish in which telomerase activity was disabled displayed a variety of traits that are similar to those seen in humans with a disorder called dyskeratosis congenita, which is also due to a mutation in telomerase.
“Very quickly we began to see an effect on rapidly dividing tissues such as the blood, gut and sperm,” said Harel. “The fish rapidly become sterile, their intestines began to atrophy and they made fewer types of blood cells than their peers.”
The researchers conclude that the killifish is currently the fastest way to study diseases of telomere shortening in vertebrates. They are hopeful that the other mutant strains will be equally useful in their lab and in other labs worldwide.
https://www.youtube.com/watch?v=dG2mMU1loGk
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
Abstract
The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown. Here we report that oxytocin–a hormone best known for its role in lactation, parturition and social behaviours–is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Inhibition of oxytocin signalling in young animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves muscle regeneration by enhancing aged muscle stem cell activation/proliferation through activation of the MAPK/ERK signalling pathway. We further show that the genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia. Considering that oxytocin is an FDA-approved drug, this work reveals a potential novel and safe way to combat or prevent skeletal muscle ageing.
https://www.ncbi.nlm.nih.gov/pubmed/24915299
Scholarly articles for oxytocin AND stem cells |
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Oxytocin induces differentiation of P19 embryonic stem … – Paquin – Cited by 291
… differentiation of human mesenchymal stem cells and … – Elabd – Cited by 139
… differentiation from mouse embryonic stem cells – Hatami – Cited by 39
|
Search Results
Oxytocin controls differentiation of human mesenchymal stem cells …
Preconditioning of stem cells by oxytocin to improve their therapeutic …
https://www.ncbi.nlm.nih.gov/pubmed/23024264
Preconditioning of stem cells by oxytocin to improve their therapeutic potential. … We investigated the mechanism of preconditioning of mesenchymal stem cells (MSCs) with oxytocin (OT), which has been proposed as a novel strategy for enhancing therapeutic potential of these cells in ischemic heart.
Oxytocin improves proliferation and neural differentiation of … – NCBI
https://www.ncbi.nlm.nih.gov/pubmed/24548623
Neurosci Lett. 2014 Apr 3;564:105-10. doi: 10.1016/j.neulet.2014.02.012. Epub 2014 Feb 16. Oxytocinimproves proliferation and neural differentiation of adipose tissue-derived stem cells. Jafarzadeh N(1), Javeri A(1), Khaleghi M(1), Taha MF(2). Author information: (1)Department of Medical Biotechnology, National …
Oxytocin is an age-specific circulating hormone that is necessary for …
https://www.ncbi.nlm.nih.gov/pubmed/24915299
Jun 10, 2014 – Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Elabd C(#)(1), Cousin W(#)(1), Upadhyayula P(1 ), Chen RY(1), Chooljian MS(1), Li J(1), Kung S(1), Jiang KP(1), Conboy IM(1). Author information: (1)Department of Bioengineering, Stem Cell …
Oxytocin controls differentiation of human mesenchymal stem cells …
https://www.ncbi.nlm.nih.gov/pubmed/18583541
Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. … Whereas increase in bone resorption is considered as the main contributor of bone loss that may lead to osteoporosis, this loss is accompanied by increased bone marrow adiposity.
Preconditioning of Stem Cells by Oxytocin to Improve Their …
https://academic.oup.com/endo/article/153/11/5361/2424443
Nov 1, 2012 – Principal limitation of cell therapy is cell loss after transplantation because of the interplay between ischemia, inflammation, and apoptosis. We investigated the mechanism of preconditioning of mesenchymal stem cells (MSCs) with oxytocin ( OT), which has been proposed as a novel strategy for enhancing …
Oxytocin improves proliferation and neural … – ScienceDirect.com
Apr 3, 2014 – However, the exact role of oxytocin in neural development is still not well understood. In the present study, we evaluated the effect of oxytocin on neural differentiation of mouse adipose tissue-derived stem cells (ADSCs). For this purpose, ADSCs were cultured in a medium containing Knockout™ Serum …
[PDF]Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells …
meridianvalleylab.com/…/oxytocin-controls-differentiation-of-human-mesenchymal-s…
Mesenchymal stem cells • Osteoblast • Adipocyte • Differentiation • Osteoporosis • Oxytocin. ABSTRACT. Osteoporosis constitutes a major worldwide public health burden characterized by enhanced skeletal fragility. Bone metabolism is the combination of bone resorption by osteo- clasts and bone formation by osteoblasts.
Love, Death, and Oxytocin | Josh Mitteldorf
https://joshmitteldorf.scienceblog.com/2014/08/09/love-death-and-oxytocin/
Aug 9, 2014 – Aging mice with extra oxytocin retained muscle mass that was lost by mice of similar age as their oxytocin naturally declined. Oxytocin signals the muscle stem cells (aka satellite cells) to actively divide and make more muscle cells. The study’s authors note, however, that the satellite cell receptor for oxytocin …
Restoration of angiogenic capacity of diabetes … – BMC Cell Biology
https://bmccellbiol.biomedcentral.com/articles/10.1186/1471-2121-14-38
Restoration of angiogenic capacity of diabetes-insulted mesenchymal stem cells by oxytocin. Yong Sook Kim,; Jin Sook Kwon,; Moon Hwa Hong,; Wan Seok Kang ,; Hye-yun Jeong,; Hye-jin Kang,; Myung Ho Jeong and; Youngkeun AhnEmail author. BMC Cell Biology201314:38. https://doi.org/10.1186/1471-2121-14-38.
Neuromodulation by Oxytocin and Vasopressin: Neuron – Cell Press
www.cell.com/neuron/abstract/S0896-6273(12)00860-4
Oct 4, 2012 – Oxytocin (OT) and vasopressin (VP) are two closely related neuropeptides, widely known for their peripheral hormonal effects. Specific receptors have also been found in the brain, where their neuromodulatory actions have meanwhile been described in a large number of regions. Recently, it has become …
.
The “love hormone” does more than trigger labor and cement emotional ties between people. Oxytocin also helps repair damaged muscles, at least in mice.
Oxytocin stimulates muscle stem cells to divide when muscle is damaged, researchers report June 10 in Nature Communications. Experiments with mice also showed that the hormone’s levels in the animals’ blood declines with age. Giving old mice shots of oxytocin restored their muscle-regeneration capabilities to match those of much younger rodents. But extra doses of the hormone did not boost muscle-building in young mice.
“This is not a performance-enhancing drug,” says study coauthor Irina Conboy, a stem cell scientist at the University of California, Berkeley.
The findings raise the possibility that oxytocin may stave off muscle atrophy in aging people.
https://www.sciencenews.org/article/oxytocin-stimulates-repair-old-mice’s-muscles
Nutrients Boost Stem Cell Function
March 2017
By Caroline Meyers
Recent scientific findings indicate that aging is closely associated with a loss of the number and function of adult stem cells throughout the body.1-5
Researchers have concluded that protecting those essential stem cells could play an important role in slowing and partially reversing aging.
Three studies published last year demonstrate that several nutraceutical compounds are capable of boosting stem cell function.
These studies revealed that extracts from berries and green tea, the dipeptide carnosine, and vitamin D—have the ability to favorably alter gene expression, and are capable of exerting powerful regulatory effects on stem cells and their environment.
These findings should help to crystalize the importance of utilizing natural molecules as a means of slowing aging.
Nutraceuticals Rescue Aging Stem Cells
Aging is associated with the loss of adult stem cell function (see sidebar). This has prompted interest in ways of improving stem cell functionality in maturing individuals.6-8
It has been shown that connecting the circulation of an older animal with that of a younger one reduces the function of the younger animal’s muscle and brain stem cells and appears to accelerate aging.4,7 Components in the blood of the older animal interact with stem cells in the younger one, impairing their function.
Scientists at the James A. Haly Veterans Affair Hospital in Tampa tried to reverse that effect by treating older rats with a specific nutrient formulation, then observing the effects of the rats’ nutrient-rich blood on stem cells from other animals, both young and old.7
They fed young and aged rats either a standard diet or a nutrient-rich diet composed of a mixture of blueberry, green tea, vitamin D, and carnosine—all nutrients with known cell-protective effects—for 28 days. At the end of that period, the researchers collected blood serum from the older, supplemented rats and applied it to cultures of adult rat stem cells. One group of stem cells came from the memory-intensive brain area called the hippocampus, and the other from bone marrow, where blood cells and platelets are formed.
Serum from aged rats that were on the control diet had the expected effect on the cultured stem cells: their division rates slowed dramatically, producing fewer newstem cells. But serum from the supplemented aged rats did not cause those changes, and in fact produced results not different from those of serum obtained from young rats. This study demonstrated that targeted nutrient supplementation alone could rescue aging stem cells involved in both brain and blood system functions.
STEM CELLS AND AGING
Stem cells, unlike any other cells in the body, can self-renew and differentiate into many different kinds of cells.5
Early embryonic stem cells can differentiate into virtually any kind of cell, in any kind of tissue. Adults retain stem cells in all of their organs and tissues. Adult stem cells can still regenerate and differentiate, but usually only into mature cells in their particular tissue type.4,5
When tissue is damaged, tissue-specific stem cells leap into action, quickly forming into functional replacements for the damaged cells.4,5 In short, adult stem cells account for the healthy adult body’s ability to self-heal, and to retain its youthful vigor.
Recent studies now show that stem cell function declines with advancing age—falling victim to such threats as oxidative stress, inflammation, and DNA damage—and results in impaired ability of tissues and organs to repair themselves.1 In this way, aging itself is closely related to the accumulation of dysfunctional stem cells.1-5
Fortunately, one of the very causes of stem cell dysfunction can now be leveraged to prevent or reversesuch dysfunction. Regulation through favorable alterations in gene expression is considered a major means of establishing and maintaining normal stem cell activities.2,4 We can now provide to living stem cells substances that exert favorable changes.
A growing number of studies demonstrate that application of a number of molecules that support metabolic function, protect against oxidative stress, prevent inflammation, and protect DNA repair can enhance the numbers – and function – of aging stem cells.9,11,12
The studies discussed in this article demonstrate that many commonly-used nutraceuticals may in fact produce their age-decelerating, organ-protecting, and life-extending effects at least in part by protecting adult stem cells.
Hope for Multiple Sclerosis
The second important study recently published demonstrated the impact of vitamin D on brain stem cells in a mouse model of multiple sclerosis (MS). MS is an autoimmune disease that damages nerve cells by impairing their ability to conduct signals. While treatments can slow the disease, it is considered incurable.8
Researchers used a mouse model of MS to determine whether vitamin D treatment could improve nerve function by protecting neuronal stem cells and by promoting their functions. Amazingly, they found that vitamin D supplementation reversed the nerve cell damage created by MS.8 Furthermore, they found that the supplement promoted the proliferation of neuronal stem cells, which contributed directly to improved brain function, and to their apparent recovery from MS. This study offered additional insights into how vitamin D could directly contribute to alleviating a condition in which adult stem cell function is compromised.
Beneficial Epigenetic Changes

The third important study also focused on stem cells in the brain and the impact of specific nutrients on brain function. Here, the researchers based their work on the observation that the decline in aging brain stem cells appears to be closely associated with increased levels of inflammatory signaling molecules, or cytokines.6
They supplemented rats with carnosine, blueberry, green tea, and vitamin D, the same group of nutrients previously proven to rescue aging stem cells. They found that supplemented animals had a large number of changes in the expression of genes concerned with a range of cellular functions.6 More specifically, they helped reduce proinflammatory cytokines, while increasing anti-inflammatory cytokines. The reduction in inflammation would explain the beneficial effects of the nutrients on stem cell function demonstrated in previous experiments.9
But the researchers dug deeper and made a remarkable discovery—the nutrient combination increased the production of genes that prompt progenitor cells (stem-like cells living in brain tissue) into becoming functioning adult neurons. In other words, it helped create healthy new brain cells.
This study powerfully demonstrates how targeted nutrients can favorably alter the environment faced by tissue stem cells in the brain, reducing the risk that they will develop into impaired, aged stem cells, and promoting their development instead into functioning adult brain cells. This is especially important for those at risk for neurodegenerative diseases like Alzheimer’s and Parkinson’s. These diseases are known to be associated with declining rates of brain cell renewal, which we now recognize requires healthy stem cells.6,10
Together, these three recent studies strongly indicate that specific nutrients can produce tremendous effects on adult tissue stem cells, helping protect them against the destructive impact of environmental factors, and preserving their ability to naturally heal tissues and restore their youthful function.
Let’s now turn to a brief review of the stem cell-protecting properties of some other familiar nutrients.
Nutrients Promote Stem Cell Vigor
One large group of researchers has published extensively on their studies with a nutrient combination containing polyphenols from blueberry and green tea, as well as carnosine and vitamin D. Their work has shown that these nutrients promote the proliferation of healthy human adult stem cells, protect those cells from the destructive effects of oxidative stress, and produce improved cognitive and memory function in animals as a result of enhanced brain stem cell proliferation.9,11,12
Numerous other studies show that other common, readily-available nutritional supplements can also boost stem cell function in a meaningful way, to further slow stem cell-related aging. Let’s take a look at the highlights:
- In one study, a supplement containing green tea, astragalus, goji berry extracts, ellagic acid, and vitamin D fermented with a probiotic Lactobacillus species, was given to human volunteers twice daily for 2 weeks. Within a day, and continuing for the rest of the study, researchers detected significant increases in circulating bone marrow stem cells. They believe this was caused by stimulation of the body’s natural repair mechanisms (stem cells) by the nutraceutical combination.13
- Blueberry extracts are rich in polyphenols, which are highly protective molecules associated with a host of health benefits. A study in rats showed that supplementing animals in early life with a blueberry-enriched diet prevented bone loss (osteoporosis) at menopause.14 Closer examination of the protective effect revealed that the blueberry supplement stimulated bone-forming stem cells to mature into active bone-mineralizing cells. This action reduced the high post-menopausal rate of bone turnover that, in humans, results in easy fractures.14,15
- Spirulina is a blue-green algae that is known for its anti-inflammatory properties. A recent study showed that spirulina could prevent inflammation-induced decreases in brain stem cell proliferation that accumulates with aging.16 This resulted in improved functioning of stem cell mitochondria, which improved energy utilization and reduced oxidative stress.
Summary

Recent research has revealed the crucial role of adult stem cells in promoting healing and regeneration following damage. Over time, their loss of function deprives our tissues of their youthful ability to recover from damage and regenerate themselves. This contributes to the loss of function that we see as aging.
The good news is that rejuvenating those adult stem cells can lead to a partial reversal of aging in our tissues. Even better, three landmark studies have shown us that rejuvenation of adult tissue stem cells is within our reach.
Supplementation with a variety of nutrients has been shown to restore the healing and regenerative capacities of aging adult stem cells, and results in the restoration of youthful function to the tissues where those stem cells reside.
The pace of scientific discovery in the nutrients realm continues to accelerate, opening the real possibility that many other nutraceuticals will be found to exert their health-promoting effects at least in part by stimulating stem cell recovery.
If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.
References
- Liang R, Ghaffari S. Stem cells, redox signaling, and stem cell aging. Antioxid Redox Signal.2014;20(12):1902-16.
- Beerman I, Rossi DJ. Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. Cell Stem Cell. 2015;16(6):613-25.
- Blau HM, Cosgrove BD, Ho AT. The central role of muscle stem cells in regenerative failure with aging. Nat Med. 2015;21(8):854-62.
- Goodell MA, Rando TA. Stem cells and healthy aging. Science. 2015;350(6265):1199-204.
- Schultz MB, Sinclair DA. When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development. 2016;143(1):3-14.
- Flowers A, Lee JY, Acosta S, et al. NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats. J Neuroinflammation. 2015;12:174.
- Bickford PC, Kaneko Y, Grimmig B, et al. Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells. Age (Dordr). 2015;37(5):103.
- Gu SG, Wang CJ, Zhao G, et al. Role of vitamin D in regulating the neural stem cells of mouse model with multiple sclerosis. Eur Rev Med Pharmacol Sci. 2015;19(21):4004-11.
- Acosta S, Jernberg J, Sanberg CD, et al. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation Res. 2010;13(5):581-8.
- Hoglinger GU, Rizk P, Muriel MP, et al. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat Neurosci. 2004;7(7):726-35.
- Bickford PC, Tan J, Shytle RD, et al. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006;15(1):118-23.
- Shytle RD, Ehrhart J, Tan J, et al. Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds. Rejuvenation Res. 2007;10(2):173-8.
- Mikirova NA, Jackson JA, Hunninghake R, et al. Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects. J Transl Med. 2010;8:34.
- Zhang J, Lazarenko OP, Blackburn ML, et al. Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats. PLoS One. 2011;6(9):e24486.
- Chen JR, Lazarenko OP, Zhang J, et al. Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. J Bone Miner Res. 2014;29(5):1043-53.
- Bachstetter AD, Jernberg J, Schlunk A, et al. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PLoS One. 2010;5(5):e10496.
Search Results
Nutrients Boost Stem Cell Function | Life Extension Magazine
www.lifeextension.com/Magazine/2017/3/Nutrients-Boost-Stem-Cell…/Page-01
Nutrients Boost Stem Cell Function. … Researchers have concluded that protecting those essential stem cells could play an important role in slowing and partially reversing aging. Three studies published last year demonstrate that several nutraceutical compounds are capable of boosting stem cell function.
5 Ways Stem Cell Anti Aging Treatment Works | NSI
https://nsistemcell.com/5-ways-stem-cells-for-anti-aging-treatment-works/
Jul 19, 2017 – Stem cell therapy as an anti aging treatment helps to increase the levels of stem cellscirculating through the bloodstream. By harvesting the cells from an easily accessed source –the fatty layer that lies just beneath the skin- a person’s own stem cells can be concentrated and released back into the …
Researchers study secrets of aging via stem cells | Harvard Gazette
https://news.harvard.edu/gazette/…/researchers-study-secrets-of-aging-via-stem-cells/
Apr 18, 2017 – Stem cells, which can differentiate into many cell types, are important parts of the body’s repair system, but lose regenerative potency as we age. … and Milton Flier Associate Professor of Biomedical Science and Genetics, that identified age- related changes in the blood that can increasethe risk of diseases …
Exercise is a Powerful Tool to Increase Your Stem Cells
https://fitness.mercola.com/…/new-study-shows-powerful-tool-to-increase-your-stem-…
Feb 24, 2012 – Researchers have discovered that exercise affects the behavior of your muscle stem cells. This finding could lead to new rehabilitation techniques for muscle injuries, and may help prevent or even restore age-related muscle loss. It has long been known that mesenchymal stem cells (MSCs) in skeletal …
Thumbs Down on Stem Cell Enhancers? – Dr. Weil
https://www.drweil.com › Health & Wellness › Balanced Living › Healthy Living
Read more about products sold as stem cell enhancers and learn more information from your trusted health advisor, Dr. Weil. … I believe it contains neurotoxins that can increase the risks of degenerative diseases of the central nervous system. Of particular concern is a compound called beta-methylamino-L- alanine (BMAA) …
Saunas could heal your mood and your heart | New Scientist
https://www.newscientist.com/…/dn21206-saunas-could-heal-your-mood-and-your-he…
Nov 23, 2011 – The little hot rooms may improve heart function and boost levels of “happinessmolecule” serotonin, improving mood too. … The researchers also found more circulating endothelial progenitor cells – adult stem cells that can turn into endothelial cells (The American Journal of Cardiology, DOI: …
New Method of Creating Stem Cells is a “Game Changer” – D-brief
blogs.discovermagazine.com/…/new-method-of-creating-stem-cells-is-a-game-change…
Jan 30, 2014 – Researchers have observed that plants, when stressed, can reprogram their cells into stem cells, capable of differentiating into many different cell types. … My son had a Spinal Cord injury and if these new therapies progress, he will be able to improve his life to recover even more and live a happier and …
Making Old Muscle Young – MIT Technology Review
https://www.technologyreview.com/s/410275/making-old-muscle-young/
Jun 16, 2008 – Researchers boost growth of muscle stem cells to stop age-related muscle deterioration. … Manipulating stem cells in old muscle can restore youth to aging tissue, according to research from the University of California, Berkeley. Scientists altered the activity of a molecular pathway to make stem cells in …
Cell-Seeded Sutures to Repair the Heart – MIT Technology Review
https://www.technologyreview.com/s/422044/cell-seeded-sutures-to-repair-the-heart/
Dec 16, 2010 – One major challenge has been to get an adequate number of cells to remain in the area of injury. For example, in human studies of injected mesenchymal stem cells, only one percent to about 10 percent of injected cells remained at the site after injection. “Presumably the cells will be much happier if they …
Save Our Bones Bulletin: Just Discovered Stem Cells Grow Bone, Non …
https://saveourbones.com/the-save-our-bones-bulletin-just-discovered-stem-cells-grow…
Thank you for this informatiion. So grateful that you have resources that are tracking the latest research about bone health etc. We are very fortunate to have this resource you have provided. Hopefully other scientists on the nutritional side of health will be able to track that possibility in this newest release on stem cells.
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Put for book
Medical researchers, both in the conventional and integrative fields, continue to search for new ways to accumulate cash flow while characterizing old realities with marketable fanfare that appear to be innovations, but in reality tend to. Thanks to which these modern marketing troubatours can get millions of social medial “likes” thereby ensuring some semblance of cash-flow clientele. In a mercantile civilization, we can’t really expect more from medical researchers and scientists.
Conventional mainstream medicine is only useful for emergency care. Over 95 percent of conventional medicine and its pharmaceutical backbone is inconsistrnt with science must be composed. This is the Institute’s secondary mission.
Given the avoidable ravages of the first three causes of collective suffering and premature death, (cardiovascular diseases, cancer and iatrogenic/nosocomial diseases/deaths), the Institute’s research, publications and, inter alia, education workshops prioritize these areas of concern as well as optimized holistic longevity medicine, if only because once a person has mastered the key areas of optimal longevity medicine, he or she rarely contracts a chronique disease.
Happiness Medicine is based on a holistic evidence-based approach to medicine, the health sciences, lifestyle, attitude and public health policies. via research, publication, documentaries, public campaigns and teaching.
Subsidiary Mission
The Building of a European-flavored Holistic Rejuvenation Retreat center in the US,
In order to promote the best of European and French health-care in the United States, the Happiness Institute is preparing a project and business plan to build a mountain European-flavored Holistic Rejuvenation Education Retreat Center in the United States, either in California, Colorado or wherever possible. This Rejuvenation and Holistic Medicine Retreat Center would be associated to the Mediterranean one that Christian founded in France Click here for details.
Thanks to this new Center, with more European holistic health experts in the United States and with more American holistic health experts in Europe, we would be able to enhance the medical standards of care on the two continues, that which would benefit public health, prosperity and peace.
(5). A citizen’s arrest is an arrest made by a person who is not acting as a sworn law-enforcement official. In common law jurisdictions, the practice dates back to medieval England and the English common law, in which sheriffs encouraged ordinary citizens to help apprehend law breakers. In the United States a private person may arrest another, without a warrant, for a crime occurring in their presence. For which crimes this is permitted may vary state by state, depending on local law.Most states have codified the common law rule that a warrantless arrest may be made by a private person for a felony, misdemeanor or “breach of peace”. (Daily, JD, James. “Superheroes and Citizen’s Arrest”. Law and the Multiverse) A breach of peace covers a multitude of violations in which the Supreme Court has even included a misdemeanor seatbelt violation punishable only by a fine. The term historically included theft, “nightwalking”, prostitution and playing card and dice games. (“Atwater v. Lago Vista ( No. 99-1408 )”. Supreme Court of the United State.
(5). Furthermore, once there is compelling evidence that shows the systemic destruction of the People’s health and optimal lifespan, (i.e., see Mission Four for the proof) the People have the right to carry out “citizens’ arrests” against those who blatantly commit crimes against the People’s birthrights
(6) In this real, not only are the People free do civically disobey, but they have the constitutionally duty to disobey arbitrary laws that stifles basic needs, systematically violates their fundamental rights, kills the People’s health and significantly shortens their lifespan. From the viewpoint of both the Bible and Darwin’s evolutionary ethics, when the People’s endowed healthy lifespan and the resources they need to self-replicate and satisfy their basic needs are being destroyed, they have the utmost duty to petition the Government’s leaders to step down.
(7). Thus, medical doctors need to go to comedy schools to get retrained, thanks to which their symptom alleviating tool boxes will have humor sketches, comedy stunts, new age technology, placebo inventions and the like to better captivate the patient’s spirit, thanks to which his or her symptoms will start subsiding. (7)Dr Seigel. Humor and happiness cures
(8). Dr means to teacher….
(9)By definition, a happiness-based holistic technique is safe, efficient, cost-friendly and evolutionarily good for both the individual and the Community as a whole. (9) When chronic
(10). 1). Diktat is defined as an order or decree imposed by a ruler or a Force. In this perspective, Darwin proved beyond any reasonable doubt that Life’s Natural Selection’s mechanism favors the conditions that lead to biological replicability. Whatever or whomever survives rugged competition does so in order to replicate, thus natural selection is engineered to favor sexual reproduction conditions. In this perspective, the Bible’s Genesis validates this “Diktat”, in its command to procreate and multiply. (Genesis 9:7: “As for you, be fruitful and increase in number, multiply on the Earth and increase upon it” (The new American Standard Bible calles this diktat “the Covenant of the Rainbow. This Diktat is also confirmed in Genesis 1:28). Darwin’s writings, like his Jewish collaborator Karl Marx’s writings are thus consistent with the reproductility principle, the essence of which is also in Genesis. Thus, with Darwinism, Marxism and Christianity, this diktat concerns most of Humanit
(10). Con med emergency care.
Bible on sorcellerie and Pharma.Even the Bible’s authors note that pharmakeia is synonemous with pseudo-science, “Satan” and sorcery. “… the light of a lamp will not shine in you (the great city Babylon) any longer; and the voice of the bridegroom and bride will not be heard in you any longer; for your merchants were the great men of the earth, because all the nations (ethnos) were deceived by your sorcery (pharmakeia)”. (Revelation 18:23) (See the Institute’s analysis on this issue, via mouse click here).
(16). Hormones are signaling molecules governing the body’s network of glands. Neurotransmitters are signaling molecules governing synapses and the central nervous system’s networks. And cytokines are the immune system’s signaling molecules governing “security”, either via the triggering of the inflammatory response or via anti-inflammation pathways.
(17). The historian Arnold Toynbee spent over 60 years of his life showing that during the last 10,000 years, there have been only three types of civilizations: military, mercantile and spiritual. And within these three civilizations, there have been thousands of societies, most of which eventually got crippled and died. In light of the past, it is thus reasonable to assume that today’s narcissitstic and predatory based mecantile-militarist modern societies will not last. The Insittute’s job is to contribute in helping this “system of things” to peacefully evolve toward evolutionary and ethical progress.
(18). But in small dosage and quality wine. It can even be one or two tablespoons. As Paraclesus wrote: “Wine can be a poison, a food or a medicine depending on the dosage” When the Greeks introduced a more systematized approach to medicine, wine retained its prominent role. The Greek physician Hippocrates considered wine a part of a healthy diet, and advocated its use as a disinfectant for wounds, as well as a medium in which to mix other drugs for consumption by the patient. Cf., Robinson, J., ed. (2006). The Oxford Companion to Wine (3rd ed.). Oxford University Press. p. 433 Hippocrates also prescribed wine as a cure for various ailments ranging from diarrhea and lethargy to pain during childbirth and depression, what he called “melancholia”.
Although telomerase is not normally active in most cells of an adult animal, it does work to maintain telomere length in rapidly dividing cells such as male germ cells, which make sperm, as well as tissues with high turnover such as blood and gut. In its absence, the telomeres of those cells shrink rapidly as they repeatedly divid
Current animal models of aging, such as the mouse, have telomeres that are much longer than humans — about 50,000-100,000 nucleotides — making it difficult to compare with humans.”
Abstract
Telomere extension has been proposed as a means to improve cell culture and tissue engineering and to treat disease. However, telomere extension by nonviral, nonintegrating methods remains inefficient. Here we report that delivery of modified mRNA encoding TERT to human fibroblasts and myoblasts increases telomerase activity transiently (24-48 h) and rapidly extends telomeres, after which telomeres resume shortening. Three successive transfections over a 4 d period extended telomeres up to 0.9 kb in a cell type-specific manner in fibroblasts and myoblasts and conferred an additional 28 ± 1.5 and 3.4 ± 0.4 population doublings (PDs), respectively. Proliferative capacity increased in a dose-dependent manner. The second and third transfections had less effect on proliferative capacity than the first, revealing a refractory period. However, the refractory period was transient as a later fourth transfection increased fibroblast proliferative capacity by an additional 15.2 ± 1.1 PDs, similar to the first transfection. Overall, these treatments led to an increase in absolute cell number of more than 10(12)-fold. Notably, unlike immortalized cells, all treated cell populations eventually stopped increasing in number and expressed senescence markers to the same extent as untreated cells. This rapid method of extending telomeres and increasing cell proliferative capacity without risk of insertional mutagenesis should have broad utility in disease modeling, drug screening, and regenerative medicine.
https://www.ncbi.nlm.nih.gov/pubmed/25614443
(7)
This mindset characterized by feelings of awesomeness, pleasure and deeply satisfying wellbeing, in contradistinction to the generalized fatigued, paranoid and depressed “mal-etre” attitude that is pervasive in decadent Societies.
, versus for the exclusive benefit of the One to Five percent of a Society’s controlling parasitic agents.
(3)Public agents who hamper these two fundamental historic and evolutionary forces (health and happiness) need to either step down or be removed by via the People’s endowed “civil arrest” powers and duties. In this way, a new team of evolved public agents who better understand holistic Evolution and God’s intent can be be elected for the benefit of the entire Community. (3)
at which point the Government ‘s mission is to activate its whithering away “genes” or “memes”. (1)
(5) (what the community of medical practitioners believe should be the standard)
(5). Avastin…20 k month…toxic env…immuno one million when holistic 100 dallars
(x)In Governments that promote sickness and unhappiness, the historic malady of totalitarianism has cancerized public institutions. Those who control and profit from these totalitarian regimes control or attempt to control the People by attacking their health and happiness.
(1). Diktat is defined as an order or decree imposed by a ruler or a Force. In this perspective, Darwin proved beyond any reasonable doubt that Life’s Natural Selection’s mechanism favors the conditions that lead to biological replicability. Whatever or whomever survives rugged competition does so in order to replicate, thus natural selection is engineered to favor sexual reproduction conditions. In this perspective, the Bible’s Genesis validates this “Diktat”, in its command to procreate and multiply. (Genesis 9:7: “As for you, be fruitful and increase in number, multiply on the Earth and increase upon it” (The new American Standard Bible calles this diktat “the Covenant of the Rainbow. This Diktat is also confirmed in Genesis 1:28). Darwin’s writings, like his Jewish collaborator Karl Marx’s writings are thus consistent with the reproductility principle, the essence of which is also in Genesis. Thus, with Darwinism, Marxism and Christianity, this diktat concerns most of Humanity.
(2). Just one out of many examples that supports this piece of allegation. At Harvard University’s medical school, an experiment was performed between a group of ladies who practiced LKM (loving kindness meditation) versus another group of similarly situated ladies who did not. The ladies who practiced LKM had significantly longer telomeres. After reviewing the studies methodology, the Institute has ascertained it as flawless. Telomeres are biomarkers not only for healthy living, but also for optimal longevity, that which can extend the Hayflick clock from 50 cell divisions to 70 or more cyclical division, which means that there is much more Life Span and vitality within these cells and therefore, with the person who carries these cells.
(3). Multiple published peer reviewed studies supports this claim. Among others, the Transcendantal Meditation University in Iowa has published proof that in those cities where there is a certain percentage of meditators who practice meditation regularly, usually at least 4 to 5 percent of the city population, there have also been a significant decrease of violence, accidents and diseases. ( ). Another study showed that where there is one super-happy individual who radiates powerful and special frequencis “tous azimuths”, in what Thaillard de Chardin called “la noosphère”, the human collective behavior with a measurable distance from that “awakened” individual behaves in a more peaceful and disease-free manner (pp ). These “field frequencies” can also explain why some countries and epoques are more prone to violence and diseases than others. These then are a few of Happiness Medicine’s effects. There are many more.
(4). Among other examples, consider these two. Similar oppressions have been seen with those refusing to destroys their childs immunity and natural defense systems with corporate toxicity laden vaccines.
These ft in the banning section
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