For example, rat pups exposed to extensive maternal deprivation have enduring dendritic retraction in the PFC and increased anxiety-like behaviours. (Source). By contrast, exposure to a mild stress, for example when a juvenile monkey learns that the mother will return after a short period of separation, seems to encourage resilient responses to stress in adulthood. (Source) and reduces glucocorticoid receptor expression in the dorsolateral PFC. (Source) Likewise with the microbiota. Its genome can impact human motivation, if only because its millions of genes cross-talk to our 23,000 eukaryotic human genes. For example, an abundance of serotonin and dopamine neuropeptides are made in the gut depending on signaling molecules, which themselves depend on Lifestyle choices. This is relevant because the microbiota is directly linked to the brain via the nerve-rich enteric system and vagus nerve. And recent studies have shown that the “extreme” elderly have a set of microbiota that corresponds to those who are in their thirties while those who age in an accelerated way carry a microbiota habita characterized by a lack of diversity and an abundance of deleterious bacterial species. Furthermore, there are “fear-laden insecurity” issues that can subvert one’s JDV and consistently, though subconsciously feed the “disability” identity.
“These findings suggest that 2 forms of volitional medical self-sabotage—preventing wounds from healing and making medical situations worse on purpose—may be associated with and contribute to numerous physical symptoms on a review of systems. They also broach the deeper question of whether, in some patients, medical self-sabotaging symptoms and multiple self-reported symptoms in the review of systems purposefully function to engage health care professionals, maintain an illness identity, and/or self-sabotage a healthy lifestyle by promoting a sense of disability” Medically Self-Sabotaging Behavior and Multiple Symptoms on the Review of Systems (Source)
Subconscious’ programing or willful self-sabotage ?
The idea of “the saboteur within” sabotages conscious self-improvement efforts that express the Joie de Vivre (JDV) consciousness that is embedded within our genome and soul (ie, soul = consciousness minus (-) the “mind” = mindless awareness). Within this context, and according to the lastest findings of the “positive psychology” and “consciousnes” experts, the task of the subconscious is to record & interpret each experience and thereafter, file the data in the memory storage area or the brain-consciousness network for future reference and guidance. This means that regardless of right or wrong and good or bad, the subconscious files quanta of relevant information and personal “truths” that determines one’s future course of action. These truths may not necessarily be true when seen from someone else’s perspective, but as the subconscious has interpreted them, they are part of the “karma” and “survival” program that makes up one’s core belief system. In this perspective, as one goes through life’s adventures, the subconscious is continually referring to these records and then prompting the brain to signal to the body to produce the appropriate messaging chemicals, (ie, hormones, neurotransmitters, cytokines etc). Thereafter, the mind applies Reason to give meaning to the body’s cues.
When humans try to improve their lives, in particular nurture a behavior that is consistent with a healthy lifespan, their conscious mind will generally attempt to make new choices that may appear, for the subconscious, risky. As long as there is no real threat of a major change in the core belief system, the subconscious should not react. However, as one begins to get closer to making conscious core changes affecting one’s subconcious belief system, the subconscious tends to do whatever it takes to maintain the status quo. In psychological terms, this is called the “comfort zone” and explains why most people prefer the status quo and have a hard time nurturing a holistic lifestyle that would be more favorable to their goals of living a healthy long life.
The evidence suggests that the unwillingness to embrace positive change by adopting a holistic lifestyle does not appear to be motivated out of intentional “sabotage”. The subconscious appears to be merely doing its job of keeping its host aligned with the dusty “files” in the brain-consciousness network. If the prevailing files are mostly trauma, indoctrination, fear of excommunication from one’s group, mistrust from bad experiences, repeated criticisms from sabotaging family members (“you will never be able to acheive that”, “eat thy lard-laden cookie and be quiet”, “honor my idols” etc), then these recorded “files” would impact healthy lifespan decision-making. Likewise with files that are centered on one’s trust-laden upbringing, deep dreams, hidden passions, especially when the person is from 0 to 7 years old. Furthermore, certain species in mammilian microbiota communicate directly with the brain for the maintenance of the status quo. It’s been proven that humans have different species of bacteria which will produce chemicals to tell the human brain to crave for the foods they need to thrive and survive. And there are inflammatory and addictive foods that can also affect healthy lifespan behavior. For example, studies have shown that cortisol-rich and acidifying meats as well an excess hypoglycemia from refined sugar and even omega 6s long fatty acids that cross the brain blood barrier have promoted violent-types of behavior and unhealthy outcomes that hinder the person’s self-love potential. And the casein-morphine molecules of A1 cheese tend to be all the more addictive that it’s full of artificial hormones, antibiotics and other deleterious molecules.
“The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.” Nikola Tesla
The inner sabotage then appears to be less sabotage than a computer program to maintain the status quo and-or one’s core belief system as well as the deleterious “addiction” signals that appear to come from the gut’s microbiota and inflammatory toxic diets. Therefore, when and if the conscious being decides to behave in a way that is consistent with fulfillment, JDV, optimal health and longevity, he or she proactively needs to change the “core belief” program as well as the composition of the microbiota and his-her diet and lifestyle. The process for changing the subconscious’ “file-records” can be long and tedious if only psychotherapy, too much thinking and Big Pharma’s drugs are used. Worse, it’s been well established that psychotropic drugs tend to shorten healthy lifespans. However, with different consciousness and microbiota holistic techniques, it’s possible to activate a state of Consciousness or mindless awareness (ie, awareness without the thinking) that can help to promote the restoration of this “formless eternal Presence” different Consciousness experts like Deepak Chopra, Ekhart, Tanzi, Wayne Dyer, Boudhist, Tao & Zen masters recommend. Once this “space” of non-duality has been reached, then it is easier to reprogram the subconscious to be more proactive and positive. Furthermore, when the mind is cleansed of past constructs, traumas and negativities, it would appear that harmonic resonance raises the Field’s frequency, at which point the different sections of the brain get reconnected or rewired via the activation of billions of synapses. (cf, Dispenza’s work). At this point, according to Dispenza, a stronger harmonic resonance and frequency coherence ensue and that this awareness state can be expressed via millions of milli-volts measured via functional MRI. (cf Dispenza et al and Lipton). While some of these claims sound speculative and-or mystical, others appear to be grounded in Science.
In summary, the data seems to suggest that when diet and the body’s microbiota are out of whack and out of synch (ie, as well as the body’s hippocampus-pineal-adrenal-gonad axes and heart rate variabilities) and when the Conscious and Subconscious are not aligned, behavior tends to be self-sabotaging, not conducive to healthy lifespans, at which point low frequency living (characterized by deleterious habit, fear, intolerance, negativity, auto-immune diseases and sabotage, both of others and of self) appears to prevail. As a consequence, the JDV (joie de vivre) Consciousness can’t be expressed. There is also some evidence that shows a correlation between intense emotional “feel-good” intentions and synchronistic events, many of which can spur personal evolution in a way that is more consistent with growth, JDV, healthy lifespans and self-replication, in conformity with both Darwinian “science” and Biblical tradition. So intense “prayer” and the activation of different meditation and breathing techniques may be of benefit. In this Presentation, we will look at a few studies that support some of these claims and assumptions.
Proof that JDV Medicine is even better than General Wellbeing medicine
JDV (Joie de vivre) = Purposeful joy, holistically expressed in a meaningful “now” existence
The clinical evidence that Joie de Vivre (JDV) is superior to general wellbeing (satisfaction-based happiness) has been overwhelming for those on the terrain for millennia and millennia. Even the great historian Arnold Toynbee talked about this in his keen analyses on neolithic villages. The French historian Michelet as well. As did the Hebrew Flavius. But it’s only been since 2013 that scientists have been able to test this hypothesis and prove beyond any reasonble doubt that JDV (Joie de vivre) is the way to go in terms of metabolic smoothness and healthy aging. As stated, JDV is more than contentement, well-being, happiness or downing a glass of organic beer on a hot sunday afternoon. It is a state characterized by purposeful joy, holistically expressed in a meaningful “now” existence. JDV is beyond Existentialism, but there are teleological elements of existentialism therein.
In this perspective then, researchers from UCLA and the University of North Carolina put to the test this hypothesis, by comparing two groups of people, one happy in the mainstream tradition and the other super happy in the holistic tradition. What they showed was that the individuals who had high levels of what they called “eudaimonic well-being” (which in French would be translated by joie de vivre) showed very favorable gene-expression profiles in their immune cells. They had low levels of inflammatory gene expression and strong expression of antiviral and antibody genes. However, people who had relatively high levels of hedonic well-being (the type of happiness that comes from today’s consumption society spurred by selfies and auto-gratification behavior) showed just the opposite. They had an adverse expression profile involving high inflammation and low antiviral and antibody gene expression.
“To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.” (Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13684-9.”A functional genomic perspective on human well-being”. (Source)
Now that the entire human genome has been mapped, we can ascertain with a strong sense of certitude to what degree this genetic bleuprint is fluid, dynamic and “open” to human consciousness, mindful awareness, hutzpah and creative imagination, the same one that assisted Professor Einstein in ascertaining his E = MC2. In this perspective, what this experimentation proved was that the genetic expression of the Life Code depends less on the evolutionary principle of adaption than on a person’s passion, belief system, convictions, deep thoughts, feelings, moods, expectations and the like, all of which contribute to create a vibrational and sometimes healing “field”. Which is one reason why both placebo and nocebo effects have strong biochemical consequences. Just believing in the conventional doctor’s “terminal verdict” nocebo will put in place the very biochemical phases of accelerated aging and painful death.
How to Sabotage one’s Health-care Self Interests and go into Extinction
“It is believed that as much as 80% of all disease and illness is initiated and aggravated by stress.” The National Safety Council
In this section, we will review the new medical discipline called “psycho-neuro-endocrine-immunology”. Research in this field indicates that our thoughts and emotions can markedly affect the activity of the physiological systems (e.g., immune, endocrine, cardiovascular) connected to the brain. In other respects, neuroimaging studies of emotional self-regulation, psychotherapy, and the placebo effect demonstrate that mental events significantly influence the activity of the brain. In this context, we will look at case studies where people allow themselves to be stressed out, take in the Government’s sanctioned fast foods, quick allopathic fix medicine, pollution, statutory inanities, inter alia, thereby sabotaging their health, their family’s welfare and the integrity of future generations.
In other words, there is a price to pay when a person chooses to be conformist and well adapted to a toxic Society. I think it was Krishnamurti who said that being adapted to a sick society was no measure of health. In the same way, accepting most of the EPA, FDA, CDC, NIH, DEA’s USDA, Big business influenced norms with regard to public health and conventional medicine tends to invite more chronic diseases and accelerates aging and even the Society’s ultimate demise, just like in Rome and other civilizations that have deviated from holistic lifestyles.
Integrative Versus Conventional Oncology Clinics: Strengths and Limitations
« …si j’avais un cancer, je n’irai jamais dans un centre anticancéreux classique. Seules les victimes du cancer qui vivent loin de ces centres ont une chance. » “If i had a cancer, i would never to to a conventional anti cancer center. Only cancer victims who live far from these centers have a chance”. (Source) Pr Georges Mathé (famous contemporary French oncologist)
For H.M. Institute, there is no question that integrative oncology’s modalities and clinics are much better than conventional oncology clinics. The well known Professor Georges Mathé (oncologist) used to say: “Si j’avais une tumeur, je n’irais pas dans un centre anticancéreux » (Le Monde, 4 mai 1998) (“If i had a tumor, i would not go to an anticancer center”) (Source). Among a few other French oncologists who have questioned the very legitimacy of conventional oncology’s thinking and modalities, I’m invoking Georges Mathé because he was recognized in the US as a cancer, stem cell and bone transplant pioneer in that he proved as early as 1963 that cancer was curable via the immune system. He also demonstrated that stem cells could both heal radiation damage and fight cancer. Dr. Joseph H. Antin, chief of stem cell transplantation at the famous Dana-Farber Cancer Institute in Boston, summed up Mathé’s work: “It was quite a leap of scientific genius. He’s one of the original innovators. Much of what we have accomplished can be linked back in a fairly direct way to the work that he did in the 1950s and ’60s.” (“Dr. Georges Mathé, Transplant Pioneer, Dies at 88”. New York Times, Source).
However, because American integrative oncology clinics are required by law to not deviate from the standard of care, their experts are still necessarily tied to some toxic and-or invasive treatments, often by necessity in order not to loose their license. Moreover, integrative oncology clinics focus mostly on trying to mitigate and repair the collateral damages that is precipitated by the State’s conventional weapons of mass cellular death while continuing to follow the conventional standard of care, whether it be chemo, radiation, surgery or another hi-tech conventional modality. Furthermore, I have seen outdated and unsubstantiated “integrative oncology” practices and for the most part, this type of oncology remains intrinsically stressful, in that most of the integrative alternative treatments costs are not covered by Medicare, Medicaid or private insurances. In reality, as mentioned before, the “zip code” (social status) is key. Most cancer patients can’t pay 200 to 500 dollars an hour for integrative oncology consultation fees, let alone 1500 dollars for one IPT (insulin potentiated therapy) I.V.. And for those who are not wealthy who do make that sacrifice, the financial burden tends to become so stressful that they can’t even afford to eat organic, destress with wome quality beach time let alone sleep deep with equanimity, being worried about finance. Thus, the Happiness Medicine Institute prefers holistic and happiness medicine first. Bottom line: While some of these integrative oncology and even “anti-aging” clinics appear to be useful in comparison to conventional oncology clinics, the H.M. Institute recommends first informed self-care on the part of the patient with holistic guidance based on hard evidence and friendly alertness.
In this perspective, a holistic practitioner will teach the patient how to gently outsmart cancer by switching off the expression of cancer’s oncogenes as well as certain cancer pathways and enzymes, including, but not limited to nagalese. Holistic cancer patients also learn how to activate their own longevity and tumor suppressor genes and renew their red and white blood cells with holistic stem cell therapy, to the point where cancer patients will be able to put in place new defense and dendritic-based surveillance networks that will help with both the body’s autophagy-based clean-up system as well as with the immune system’s recognition of cancer cells. Just like in war, to fight cancer’s symptomatology with conventional weapons of mass cellular destruction tends to make both nefarious bacteria and cancer cells stronger, more inflammatory and more virulent in the vast majority of cases. And yes, there are deep connections between bacteria and cancer, some of which have only been recently identified. Medically speaking, in the field of systemic cytotoxic chemotherapy, this process is called “chemo-resistence”, a medical epiphenomenon that has proliferated within cash-flow based conventional oncology for the last sixty years, the evidence is compelling on this question as we will see via power point slides.
Furthermore, most of the State’s licensed conventional oncology experts not only never address the deep root causes of cancer, but they summarily reject alternative and holistic approaches that do. In integrative and holistic oncology, there are hundreds of proven integrative and holistic techniques that have been successful in controling and treating cancer without the use of conventional medicine’s toxic modalities, some of which are detoxification, hyperthermia, aromatherapy, oxidative therapies (eg, hbot, ozone, hydrogen peroxide, high dose pro-oxidant vitamin C and others), natural anti-fungal substances, phytotherapy (herbs and formulas like those of Drs Méssegué, Lévy, Lautier, Hoxey or from the Canadian Essiac nurse) enzymes, different supplements (artemisia – from which the med. artesunate comes from –, selenium, amygdaline, benzaldehyde, berberine, mistletoe, DCA, PMVA, MCP, ribose, Key vitamins and minerals, probiotics, botanical-based IPT, PH therapy, clinical nutrition, (ie, including protein restricted, raw-vegan, cultured Mediterranian and ketogenic diets, for certain malignancies), “glutamine, IGF-1 & mTOR” inhibition, restricted caloric nutrition, targeted juicing, stress management, exercises, wild seeds, cordyceps fungus, tree mushrooms, dentretic cell strategies and many other holistic interventions that target the so-called “hallmarks” of oncogenesis’ engines and their signaling, from angiogenesis to metastases and another dozen pathways. In this perspective, thermal therapy, inflammation inhibition and vibrancy (electromagnetic) enhancement strategies are three important statagems that most American conventional oncologists miss. Hyperthermia, a German and French speciality and electro-medicine (a French and Israeli speciality) have had great results with cancer control and reversal, especially when these are combined to clinical nutrition, inter alia.
“Cancer-related frequencies appear to be tumor-specific and treatment with tumor-specific frequencies is feasible, well tolerated and may have biological efficacy in patients with advanced cancer. (Source) (See also the acupuncture litterature, electro-magnetic technology and tumor treating fields for other electro-medicine examples)
One reason most conventional oncologists refuse to try, even “off-label” many of the integrative and holistic cancer therapies that are supported by Science is because of the way they were trained and not trained, in particular, most American MD physicians don’t understand or don’t want to understand that cancer is more of a lifestyle and metabolic disorder then a genetic one. Even though the genetic code matters with regard to carcinogenesis, the zip code and even more the holistic code are more important. Prefering to characterize cancer less as a DNA mitochondrial and cellular respiration dysfunction than as a nuclear genetic disorder should be at least recognized as a medical mistake. But, alas, good medicine continues to be sacrificed on the altar of greed, arrogance and the stubborn forces of ignorance. If anything, official cancer sites should at least inform people on a regular basis that two weeks of dietary change is enough to significantly reduce cancer biomarkers.
“They found that only two weeks of diet exchange was enough to change the makeup of the intestinal microbiota and affect a number of biomarkers associated with colon cancer risk. The rate of cell turnover in the intestinal lining, levels of fiber fermentation, bacterial metabolic activity, and inflammation all reflected the change in eating patterns”.(Source)
Same duty with regard to the evidence that within 30 to 90 days, most cancer patients who are compliant with proven holistic cancer protocols can have their malignancies safely and efficiently declared N.E.D. (no evidence of disease) with few if any recurrence risks. In this perspective, and among others scientists, Professor Ornish has proven with an overwhelming preponderance of the evidence that cancer genes and tumor suppress genes can be favorably modulated just with inexpensive holistic and happiness medicine, even without supplementation, let alone patented drugs, surgery, radiation, targeted therapies, genetic interventions, inter alia.
In this Presentation, we will give a few tips on how to holistically restore the body’s hijacked immune-surveillance mechanisms and revitalize the entire metabolism (the body’s “soil” or “bioterrain”) with holistic savoir-faire so that cancer can’t grow and in many cases, starts to shrink within 2 to 5 weeks. To help the workshopee understand that the human body has it’s own T-cell based “chemo” that selectively zaps cancer cells and creates a tag-based memory system to destroy these cells if they decide to reappear, we will show a short university-made video. Likewise with the proof that cancer is more of a mitochondrial disorder than a genetic one, (genes do matter, but they are downstream consequences, like tumors, part of symptomatology). If we have time, case studies and key cancer tests (including the genetic and supplement sensitivity Greek test as well as CTS, CSC, Phi, nagalese, oncoblot, French and European tests) and some of the latest holistic breakthrough protocols will be reviewed. To which we may include new findings with regard to focused sound therapy as well as other frequency and ultrasound modalities concerning tumor regression, angiogenesis, mestastatic control, the tumor micro-environment, epigenetics and the like. During Day three’s Seminar, we will finish and complete what was not finishied in this present Session. Meanwhile, the workshopee can check out H.M. Institute’s sister Cancer Research Institute via mouse click as well as its cancer documentary based on the interviews of over sixty cancer experts, from Gerson, Gonzalez, Bergson and Beljanski to Seigfried, Yu, Cousens, Weeks, Lucan, Simoncini and many others.
Session S: Regulating Cytokines, Optimizing balanced Hormones & Neuro-transmitters & Tweaking Longevity Genes
There are over fifty known hormones. Almost all affect personality and physiology. At least seven vary greatly with gender. With the gift of Life, we have been equipped with key messaging molecules, three are central: neurotransmitters, cytokines and hormones. With the passage of time, many of these molecules get roughed up and imbalanced. This is why these messaging molecules need regular holistic “tune-ups”, especially then someone is trapped in the vicious cycle of accelerated aging. By holistic tune-ups, we don’t necessarily mean hormone or even bio-identical hormone replacement therapies. We are first and foremost talking about epigenetical fine-tuning of molecules that help us to be in coherence with our purpose, thereby optimizing healthy longevity and JDV.
The Bliss Hormone Chemistry Network
The human body is equipped with dozens and dozens of key hormones and neuropeptides that need to be holistically tweaked, activated and balanced if humans are to live healthy lifespans with JDV to 120 and beyond in accordance to Genesis and human potential. The bonding and “love” chemical called oxytocin is key. This “double casquette” molecule is both a peptide hormone and a neuropeptide, as a result, its tasks are widespread and key, especially if humans are to shift from a morbid fear-based society to a more spiritual trust-based civilization. Not enough of it leads to distrust, fear and defeat, while just enough, the right balance will be conducive to bonding, trust and biological Life’s mission, self-replication.
Then we have the “mother” hormone, pregnenolone as well as the more common “trio soldiers”, estrogen, progesterone and testosterone, all of which are key for happy and healthy lifespans and offspring reproduction. Cortisol and thyroid hormones are also necessary as well as many other endogenous compounds that make up the human neuropeptide-hormonal communicatory network. When thyroid gland dysfunctions, the body’s entire metabolism is off. So this endocrine organ should be promptly fined-tuned. The adrenal glands often get exhausted and can’t produce enough of its stress-related hormones, as a result, energy exhaustion and mitochondrial dysfunction tend to follow. So it’s important to maintain healthy the thyroid and adrenal glands with the H.M Institute’s holistic restorative program. As for one of the “Kings” of the longevity hormones, DHEA, we need a separate section.
Exempted from classification as a controlled substance by Congress, thanks to powerful industry lobbying (DHEA’s chief protector was Senator Orrin Hatch of Utah, where supplement makers are heavily concentrated), DHEA can be acquired without a prescription while in Canada and many other countries, DHEA is available only by prescription. DHEA is the most abundant steroid hormone in the body. The supplements are made in labs from chemicals found in wild yams and soybeans. Endogenously, DHEA is made from cholesterol by multiple tissues, but essentially by the adrenal glands and is a precursor to 18 steroid hormones including the commonly known sex hormones estrogen and testosterone. That’s why it is known as one of the “Master Hormones” of our Body-Temple. Healthy DHEA production is critical for lean muscle development, fat burning, bone growth, cardiac-health, including nitric oxide production, bedroom gymnastics, skin health, immunity and more. (Source) . DHEA also provides protection against the effects of physical stress and inflammation.
However, just swallowing DHEA pills may not be the optimal way to boost one’s DHEA. The biochemistry is complex, and DHEA supplementation results are highly variable and regularly unpredictable. There may be better ways to up this hormone than via capsules. DHEA appears to also have biological effects independent of its conversion into other hormones. After age 25, DHEA production begins to decline, and by age 70 it typically has fallen by about 80 percent. People with certain major chronic diseases tend to have more rapid declines in DHEA. Many hormones and other compounds in the body also decline with age.
Human Growth Hormone (HGH)
Human growth hormone is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. Stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland, HGH is also a stress hormone in that it raises the concentration of glucose and free fatty acids while stimulating the production of IGF-1, which is also another powerful growth hormone. Many integrative medicine physicians have used HGH to help their older patients to have younger and sexier bodies. Especially since a 1990 NEJM published study showed that all of those who took this hormone got a younger body without significant side effects.
“The findings in this study are consistent with the hypothesis that the decrease in lean body mass, the increase in adipose-tissue mass, and the thinning of the skin that occur in older men are caused in part by reduced activity of the growth hormone—IGF-I axis, and can be restored in part by the administration of human growth hormone.1 , 2 The effects of six months of human growth hormone on lean body mass and adipose-tissue mass were equivalent in magnitude to the changes incurred during 10 to 20 years of aging” (Source)
Subcutaneous administration of recombinant biosynthetic human growth hormone was injected three time a week with no evidence of tachyphylaxis or hormone resistance or anything else of significance in terms of toxic side effects. The doses where not hefty, approximately 0.03 mg per kilogram which corresponds to a physiological dose.
However, in the U. S. of A, HGH prescribing medical doctors have often gotten their medical license suspended or revoked for having prescribed this peptide hormone. The only FDA-approved use of HGH is for replacement therapy in adults with GH deficiency of either childhood-onset (when a child does not grow) or adult-onset (usually as a result of an acquired pituitary tumor, that’s why Tony Robbins is so tall). While there are couple other “off label” uses, these are restrictive and for most anti-aging longevity uses, the prescribing doctor can get machine-gunned coerced into submission, his business shut down and jailed with hard-core criminals on felony charges. In 1990, the US Congress passed an omnibus crime bill, the Crime Control Act of 1990, that amended the Federal Food, Drug, and Cosmetic Act, that classified anabolic steroids as controlled substances and added a new section that stated that a person who “knowingly distributes, or possesses with intent to distribute, human growth hormone for any use in humans other than the treatment of a disease or other recognized medical condition, where such use has been authorized by the Secretary of Health and Human Services” has committed a felony”(Source).
On the other hand, for livestock use, bovine Growth Hormone (to increase the secretion of cow milk full time (360 days a year), inter alia), is fully legal, even if this type of modified milk spurs health problems, including cancers, in particular, breast, ovaries and prostate malignancies while significantly shortening the lives of these mother cow ruminants, inter alia. But for those anti-aging guerrilos who are not afraid of cancers and desire a younger sexy body, they can legally “cheat” by gulping down as much GH steroid-laden cow milk as their stomachs can handle. But the Happiness Medicine Institutes’ Executive Committee prefers to recommend more holistic ways to help the body produce this important hormone endogenously. In this Presentation, we will therefore examine holistic and natural ways to produce DHEA and HGH for the benefit of healthy longevity optimization, cow welfare and future generations.
The Vasopressin & Oxytocin
Vasopressin is made in the brain. Both men and women make it. However, just likek the female hormone estrogen synergiizes with oxytocin, the male hormone testosterone synergizes with vasopressin, the two greatly enhance each other. A woman and man might have equal levels of vasopressin but the man experiences stronger effects. Physically, vasopressin causes water retention and high blood pressure; high levels may increase forehead size. Personality wise, vasopressin influences male social and sexual behavior, public communication, and paternal behavior and more
The Oxytocin-Vasopressin Pathway in the Context of Love and Fear
“There is no fear in love: but perfect love casteth out fear”. (1 John 4: 18)
Oxytocin (OT) and vasopressin (VP) are ancient peptide molecules with many behavioral and physiological functions. These pleotropic peptides evolved from a single genetic source OT and VP, with their receptors, function as an integrated, adaptive system, allowing the mammalian body to survive, maintain homeostasis, and reproduce. For optimized results, need to be tweaked synergistically.
“..complex behavioral functions, including selective sexual behaviors, social bonds, and parenting require combined activities of OT and VP. The behavioral effects of OT and VP vary depending on perceived emotional context and the history of the individual.” Front Endocrinol (Lausanne). 2017; 8: 356. (Source)
Adding to the complexity of this pathway, the OT and VP receptors are quite variable and need to be epigenetically tuned. In this Presentation, we will look at a few techniques that optimizes this combo.
The Klotho Hormone
Klotho is a pleiotropic protein that circulates as a hormone following cleavage from its transmembrane form. It regulates insulin (Kurosu et al., 2005), Wnt (Liu et al., 2007), and fibroblast growth factor (FGF) (Urakawa et al., 2006) signaling. Overexpression of klotho extends life in organisms (Château et al., 2010, Kurosu et al., 2005), up to 31% in one study (Source), whereas lowering klotho shortens it (Kuro-o et al., 1997). Elevated klotho levels in humans, resulting from genetic variation (Arking et al., 2002, Dubal et al., 2014, Yokoyama et al., 2017), is also associated with longer lifespan (Arking et al., 2002, Invidia et al., 2010) in some populations. In model organisms and humans, levels of klotho decline with age (Duce et al., 2008, Semba et al., 2011), chronic stress (Prather et al., 2015), cognitive aging (Shardell et al., 2016), neurodegenerative disease (Semba et al., 2014), and models of neurodegenerative disease (Dubal et al., 2015, Massó et al., 2015). In addition, variations in the Klotho gene (SNP Rs9536314) are associated with both life extension and increased cognition in human populations. (Cf., Dena B. Dubal et al., Life Extension Factor Klotho Enhances Cognition, Cell Reports, 2014). In addition, several studies have shown promising results in the use of Klotho proteins as therapeutic agents to help in slowing down the progression of kidney diseases, diabetes, and cancer.
In this Presentation, we will show via power point different holistic techniques, nutrients and, among other elements supplements and that can significantly help to activate this protein-hormone. We will also learn what undermines this protein-hormone.
Neuropeptides, Neuro-transmitters & Healthy Longevity
Neuropeptides are small protein-like molecules (peptides) used by neurons to communicate with each other. They are neuronal signalling molecules that influence the activity of the brain and the body in specific ways. Different neuropeptides are involved in a wide range of brain functions, including analgesia, reward, food intake, metabolism, reproduction, social behaviors, learning and memory. Neuropeptides are related to peptide hormones, and in some cases peptides that function in the periphery as hormones also have neuronal functions as neuropeptides In this perspective, the human genome contains more than 70 genes that encode precursors of neuropeptides. At present about 100 different peptides are known to be released by different populations of neurons in the mammalian brain.
“…neuropeptides are the most diverse class of signaling molecules in the brain engaged in many physiological functions. According to this definition almost 70 genes can be distinguished in the mammalian genome, encoding neuropeptide precursors and a multitude of bioactive neuropeptides” (Methods Mol Biol. 2011;789:1-36)
Neurotransmitters are endogenous chemicals that enable neurotransmission. It is a type of chemical messenger which transmits signals across chemical synapses which are associated to neurons. Neurons form elaborate networks through which nerve impulses (action potentials) travel. Each neuron has as many as 15,000 connections with neighboring neurons. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available from the diet and only require a small number of biosynthetic steps for conversion. Neurotransmitters play a major role in shaping everyday life and functions. Their exact numbers are unknown, but more than 100 chemical messengers have been uniquely identified. (Source)
Excitatory and inhibitory processes
A neurotransmitter can influence the function of a neuron through a remarkable number of mechanisms. In its direct actions in influencing a neuron’s electrical excitability, however, a neurotransmitter acts in only one of two ways: excitatory or inhibitory. A neurotransmitter influences trans-membrane ion flow either to increase (excitatory) or to decrease (inhibitory) the probability that the cell with which it comes in contact will produce an action potential. Thus, despite the wide variety of synapses, they all convey messages of only these two types, and they are labeled as such. Type I synapses are excitatory in their actions, whereas type II synapses are inhibitory. Each type has a different appearance and is located on different parts of the neurons under its influence. Each neuron receives thousands of excitatory and inhibitory signals every second.
Biochemically derived from tryptophan, serotonin is a monoamine neurotransmitter that is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. It has a big job in helping animals experience feelings of well-being and happiness. It does have a drawback in that it can promote a feeling of obsession and addiction. But if the addiction is healthy wellbeing, then long live longevity addiction.
Dopamine is also an important neurotransmitter. The brain includes several distinct dopamine pathways, one of which plays a major role in the motivational component of reward-motivated behavior. The anticipation of most types of rewards increases the level of dopamine in the brain. The right quantity, a feel good “reward” type of feeling. As Jeanne Calment showed, it’s helpful to anticipate the daily “reward” of a big piece of dark non-GMO chocolate each day. According to her testimony, this holistic technique (of expecting each day something she considered to be a reward) helped to make her outlive her peers. Dopamine also modulates the sympathetic system. Disorders due to its deficiency include depression, sadness and parkinsonism. Dopamine affects movement, attention, learning, reinforcement and, inter alia, pleasure.
Acetylcholine: One of the major neurotransmitter in the brain, spinal cord and peripheral nerves. It also found in RBC’s and other cells in the body. It is synthesized in the neurons and released at nerve ending to pass on the nervous stimuli post synaptically. It is a part of parasympathetic system. It exerts actions opposite to that of sympathetic system. Acetyl choline is involved in almost all the body functions like heart beat, respiration, digestion, excretion, reproduction etc. Deficiency and rise in the levels of acteylcholine leads to many diseases and also toxic effects. Examples of diseases include parkinsonism, Alzheimer disease, glaucoma etc. Acetylcholine affects movement, learning, memory, REM Sleep and other processes.
Norepinpehrine: This also widely distributed like acteyl choline. It covers all of the sympathetic functions and has actions opposite to acetyl choline. Norepihephrine affects eating, alertness, wakefullness. Epinephrine is similar to nor-epinephrine in terms of actions and also chemistry. But it is present in more quantities in blood and peripheral body organs and to a small extent in brain. In periphery it is released by adrenal medulla. It is involved in stress regulation and is also called as flight or fight hormone. It acts through similar receptors as that of epinephrine. Its quantity levels rise is in the body is indicative of stress or struggle. Epinephrine also affects metabolism of glucose and energy release during exercise.
Serotonin: This is found in large quantities in intestine, platelets and also brain. It is an important transmitters in stress, mood and also coagulation. Its deficiency or change is seen in disorders like depression, schizophrenia etc. Gluatamate is a neurotransmitter found predominantly in brain. It is also an amino-acid. It is involved in memory and learning. When the brain undergoes oxygen deficient stress or physical injury its release in the extracellular space can be devastating leading to nervous tissue damage (excito-toxicity).
GABA (gamma amino benzoic acid) is another neurotransmitter present predominantly in brain. It acts to control nerve conduction and electric potential in the brain and also muscle tone. Its deficiency leads to epilepsy. It acts through GABA receptors. This neurotransmitter plays a key role in epilepsy or convulsion disorder. Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.
Because neurotransmitters are functionally integrated with the immune system and the endocrine system (including the adrenal glands), neurotransmitter imbalances can cause widespread health problems such as Brain fog: loss of mental focus, ADD, ADHD, impaired memory, poor decision making. Insomnia: difficulty falling asleep, staying asleep, or both; Pain: migraines, fibromyalgia, fatigue. Obesity: metabolic syndrome, insulin resistance, and diabetes; Mood disorders: depression, mood swings, irritabilit Anxiety: panic, obsessions, PTSD Behavioral disturbances addictions, binge eating, compulsions impulsivity, gambling, autism and more.
Cytokines Signaling Molecules, Cytokines-Storms, Inflammaging & the Body’s integrity
Cytokines are a broad group of signaling proteins that are produced transiently, after cellular activation, and act as humoral regulators which modulate the functions of individual cells, and regulate processes taking place under normal, developmental and pathological conditions (Dinarello et al. 1990; Meager 1998). Unlike hormones, cytokines are produced by cells which are not organized in special glands and which act systemically to affect biological phenomena such as inflammation, wound healing, organogenesis and oncogenesis. Cytokines include, but are not limited to chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors.
The Role of endogenous cytokines in premature death, disease, health and longevity
While cytokines are important for embryogenesis and fighting off infections and in other immune responses, they can get dysregulated, lose their balance, at which point conditions like inflammation, trauma, sepsis, schizophrenia, major depression, Alzheimer’s disease and, inter alia, cancer can ensue.
Homeostatic Imbalance and Cytokine-storms
Normal tissue integrity is preserved by feedback interactions between diverse cell types mediated by adhesion molecules and secreted cytokines, inter alia. Disruption of normal feedback mechanisms threatens tissue integrity. Over-secretion of cytokines can trigger a dangerous syndrome known as a cytokine storm which is seen in acute pancreatitis and other conditions. Cytokine storms are suspected to be the main cause of death in the 1918 “Spanish Flu” pandemic that killed over 50 million people within a short time. A cytokine storm is an overproduction of immune cells and their activating compounds (cytokines), which, in a flu-like infection for example, is often associated with a surge of activated immune cells into the lungs. The resulting lung inflammation and fluid buildup can lead to respiratory distress and can be contaminated by a secondary bacterial pneumonia, often enhancing the mortality in patients. (Source). Ironically, the stronger and healthier these victims were, the quicker they died. This is why so many young people with a strong immune system died during the Spanish flu. Recently, this 1918 flu virus was resussitated and injected to primate macaques. The results where as devastating as in 1918.
“Scientists said they were struck by how suddenly and overwhelmingly the 1918 flu struck seven macaques that were tested (…) The virus spread faster than a normal flu bug and triggered a “storm” response in the animal’s immune systems. Their bodies’ defenses went haywire, not knowing when to stop, researchers said. The lungs became inflamed and filled with blood and other fluids. (…) “There was some surprise that it was that nasty,” University of Washington virologist and study co-author Michael Katze said. “It was the robustness of the immune system that helped victimize them.” (Source)
With so many unhealthy conditions that pervade the American Nation, from over 80,000 unregulated toxic chemicals (toxicants), electrical pollution, chronic stress, massive autoimmunity, desertification, drought and bacterial resistance, it is likely that there will be in the not too distant future pubic health crises and cyto-storms that will lead hundreds of thousands if not millions of tax-paying Americans into the death throes of cyto-storms and other biological and chemical onslaughts. It will therefore be useful to teach a few holistic techniques which can turn off cytokines switches. Furthermore, as inflammation accumulates, even and especially slow-growing inflammation, aging accelerates. Biogerontologists call this condition “inflammaging”. In this Presentation, we will look at different holistic ways to turn “off” inflammatory switchs, thanks to which we can reduce premature senescence.
Case in Point: Sepsis
In order for the elderly and less elderly to achieve 120 years, they must be knowledgeable about what can quickly kill them. One of these quick-kill modalities is a trip to a conventional hospital where a patient can acquire some form of infection, and acquire sepsis. Sepsis is a common American cause of death in conventional hospitals. Each year, an estimated 1 million Americans get sepsis (Source) and up to half of them die from this condition and-or the conventional treatment. (Source) From a serious examination of the facts, it appears that Conventional hospital treatments for most chronic diseases, including sepsis are crafted more to maximize cash-flow than to optimize the People’s “blood-flow”, the public good, public health, good medicine, healthy longevity. According to the Agency for Healthcare Research and Quality, sepsis is the most expensive (i.e. lucrative) condition being treated in U.S. hospitals, costing more than $24 billion in 2014. (Source). A big proportion of the hospitalized elderly will die from this nosocomial disease. The condition becomes particularly deadly if the infection involves methicillin-resistant or vancomycin-resistant Staphylococcus aureus (MRSA or VRSA) bacteria, both of which, like cancer cells, have become resistant (stronger) to conventional medicine’s weapons of massive cellular destruction. These and other common hospital-acquired infections starts with symptoms of infection and can too often progress to septic shock, (Source) at which point the throes of death become a both a credible and creeping reality.
In effect, unless correctly (holistically) treated, sepsis can quickly result in extremely low blood pressure that is unresponsive to fluid replacement, that which weakens the heart and provokes multiple-organ failure and, inter alia, respiratory arrest. Other illnesses such as bronchitis, pneumonia, strep throat or kidney infection can lead to septic shock as well as certain localized infections caused by bacteria, fungi or viruses. As a result, vigilance and preventive proactiveness should always be one’s duty, especially if the infection is contracted in the hospital setting. There was a study I read years ago that showed a NYC hostical’s death curve going significantly down when its staff went on strike. This too is a relevant piece of evidence insofar as the limitations of conventional medicine is concerned.
In this Presentation, we will review what to do (and take) and not do (and not take) when one needs to be present in infected areas. As we saw in the case above on the Spanish Flu, “cytokine storms” usually hit the worse those who have a healthy immune system, so the holistic preventive and curative solutions are not always to have the strongest immune system, albeit robust immunity is needed for most conditions. Thereafter, we will hone in on different holistic treatments that can resolve infections in generals and sepsis in particular. While antiobiotics are not always counter-indicated, they should only be used at the last resort since holistic medicine can be much safer, cost-friendly and effective in resolving infections and septic shocks without damaging the human organism. Consultation with one’s competent holisticlly trained doctor is encouraged.
An estimated one third of the world’s population (or ≈500 million persons) were infected with the Spanish Flu (Source) during the 1918–1919 influenza pandemic. The disease was exceptionally severe. Case-fatality rates were >2.5%, compared to <0.1% in other influenza pandemics. Total deaths were estimated at more than 50 million and were arguably as high as 100 million. (Source) The impact of this pandemic was not limited to 1918–1919. All influenza “A” pandemics since that time, and indeed almost all cases of influenza “A” worldwide (excepting human infections from avian viruses such as H5N1 and H7N7), have been caused by descendants of the 1918 virus, including “drifted” H1N1 viruses and reassorted H2N2 and H3N2 viruses. The latter are composed of key genes from the 1918 virus, updated by subsequently incorporated avian influenza genes that code for novel surface proteins, making the 1918 virus indeed the “mother” of all pandemics, including future pandemics. In 1918, the cause of human influenza and its links to avian and swine influenza were unknown. That question did not begin to be resolved until the 1930s, when closely related influenza viruses (now known to be H1N1 viruses) were isolated, first from pigs and shortly thereafter from humans. Seroepidemiologic studies soon linked both of these viruses to the 1918 pandemic (Source) Subsequent research indicates that descendants of the 1918 virus still persists enzootically in pigs. They probably also circulated continuously in humans, undergoing gradual antigenic drift and causing annual epidemics, until the 1950s. With the appearance of a new H2N2 pandemic strain in 1957 (“Asian flu”), the direct H1N1 viral descendants of the 1918 pandemic strain disappeared from human circulation entirely, although the related lineage persisted enzootically in our swine cousins. But in 1977, human H1N1 viruses suddenly “reemerged” from a laboratory freezer (Source). They continue to circulate endemically and epidemically. H1N1 viruses descended from the 1918 strain, as well as H3N2 viruses, have now been cocirculating worldwide for three decades and show little evidence of imminent extinction. Vigilance is therefore recommended. In this Presentation, we will examine options people have if ever a virulent viral pandemic were to spread again. Including homeopathic options that were used in France during the 1918-19 viral attack. Difficult to achieve healthy 120 years lifespans if our bacteria and virus co-evolution partners (including in human microbiota) decide to reflect the sad state of human affairs, as they did during the First (technically the Fifth) World War, where chemical warfare and other barbaric weapons of massive cellular destruction were legally distributed by the misguided Governmet officials of those times. Activating Key Longevity Genes In this Presentation, we will focus on activating three families of Longevity genes: the 7 members Sirtuin family, the APOE tribe and the wild FOXOs, a few members of whom can be helpful insofar as keeping human cellular repair and other longevity systems in decent shape. FOXO4 for example is elevated in senescent cells. (Source). Thus, to efficiently address senescent cells, we must also modulate this SNP (gene variation). Among other examples, let us consider one FOXO activator that is presently in the public debate. SNPs, Methylation & other Pathways Section under construction FOXO3 Activators and Rejuvenation Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity. FOXO proteins represent a subfamily of transcription factors conserved from Caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin and insulin-like growth factor signaling. In particuar FOXO3 appears to be especially interesting for optimal longevity. “…Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample sizes, lack of precise phenotyping, and population stratification, among other challenges. Therefore, to more precisely assess potential genetic contributions to human longevity from genes linked to IIS signaling, we chose a large, homogeneous, long-lived population of men well-characterized for aging phenotypes, and we performed a nested-case control study of 5 candidate longevity genes. (….) Genetic variation within the FOXO3A gene was strongly associated with human longevity. The OR for homozygous minor vs. homozygous major alleles between the cases and controls was 2.75 (P = 0.00009; adjusted P = 0.00135). Long-lived men also presented several additional phenotypes linked to healthy aging, including lower prevalence of cancer and cardiovascular disease, better self-reported health, and high physical and cognitive function, despite significantly older ages than controls. Several of these aging phenotypes were associated with FOXO3A genotype. Long-lived men also exhibited several biological markers indicative of greater insulin sensitivity and this was associated with homozygosity for the FOXO3A GG genotype. Further exploration of the FOXO3A gene, human longevity and other aging phenotypes is warranted in other populations. (Source) In this Discussion, we will discuss what the ongoing research is with FOXO genes as well as holistic and nutritional approaches to activate and optimize the best of this Gene group. The Continuum of Ancestral Genes The genetic code appears to be nearly identical for all known lifeforms, from bacteria and archaea to animals and even plants, who have their own energy “mitochondria” in the form of chlorophyll-rich chloroplats, an immune and communicatory system and much more. The universality of this code is generally regarded by biologists as definitive evidence in favor of universal common descent. (Cf. “The universal nature of biochemistry”. Proceedings of the National Academy of Sciences of the United States of America. 98 (3): 805–08) This “common universal ancester” construct has been debated for a long time. (cf. Steel, Mike; Penny, David (13 May 2010). “Origins of life: Common ancestry put to the test”. Nature. 465 (7295): 168–169. doi:10.1038/465168a. PMID (Source). Common ancestery describes how, in evolutionary biology, a group of organisms share a most recent common ancestor. There is an abundance of evidence of common descent of all life on Earth from the last universal common ancestor (LUCA). (Source), whose gene pool (determined to be 355 groups of genes) continues to be shared by the genomes of the three main domains of life: archaea, bacteria, and eukaryotes. (Wade, Nicholas (25 July 2016). “Meet Luca, the Ancestor of All Living Things”. New York Times). From what the experts can tell, at this juncture, LUCA could have been a deep sea anaerobic bacteria or archaea that started to evolve within extreme deep ocean vents. Other experts claim that this universal ancester came from the Cosmos. Biologists often point to the universality of many aspects of cellular life as supportive evidence of this common Genetic Life Code. These similarities include the energy carrier adenosine triphosphate (ATP), and the fact that all amino acids found in proteins are left-handed, (and sugars right handed), including those amino acids that come from outer space. For example, the sirtuin gene group regulate important biological pathways in bacteria, archaea and eukaryotes. The name Sir2 comes from the yeast gene ‘silent mating-type information regulation 2’, which is the gene responsible for cellular regulation in yeast. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation[ and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis (Borenstein, Seth (13 November 2013). “Oldest fossil found: Meet your microbial mom”). In 1859, Charles Darwin published On the Origin of Species in which he twice stated the hypothesis that there was only one progenitor for all life forms. “Therefore I should infer from analogy that probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed.” (Darwin, Charles. On the Origin of Species. London: John Murray, Albermarle Street. 1859. pp. 484, 490) The last sentence of his book begins with a restatement of his hypothesis: “There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one…” (Ibid). However, as Darwin’s intellectual challenger Lamarck suggested, decades before Darwin wrote his treatise, the awesome force of cultural and family inheritance (a form of epigenesis) is such that the evolutionary-inspired Life Code is based less on natural selection than on the Inheritance of Acquired Characteristics, an idea that was first presented in 1801. In other words, if an organism changes during life in order to adapt to its environment, those changes are passed on to its offspring.