Holistic Oncology’s Rationale & Protocol


A few years ago, the father of modern oncology, Professor Weinberg had identified 6, then 10 major Hallmarks of cancer. (1)  A hallmark is a biochemical pathway. Since these hallmarks have been published, a few other hallmarks have been identified. At the ACR (advanced cancer research) and HM (happiness medicine) institutes, we have identified a few more pathways, for a total of 17 hallmarks. Thus, the Institute’s cancer approach is one of the most comprehensive one in terms of addressing all of the pathways cancer cells use to outmaneuver the immune system and proliferate en mass.

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The Limitation of Conventional and Integrative Oncology

On the other hand, conventional oncology usually addresses only 4 of these pathways: Apoptosis, Genes, microtubules and angiogenesis with multiple tumor shrinking tools, most of which spur future cancers or reinforce existing metastastic mechanisms. Drug immunotherapies in the form of monoclonal antibiodies,  BCG, cytokine therapy, checkpoint inhibitors, targeted growth inhibitors,  cancer vacines and the like are safer and more efficient, but these drug therapies are still laden with adverse effects and so far, there is no conclusive evidence that this technology will stop the present cancer epidemic. (See blog).

Integrative and functional oncology addresses 6 or 7 of these pathways and used genetic testing to determine which chemo will be adapted to which cancer. This personalized approach is better then mainstream conventional oncology’s approach, but it is still not sufficiently comprehensive and is laden with toxic effects, in particular with chemo and radiation, because both these two techniques make cancer stem cells stronger while creating new cells. (See Disease section).

Holistic Oncology’s Principles

Holistic Oncology, on the other hand, addresses all 17 hallmarks and biochemical pathways without using radiation nor chemotherapy and rarely recommending surgey.

Because chime, RT and surgery are the basic three standards of care, all medical doctors, from conventional to integrative and functional and doctors of osteopathy have the legal obligation to use in some form all of these three major standards of care. They thus have designed lesser chemo protocols in the form of IPT or chemo fractionated or using radiation with hyperthermia etc. All of this is better than strict conventional oncology, but from the Institute’s perspective, there are still adverse effects and the approach is not holistic, let alone comprehensive or cost-friendly.

Thus, no medical doctor can offer a truly holistic approach to cancer. Holistic oncology’s first two principles are “first do no harm” and second, “bring back the Joie de Vivre”, and both these principles are inoperable with conventional and integrative oncology.

For cancer reversals to take hold, the body’s integrity needs to be respected as much as possible so that the proper molecular signaling based on millions of years of cellular evolution can take place. Thus, whenever there is some form of trauma, be it surgical, radiation or chemo, the body goes into sympathic “flight, fight and freeze” mode and as such, its signaling system as well as the immune system don’t work well.

Furthermore, by bringing back the Joy in one’s life as well as in  medicine, versus the stress of a “death or terminal verdict”, the stress of trauma (losing both breasts, one’s prostate or part of the colon is stressful) and the stress of getting bankrupt with hefty bills, inter alia, the immune, metabolic and vitality systems work much better. In the Institute’s pending book, all of these claims will be supported via an abundance of published peer reviewed evidence.

The Institute’s Holistic Protocol

The Institute’s General Holistic Protocol is outlined below in terms of 17 mini-protocols (17 sections), inside of which there are many cancer control and reversal techniques. Each “ ection” (mini-protocol) below targets a specific pathway or a series of biochemical pathways and signaling molecules that have been proven to have an important “anti-cancer” impacts in terms of cancer control and reversal, the most “holistic” impact of which is the activation of signaling pathways that can encourage cancer cells to revert back into normality, (via the redifferentiation pathway). When this approach is not unattainable, the other general reversal strategies are based on upregulating cancer’s suicidal apoptosis mechanisms, on tissue necrosis, on holistic genetic reprogramming, inter alia, so that the T-cells’ endogenous cytotoxic chemicals can selectively poison the tumor or tumors quasi-permanently. (1)  Thereafter follows phagocytosis (2) and tumor lysis draining, where the billion of dead cancer cells can be properly eliminated without harming the body.

Being holistic in nature, the cancer control and reversal techniques below have been evaluated by strong science to be safe, efficient, cost-friendly and when possible, “fun”. (3) These protocols are the result of many years of European clinical practice and international symposia participation, including, but not limited to the analysis of thousands of studies we have sifted in order to distill the quintessential elements that have been shown to benefit cancer control and malignant reversal.


Activating  detoxification pathways  (metabolic and extrinsic). Conventional oncology’s experts still ignores this pathway while integrative oncologists have a better grasp on it. But even if integrative oncology is a progress, it remains difficult to keep the body clean and strong with integrative and functional oncologists are legally obligated to use a number of toxic procedures, from  cytotoxic chemodrugs, to ionic radiation and other targeted synthetic modalities.

Two of the most important actors who are missing in the conventional oncology team is the toxicologist and the detoxification practitioner. The majority of cancers are triggered chemically, via pesticides, food additives, heavy metals, pollutants and the like. They therefore need to be first identified by the toxicologist and second, removed as best as possible by the patient thanks to the professional detoxifier’s skills, all of which target metabolic and extrinsic detoxification pathways, from the liver’s gluthione-assisted metabolic detox mechanisms, to kidney, colon, blood, lung and skin extrinsic  pathways that holistic oncology practices via many modalities. In the Institute’s pending book, the evidence fully supports the claim that removing toxic metals like lead, mercury (including from the teeth), pesticides and the like will help to clear the cancer.


Once the major emonctory (i.e. elimination) organs have completed their detox task, ACR Institute recommends one of three types of diets adapted to the patient’s genome, constitution and health challenges.   Although each of these anti-cancer diets work on common pathways, including, but not limited to the strengthening of the immune-surveillance system and the targeting of the glycolysis pathways, each of them has biochemical specificities, the targeting of which is bilaterally determined by both the patient and the nutritionist counselor. Food-medecine is usually not enough to completely reverse cancer, but it’s an important part of the Institute’s cancer control and reversal strategy. The Institute scientists have determined multiple diet varieties within three general diet categories: plant-based, ketogenic and the Mediterranean. Homeopathic and-or moderate dosage of organic wine with meals is also considered part of the Institute’s clinical nutrition protocol as is vibrant spring alkalinic water. Focus on correctly feeding the microbiota is also essential.


Bacteria gene cross talk with human’s genome and immune system. By not addressing this parameter, conventional oncology’s immunotherapies will not be very long term efficient. See evidence.


The body having been cleansed, remineralized and correctly nourished, the third protocol focuses on stress management and brain-wave regulation. Nurturing emotional wellbeing and spiritual health is too often neglected in the mainstream. In this field, the Institute’s team teaches multiple psycho-neuro and neuro-science techniques, from different forms of meditation, to sophrology, visualization, breathing, tapping, trauma therapy, musicotherapy and mindfulness, the effectiveness of which has been corroborated by many studies, including a published Harvard study.


The turning off the fire of excessive free radicals, cytokines, the master Kappa switch and other inflammatory processes is an important  anti-cancer front because one of the drivers of the malignancy process is inflammation.


Cancer’s goal being the total invasion of the host, the malignancy process puts in place many growth factors, from IGF-1, to VGF, EGFR, FVGT and many other growth pathways, all of which are inter-connected. Up to 2 millimeters, a tumor can not survive without the activation of angiogenesis, one of the key growth factors. It is therefore imperative to timely address this hallmark of the cancer process.


Cancer thrives on glucose and glutamate pathways. Food, drugs and supplements can have an impact on this front. Techniques that target autophagy and  cellular respiration holistically will be emphasized.


One of cancer’s characteristics is to thicken the blood so that its seeds (i.e., micro-metastasis) can better embed within distant tissues. To this end, the cancer process alters the coagulation cascade as well as the cell’s sodium-potassium pump and dispatches “adhesion” molecules to better colonize distant tissues. In addition to the promotion of metastasis, this process also produces clot formation, from which many cancer patient die. It is therefore necessary to correctly address this aspect of the disease.


Immune-building, immune-modulation, re-activation of the innate immunity and the dendritic surveillance system are all “must do’s” if we are to definitely eradicate the malignancy process. Moreover, by  restoring the immune surveillance system, the immune system will store the memory of the malignancy. This means if a circulatory tumor cell starts to colonize new tissues, the immune surveillance system will be alerted.

Cancer cells produce exosomes that downregulates natural killers. This needs to be holistically addressed.


The upregulating of anti-tumor genes like the P-53 and P-21 (both of which control apoptosis, inter  alia) and the downregulating (dormancy) of tumor genes (oncogenes)  like the RAS genes are as important as the enhancing of repair and longevity genes insofar as cancer control and reversal are concerned.

11.  Glycoprotein Pump and microtubules

Cancer cells have this pump that removes toxic material like chemo drugs. Even though chemo kills a big part of the tumor cells, it doesn’t get rid of the cancer stem cells. Microtubules are the cells skeleton. Both these aspects need to be holistically addressed.  do


Cancer stem cells have been shown to be the engine of metastasis. It is therefore imperative to target both monitor the amount of circulatory tumor cells that are in the bloodstream and to find strategies that will eliminate them.


 This protocol looks into  anti-mitotic substances as well as  anti-cancer proliferation techniques, from electric regulation, electro-acupuncture, to oxygenation improvement, cellular homeostasis, atp normalization and selective malignant cyto-toxic natural substances that remove metastasis and induce apoptosis  among cancer cells. .


The evidence shows that those who exercise moderately fare better. To energy and immune boosting exercise, can be added massage, lymph activation, spinal adjustment, sacral cranium work, acupuncture, pmef, frequency modalities among other techniques. Brittle bones are often a consequence of both cancer treatment and the malignancy process. The patient needs therefore to strengthen the bones and all the more so that cancer in the bones is a painful episode. More on physiotherapy and heliotherapy


Oxygen being a key player in the recovery process, this protocol investigates different modalities of oxygen intake, from the HBOT (hyperbaric oxygen chamber), to the floating chamber, to the altitude chamber, to aromatherapy, the Bol de Jacquier technique, breathing exercises and more


Depending on the cancer and the patient, different supplements, neutraceuticals, mushrooms and herbs can be indicated. In this protocol, we examine which are the most useful and which have the most scientific backing.


Inflammation and lack of oxygen via tumor blockages create pain. It is therefore useful to know what integrative and holistic techniques exist to control and reverse pain without depressing the immune system or affecting nefariously other bodily functions. As for cachexia (muscle-wasting), this is an end-stage cancer hallmark that can often be better controlled and even reversed. Tumor Lysis (also called cancer “die-off”) is important because if there are too much necrotic cancer tissues in the bloodstream, the kidneys can get overwhelmed, among other nefarious consequences.


On integrative oncology

When  needed, the “best of the two worlds” approach (3) can be indicated. In this field,  low dose cytotoxic chemo and radiation (i.e., chemo-radiation) can be associated to hyperthermia, intermittent fasting, antioxidants, autophagy modulators and insulin potentiation therapy (IPT). Allopathic oncology’s cancer drugs can also be safer and more effective in combination, either with other drugs targeting complementary pathways or with neutraceuticals (supplements) and foods.  Low dose Naltrexone, Alpha Lipoic Acid, Vitamin C & K,  DCA, genestein, poly-mva, cannabinoids, anti-fungals, and many other molecules like metformin can be envisioned in the integrative oncology perspective.  (4)


As for the more conventional and somewhat invasive targeted therapies, in exceptional circumstances, these techniques can also be envisaged. Anti-angiogenesis targeted drugs like avastin, or growth factor inhibitors like Herceptin (e.g. HER2 + for breast cancer) or EGFT blockers among many others can as a last resort and-or as adjunctive care be considered when the more holistic and less invasive primary treatments fail. In this case, advanced monitoring of key cellular events occurring in each particular tumor category (tissue, cells, stage, autophagy levels, ROS levels etc) would be necessary to regulate the balance between ROS accumulation and ROS-induced autophagy or apoptosis and induce cancer cell death and tumor regression in vivo. (5) In this allopathic perspective, genomic individualized testing may also be needed in order to first know how the patient’s genes and proteins will react to a given drug or molecule.

The future of allopathic cancer treatment will require more and more the development of this genomic-based personalized medicine. (6)

However, with the patient’s full compliance and pro-active upbeat attitude, he or she may be able to control and reverse the malignacy, even advanced cancers, with less invasive and more holistic, safe, efficient and cost-friendly techniques, the monitoring of which is crucial. (See ACR Institute diagnosis and monitoring tests for different tests). Given cancer’s exponential growth, time is of essence, therefore, regular monitoring is important, including, but not limited to the monitoring of circulatory cancer stem cells, as they are responsible for micro-metastases. This way, when we see good lab results, we can feel confident that the chosen protocols are working. Everyone one is different, therefore an individualized approach is important. The ACR Institute’s 15 Sections are but general categories, each of which needs to be uniquely applied by the patient and with  the experienced guidance of a competent health-care practitioner.

Christian Joubert (ACR and HM Institutes Director)


(1). A special agent of our immune system, called cytotoxic T cells, seeks out and destroys foreign or detrimental cells—including cancer cells—that might be lurking in the body, a process that takes about 10 minutes from detection to death. These T cells endure cancer and damaged cells to commit suicide via apoptosis. See ACR Institute’s education videos on this T cell’s performance wherein we see a cytotoxic T cell targeting directly a cancer cell which goes into an explosive apoptosis “finish”. This cell testimony is proof that one of the keys to reversing the cancer epidemic has been neglected for too long. At ACRI, we prioritize the study of any and all credible immune-therapy option that addresses safely and efficiently the body’s innate immune system. Once the immune system is restored, it is not only possible to durably prevent most cancers, but it is also possible to start reversing the cancers that exist and all the more so human innate immune systems can store the memory of all antigens, including cancer cells, thereby ensuring sustainable protection.

(2).  Although To date the exact molecular mechanism by which macrophages recognize and phagocytose tumor cells remains unclear, we nonetheless know that these macrophages do ingest tumor cells. One of the mechanisms by which this process has been partially elucidated is via the  activation of Toll-like receptor (TLR) pathways, thanks to which  macrophages can induce the phosphorylation of Bruton’s tyrosine kinase (Btk), which then catalyzes cell-surface exposure of calreticulin. Calreticulin  secreted by macrophages plays a critical role in mediating adjacent tumor cell recognition and phagocytosis. Mingye Feng et al, Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk, Proceedings of the National Academy of Sciences of the United States, (2014) Source

(3). One of the fundamental principles of holistic medicine is to bring back the “joie de vivre” (i.e. enjoyment of life) element in medicine. We maintain that this “placebo” element is often more therapeutic than many invasive conventional anti-cancer therapeutics that use necro-interventions and nocebo-policies without fully respecting Dr Hippocrates’s “primum non nocere” rule (i.e., “first do no harm”).

(4). The science that comes out of Academia, Bio-tech companies’ R & D, the government’s cancer research centers are often relevant in terms of better understanding cancer’s diagnoses, its mechanisms of action and even regarding cancer control interventions.  But what the Industry chooses to invest in is necessarily selected, first and foremost in terms of profitability. Thus, the proposed double-blind based “standards” almost always extend time without fully reversing the malignancy.  As a consequence, it is reasonable to use the best of the two worlds. Conventional science to better understand cancer’s behavior and to control cancer growth in conjunction with holistic tradition and wisdom in order to know what intervention can be the best standard of care for the patient and the reversal of the malignancy.

(5). For example, depending on the drug used, ROS (ie, reactive oxygen species)  or autophagy can favor or inhibit the applied treatment. Therefore a potential new way of cancer treatment might be to include antioxidants or autophagy inhibitors to inhibit cytoprotective ROS-induced autophagy during the course of treatment. Cf. Poillet-Perez L1, Despouy G1, Delage-Mourroux R1, Boyer-Guittaut M2. Redox Biol. 2015;4:184-92. Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy. Redox Biol. 2015;4:184-92.

 (6). There are many other aspects to cancer control and reversal that can need prompt attention, one of which is the repairing and-or correcting of allopathic oncology’s damages, when possible, from cancer wounds that don’t heal well, to traumatizing surgeries, to radiation fibrosis, to chemo brain fog, to immune and gut destruction and cancer stem cell spread.  See ACR Institute’s European campus for the details.

This type of cancer approach, which is the Institute’s speciality, is illegal in the United States. However, the First Amendment guarantees its free expression.


Stem cell driver
Top, the cancer stem cell driver, a too often forgotten “actor”  in the malignancy process

Copyright (c) 2015: Advanced Cancer Research Institute, Christian Joubert and agents. All rights reserved. In terms of “fair use”,  the Institute allows the free use of this posted article provided it is not altered, full attribution is included as well as the Institute’s Post URL link. Furthermore, consistent with “fair use” case law,  small sections from the Institute’s posted article can be used as long as the above mentioned attributions are made and as long as the usage purpose is based on furthering education and science. For any other usage reason, written permission is required.

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