Anti-inflammatory Diet


Prostaglandins are hormone-like substances that affect the body in variety of ways, also regulating inflammatory mediation. An anti-flammatory diet includes fewer foods that create inflammation-causing prostaglandins (PGE2) in the body, and more foods that create anti-inflammatory prostaglandins (PGE1 and PGE3).[30][not in citation given]

Suggested diets to reduce inflammation include those rich in vegetables and low in simple carbohydrates, and fats such as saturated fats and trans fats.[31] Anti-inflammatory foods include most colorful fruits and vegetables, oily fish (which contain higher levels of omega-3 fatty acids), nuts, seeds, and certain spices, such as ginger, garlic and cayenne. Extra-virgin olive oil contains the chemical oleocanthal that acts similarly to ibuprofen. Those following an anti-inflammatory diet will avoid refined oils and sugars, and show a preference for so-called anti-inflammatory foods in their meal choices.[32][33]

Omega-3 fatty acids have been shown to disrupt inflammation cell signaling pathways by binding to the GPR120 receptor.[34] This benefit however can be inhibited or even reversed if the ratio of Omega-6/Omega-3 is too high as Omega-6 serves as a precursor to inflammatory chemicals (prostaglandin and leukotriene eicosanoids) in the body.[35][36] A high proportion of omega-6 to omega-3 fat in the diet shifts the physiological state in the tissues toward the pathogenesis of many diseases: prothrombotic, proinflammatory and proconstrictive.[35] Omega-6 competes with Omega-3 for the same rate limiting factor which is required for the health-benefits of Omega-3, directly reducing the action of Omega-3 in addition to pharmacologically counteracting Omega-3 benefits through its own action as a pro-inflammatory agent.


  1. “Inflammation”. Southern California College of Optometry. Archived from the original on 17 February 2013. Retrieved 29 January 2013.[unreliable medical source?]
  2. ^ “Dr. Weil’s Anti-Inflammatory Food Pyramid”. Dr Weil. Retrieved December 20,2012.[unreliable medical source?]
  3. ^ “List of 63 Anti-Inflammatory Foods to Choose from for Natural Healing”. The Natural Anti-Inflammatory Remedies. Retrieved December 20,2012.[unreliable medical source?]
  4. ^ Hyman, Mark (2006). Ultrametabolism: The Simple Plan for Automatic Weight Loss. New York, New York: Simon and Schuster. p. 137. ISBN 9781416531821. Retrieved December 20, 2012.[unreliable medical source?]
  5. ^ Willyard, Cassandra (September 2, 2010). “How Fish Oil Fights Inflammation”. ScienceNOW. Retrieved December 20, 2012.
  6. ^ Jump up to: a b Simopoulos, A.P. (2003). “Importance of the Ratio of Omega-6/Omega-3 Essential Fatty Acids: Evolutionary Aspects”. In Simopoulos, Artemis P.; Cleland, Leslie G. Omega-6/Omega-3 Essential Fatty Acid Ratio: The Scientific Evidence. World Review of Nutrition and Dietetics. 92. pp. 1–22. doi:10.1159/000073788. ISBN 978-3-8055-7640-6. PMID 14579680.

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