DHEA, a Key Longevity Hormone Can be Enhanced Holistically

Research shows that the DHEA hormone is critical insofar as optimized longevity is concerned.  In this blog-article, I will first examine what modulates DHEA (Section A) and follow up with a brief analysis of holistic techniques that can enhance this vital hormone (Section B).

Section A

Introducing The Longevity Hormone DHEA

DHEA (dehydroepiandrosterone) is one of the critical hormones that scientists are characterizing as the “fountain of youth”. This hormone is made from cholesterol by the adrenal glands and is a precursor to 18 steroid hormones including the commonly known sex hormones estrogen and testosterone. Healthy DHEA production is critical for lean muscle development, fat burning, bone growth, skin health, and immunity (1, 2, 3).

A DHEA deficiency significantly increases the risk of getting certain cancers (including breast, ovarian, prostate, and bladder), atherosclerosis, high blood pressure, Parkinson’s disease, diabetes, nervous system degeneration, and other age-related conditions (7, 8).

Human DHEA production naturally peaks between 20-25 years of age and then steadily declines.  Many in our society see a sharp decline due to overburdened adrenals that are unable to synthesize adequate DHEA.  This adrenal insufficiency syndrome is becoming more and more common due to an overstressed and malnourished American lifestyle.

The DHEA Inhibitors and Stressors

One of the biggest DHEA inhibitor are the Statin drugs that artificially lowers cholesterol and zaps Co Q 10 enzyme.  This is one of the reasons why cholesterol lowering medications have been linked to all-cause early mortality (4, 5, 6).

Elevated insulin also causes a decreased production of DHEA in the adrenals. Thus, loads of sugar and  high glycemic carbohydrate consumption should be avoided as well as blood sugar imbalances, that which creates critical vitamin and mineral imbalances that stress the adrenals and reduce DHEA production (9).

High stress and poor sleeping habits also cause increased cortisol (stress hormone) levels.  When these issues become chronic they cause a phenomenon called “pregnenolone steal”. Pregnenolone is a byproduct of cholesterol metabolism that is necessary to produce both cortisol and DHEA.

High stress causes this process to shift towards cortisol production. This shift essentially `steals` the necessary pregnenolone from the DHEA production pathway to produce more cortisol.  This process depletes DHEA levels (10, 11).

Section B

Holistic Solutions

Removing the DHEA Stressors

Many people rush out and look for DHEA boosting supplements, however, lifestyle factors that deplete DHEA levels should be addressed first. The most important factor includes reducing/eliminating adrenal stressors such as medications, stress, leaky gut syndrome, parasites and other infectious agents, chronic inflammation, physical nerve stress, nutrient deficiencies, poor sleep, & blood sugar imbalances.

An anti-inflammatory diet is a critical part to de-stressing the body and boosting DHEA levels. This diet should be very low in sugar and carbohydrates and very rich in phytonutrients and trace minerals from fresh, raw or lightly steamed vegetables.  Powerful anti-inflammatory herbs such as turmeric, ginger, rosemary, thyme, oregano, & cinnamon should be generously consumed on a regular basis.

Optimization of DHEA with Superfoods and Quality Fatty Acids

Healthy fat consumption is an essential part of creating cholesterol which is needed to produce DHEA.   Healthy fat sources include coconut products, avocados,  walnuts,  olives, nuts of all kinds, purslane, seeds including chia, hemp and flax for the ALA omega 3. And for those who can’t convert ALA to DHA and EPA, then either wild small fatty fish or purified omega-3 fish oil supplements or omega 3 rich krill oil. The adrenal gland, like the brain needs lots of fatty acid. So while the microbiota produced lots of short chain fatty acid, the longer chain fatty acid needs to come form food. And because of the ALA issue, krill or fish oil may be indicated.

Vitamin D also plays an important role in healthy DHEA levels (12).  Getting regular sun exposure is the best. If not possible then supplementation to maintain vitamin D (25-OH) levels between 60-100 ng/ml.

 Enhancing DHEA with a Holistic Lifestyle

1.  Prioritize Sleep:  You must focus on getting good sleep on a regular basis.  If you are sleeping in late in the morning, try getting up early and allowing yourself to get real tired early the following evening and going to sleep around 9-10pm and waking around 6-7am.  Use this as your regular schedule getting 8-9 hours of high quality sleep each night.

2.  Clean Up the Diet:  Follow an Anti-inflammatory high antioxydant nutrition plan. See Improved Mediterranean diet and Optimizing Vegan Diet Plans.

3. Vitamin N (Nature) & D.  Barefoot walking for electron absorption, sun exposure for hormonal boosting, deep breathing for N.O production, inter alia, breathing in green forests for soothing and sedative effect. If not enough sun (in Winters, beyond the 38th parallel, not enough vitamin D forming UVBs), 2 to 5,000 Vitamin D2 with K2 in combination.

4.  Exercise Daily around 20 minutes: Pick an exercise that is fun and stick to it each day.

5.  Breath Deeply:  Activate yoga nostril and deep diaphragmatic breathing on a regular basis.  This  helps to relax the adrenals and reduces stress.

6.  Use Essential Oils:  The aromatherapy of essential oils can help to reduce stress and improve neurotransmitter function.  Additionally, they have a positive effect on anti-aging hormone production.  Some of the best for this include lavender, ylang-ylang, sandalwood, chamomile, valerian and peppermint.

7.  Eliminate Food Sensitivities:  Food sensitivities can contribute to chronic stress in your life. See Institute’s coaching on Gut Medicine.

8.  Employ Adaptogenic Herbs and B vitamins via real wholesome organic plant-based food:  Adaptogenic herbs such as rhodiola, cordyceps, ginseng, etc. have a positive effect on DHEA production. Vitamins B5 and B6 are also key for healthy adrenal function and sex hormone expression.  Organic Strawberries are great sources of B-6, in addition they help to chelate mercury out of the bloodstream.

Reducing Cortisol with Ashwagandha and Jasmine.

In a  study large enough to produce significant findings, the herb ashwagandha was shown significantly reduce the stress hormone cortisol.

“The treatment group that was given the high-concentration full-spectrum Ashwagandha root extract exhibited a significant reduction (P<0.0001) in scores on all the stress-assessment scales on Day 60, relative to the placebo group. The serum cortisol levels were substantially reduced (P=0.0006) in the Ashwagandha group, relative to the placebo group. (…) The findings of this study suggest that a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual’s resistance towards stress and thereby improves self-assessed quality of life”. (Source). (13)

Stress, either physical or mental promotes ACTH secretion, which in turn increases cortisol levels; at times, the level may increase even 20-fold. (14)  The results of this study shows that high-concentration full-spectrum Ashwagandha root extract reduced levels of serum cortisol significantly. And when cortisol plunges, DHEA is free to secrete. Similar findings were observed in a previous study  by Auddy et al. in patients with stress. (15)

Sniffing Jasmine essential oil can also do the trick insofar as stress reduction is concerned. Jasmine volatile oils were shown to be both a GABA receptor modulator five times more powerful than sleeping pills while bestowing stress reduction benefits unto thy sniffer. (Source) (16)

Conclusion

When humans are governed by the sympathetic “flight, fight or freeze” neurological response, stress is produced, that which boosts cortisol, which in turn lowers DHEA levels. Thus, to live a healthy long life with adequate DHEA, it’s important to nurture a holistic lifestyle and keep cool.

Christian Joubert (HMI director)

Screen Shot 2017-12-25 at 9.53.18 PM

Withania somnifera, known commonly as ashwagandha or Indian ginseng is a plant in the Solanaceae or nightshade family. The species name somnifera means “sleep-inducing” in Latin. The name, ashwagandha, is a combination of the word ashva, meaning horse, and gandha, meaning smell, reflecting that the root has a strong horse-like odor. (Cf  “Ashwagandha”. MedlinePlus, US National Library of Medicine. 26 June 2017. Retrieved 21 December 2017) Image

Reference and Precision Notes

1. Johnson MD, Bebb RA, Sirrs SM. Uses of DHEA in aging and other disease states. Ageing Res Rev. 2002 Feb;1(1):29-41.
2. Yamatani H, Takahashi K, Nagase S. [Sex hormones and physiological function]. Nihon Rinsho. 2015 Apr;73(4):565-70.
3. Labrie F. DHEA, important source of sex steroids in men and even more in women. Prog Brain Res. 2010;182:97-148.
4. Peck A, Chaikittisilpa S, Mirzaei R, et al. EFFECT OF STATINS ON ESTROGEN AND ANDROGEN LEVELS IN POSTMENOPAUSAL WOMEN TREATED WITH ESTRADIOL. Climacteric : the journal of the International Menopause Society. 2011;14(1):49-53.
5. Redberg RF, Katz MH. Reassessing benefits and risks of statins. N Engl J Med. 2012 Aug 23;367(8):776.
6. Charach G, Rabinovich A, Ori A, Weksler D, Sheps D, Charach L, Weintraub M, George J. Low levels of low-density lipoprotein cholesterol: a negative predictor of survival in elderly patients with advanced heart failure. Cardiology. 2014;127(1):45-50.
7. Szathmári M, Vásárhelyi B, Treszl A, Tulassay T, Tulassay Z. Association of dehydroepiandrosterone sulfate and testosterone deficiency with bone turnover in men with inflammatory bowel disease. Int J Colorectal Dis. 2002 Mar;17(2):63-6.
8. DHEA deficiency syndrome: a new term for old age?  (Source)
9. Ryan AS. Insulin resistance with aging: effects of diet and exercise. Sports Med. 2000 Nov;30(5):327-46.
10. Boudarene M, Legros JJ, Timsit-Berthier M. [Study of the stress response: role of anxiety, cortisol and DHEAs]. Encephale. 2002 Mar-Apr;28(2):139-46.
11. Stress and its Effects on the Cortisol/DHEA Ratio and Muscle-Organ Relationships (Source)
12. Zofková I, Hill M, Zajícková K. Dehydroepiandrosterone status in postmenopausal women is determined by the gene for the vitamin D receptor. Horm Metab Res. 2002 Mar;34(3):127-31.
(13). Indian J Psychol Med. 2012 Jul-Sep; 34(3): 255–262. A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults.
(14). Guyton AC, Hall JE. Adrenocortical Hormones Textbook of Medical Physiology. 11th ed. Philadelphia: Saunders; 2006. pp. 944–60.
(15). Auddy B, Hazra J, Mitra A, Abedon B, Ghosal S. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. J Am Nutraceutical Assoc. 2008;11:50–6.  See also  Sharma S, Dahanukar SA, Karandikar SM. Effects of long-term administration of the roots of ashwagandha and shatavari in rats. Indian Drugs. 1985;29:133–9.
(16). http://www.telegraph.co.uk/news/science/7881819/Smell-of-jasmine-as-calming-as-valium.html

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Disclaimer: Nothing in this educational blog should be construed as legal or medical advise.
2017-8 (c). Happiness Medicine Institute and agents. All rights reserved

The Happiness Medicine Institute's central mission is centered on shouldering the masses (ie majority of People including, but not limited to the low and modest income categories) to meet their fundamental human birth-right of living a fulfilling, healthy and an evolutionarily designed Lifespan of 120 years and beyond. The only son of a Polish Jew mother and a Catholic Frenchmen father from Bordeaux, Christian and has come to the US, like Lafayette, to share the best of French and European experiences with Americans in order to beat the "enemy". In the 18th century, Lafayette, Rochambeau and France were the decisive forces that toppled those nasty British imperialists in Yorktown, thanks to which American sovereignty was made possible. In the 21st century, the "enemy" is chronic stress and an American food, medical and public health system that is un-necessarily maiming and killing Americans by the millions each year. Once (and if) the official standards of care become consistent with the People's basic needs and with the best Science, then Christian's mission will have been accomplished. In terms of bio, Christian was trained in French conventional medicine, Chinese acupuncture, European naturopathy, law, wine and a few other disciplines. He has partaken in thousands of seminars and conferences to corroborate what the safest, most efficient and cost friendly health restoration and lifespan techniques are. To this end, Christian established a research and education center called happiness medicine institute. A former law professor (Paris and Gonzaga School of Law), organic agriculture farmer (certified by Ecocert), professor of holistic oncology, naturopath and director of other health centers, Christian has been specializing for over twenty years in geroscience and biogerontology as both these "optimal longevity" fields of the Health Sciences are much more "holistic" and useful than conventional medicine insofar as slowing down and reversing age-related pathologies is concerned, including the aging process itself. As a result, by better tweaking the aging process and its concomitant longevity determinants, we can modulate and resolve most chronic diseases, including cancer, auto-immunity, diabetes, mental disorders, cardiovascular events and much more. The only rampant malady holistic medicine is powerless to act upon is arrogance (ie, hubris). Thus, not everyone can benefit from Joubert's expertise. If motivated people comply to a holistic lifestyle with specific longevity and happiness techniques, they can die after having peacefully reached 120 without any chronic diseases. Over 95 percent of chronic diseases are completely avoidable. This claim is not constitutive of what is called a "false promise". The evidence is overwhelmingly established, but most pharmaceutical firms and their medical and political allies ignore these claims and-or are not interested, if only because Joubert's proposed holistic techniques do not generate enough cash-flow for corporate appetite to be satieted. This extension of time to 120 years and beyond will give People more opportunities to better enjoy Life (Joie de vivre) and build the conditions that will lead to a new, lasting, healthier and happier civilization based on the exact opposite values and mechanisms of most of today's outdated and irrational standards and systems. Christian investigates Science, medicine and any other phenomena with medically and legally trained eyes. And digs deep, through multiple layers of knowledge and via multiple fields of science, thank to which he is able to identify the inter-connectiveness of relevant issues and determine the key root cause (or causes) upon which the consultee can act. Thus, over 95 percent of published material and common clinical practice is weeded out in order to get to the “crème”, the quintessence, the clinical pearl or what jurists call the “therapeutic relevance” for the benefit of whatever the health challenge may be….. So don't hesitate to schedule an appointment with Christian before he goes away. By doing so, the consultee will learn innovative, safe, efficient and cost-friendly techniques to achieve a healthy lifespan of over 120 years, as the French Mediterranean lady, Jeanne Calment has, (ie, the book of Guinness confirms she is the longest living human ever and most people don't even know why), as the most successful "bleu zone" does (i.e., the French-cultured Principality of Monaco in the Mediterranean South has the most centenarians, most bleu zoners don't know this) and as the French culture and lifestyle have abundantly shown over the last 1600 years, including, but not limited to its Mediterranean diet, Lourdes, its wine, its thermal medicine as well as to its many other health promoting techniques including France's health-vacation spas and other "joie de vivre" institutions that substantially slow down the rate at which telomeres shorten while significantly upregulating (activating) the other eleven hallmarks of Optimal Longevity. Thus, it's not for nothing that the World Health Organization ranked France as having the best health-care system in the world. To read more on France's health-vacation spas and dozens of validated longevity techniques as well as on Christian’s mission and background, click “about” and examine the website's other links. To benefit in vivo from Christian Joubert’s medical, legal, inter-disciplinary and trans-cultural training and experience, CLICK the Consult LINK in the top menu bar. Thank you.

Posted in Hormones, Neuropeptides, Monoamines & Neurotransmitters, LifeStyle, Naturopathic and Holistic Medicine, Longevity Medicine, Anti-Aging, Gerontology, Telmomeres, Telomerase, Caloric Restriction, mTOR, Sirtuins, Protein Misfoldment

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