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Probiotics

Probiotics are live microorganisms intended to provide health benefits when consumed, generally by improving or restoring the gut flora.[1][2][3][4] Probiotics are considered generally safe to consume, but may cause bacteria-host interactions and unwanted side effects in rare cases.[5][6][7]

History-wise, the medical importance of probiotics is generally attributed to Pasteur Institute in Paris, in  particular  to Nobel laureate Élie Metchnikoff who worked full time at the Institut Pasteur. Metchnikoff  felt that yoghurt-consuming Bulgarian peasants lived longer lives because of probiotics 8] In 1907, he wrote: “[T]he dependence of the intestinal microbes on the food makes it possible to adopt measures to modify the microbiota in our bodies[,] and to replace the harmful microbes by useful microbes.”[9]

A growing probiotics market has led to questionable products though, including pasteurization after having added probiotics to synthetic hormone and antibiotic-full dairy . [3]

Mainstream’s Deceptive Claims and Studies

In the Mainstream, misleading information is dessimiated alleging that probiotic products don’t reduce gastrointestinal discomfort, dont improve immune health, nor do they relieve constipation, or avoid the common cold. [3][10][11]  The Federal Trade Commission has also contributed in the mis-information.[12]

In a clinical setting however, probiotics have been found to be useful in treating specific medical conditions, such as antibiotic-associated diarrhea in children[13] and Clostridium difficile infection in adults.[14] One concern is that probiotics taken by mouth can be destroyed by the acidic conditions of the stomach. But this is claim is not supported by the evidence. Different studies show that part of the ingested probiotics make it to the small intestine. (Source) Furthermore,  there are micro-encapsulation techniques to bypass gastric juices. .[15]

Generalities and Benefits

An October 2001 report by the World Health Organization (WHO) defines probiotics as live microorganisms that, “when administered in adequate amounts, confer a health benefit on the host.”[16][4] Following this definition, a working group convened by the Food and Agriculture Organization (FAO)/WHO in May 2002 issued the Guidelines for the Evaluation of Probiotics in Food.[17] A consensus definition of the term probiotics, based on available information and scientific evidence, was adopted after the aforementioned joint expert consultation between the FAO of the United Nations and the WHO. This effort was accompanied by local governmental and supra-governmental regulatory bodies’ requirements to better characterize health claims substantiations.

That first global effort was further developed in 2010; two expert groups of academic scientists and industry representatives made recommendations for the evaluation and validation of probiotic health claims.[18][19] The same principles emerged from those two groups as were expressed in the “Guidelines” of FAO/WHO in 2002. This definition, though widely adopted, is not acceptable to the European Food Safety Authority (EFSA) because it embeds a health claim that is not measurable.[3]

A group of scientific experts assembled in London on October 23, 2013, to discuss the scope and appropriate use of the term probiotic. That meeting was motivated by developments in the field that followed the formation of the 2001 definition, and the panel’s conclusions were published in June 2014.[2]

Live probiotic cultures are part of fermented dairy products, other fermented foods, and probiotic-fortified foods.

Some fermented products that contain lactic acid bacteria (LAB) include: vegetables such as pickled vegetables,[20] kimchi,[20][21] pao cai,[22] and sauerkraut;[23] soy products such as tempeh,[24] miso,[25] and soy sauce;[26] and dairy products such as yogurt, kefir,[27] and buttermilk.[28]

The manipulation of the gut microbiota is complex and may cause bacteria-host interactions.[7] Though probiotics are considered safe, some have concerns about their safety in certain cases.[7][29] Some people, such as those with immunodeficiency, short bowel syndrome, central venous catheters, cardiac valve disease and premature infants, may be at higher risk for adverse events.[5] In severely ill people with inflammatory bowel disease there is a risk of the passage of viable bacteria from the gastrointestinal tract to the internal organs (bacterial translocation) as a consequence of bacteremia, which can cause adverse health consequences.[7] Rarely, consumption of probiotics by children with lowered immune system function or who are already critically ill may result in bacteremia or fungemia (i.e., bacteria or fungi in the blood), which can lead to sepsis, a potentially fatal disease.[6]

It has been suggested that Lactobacillus contributes to obesity in humans, but no evidence of this relationship has been found.[30]

In 2015, the global retail market value for probiotics was US$41 billion, including sales of probiotic supplements, fermented milk products, and yogurt, which alone accounted for 75% of total consumption.[31] Innovation in probiotic products in 2015 was mainly from supplements, which produced US$4 billion and was projected to grow 37% globally by 2020.[31] Consumption of yogurt products in China has increased by 20% per year since 2014.[32]

The European Food Safety Authority has rejected all petitions by commercial manufacturers for health claims on probiotic products in Europe due to insufficient research, and thus inconclusive proof of effectiveness.[3][33] Occurring over many years, the scientific reviews established that a cause-and-effect relationship had not been sufficiently proven in the products submitted.[33] The European Commission placed a ban on putting the word “probiotic” on the packaging of products because such labeling misleads consumers to believe a health benefit is provided by the product when no scientific proof exists to demonstrate that health effect.[3][34][35][36]

In the United States, the FDA and Federal Trade Commission have issued warning letters and imposed punishment on various manufacturers of probiotic products whose labels claim to treat a disease or condition.[11][12][37] Food product labeling requires language approval by the Food and Drug Administration, so probiotic manufacturers have received warning letters for making disease or treatment claims.[11][37] The Federal Trade Commission has taken punitive actions, including a US$21 million fine coordinated by 39 different state governments against a major probiotic manufacturer for deceptive advertising and exaggerated claims of health benefits for a yogurt and probiotic dairy drink.[12

The National Yogurt Association (NYA) of the United States gives a Live & Active Cultures Seal to refrigerated yogurt products that contain 100 million cultures per gram, or frozen yogurt products that contain 10 million cultures per gram at the time of manufacture.[38] In 2002, the US Food and Drug Administration (FDA) and World Health Organization recommended that “the minimum viable numbers of each probiotic strain at the end of the shelf-life” be reported on labeling,[39] but most companies that give a number report the viable cell count at the date of manufacture, a number that could be much higher than what exists at consumption.[40] Because of the variability in storage conditions and time before eating, it is difficult to tell exactly how many or how much active culture remains at the time of consumption.

Probiotics have received renewed attention in the 21st century from product manufacturers, research studies, and consumers. The history of probiotics can be traced to the first use of cheese and fermented products, that were well known to the Greeks and Romans who recommended their consumption.[41] The fermentation of dairy foods represents one of the oldest techniques for food preservation.[42]

The original modern hypothesis of the positive role played by certain bacteria was first introduced by Russian scientist and Nobel laureateÉlie Metchnikoff, who in 1907 suggested that it would be possible to modify the gut microbiota and to replace harmful microbes with useful microbes.[9] Metchnikoff, at that time a professor at the Pasteur Institute in Paris, proposed the hypothesis that the aging process results from the activity of putrefactive (proteolytic) microbes producing toxic substances in the large bowel. Proteolytic bacteria such as clostridia, which are part of the normal gut microbiota, produce toxic substances including phenols, indols, and ammonia from the digestion of proteins. According to Metchnikoff, these compounds were responsible for what he called intestinal autointoxication, which would cause the physical changes associated with old age.[43]

It was at that time known that milk fermented with lactic-acid bacteria inhibits the growth of proteolytic bacteria because of the low pHproduced by the fermentation of lactose. Metchnikoff had also observed that certain rural populations in Europe, for example in Bulgaria and the Russian steppes, who lived largely on milk fermented by lactic-acid bacteria were exceptionally long lived. Based on these observations, Metchnikoff proposed that consumption of fermented milk would “seed” the intestine with harmless lactic-acid bacteria and decrease the intestinal pH, and that this would suppress the growth of proteolytic bacteria. Metchnikoff himself introduced in his diet sour milk fermented with the bacteria he called “Bulgarian Bacillus” and believed his health benefited. Friends in Paris soon followed his example and physicians began prescribing the sour-milk diet for their patients.[44]

Bifidobacteria were first isolated from a breast-fed infant by Henry Tissier, who also worked at the Pasteur Institute. The isolated bacterium named Bacillus bifidus communis[45] was later renamed to the genus Bifidobacterium. Tissier found that bifidobacteria are dominant in the gut microbiota of breast-fed babies and he observed clinical benefits from treating diarrhea in infants with bifidobacteria.

During an outbreak of shigellosis in 1917, German professor Alfred Nissle isolated a strain of Escherichia coli from the feces of a soldier who was not affected by the disease.[46] Methods of treating infectious diseases were needed at that time when antibiotics were not yet available, and Nissle used the E. coli Nissle 1917 strain in acute gastrointestinal infectious salmonellosis and shigellosis.

In 1920, Rettger and Cheplin reported that Metchnikoff’s “Bulgarian Bacillus”, later called Lactobacillus delbrueckii subsp. bulgaricus, could not live in the human intestine.[47] They conducted experiments involving rats and humans volunteers, feeding them with Lactobacillus acidophilus. They observed changes in composition of fecal microbiota, which they described as “transformation of the intestinal flora”.[47] Rettger further explored the possibilities of L. acidophilus, and reasoned that bacteria originating from the gut were more likely to produce the desired effect in this environment. In 1935 certain strains of L. acidophilus were found very active when implanted in the human digestive tract.[48] Trials were carried out using this organism, and encouraging results were obtained, especially in the relief of chronic constipation.

Contrasting antibiotics, probiotics were defined as microbially derived factors that stimulate the growth of other microorganisms. In 1989 Roy Fuller suggested a definition of probiotics that has been widely used: “A live microbial feed supplement which beneficially affects the host animal by improving its intestinal microbial balance.”[49]Fuller’s definition emphasizes the requirement of viability for probiotics and introduces the aspect of a beneficial effect on the host.

The term “probiotic” originally referred to microorganisms that have effects on other microorganisms.[50] The conception of probiotics involved the notion that substances secreted by one microorganism stimulated the growth of another microorganism. The term was used again[51] to describe tissue extracts that stimulated microbial growth. The term probiotics was taken up by Parker,[52] who defined the concept as, “Organisms and substances that have a beneficial effect on the host animal by contributing to its intestinal microbial balance.” Later, the definition was greatly improved by Fuller,[49] whose explanation was very close to the definition used today. Fuller described probiotics as a “live microbial feed supplement which beneficially affects the host animal by improving its intestinal microbial balance.” He stressed two important claims for probiotics: the viable nature of probiotics and the capacity to help with intestinal balance.

In the following decades, intestinal lactic acid bacterial species with alleged health beneficial properties were introduced as probiotics, including Lactobacillus rhamnosus, Lactobacillus casei, and Lactobacillus johnsonii.[53]

Some literature gives the word a full Greek etymology,[54][55] but it appears to be a composite of the Latin preposition pro, meaning ‘for’, and the Greek adjective βιωτικός (biōtikos), meaning ‘fit for life, lively’,[56] the latter deriving from the noun βίος (bios), meaning ‘life’.[57] The term contrasts etymologically with the term antibiotic, although it is not a complete antonym. The related term prebiotic comes from the Latin prae, meaning ‘before’, and refers to a substance that is not digested, but rather may be fermented to promote the growth of beneficial intestinal microorganisms.[58]

As food products or dietary supplements, probiotics are under preliminary research to evaluate if they provide any effect on health.[3][59] In all cases proposed as health claims to the European Food Safety Authority, the scientific evidence remains insufficient to prove a cause-and-effect relationship between consumption of probiotic products and any health benefit.[3][33] There is no scientific basis for extrapolating an effect from a tested strain to an untested strain.[60][61] Improved health through gut flora modulation appears to be directly related to long-term dietary changes.[62] According to the National Center for Complementary and Integrative Health: “Although some probiotics have shown promise in research studies, strong scientific evidence to support specific uses of probiotics for most health conditions is lacking.”[1]

Claims that some lactobacilli may contribute to weight gain in some humans[63][64] are controversial.[65) but the totality of the evidence suggests that the right bacteria modulate weight correctly, whereby a fat person gets skinnier and a skinny person gets more chubby.

While the mainstrem still alleges that there is no good evidence that probiotics are effective in preventing or treating allergies,.[66] In the holistic field, there in an abundance of peer reviewed evidence that suggests that they are useful for allergies.

Antibiotics are a common treatment for children, with 11% to 40% of antibiotic-treated children developing diarrhea.[13] Antibiotic-associated diarrhea (AAD) results from an imbalance in the colonic microbiota caused by antibiotic therapy.[13] These microbial community alterations result in changes in carbohydrate metabolism, with decreased short-chain fatty acid absorption and osmotic diarrhea as a result. A 2015 Cochrane review concluded that a protective effect of some probiotics existed for AAD in children.[13] In adults, some probiotics showed a beneficial role in reducing the occurrence of AAD and treating Clostridium difficile disease.[14]

Probiotic treatment can reduce the incidence and severity of AAD as indicated in several meta-analyses.[67][68][69] For example, treatment with probiotic formulations including L. rhamnosus may reduce the risk of AAD, improve stool consistency during antibiotic therapy, and enhance the immune response after vaccination.[70]

The potential efficacy of probiotics to treat AAD depends on the probiotic strains and dosage.[71][72] One review recommended for children L. rhamnosus or Saccharomyces boulardii at 5 to 40 billion colony forming units/day, given the modest number needed to treat and the likelihood that adverse events are very rare.[13] The same review stated that probiotic use should be avoided in pediatric populations at risk for adverse events, such as severely debilitated or immune-compromised children.

Probiotic treatment of bacterial vaginosis is the application or ingestion of bacterial species found in the healthy vagina to cure the infection of bacteria causing bacterial vaginosis. This treatment is based on the observation that 70% of healthy females have a group of bacteria in the genus Lactobacillus that dominate the population of organisms in the vagina. Currently, the success of such treatment has been mixed since the use of probiotics to restore healthy populations of Lactobacillus has not been standardized. Often, standard antibiotic treatment is used at the same time that probiotics are being tested. In addition, some groups of women respond to treatment based upon ethnicity, age, number of sexual partners, pregnancy, and the pathogens causing bacterial vaginosis.[73] In 2013 researchers found that administration of hydrogen peroxide producing strains, such as L. acidophilus and L. rhamnosus, were able to normalize vaginal pH and rebalance the vaginal microbiota, preventing and alleviating bacterial vaginosis.[74]

The consumption of probiotics can also help to control high blood pressure.[75]

Preliminary human and animal studies have demonstrated the efficacy of some strains of lactic acid bacteria (LAB) for reducing serum cholesterol levels, presumably by breaking down bile in the gut, thus inhibiting its reabsorption (where it enters the blood as cholesterol).[76][77]

A meta-analysis that included five double-blind trials examining the short-term (2–8 weeks) effects of a yogurt with probiotic strains on serum cholesterol levels found a minor change of 8.5 mg/dL (0.22 mmol/L) (4% decrease) in total cholesterol concentration, and a decrease of 7.7 mg/dL (0.2 mmol/L) (5% decrease) in serum LDLconcentration.[78]

Hence, when eating animal flesh, having fermented foods with wine is indicated.

Some probiotics are suggested as a possible treatment for various forms of gastroenteritis,[79] and a Cochrane Collaboration meta-analysis on the use of probiotics to treat acute infectious diarrhea based on a comprehensive review of medical literature through 2010 (35 relevant studies, >4500 participants) reported that use of any of the various tested probiotic formulations appeared to reduce the duration of diarrhea by a mean of 25 hours (vs. control groups, 95% confidence interval, 16–34 hours), also noting, however, that “the differences between the studies may be related to other unmeasured and unexplored environmental and host factors” and that further research was needed to confirm reported benefits.[80][81]

Probiotics are commonly given to breast-feeding mothers and their young children to prevent eczema, but there is no good evidence they are effective for this purpose.[66][82]

Some strains of lactic acid bacteria may affect Helicobacter pylori infections (which may cause peptic ulcers) in adults when used in combination with standard medical treatments, but no standard in medical practice or regulatory approval exists for such treatment.[83]

Some strains of lactic acid bacteria (LAB) may affect pathogens by means of competitive inhibition (i.e., by competing for growth) and some evidence suggests they may improve immune function by increasing the number of IgA-producing plasma cells and increasing or improving phagocytosis, as well as increasing the proportion of T lymphocytes and natural killer cells.[84][85] LAB products might aid in the treatment of acute diarrhea, and possibly affect rotavirus infections in children and travelers’ diarrhea in adults,[84][85] but no products are approved for such indications. A large study demonstrated that probiotics may decrease dental caries in children.[86] Two reviews reported reduction of the incidence of respiratory-tract infections in adults.[87][88]

Probiotics do not appear to change the risk of infection in older people.[89]

On the contrary, the right probiotics enhances the elderly’s wellbeing and longevity. (Source)

Section under construction

Probiotics are being studied for their potential to influence inflammatory bowel disease. There is good  evidence to support their use in conjunction with standard medications in treating ulcerative colitis and no evidence of their efficacy in treating Crohn’s disease.[90][91][92]

A live formulation of lyophilized Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus bulgaricus, and Streptococcus thermophilus (VSL#3) has shown effectiveness in the clinical trials. [90][91]

Probiotics are under study for their potential to affect irritable bowel syndrome, although uncertainty remains around which type of probiotic works best, and around the size of possible effect.[90][93]

Ingestion of certain active strains may help lactose-intolerant individuals tolerate more lactose than they would otherwise have tolerated.[76]

Several clinical studies provide evidence for the potential of probiotics to lower the risk of necrotizing enterocolitis and mortality in premature infants. One meta-analysis indicated that probiotics reduce these risks by more than 50% compared with controls.[94]

A 2017 review based on moderate to low-quality evidences suggests that probiotics may be helpful in relieving pain in the short term in children with recurrent abdominal pain, but the proper strain and dosage are not known.[95]

The Mainstream experts again claim that there is no good evidence that probiotics are of benefit in the management of infection or inflammation of the urinary tract.[96] Nothing could be further from the scientific truth since the right probiotics have been shown to enhance the immune system’s role in removing infections and in healing intestinal permeability, another key health condition the mainstream official experts refuse to acknowledge, notwithstanding the preponderance of the published evidence that proves the existence of leaky gut and the anti-inflmmatory role of a probiotic-enriched  microbiota.

More later

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