Angiogenic Food Inhibitors and Cancer

In this blog-article, I will first clarify different aspects of malignant angiogenesis (Section A) and conclude with some evidence on how the simple tomato can be beneficial with regards to angiogenic modulation. (Section B)

Section A

Angiogenesis and  Cancer

Being adaptively intelligent, cancer cells send angiogenic biochemical signals that activate different pathways so that an abundance of blood vessels can feed cancer’s growth.

As noted in the ACR Institute’s research and workshops, conventional oncology (i.e., chemo, radiation and surgery, including biopies) often promote cancer’s angiogenesis process and mestastasis development. They do this by spurring cancer stem cells, activating dormant cancer cells, signaling pre-metastatic “niche” implantation and spreading malignancy via blood and lymph pathways.  Among many other supporting sources, see this pubmed one.

This doesn’t mean that everything in conventional oncology is counter-indicated. But it does mean that it would be more reasonable to first use anti-angiogenic nutrients, cancer fighting foods and holistic oncology to preliminarily control and dissuade tumor growth.Screen Shot 2017-11-25 at 10.49.22 AM

Top: Source: Dr Li

Section B

Can Medical Foods like tomatoes inhibit malignant angiogenesis ?

Among other medical foods, consider the tomato, one of the richest sources of lycopene.

“Dietary intake of lycopene was associated with reduced risk of lethal prostate cancer and with a lesser degree of angiogenesis in the tumor” (J Natl Cancer Inst. 2014 Feb;106(2)) (1)

Furthermore, lycopene, tomatoes and holistic mediterranean diets (deprived of dairy) can also deregulate one of the key pathways that spurs the malignant growth of prostate cancer, the androgen pathway.

“Collectively, these studies demonstrate a profile of testosterone-regulated genes associated with early stages of prostate carcinogenesis that are potential mechanistic targets of dietary tomato components” (2) (Source)

Although current cancer research experts acknowledge that angiogenesis inhibitors in the form of food (See chart above) have been shown to be safe, inexpensive and effective, (Source) they should not be a “stand-alone” therapy and the patient should always consult with as many different oncology schools ‘ experts as possible, if only because most cancer schools and oncology experts only have a piece of the puzzle.

Discussion

From this above-mentioned piece of evidence and from all of what current research has demonstrated, it can be asserted that Holistic oncology is generally much more cost friendly, efficient and safe than anti-angiogenic drugs like Avastin. Avastin can cost over one hundred thousands dollars a year and be laden with many side or toxic effets. Furthermore, the data shows that it is not a cure, at best, it gives the patient a few more months of life. Likewise with androgen deprivation therapies that target testosterone. (3)

In this perspective, the Happiness Medicine and ACR Institutes thus recommend the use of advanced clinical nutritiondetoxification and holistic oncology’s other basic techniques before any surgery, cytotoxic chemotherapy, ionic radiation, drug combinational therapies and targeted synthetic drugs are employed, if only because these conventional mainstream interventions are usually irreversibly invasive and laden with toxic side effects. Even surgery. And when angiogenic animal foods are combined with conventional oncology, there is a synergistic “entourage” effect that tend to accelerate the patient’s demise, at which point he or she becomes a likely candidate for baterial composting.

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Conclusion

While many conventional techniques do shrink tumors,  most times, this is a smokesreen, as most allopathic treatments promote “resistance”. Like in any other evolutionary “prey-predator” and “host-parasite” relationship, the attacked biological entity, in this case the cancer cell, like MRSA bacteria vis a vis the fire of antibiotics, will defend itself by up-regulating self-repair and metastatic genes and mechanisms, inter alia. For example, the data shows that fibronectin proteins and cancer stem cells not only adapt to Conventional Oncology’s symptomatic and violent suppression campaigns, they also get activated to put in place the final “coup de grace” strategy, metastasis. (4)

The bottom line is this: In the face of radiation’s fire and chemo’s poisons, cancer stem cells will not only “resist”, they will mutate and upregulate the disease’s metastatic pathways including premetastatic niches, bypassing immune-surveillance, becoming stronger, “angrier”, at which point the host-patient is often overwhelmed and dies from conventional medicine’s invasive treatments, its concomitant toxemia, the deleterious symbiosis-based “entourage” effect that is often connected with the culture of conventional oncology, including, but not limited to the MAD (modern American Diet) and the ultimate morphin drip.

Christian Joubert (HMI director and CSO)

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Reference and Precision Notes

Reference note 1

J Natl Cancer Inst. 2014 Feb;106(2)

Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era.
Zu K1, Mucci L, Rosner BA, Clinton SK, Loda M, Stampfer MJ, Giovannucci E.

Abstract

BACKGROUND:

The role of lycopene in prostate cancer prevention remains controversial. We examined the associations between dietary lycopene intake and prostate cancer, paying particular attention to the influence of prostate-specific antigen screening, and evaluated tissue biomarkers in prostate cancers in relation to lycopene intake.

METHODS:

Among 49898 male health professionals, we obtained dietary information through questionnaires and ascertained total and lethal prostate cancer cases from 1986 through January 31, 2010. Cox regression was used to estimate multivariable hazard ratios (HRs) and 95% confidence intervals (CIs). Tissue microarrays and immunohistochemistry were used to assess tumor biomarker expression in a subset of men. Two-sided χ(2) tests were used to calculate the P values.

RESULTS:

Higher lycopene intake was inversely associated with total prostate cancer and more strongly with lethal prostate cancer (top vs bottom quintile: HR = 0.72; 95% CI = 0.56 to 0.94; P(trend) = .04). In a restricted population of screened participants, the inverse associations became markedly stronger (for lethal prostate cancer: HR = 0.47; 95% CI = 0.29 to 0.75; P trend = .009). Comparing different measures of dietary lycopene, early intake, but not recent intake, was inversely associated with prostate cancer. Higher lycopene intake was associated with biomarkers in the cancer indicative of less angiogenic potential.

CONCLUSIONS:

Dietary intake of lycopene was associated with reduced risk of lethal prostate cancer and with a lesser degree of angiogenesis in the tumor. Because angiogenesis is a strong progression factor, an endpoint of lethal prostate cancer may be more relevant than an endpoint of indolent prostate cancer for lycopene in the era of highly prevalent prostate-specific antigen screening.

Reference Note 2

Dietary tomato and lycopene impact androgen signaling  and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis. Cancer Prev Res (Phila). 2014 Dec; 7(12): 1228–1239.

Reference-Precision note 3

Targeting testosterone in patients who have been diagnosed with prostate cancer has been a stubborn mistake for the last 60 years. The hormone testosterone is needed to definitely reverse cancer and prevent recurrence and metastasis. Testosterone is also needed to prevent accelerated aging and other non malignant diseases.  There is a connection between hormones and prostate cancer growth. But it is not by inhibiting or destroying testosterone that progress can be made.  What needs to be better addressed is testosterone’s excessive conversion into DHT and testosterone’s relationship with estrogen, in particular estrodial and progesterone. The evidence shows that all of this can usually be done holistically, without toxic and invasive interventions.

Reference-Precision Note 4

Cells at the site of the metastasis multiply and produce a protein called fibronectin, which acts like a glue to attract and trap the bone marrow cells to create a landing pad or nest for the cancer cells to land on and flourish. “These nests provide attachment factors for the tumor cells to implant and nurture them. It causes them not only to bind but to proliferate. Once that all takes place we have a fully formed metastatic site or secondary tumor,” said Lyden. “This is the first time anyone has discovered what we call the pre-metastatic niche.” (Source)

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Professor Joubert is presently working on a new book on Holistic Medicine and Biogerontology, whose content invokes the compelling evidence that supports the following assertion: humans have been genetically designed to live a happy and healthy lifespan to at least 120 years. On this age limit, both evolution-based Science (Cf the Hayflick's limit) and the Bible (Genesis 6:3) concur. The “Joie de Vivre” Vibe that can eradicate today’s chronic disease epidemics and un-necessary suffering is thus within reach. See link on mission for more details.

Posted in Cancer & Auto-Immune Diseases, Homeostasis, Self-Repair Mechanisms, Autophagy, Bio-Terrain, Microenvironment, Stem cells, Differentiation, Genomic Instability Biology

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