Endocannabinoid Boosting Therapy

Cannabinoids from both the body’s resources and Nature’s plants activate one of the most healing and anti-aging endocannabinoid system. In this analysis, I will examine the cannabinoids benefits (Section A) and conclude on different ways to boost these molecules (Section B).

Section A

Benefits

Among canabis’ three main species,  Cannabis sativa, Cannabis indica and Cannabis ruderalis, there are a little over 100 cannabinoids, the most known of which are cannabidiol (CBD), THC and CBN.

1. Relieves Pain and Inflammation

Among common CBD benefits, natural pain relief tops the list for many. Evidence suggests that cannabinoids may prove useful in pain modulation by inhibiting neuronal transmission in pain pathways. A 2012 study published in the Journal of Experimental Medicine found that CBD significantly suppressed chronic inflammatory and neuropathic pain in rodents without causing analgesic tolerance. Researchers suggest that CBD and other nonpsychoactive components of marijuana may represent a novel class of therapeutic agents for the treatment of chronic pain. (Source).

According to a 2007 meta-analysis conducted in Canada, the combination of CBD and THC buccal spray was found to be effective in treating neuropathic pain in multiple sclerosis, which can be debilitating for 50 to 70 percent of MS patients. (Source)

2. Has Antipsychotic Effects and Nourishes the Brain (neurogenesis)

Research shows that CBD benefits include producing antipsychotic effects. It appears to have a pharmacological profile similar to that of atypical antipsychotic drugs as seen using behavioral and neurochemical techniques in animal studies. Additionally, studies show that CBD prevents human experimental psychosis and is effective in open case reports and clinical trials in patients with schizophrenia, with a remarkable safety profile. (Source)

Furthermore, studies show that when cannabis is consumed holistically and reasonably, it can impact neurogenesis, meaning  that it has to ability to spur the creation of new brain cells. Without neurogenesis, the elder would quickly become zombies and die.

3. Reduces Anxiety

Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Cannabidiol has shown to reduce anxiety in patients with social anxiety disorder and researchers suggest that it may also be effective for panic disorder, obsessive compulsive disorder, social anxiety disorder and post-traumatic stress disorder. (Source)

A 2011 study aimed to compare the effects of a simulation public speaking test on healthy control patients and treatment-native patients with social anxiety disorder. A total of 24 never-treated patients with social anxiety disorder were given either CBD or placebo 1.5 hours before the test. Researchers found that pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alertness in anticipation of their speech. The placebo group presented higher anxiety, cognitive impairment and discomfort. (Source)

4. Helps to Fight Cancer

Several scientific reports demonstrate that CBD benefits include possessing antiproliferative, pro-apoptotic effects that inhibit cancer cell migration, adhesion and invasion. (Source) A 2006 study published in the Journal of Pharmacology and Experimental Therapeutics found for the first time that CBD potently and selectively inhibited the growth of different breast tumor cell lines and exhibited significantly less potency in non-cancer cells. (Source)

In 2011, researchers added light on the cellular mechanism through which CBD induces cell death in breast cancer cells. They showed that CBD induced a concentration-dependent cell death of both oestrogen receptor-positive and oestrogen receptor-negative breast cancer cells. They also found that the effective concentrations of CBD in tumor cells have little effect on non-tumorigenic, mammary cells. (Source)

CBD behaves as a non-toxic compound and studies show that doses of 700 milligrams per day for 6 weeks did not show any overt toxicity in humans, suggesting that it can be used for prolonged treatment. Not only does the research show that CBD benefits including being effective in fighting breast cancer cells, data also suggests that it can be used to inhibit the invasion of lung and colon cancer, plus it possesses anti-tumor properties in gliomas and has been used to treat leukemia. (Source)

5. Relieves Nausea

Cannabis has been used for centuries for the suppression of nausea and vomiting. Research has revealed that among more than 80 cannabinoid compounds found in marijuana, both the intoxicant THC and the non-intoxicant CBD helps to get rid of nausea and vomiting in animal studies. A 2012 study published in the British Journal of Pharmacology found that CBD benefits including possessing anti-nausea and antiemetic effects when it was administered to rats. (Source) Researchers found that CBD acts in a diphasic manner, meaning that in low doses it suppresses toxin-induced vomiting, but in high doses it increases nausea or has no effect.

6. May Treat Seizures and Other Neurological Disorders

A 2014 survey conducted by researchers at Stanford University was presented to parents belonging to a Facebook group dedicated to sharing information about the use of cannabidiol-enriched cannabis to treat their child’s seizures. Nineteen responses met the inclusion criteria for the study: a diagnosis of epilepsy and current use of CBD-enriched cannabis. The average number of anti-epileptic drugs tried before using CBD cannabis was 12. Sixteen (84 percent) of the 19 parents reported a reduction in their child’s seizure frequency while taking CBD cannabis. Of these, two (11 percent) reported complete seizure freedom, eight (42 percent) reported a greater than 80 percent reduction in seizure frequency, and six (32 percent) reported a 25–60 percent seizure reduction. Other beneficial effects included increased alertness, better mood and improved sleep; while side effects included drowsiness and fatigue. (Source)

Later in 2014, researchers reported on preliminary results of a study involving children with treatment-resistant epilepsies in an expanded access “compassionate use program.” Patients received a purified 98 percent oil-based CBD extract called Epidiolex, which is made by GW Pharmaceuticals. After 3 months of treatment, 39 percent of the 23 patients had more than a 50 percent reduction in seizures, with a 32 percent median reduction. These preliminary results support the animal studies and survey reports that CBD may be a promising treatment for treatment-resistant epilepsy and it is generally well-tolerated in doses up to 25 milligrams per kilogram of body weight. (Source)

7. Lowers Incidence of Diabetes

A 2006 study found that CBD treatment significantly reduced the incidence of diabetes in non-obese diabetic mice from an incidence of 86 percent in non-treated mice to an incidence of 30 percent in CBD-treated mice. CBD benefits also showed a significant reduction of plasma levels of pro-inflammatory cytokines. A histological examination of the pancreatic islets of the CBD-treated mice revealed significantly reduced insulitis. (Source)

In 2013, the American Journal of Medicine published a study that highlighted the impact of marijuana use on glucose, insulin and insulin resistance among U.S. adults. The study included 4,657 adult men and women from the National Health and Nutritional Examination Survey from 2005 to 2010. Of the participants, 579 were current marijuana users and 1,975 were past users. The researchers found that current marijuana use was associated with 16 percent lower fasting insulin levels. They also found significant associations between marijuana use and smaller waist circumferences, a factor connected to the onset of diabetes symptoms. (Source)

8. Promotes Cardiovascular Health

A 2013 study published in the British Journal of Clinical Pharmacology reports that CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models; plus, CBD proved to reduce the vascular hyperpermeability (which causes leaky gut) associated with such environments. (Source)

9. Boosts Appetite and the Enjoyment of Eating

In the Int Rev Psychiatry. 2009 Apr;21(2):163-71. entitled “Cannabinoids and appetite: food craving and food pleasure”, the author concluded that the ability of Cannabis sativa to promote eating has been documented for many centuries, with the drug reported by its users to promote strong cravings for, and an intensification of the sensory and hedonic properties of food. These effects are now known to result from the actions of cannabinoid molecules at specific cannabinoid receptor sites within the brain, and to reflect the physiological role of their natural ligands, the endocannabinoids, in the control of appetite. Recent developments in the biochemistry and pharmacology of endocannabinoid systems have generated convincing evidence from animal models for a normal role of endocannabinoids in the control of eating motivation. The availability of specific cannabinoid receptor agonists and antagonists raises the possibility of improved therapies for disorders of eating and body weight: not only in the suppression of appetite to counter our susceptibility to the over-consumption of highly pleasurable and energy-dense foods; but also in the treatment of conditions that involve reduced appetite and weight loss. (Source)

THC vs CBD

Both compounds have important health benefits: THC has antispasmodic, analgesic, anti-tremor, anti-inflammatory, appetite stimulating and anti-emetic properties, and CBD has anti-inflammatory, anticonvulsant, antipsychotic, antioxidant, neuroprotective and immunomodulatory effects.

The clinical use of THC is  limited by its unwanted psychoactive side effects for those who don’t get organic cannabis and are not educated to use it holistically. Futhermore, when too much THC and cannabis are consumed, like with wine, it becomes counterproductive. So the key question is knowing when to stop using THC ganja and growing or finding wild, organic healthy plants. There are still benefits from this cannabinoid even if they are mainstream laden with toxicants. In this case, an extra vap hit of CBD will help to reduce the intoxicating effects of THC, such as paranoia and memory impairment. (Source) Most of the time, this is because cannabis breeders have so manipulated the plant to have more THC, like over 20 times its natural potency.

CBD also appears to counteract the sleep-inducing effects of THC. This is what makes CBD so appealing to the medical community, as the cause of psychoactive side effects has been a major barrier in the acceptance of medical marijuana. (Source) While THC is known to cause anxiety and paranoia in some people, CBD works to counteract those side effects. For this reason, CBD benefits extend to being used in clinical trials on young children with epilepsy. Another related difference between THC and CBD is that marijuana with high levels of THC is commonly used for its sleep-inducing effects, while CBD appears to promote wakefulness instead. (Source)

Section B

Endocannabinoid-Enhancing Foods, Exercises and More

Endocannabinoids and their receptors are found throughout the body, in particular,  in the brain, organs, connective tissues, glands, gastrointestinal system and immune cells. In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment. In this process, the body naturally produces its own cannabinoids. Proper dosages of cannabis can also up-regulate and tonify one’s ECS. The plant, however, is not the only way to support your ECS. You can stimulate your ECS naturally with delicious endocannabinoid-enhancing foods and enjoyable activities which can lead to widespread health benefits

To produce endogenously cannabinoids, the ganja enthusiast should focus on the following foods and activities. The more cannabinoids are produced internally, the less the body-mind is attracted to exogenous sources of cannabinoids.

Essential Fatty Acids

A healthy ratio of omega-3 and omega-6 fatty acids can enhance the activity of the ECSEndocannabinoids (made by the body) like anandamide and 2-AG are produced from arachidonic acid, an omega-6 fatty acid. Having enough arachidonic acid is essential for endocannabinoid production, but having too much may lead to down-regulation of cannabinoid receptors. (Excessive omega-6 intake is also pro-inflammatory. Most western diets already contain an excess of omega-6 oils, commonly found in cooking oils such as safflower, sunflower, corn, and soy, and in animal products like meat, poultry, and eggs.) (1)
Pig Studies have shown that dietary levels of arachidonic acid as well as other essential fatty acids affect the levels of anandamide and other endocannabinoids. (Source).  Different studies have shown that high-fat diet feeding in mice increases levels of anandamide in the liver (Source) as well as the CB1 receptor.(Source) But one need not go an abundance of animal fat to produce these endogenous endocannabinoids. Good essential fatty acids found in nuts, seeds, avocados, coconuts, palm kernels and the like can suffice. One just should make sure his or her ALA converts to EPA and DHA. If not, then algae supplements may be needed or going Mediterranean on occasion, as small wild fish like salmon can provide close to 2 grams of omega 3 per serving, in particular DHA, a key molecule that has been shown  to increase cannabinoid synthesis as well as CB1 and CB2 receptors (Source).

Omega-3 fatty acids are needed to balance the omega-6 fats so the ECS can function properly. These fatty acids are much harder to come by in the diet, and are also proven to have cardiovascular and neurological health benefits. An ideal ratio of omega-3 to omega-6 in the diet is 1:1. However,  the typical western diet often has a 1:10 to 1:30 ratio. Animal sources of omega-3 are the most potent, but the vegetarian sources tend to provide other excellent health benefits with the negatives of most animal foods.

Because cannabinoid recptors are part of a lipid-based ECS system, it needs an abundance of  endocannabinoid-enhancing fatty acids: These can be found in hemp seeds and hemp oil,  flax seeds, chia sees, walnuts, purslane, salmon and sardines or anchovies.

Chocolate

Cacao powder contains three compounds that are structurally very similar to endocannabinoids. (2) These compounds can inhibit the breakdown of your body’s own endocannabinoids, resulting in higher endocannabinoid levels with longer euphoric periods.  Cacao can have some  cannabinoid activity of its own. The darker and more raw the better. Furthermore,  chocolate contains compounds which can increase anadamide levels in the body. Lots of literature indicates that the anandamide cannabinoid mimics the euphoric sensation created by the cannabinoids in marijuana. Aside from being a mood-enhancer, cacao’s other benefits range from being nutritious, to neuroprotective, can speed healing, fight cancer and slow down the aging process as Jeanne Calment and others have shown. Indeed, thank’s to her 2.2 kilos of dark chocolate intake, Jeanne Calmentwas able to use cacao’s N-acylethanolamines (NAEs), N-linoleoylethanolamide and N-oleoylethanolamine to inhibit FAAH and therefore enhance to entourage effect.  (Source).

Black Pepper

Caryophyllene, or beta- caryophyllene (ß-caryophyllene/BCP), is a terpene found in the essential oils of many plants like clove, hops, black pepper, rosemary and cannabis. This terpene is like others in that it contributes to the highly aromatic qualities of the plants it is found in. BCP is an approved food additive as well as a dietary cannabinoid. The terpene is already in many foods like black pepper, cinnamon and oregano. It is commercially used as an additive to not only foods, but also cosmetics due to its mild aromatics.

Terpenes, like cannabinoids, have their own therapeutic qualities that are just as far-spread. They too can fight against inflammation, anxiety, nausea, seizures and much more. ß-caryophyllene is one of these terpenes that also acts as a cannabinoid by binding to the cannabinoid receptor subtype two (CB2) in the body. 

Researchers are delving more deeply than ever into the medicinal properties of the active ingredients in cannabis, chiefly cannabinoids and terpenes, two of more than 480 natural components found within the cannabis plant

Black pepper contains beta-caryophyllene (BCP) terpene which is also one of Cannabis’s key terpenes. Research has shown to provide anti-inflammatory benefits. Other studies  also indicate that BCP could be useful for preventing cancer.

Herbs and Tea

Numerous herbs and teas contain compounds that can enhance the ECS. Beta-caryophyllene is a terpene found in black pepper, lemon balm, hops, cloves, cannabis, oregano, cinnamon, and several other herbs. It selectively stimulates the CB2 receptor, a sought-after property in the development of treatments for inflammatory disorders. Echinacea, often used by herbalists for up to two weeks to stimulate the immune system during infections, also contains CB2 agonists. Camelia sinensis, commonly known as “tea,” contains a compound that prevents the breakdown of endocannabinoids,  and another compound that may stimulate the cannabinoid receptors. (3) Turmeric, the yellow spice in curry powder, contains curcumin, which also raises endocannabinoid levels amongst numerous other health benefits (4) Green Teas and its EGCG molecules are agonist thereto, and hence augment the ECS experience. (Source).

The Microbiome, Food & Wine

When the microbiome functions well,  short chain fatty acids and butyrate are produced, thanks to which the CB1 gene is better expressed. (Source) Organic Extra Virgin Olive Oil is always a good idea (Source) as well as lots of folate-rich dark veggies, both of which will increase CB1 expression. (Source)  Wine’s Resveratrol potentiates the ECS (Source) as well as Capsaicin (in chili). (Source) as well as Kava (Source). Alcohol and acetaldehyde will also better expression CB1. (Source)

Endocannabinoid-Enhancing Activities

Certain activities can naturally enhance the ECS’s function, improve  health as well as increase the effectiveness of medicinal cannabis.

Stress-Reducing Activities

While chronic stress can deplete your ECS, a highly tuned ECS can protect you from the detrimental effects of stress. (5) Incorporating exercise into your daily routine will keep your ECS well-tuned, but only if you enjoy it! Animal studies teach us that if you force yourself to exercise, your ECS will interpret the activity as stress, but freely choosing and enjoying the same activity can have the opposite effect of stress and actually increase endocannabinoid levels. Socializing can also be great for stress reduction and enhancing ECS function. Rats in social isolation produced less cannabinoid receptors, while social play and grooming behavior increased function of the ECS.

As the evidence shows, emotional stress also decreases CB1 receptors (Source), including social defeat stress (Source). Thus, the maintain a good endocannabinoid-based homeostasis, it’s better to get involved in “win-win” situations, including over small amounts of quality wine. This habit can help to avoid prolonged exposure to elevated glucocorticoids (cortisol), such as those induced by chronic stress conditions, as these stressors significantly reduces hippocampal CB1 receptor sensitivity (Source), leading to lower cannabinoid homeostasis. In this perspective, a published study confirmed that that CB1 receptor deficiency may mimic the effects of chronic stress on emotional behavior (Source).

Physical Activity

Exercise also increases the sensitivity of the CB1 receptor (Source) and also increases anandamide, mammals’ natural CB1 enhancer (Source). Best to have feel-good and intense exercises to produce endorphoins as these molecules also boosts the ECS. (Source)

 Cold & Sun Exposure

Cold showers  or just being in the cold from time to time also stimulates the cannabinoid system (Source) Similarly, the Sun’s  UVAs are potent inducers of nitric oxide in the body, which is another molecule that increases the expression of CB1 receptors. (Source). As a bonus from Sun exposure, testosterone can be boosted, thanks to which the CB1 receptors are better expressed. (Source)

The Endocannabinoid System’s Plant Activators

Helichrysum

Helichrysum is a genus composed of 600 different flowers within the sunflower category. This plant is native to South Africa. It does contain a cannabinoid called cannabigerol (CBG). This chemical is proven to aid sleep, fight infection and even reduce eye pressure to alleviate glaucoma. (Source), according to an article by Montana Biotech.

Heliopsis

Research into the heliopsis plant by the Autonomous University of the State of Morelos in Mexico has discovered that this sunflower variation contains alkamides. Alkamides are found in 33 types of plants (so far), cannabis sativa being one of them. Alkamides are known to boost immunity, fight bacteria, relieve pain (analgesic) and provide antioxidant benefits, to name a few.

Echinacea

Another common herb, Echinacea is pretty well-known amongst health food enthusiasts. But even seasoned fans may not be aware that certain Echinacea species contain cannabinoids called N-alkylamides (NAAs). These belong to the alkamide family found in the heliopsis plant we mentioned earlier. By targeting the CB2 endocannabinoid receptor, the NAAs in Echinacea help strengthen the immune system, relieve pain and reduce inflammation. CB2 receptors are concentrated in the immune system.

New Zealand Liverwort

Scientists studied extract of the New Zealand liverwort (radula marginata). According to a publication by The Pharmaceutical Society of Japan, the extract yielded one known cannabinoid called perrottetinene and a new one classified under the chemical category called “bibenzyls.” The newly discovered bibenzyl in this plant variation is a compound identified as perrottetinenic acid. Specifically, perrottetinenic acid appears to be chemically similar to tetrahydrocannabinol (THC), which is the psychoactive substance found (in varying concentrations) in marijuana and hemp plants. New Zealand liverwort has been used for a variety of medicinal purposes, such as helping with liver, bladder and gallbladder problems, as well as treating bronchitis.

Lastly, there is even a plant known as the New Zealand liverwort, which produces an unusual type of cannabinoid (called perrottetinenic acid) that appears to be very closely related to THC, so much so that it may actually act on the CB1-receptor! If this is the case, it will be the only other known plant compound found in nature that is capable of doing so. However, whether

Japanese Liverwort

Similar research was also done on the Japanese liverwort variant (radula perrottetii). Aside from several different known bibenzyls, a new one called isoperrottetin A was also isolated. Like the New Zealand variety, the cannabinoids within the Japanese liverwort have similar effects to THC. As a result, people can reap some of its benefits without marijuana (or its impairing effects).

Black Truffles

No, we’re not talking about candies here. Black truffles are actually a very expensive variety of mushrooms. Because they grow underground, humans need help from specially trained dogs or pigs to sniff them out. At $95.00 per ounce – and often smuggled or faked – these rare foods are hopefully worth the cannabinoids they contain. Specifically, truffles have been found to contain anandamide, a major player in our endocannabinoid system.  Consequently, they provide similar benefits to many cannabinoids, most notably immune system regulation and anti-cancer properties.

Other molecules that modulate  Cannabinoids

We also have an important class of non-classical cannabinoids known as cannabimimetics. They are called cannabimimetics as they literally mimic the biological activity of the classical cannabinoids, despite not sharing their structure. Cannabimimetics are of increasing importance within the world of medicinal cannabinoid research. Classically, the EC system has been viewed as a simple set of two receptors and two ligands (a ligand is the term for a compound that binds to a receptor).

However, it is now increasingly being shown that the EC system is far more complex than this. Dozens of different compounds are now known to act either directly or indirectly on the EC system, and many of these compounds also work on other important biological messaging systems such as the opioid, serotonergic and dopaminergic signalling systems. Some examples of known cannabimimetics: NAE’s & N-alkylamides: N-acylethanolamines are a class of fatty acid compounds which are known to be heavily involved in biological signaling. NAE’s include N-arachidonoylethanolamine (better known as anandamide), N-palmitoylethanolamine (PEA), N-linoleoylethanolamide (LEA), and N-oleoylethanolamine (OEA).

Anandamide is well known for being the biological compound which most closely resembles the activity of THC, as it directly agonizes the principal cannabinoid receptors. It is now also known that anandamide also directly agonizes a third cannabinoid receptor known as GPR119, which is also affected by N-oleoylethanolamine.

N-alkylamides are a similar but less well-researched class of cannabimimetic compounds that have been shown to exert selective effects on the CB2-receptors, and have been shown to exert anti-inflammatory effects similar to anandamide.

Beta-caryophyllene is an important terpene is found in cannabis, and its oxide (which forms on contact with air) is the compound detected by drug-sniffing dogs! B-caryophyllene has been shown to act as a full agonist of the CB2-receptor, although it does not act on the CB1-receptor. It has also been shown to exert anti-inflammatory and analgesic effects in mice, but not in mice bred to lack CB2-receptors—showing that this biological activity is exerted via the receptors themselves.

There are abundant plant sources of terpenes such as β-caryophyllene and myrcene, although of course, some sources are better than others. Myrcene is found in extremely high concentrations in hop oil, making up almost 80% of the extracted volume in some varieties, and is also found in high levels in mangoes, lemongrass, thyme, and verbena. B-caryophyllene is found in black pepper, cloves, rosemary, hops, caraway, oregano, basil, lavender, cinnamon, and many more plant species. In most of these species, β-caryophyllene is a major constituent of the essential oil (comprising 20% in some hop species).

Salvinorin A is the main component of the psychoactive plant species Salvia divinorum. Unusually for a hallucinogenic plant compound, salvinorin A is a terpenoid, not an alkaloid like mescaline, psilocybin and DMT. Furthermore, it is a dissociative, rather than a classic hallucinogen.

Interestingly, it seems that salvinorin A does not interact with the classic cannabinoid receptors, but in fact interacts with a putative third cannabinoid receptor that apparently forms only in inflammatory conditions, and which also acts as a kappa-opioid receptor. The κ-opioid receptors are fundamental to pain regulation, and are also the principal target of most hallucinatory compounds!

The Chinese rhododendron has been shown to contain CBC or related compoundsAnother very important terpene found in cannabis, and one that is also a major constituent of the essential oil of hops. Although it is not thought that myrcene directly acts on the cannabinoid receptors, it is now known that its biological activity alters the psychoactive effect of THC.

Myrcene is known to be present in high levels in strains that exert a ‘stoney’ or ‘couchlock’ effect on the user. The sedative effects of myrcene-containing plants such as hops and verbena have been known for millennia, and it is now thought that the sedative effect is due to myrcene’s ability to agonise (activate) the opioid receptors (studies have shown that the opioid antagonist naxalone blocks myrcene’s effects, suggesting that myrcene is an agonist). Thus, although myrcene isn’t typically classed as a cannabinoid in the currently existing scientific literature, it certainly affects the subjective experience of the cannabis ‘high’. Further research will no doubt determine the exact nature of the link; presently, while testing labs such as Steep Hill Halent in California have been collecting data on the association for years, no formal studies have as yet been conducted.

In 2012, it was discovered  that flax (linen) seeds produce cannabidiol (CBD)! Or at least, that they produce cannabinoid-like compounds very similar to CBD, which appear to have similar anti-inflammatory effects.

However, there is in fact a much earlier piece of research suggesting that the compound cannabigerol (CBG) and its precursor cannabigerolic acid (CBGA) are present in South African herbs, and a  2011 study suggested that cannabichromene (CBC) and some related compounds are present in Chinese rhododendron.

 Avoid Plastics, pesticides, hard alcohol and other toxicants that Disrupt the ECS

Certain pesticides (e.g. chlorpyrifos and piperonyl butoxide) are known to disrupt the ECS. It’s especially important to choose organic foods when shopping for meat, dairy, and the highest pesticide-containing produce. (6) Phthalates, frequently added to plastic and tin food containers and water bottles, are known to block cannabinoid receptors and disrupt the body’s hormonal system. (7) Choose glass or stainless steel food containers and packaging whenever possible, and never eat food that’s been heated in plastic.

Alcohol isolated from it’s Wine Context is deleterious. In effect, regular use of moderate to high quantities of hard alcohol or the use of too much bad quality wine and other beverages that has some alcohol in it, including Kumbucha and Beer,  can also impair the ECS.

Synthetic Endocannabinoid Enhancers.

An endocannabinoid enhancer  is a type of cannabinoidergic[1] drug that enhances the activity of the endocannabinoid system by increasing extracellularconcentrations of endocannabinoids. (8) Examples of different types of eCBEs include fatty acid amide hydrolase (FAAH) inhibitors, monoacylglycerol lipase(MAGL) inhibitors, and endocannabinoid transporter (eCBT) inhibitors (or “endocannabinoid reuptake inhibitors” (“eCBRIs”)). (Ibid) An example of an actual eCBE is AM404, the active metabolite of the analgesic paracetamol (acetaminophen; Tylenol) and a dual FAAH inhibitor and eCBRI (9)

Plant Cannabinoids in the Kitchen

Culinarily, there are different ways to use Cannabis. First, in its unheated, raw state. This is usally done via whole plant juicing. The plant actually makes THC acid (THCA) and CBDA. So when you eat it raw, you get the THCA, not THC, which relieves pain and spasms. THCA is a synergizing agent, but it doesn’t have the psychoactivity associated with THC.

Cannabis with Coconut Oil is also an option. These can be poured on directly on the food or taken via capsules. Infusing cannabis in coconut oil promotes easier entry into the liver.  Coconut oil’s fatty acids act as good binding agent for the cannabinoids. Furthermore, coconut oil contains lauric acid, acid which is found in mother’s milk. Lauric acid turns into monolaurin in the body, a powerful antibacterial, antiviral, and antiprotozoal compound which can zap molds that may be present in any raw plant, including cannabis. Moreover, given the fact that coconut oil is  a monoglyceride, it has the ability to destroy lipid-coated viruses, such as influenza, HIV, herpes, measles, and many pathogenic bacteria.

Mindful of the Optimal THC-CBD ratio: There is no fatal toxicity associated with cannabis. But when cannabis is not used holistically, there can be side effects, all of which are dose-dependent. Both  THC and CBD are both agonist and anti-agonist in that they both are under the influence of a bell-shaped response curve, which means there’s a sweet spot where the balance is optimal, at which point there are no side or toxic effects, just the good stuff.  The rule of thumb is to go low with THC, as low dose is relaxing to the stomach and higher doses of CBD, especially with people who have an abundance of inflammation.  Indeed, too high a dose of THC can trigger anxiety. It can also cause nausea, confusion and/or disorientation, all of which goes away within a few hours.

Low Dose THC for the elderly: Recent findings fully justifies that all or  the vast majority of elders should supplement with natural cannabinoids.

Researchers here demonstrate a role for cannaboids in the age-related decline of memory function. (Source) Levels of natural cannaboids decline with aging, and the researchers provide evidence for this to be a proximate cause of the loss of memory function in later life. They also show that it is possible to stave off this decline in laboratory mice by using low doses of tetrahydrocannabinol (THC) to supplement natural cannabinoids:

Like any other organ, our brain ages. As a result, cognitive ability also decreases with increasing age.In this perspective, researchers have long been looking for ways to slow down or even reverse this process and have now achieved this in mice. These animals have a relatively short life expectancy in nature and display pronounced cognitive deficits even at twelve months of age. The researchers administered a small quantity of THC, the active ingredient in the hemp plant (cannabis), to mice aged two, twelve and 18 months over a period of four weeks. Afterwards, they tested learning capacity and memory performance in the animals – including, for instance, orientation skills and the recognition of other mice. Mice who were only given a placebo displayed natural age-dependent learning and memory losses. In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. “ he treatment completely reversed the loss of performance in the old animals.” (10)

Discussion

The endocannabinoid system is constantly maintain homeostasis (or dynamic balance) at a cellular level. It was named the endogenous cannabinoid system (endocannabinoid) after the plant that led to its identification. It is one of the most important physiologic systems involved in establishing and maintaining human health. There’s evidence that some people’s endocannabinoid system (ECS) may not be functioning optimally; this can be addressed by adding the right dosage of supplemental cannabinoids from the plant cannabis. Beyond cannabis, however, certain foods and activities can also help the ECS to function optimally, improve health, better sensitize ECS’s CB receptors thereby enhancing the effectiveness of medical cannabis as a rejuvenating technique for the brain. (11)

Some are saying it is the body’s most important system when it comes to homeostasis and maintaining the overall the healt of the body. It a lipid-based system that regulates the immune system, brain cell formation, the reproductive system, hormones, connective/joint tissue, and perhaps even more we have yet to discover. The endocannabinoid system is based on a network of receptors throughout the body. Healthy fats are crucial to keep these receptors in good working order, so CBD oil works better in a body that is ingesting and absorbing lots of healthy fat. The body naturally creates its own endo-cannabinoids, and there are many different ones. Some cannabinoids the body creates and others can be found in various plants to varying degrees. Different cannabinoids induce different effects on the body. They can be thought of as messengers, each one telling the body to do something in particular. The reason for such a system is the need for homeostasis; the body has an unending need to keep making adjustments to compensate for changing conditions. It uses as “messengers” components which are also found in some plants. The result is that we have some degree of control over our body’s regulation if we know how to supplement the right herbs.

Conclusion

Like Testosterone, THC, tetrahydrocannabinol is a “driver” molecule and specific to the cannabis plant. No other plant aside from cannabis produces THC. But cannabis ultra-hybridized cannabis plants tend  to have too high THC doses, which then has side effects that don’t serve health and longevity, if only because the plant was not evolutionarily designed to have intense psycho-active properties. Like with wine, small to moderate amounts of organic top quality of cannabis can be a longevity elixir and mild euphoria herb. As we saw, the Science fully supports this piece of allegation. However, Government officials continue to subvert the Republic as well as to discredit themselves by locking up cannabis’ cannabinoids in the jail of Schedule I and only funding what these individuals perceive or misperceive as the “negative” effects of cannabis, like questioning the rule of law and public authority. Doing that is a form of paranoia and psychosis. So the conventional system is targeting big time the ECS in order to find a pathway amenable to  pharmacological control, to a patented billion dollars synthetic drug that can suppress the People’s endowed right to live a healthy lifespan to 120 years minimum.

The cannabis plant is unique in the plant kingdom for its cannabinoids and terpenes. No other plant like it has ever been found, but a few others do have some cannabinoids. Several different cannabinoids have been discovered (CBC, CBN, CBG, and others), but CBD is by far the most interesting cannabinoid known to date. The entire function of most cannabinoids including CBD is still not fully understood. Once the complete cannabis Genome is mapped we may benefit from additional tips. Meanwhile, we have known for millennia that Cannabis is a simple and heavenly plant that has many benefits, from detoxification, detoxification, neurogenesis  to rejuvenation. It should be at least as much an essential nutrient as vitamin A, zinc or oxygen.

From the viewpoint of a healthy lifespan, what we want, is to activate our cannabinoid protein receptors (which are the most numerous and of another class from our other receptors) with all means at our disposal, from exercise, heliotherapy to black pepper and cannabis. In this way the melody of Joie de Vivre can radiate throughout the body’s endocannabinoid system, thanks to which all of our 70 trillion eukaryote cells as well as our 700 trillion microbiome critters and their genes will cross-talk and get organize to become the next new human being, one who will be motivated less by money, greed and insecurity than by acts of evolutionary kindness and a healthy holistic Life.

 Ch. Joubert (HM Institute director)

Reference and Precision Notes

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[5] McPartland JM, Guy GW, Di Marzo V. Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System. Romanovsky AA, ed. PLoS ONE. 2014;9(3):e89566.
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[7] Bisset, Kathleen M., et al. “The G protein-coupled cannabinoid-1 (CB 1) receptor of mammalian brain: inhibition by phthalate esters in vitro.” Neurochemistry international 59.5 (2011): 706-713.
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(10). This treatment success is the result of years of meticulous research. First of all, the scientists discovered that the brain ages much faster when mice do not possess any functional receptors for THC. These cannabinoid 1 (CB1) receptors are proteins to which the substances dock and thus trigger a signal chain. CB1 is also the reason for the intoxicating effect of THC in cannabis products, which accumulate at the receptor. THC imitates the effect of cannabinoids produced naturally in the body, which fulfill important functions in the brain. “With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces. When the activity of the cannabinoid system declines, we find rapid ageing in the brain.”To discover precisely what effect the THC treatment has in old mice, the researchers examined the brain tissue and gene activity of the treated mice. The findings were surprising: the molecular signature no longer corresponded to that of old animals, but was instead very similar to that of young animals. The number of links between the nerve cells in the brain also increased again, which is an important prerequisite for learning ability. A low dose of the administered THC was chosen so that there was no intoxicating effect in the mice. Cannabis products are already permitted as medications, for instance as pain relief. As a next step, the researchers want to conduct a clinical trial to investigate whether THC also reverses ageing processes in the brain in humans and can increase cognitive ability. https://www.uni-bonn.de/news/128-2017
(11). There are cannabinoid receptors both in the brain as well as other parts of the body. Some cannabinoids only act on receptors in one or the other. Based on our current knowledge, the number of cannabinoid receptors in the brain far outnumber any other type of neurotransmitter receptor. (Source) The brain cannabinoid receptors are found in: cerebral cortex (higher cognition), cerebellum (motor coordination), basal ganglia (movement), hypothalamus (appetite), amygdala (emotions) and hippocampus (memory) Out of all these locations, CBD especially targets the hippocampus, new studies are showing.This study from 2013 also gave additional support to the observation that CBD induces the formation of new neurons (brain cells), which is a process in the body known as neurogenesis. This is especially important to anyone who is interested in longevity, because the formation of new brain cells is one of the body’s critical processes that is observed to decline with age, and is directly associated with longer lifespans. (Cf.  See 2013 study on mice published by Cambridge University Press)
 Disclaimer: Nothing in this Education blog should be construed as medical advise.
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