- 1 Section A
- 2 Introductory Remarks
- 3 Regulation: American exceptionalism
- 4 Glyphosate Inhibits the body’s Detox pathways
- 5 Section C
- 6 Avoiding Glyphosate
- 7 Section C
- 8 How to Detoxify from Glyphosate
- 9 General metabolic Detox Strategy
- 10 Binders
- 11 Microbiota
- 12 Discussion
- 13 Conclusion
- 14 General References
- 15 Where to get some of the recommended products
“Glyphosate is the world’s most widely produced herbicide, by volume. It is used extensively in agriculture and is also found in garden products in many countries. The chemical is an ingredient in Monsanto’s weedkiller product Roundup, and glyphosate has become more popular with the increasing market share of crops that are genetically engineered to be tolerant to the herbicide”.
Glyphosate, also known chemically as N-(phosphonomethyl) glycine is a broad-spectrum systemic pesticide/herbicide and crop desiccant. It belongs to the organophosphorus family of compounds.It was developed and discovered by Monsanto in 1970. (Source) and brought to market in 1974 under the trade-name Roundup. It is used to kill weeds that compete with crops. The crops that it is sprayed on include sugar, corn, soy and wheat, among others.
More than 130 countries permit the extensive use of glyphosate which makes it the most widely used herbicide in the world today. Twenty percent of the worlds Roundup is used in the United States. Latest statistics from the U.S. Geological Survey indicate that 280 million pounds were used in 2012 which is equivalent to about one pound per American. (Annual Agricultural Glyphosate Use in the United States for 2014 (Preliminary) (Source: U.S. Geological Survey)
Then a 2014 study showed glyphosate levels in mother’s breast milk 700 times higher than the maximum contaminant level (MCL) set for glyphosate by EPA (Source) Not only is this pesticide carcinogenic, it also deteriorates the tight junctions in the intestinal wall, thereby leading to leaky gut and over a dozen of other disease conditions. (Source)
In 2015 the World Health Organization’s cancer agency IARC declared that glyphosate is a probable human carcinogen.
Tests have shown that most Americans have glyphosate in their bodies. A Friends of the Earth Europe study done in 2013 tested urine samples from people in 18 countries for glyphosate. The results showed that traces of the chemical were found in samples from all countries. (Source)
Regulation: American exceptionalism
France’s highest court found Monsanto guilty of lying as far back as 2008 about the toxicity of it’s popular weedkiller, Roundup. “The court confirmed an earlier judgment that Monsanto had falsely advertised its herbicide as “biodegradable” and claimed it “left the soil clean” ( Source)
California recently became the first state to issue plans to list glyphosate as a chemical known to cause cancer according to EcoWatch. The use of glyphosate has nearly doubled from 95 million pounds in 2001 to nearly 185 million pounds in 2007, according to the latest released report form the EPA. This is in part due to the increase usage of Round-up Ready genetically modified crops during that same time period. Dr. Anthony Samsel and Dr. Stephanie Seneff state in their recent article published August 2015:
Glyphosate has a large number of tumorigenic [cancer-causing] effects on biological systems, including direct damage to DNA in sensitive cells, disruption of glycine homeostasis, succinate dehydrogenase inhibition, chelation of [minerals such as] manganese, modification to more carcinogenic molecules, such as N-nitrosoglyphosate and glyoxylate, disruption of fructose metabolism, etc…
Epidemiological evidence supports a strong correlation between the dramatic rise in use of glyphosate on crops and the multitude of cancers reaching epidemic proportions, such as breast, pancreatic, kidney, thyroid, bladder, and liver cancers.
Glyphosate Inhibits the body’s Detox pathways
Worse, glyphosate has proven highly toxic to the basic phase one detoxification of the liver, the cytochrome pathways. Below an excerpt from Entropy 2013, Glyphosate’s Suppression of Cytochrome P450 enzymes and amino acid biosynthesis by the gut microbe:
Glyphosate’s inhibition of cytochrome P450 (CYP) enzymes is an overlooked component of its toxicity to mammals. CYP enzymes play crucial roles in biology, one of which is to detoxify xenobiotics. Thus, glyphosate enhances the damaging effects of other food borne chemical residues and environmental toxins. Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body.
Text under construction
Shakeme pathway Seneli
Nearly one billion pounds of glyphosate are doused on both conventional and genetically modified crops world-wide each year but GMO crops receive the largest amounts. Processed foods undoubtable expose you to this toxic contamination, courtesy of wheat, corn, soy and the vegetable oil used. And the meats from conventionally raised animals in confined feed lots are given fed that contains glyphosate-laden corn and soy.
The most important thing to realize is that you cannot wash glyphosate off food since it is incorporated into each cell of plant.
Here are some tips to keep your diet free of glyphosate:
Only way to 100% eliminate from your diet is to avoid conventionally grown and processed foods
Glyphosate accumulates in animal tissues, so better to lean toward a plant-based diet.
The best way to avoid glyphosate is by avoiding GMO’s and all grains that get desiccated. Because glyphosate is applied by aerial spraying, many other non GMO crops have been contaminated. With rain run-off, even organic produce can be impacted.
How to Detoxify from Glyphosate
The way to survive all this exposure to toxic chemicals is to assist your body’s detox system, which is very overloaded. The two approaches are to 1) support your detox organs (liver/intesties and kidneys in particular, or to do things that remove toxics directly, such as taking liquid zeolite or spend time in a sauna.
The difficulty in choosing a detox for a particular substance is that you need to pick a detox that matches the characteristics of the toxic substance that needs to be removed.
Friends of the Earth Europe says, “Glyphosate (N-(phosphonomethyl)glycine) is a systemic, broad-spectrum herbicide, that works by blocking an enzyme used to make protein in plants. This means it is toxic to any plant that has not been genetically modified to resist it.”
Sachemé pathway, our bacteria microbiota.
The use of sauna, a mobilizer (homeopathic or laser detox), and zeolite to bind mobilized pesticides may be a good approach for detoxifying glyphosate. Vitamin E, zinc, and glycine are also helpful. Liposomal melatonin may be helpful as well
Spriulina Barley grass juice powder and chlorella regularly is said to detox glyphosate
Glyphosate’s is water soluble and it can be excreted in the urine. water-soluble toxins become fat soluble in the presence of fat-soluble toxins.
Glyphosate Detox Protocol
There are a number of different studies that claim that glyphosate accumulates in the bones, intestine, spleen, liver, muscle and kidney. Thus each of these tissues should be the target of detoxification.If a urine test is positive for glyphosate exposure, then the first stage of detoxification is to follow these guidelines:
General metabolic Detox Strategy
Infrared sauna for sweating out toxins
Probiotic foods and probiotic supplements to repopulate the microbiota which glyphosate destroys. Fibers too.
Organic foods rich in sulfur from both the allicin and cruciferious families
Key detox minerals: zinc, manganese, magnesium.
Researchers have investigated specifically how to the detoxify glyphosate from the human body. Although there are not many of these studies to date, more interest is being dedicated to finding natural substances that may detoxify glyphosate.
A combination of natural substances have been studied for reducing the activity of glyphosate in the gastrointestinal tract. These natural substances act as binders or neutralizers that could be a solution to remove the glyphosate contamination.
A study published in the December 2014 issue of the Journal of Environmental & Analytical Toxicology found that the oral application of certain natural substances were able effectively reduce urinary levels of glyphosate. The researchers used a combination of the following substances: fulvic acids, humic acids, activated charcoal bentonite clay and sauerkraut juice (Source)
The study used Schleswig Holstein cows suffering from symptoms of chronic botulism. They were fed sequentially with 400 g/animal charcoal daily for 4 weeks (weeks 1-4 of the study), 200 g/ animal charcoal (weeks 5-10 of the study), 200 g charcoal and 500 ml Sauerkraut juice/animal (weeks 11-14 of the study), 120 g/animal humic acids (weeks 15-18 of the study) 200 g charcoal and 100 mL Aquahumin/animal (weeks 19- 20 the of study), or 100 g charcoal and 50 mL Aquahumin (weeks 21-22 of the study) followed by 4 weeks without any supplementation.
There was a significant reduction of glyphosate in urine following supplementation with a combination of 200g charcoal plus either 500 mL sauerkraut juice or humic acid.
They concluded that a charcoal-sauerkraut juice combination and humic acids reduced glyphosate excretion by urine and led to the improved health of animals. (Source)
Another study from January 2011 published in the Journal of Occupational Medicine and Toxicology tested the common pathways of intoxication and detoxification in human embryonic and liver cell lines. The authors used various pollutants such as Roundup residues, Bisphenol-A and Atrazine, and five precise medicinal plant extracts called Circ1, Dig1, Dig2, Sp1, and Uro1 in order to understand whether specific molecular actions took place or not.
The analysis of underlying mechanisms revealed that plant extracts were not capable of preventing radiolabelled glyphosate from entering cells; however Dig2 did restore the CYP1A2 activity disrupted by Roundup, and had only a mild preventive effect on the CYP3A4, and no effect on the glutathione S-transferase. (Source)
Dig2 is a plant extract formula that is manufactured by Sevene Pharma Company. Dig2 consists of the following plant extracts: Taraxacum officinalis (Dandelion), Rhamnus frangula (Alder buckthorn), Raphanus sativus (Radish), Carduus marianus (Silybum marianum; milk thistle)
An interesting study from October 2010 published in the Journal of Occupational Medicine and Technology investigated the mechanism of action of liver cells exposed to glyphosate and possible protection by precise medicinal plant extracts called Dig1. (Source)
Glyphosate, in the form of the Monsanto product Roundup, is able to provoke intracellular disruption in hepatic (liver) cell lines at different levels, but a mixture of specific medicinal plant extracts can protect to some extent human cell lines against this toxin. The researchers tested the ability of a new natural substance formula called Dig1 to protect cells from glyphosate intoxication.Dig1 contains the following plant extracts: Taraxacum officinalis (Dandelion) Arctium lappa (Burdock root), Berberis vulgaris (Barberry; the active ingredient in barberry is berberine) and Chelidonium majus (Greater celandine) D ig1 is a mixture of diluted plant extracts obtained by Sevene Pharma (Monoblet, France) and were chosen by the researchers for their digestive detoxification or hepato-protective effects. Sevene Pharma markets Dig1 under the brand name Digeodren.
Dig1, non cytotoxic and not inducing caspases by itself, is able to prevent Roundup-induced cell death in a time-dependant manner with an important efficiency of up to 89%, within 48 hours. In addition, the researchers evidenced that it prevents Caspases 3/7 activation and CYP3A4 enhancement, and not GST reduction, but in turn it slightly inhibited CYP2C9 when added before Roundup. (Source)
Dig1 was also used in a study published in July 2016 the BMC Complementary and Alternative Medicine. In this study, written by most of the same authors of the October 2010 study, they tested the in vivo effects of Dig1 prior to and during 8 days of glyphosate intoxication in a total of 4 groups of 40 adult Sprague-Dawley male rats each. After treatments, horizontal and vertical locomotor activities of the animals were measured.
Dig1 did not have any physiological or biochemical observable impact alone at 2%. Out of a total of 29 measured parameters, 8 were significantly affected by R absorption within only 8 days. On these 8 parameters, only 2 were not restored by D (GGT activity and plasmatic phosphate), 5 were totally restored (horizontal and vertical locomotor activities, CYP2D6 activity, plasmatic Na + and estradiol), and the 6th was almost restored (plasmatic K+). (Source)
Thus, Dig1, without any side effects observable in these conditions, presented strong preventive and therapeutic properties in vivo after a short-term intoxication by the widely used pesticide Roundup.
Stephanie Seneff saying that glyphosate has nearly the same chemical formula as glycine. When glycine is not available, the next closest thing, glyphosate, is plugged into the slot in the DNA where the glycine should be. As a result, the sulfurtransferase enzyme does not work; thus, you don’t detox mercury very well. Therefore, I think it would be a good idea to consume glycine rich foods like gelatin, or maybe take a supplement
The most important thing to realize is that you cannot wash glyphosate off food since it is incorporated into each cell of plant. Here are some tips to keep your diet free of glyphosate: Only way to 100% eliminate from your diet is to avoid conventionally grown and processed foods Glyphosate accumulates in animal tissues, so make sure your meat was not fed GMO grains and your butter and dairy is organic Switch over to a 100% organic diet Take activated charcoal or rice bran powder in aiding elimination of organophosphates and glyphosate after exposure Maintain adequate mineral status by taking a multi-mineral supplement that includes trace minerals Support glutathione production with N-acetylcysteine, glycine and glutamine or oral liposomal glutathione Support phase 1 and phase 2 liver detoxification by avoiding alcohol and taking liver support, like silymarin, lipoid acid It is much harder to reverse damage once it’s done, so best to avoid glyphosate from the start—especially in children.
When glyphosate sticks around in the body, it prevents red blood cells from maintaining healthy levels of vitamin C, which is important not only for immunity but also for blood vessel and heart health. Glyphosate can further lead to fatty liver disease, as it disrupts fructose metabolism and sulfate synthesis.
Dr. Seneff recommends consuming a diet high in cholesterol, as glyphosate tends to strip this important nutrient from the body – seeing as how it’s a chelator and all. Eating wild-caught seafood and pastured, organic eggs is also important, as is consuming plenty of probiotic foods like yogurt, kefir, and kombucha, as well as sulfur-rich cruciferous vegetables like Brussels sprouts, broccoli, and cauliflower.
Supplementing with sulfur-containing supplements such as alpha-lipoic acid and methylsulfonylmethane, or MSM, will also help to replenish the minerals that are lost in the body as a result of glyphosate exposure. Be sure to also consume plenty of greens, herbs, and spices, including things like garlic, parsley, onions, cilantro, basil, and dandelion greens, all of which are powerful, natural detoxifiers.
Glyphosate is found regularly in food and water.
There is no safe level of glyphosate according to independent science
Glyphosate is probably a hormone hacker (endocrine disruptor) according to independent science.
90 % of the soybeans and 70 % of the corn and cotton grown in the United States are glyphosate-tolerant GM crops.
Monsanto’s Roundup herbicide is the world’s top-selling weed killer. Its active ingredient is glyphosate.
The global glyphosate herbicides market was valued at USD $ 5.46 billion in 2012 and is expected to reach USD $ 8.79 billion by 2019. That will but many politicians.
Glyphosate-tolerant GM crops represent more than 80% of the 120 million hectares of GM crops grown annually worldwide.
Based on the scientific studies to-date, there are a number of natural substances that have shown positive results in detoxifying and reducing the toxic effects of glyphosate exposure.Foods: Raphanus sativus (Radish), the allium and cruciferous family. Probiotic foods: Sauerkraut and sauerkraut juice Minerals Sulfur (Methylsulfonylmethane (MSM)), Manganese, Fulvic acid, Humic acid: Charcoal and Clay Activated charcoal and Bentonite clay Herbs: Taraxacum officinalis (Dandelion), Rhamnus frangula (Alder buckthorn), Raphanus sativus (Radish), Carduus marianus (Silybum marianum; milk thistle), Arctium lappa (Burdock root), Berberis vulgaris (Barberry; the active ingredient in barberry is berberine), Chelidonium majus (Greater celandine)
Ch. Joubert (HM Institute Director)
For Glyphosat Testing, see this link.
For additional info on Glyphosate’s rule in over 15 diseases, see this link.
The Mineral Power for Your Body’s Electrical Supply | Stephanie Seneff | TEDxNewYorkSalon
The Health Dangers of Roundup (glyphosate) Herbicide. Jeffrey Smith & Stephanie Seneff
Stephanie Seneff, PhD on Glyphosate (RoundUp) Poisoning
Understanding Glyphosate: Presence in Foods and Potential for Influence on Human Health
Where to get some of the recommended products