Given the cancer pandemic and conventional oncology’s relative failure, a paradigm shift in cancer theory and treatment is needed. In this blog-article, I will first examine the Advanced Cancer Research Institute’s progress in determining the best approach to cancer (Section A) and follow-up with a discussion on what hurdles remain before a long-term successful cancer treatment plan can be implemented. (Section B).
Innovative Cancer Research
Given the relative failure of conventional oncology, (See blog) the Institute’s Scientific Team believes that a more holistic paradigm is needed if we are to reduce the epidemic of cancer.
Among other complementary approaches, we need approaches that can activate metabolic and mitochondrial pathways that impact the cancer cell’s micro-environment and energy production system (1) in conjunction with metabolic, holistic, detoxification and happiness protocols.
The Institute’s holistic approach to cancer is based on individualized nutrient-dense Ketogenic (fat-based) (2), Plant-based and Mediterranean diets (3), including, but not limited to alkalinic structured Spring water and small quantities of quality organic wine, (4) in combination with a specific type of caloric restriction in synergistic association with herbal combinations, hyperthermia (heat), energy medicine (including acupuncture) supplementation, metabolic detoxification and, among other constituent elements, growth receptors inhibitors and metabolic blockers that beneficially affect cancer cell metabolism and their ATP energy production, to the point of significantly controlling and reversing cancer growth.
TEXT UNDER CONSTRUCTION
Mechanisms of Action
Professor Otto Warburg showed over 90 years ago in 1923, (5) this epi-genomic wellbeing restoration occurs primarily because cancer cells use predominately glycolysis (fermentation) energy, given the fact that cancer cells’ mitochondrial energy production is defective, in that is it is incapable of using oxidative phosphorylation (Krebs Cycle) efficiently. (6)
In this perspective, the emerging evidence shows that when key molecules malignancy thrives on are inhibited cancer cells oncogenes will get down-regulated to the level of promoting pro-apoptotic pathways that lead to the suicidal disappearance of cancer cells.
Furthermore, the evidence also shows that when key micro phytonutrients are promoted, wellbeing genes get switched on, in particular tumor suppressor and longevity genes. (See ACR Institute’s work in this area).
Case in Point for Brain Cancers
For neuroblastoma malignancy, the current standard of care instructs maximal surgical resection, radiation therapy, chemotherapy and temozolomide (TMZ), including the selective use of glucocorticoids for symptom control and complementary drugs for pain management. While this treatment plan does shrink much of the tumor, the damaged micro-environment created from the use of these conventional weapons will actually promote cancer stem cells’ twin mutation and activation process, the result of which is metastasis, recurrence and, too often, premature death of the host. (7)
By using part of the Institute’s recommended protocol on nude mice, neuroblastoma was resolved, without any invasive intervention.
To this end, the following is what was done to them by the lab technicians: Xenografts were established in CD-1 nude mice (8) by subcutaneous injection of two neuroblastoma cell lines having distinct genetic characteristics and therapeutic sensitivity: SH-SY5Y and SK-N-BE(2). (9)
The nude mice thereafter were randomized to four treatment groups receiving standard diet, calorie-restricted standard diet, long chain fatty acid based ketogenic diet or calorie-restricted ketogenic diet.
Tumor growth, survival, metabolic parameters and weight of the mice were monitored. Cancer tissue was evaluated for diet-induced changes of proliferation indices and multiple oxidative phosphorylation system parameters (respiratory chain enzyme activities, western blot analysis, immunohistochemistry and mitochondrial DNA content). The results were as follow:
“Ketogenic diet and/or calorie restriction significantly reduced tumor growth and prolonged survival in the xenograft model. Neuroblastoma growth reduction correlated with decreased blood glucose concentrations and was characterized by a significant decrease in Ki-67 and phospho-histone H3 levels in the diet groups with low tumor growth. As in human tumor tissue, neuroblastoma xenografts showed distinctly low mitochondrial complex II activity in combination with a generalized low level of mitochondrial oxidative phosphorylation, validating the tumor model. Neuroblastoma showed no ability to adapt its mitochondrial oxidative phosphorylation activity to the change in nutrient supply induced by dietary intervention.” (10)
Observation inferred from the Data
By targeting the metabolic characteristics of neuroblastoma with a precise caloric-restricted based ketogenic diet, most of the rodents were gently guided toward cellular stabilization.
In addition to in vitro and in vivo evidence, we also have human anecdotal evidence from several ketogenic cancer survivors that show that humans behave like the mice mentioned above. When gently treated with a more holistic approach, they too had their cancerous cells stabilized. (Cf the Institute’s cancer testimonial register). (11)
Discussion on Clinical Findings
Ketogenic Diets are Not long-lasting in their anti-cancer benefits
Although we are making progress in both understanding Cancer’s mechanisms and reversing some cancers holistically, there are still many hurdles.
First off, the ketogenic approach as a stand alone is usually not enough to stop cancer growth. Cancer DNA finds other pathways to further its spread, including, but not limited to the glutimate path.
Second, this ketone approach works better for brain tissue than other tissues. But for other tissues, there is evidence that cancer adapts to ketones and use this fuel for its continued growth. (12)
Third, even if mice are mammals like humans, they are differently designed, thus without human clinical trials that look at the long term, we can’t be certain that the ketogenic approach is the best for cancer control.
The fact that human anecdotal evidence exists for brain cancers can’t be hard evidence. If only because we can always find cancer patients who will defy all odds with whatever the treatment.
What is needed are prospective studies where we can determine a protocol’s the rate of success. Five “cancer cures” out of 100 is only 5 percent. Chemo, radiation and surgery can do as good.
The ketogenic diet in itself is thus not the “magic bullet” or the decisive solution to the cancer challenge. Dr Atkins and other physicians have confirmed that cancer can outsmart this glucose fuel deprivation ketogenic approach by switching genes that activate other pathways, (13) this OLD 12 including but not limited to the glutamine pathway.
In this way, cancer cells use other fuels than glucose to overwhelm the host.
The data does suggest that many cancer cells are still weakened when the cancer patient goes into ketosis. There is also evidence that cancer cells have some difficulty using ketone as fuel. But there is also evidence that they eventually adapt to ketones. n.
This is why the Institute prefers to use a ketogenic-based diet in association with Mediterranean and Plant-based diets rather than Paleo or other diets. Paleo and mainstream diets are just too rich in growth factors like IGF-1 that help to promote cancer growth. .
Thus, for more durable remissions and permanent reversals, other holistic modalities are needed.
Discussion on Carcinogenesis (Cancer Theory)
One piece of emerging evidence that shows that cancer is not a genetic disease comes from the experimentation with the transfer of the tumor cell’s nucleus to the cytoplasm of normal cells containing normal mitochondria. That nucleus-changed cell did not become cancerous. If cancer were a genetic caused disease, the normal cell would have become cancerous. (See image above)
The genomic instability observed in tumor cells and all other recognized hallmarks of cancer highlighted by Professor Weinberg have been considered downstream epiphenomena of the initial disturbance of cellular energy metabolism, including the inflammatory process, as had noted Professor Otto Warburg decades ago.
Replacing fermentable metabolites like glucose with respiratory metabolites, primarily ketone bodies, does help, especially for brain cancers. ( )
Cf. Cao, S. X. Dhahbi, J.M., Mote, P.L. & Spindler, S. R. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 10630-10635.
This metabolic dietary intervention appears to be anti-angiogenic (ie reduction of tumor vascularity) and even anti-inflammatory, while enhancing apoptosis (tumor cell death). But without other holistic interventions, the cancer cells adapt.
In the field of cancer research and praxis, that is more and more certain is that the 60 years old cancer standard of care ia outdated and flawed. Based on the postulate or dogma that cancer is solely a genetic disease, the mainstream treatment plan centers on the destruction of the tumor by cytotoxic chemo, ionic radiation and surgery. Even though there has been some improvements, especially for the liquid cancers, over-all the “War” President Nixon declared on cancer has failed. ( )
( ) Then, one in ten Americans got a cancer diagnosis, while 4 and 2.
Today, emerging and compelling scientific evidence, a tiny amount of which we produced in this article, corroborates that impaired cellular energy metabolism is the central defining characteristic of nearly all cancers regardless of cellular or tissue origin. Genes may still have their importance, but they can no longer be seen as the central hallmark of carcinogenesis.
In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. We have seen that the fermentation cancer energy system that allows the cancer cell to prosper is a nefarious growth that occurs at the expense of the host’s integrity and longevity.
For now, it does appear that genomic instability and all or most of the other hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be traced to this mitochondrial impairment.
Although the biotech Industry’s cytotoxic chemotherapeutic agents, allopathic drugs and radiotherapy can be useful when properly applied as adjunctive and in extreme cases as needed, (8) too often chemo and radiotherapy techniques destroy the host’s immune system and other important tissues while making cancer stem cells, one of the engines’s of metastasis, mutate and get stronger.
As a proximate result, like with MRSA bacteria in the face of antibiotics, these cancer stem cells become more resistant to conventional target therapy, they become more aggressive and are spurred to metastasize as circulatory tumor cells, thereby leading to distant colonization, that which precipitates higher recurrence rates, more suffering and premature deaths.
While Research and clinical practice have shown both safety and efficiency in the nutritional aspect of the metabolic and holistic approach to cancer, there is still room for improvement, including, but not limited to combination therapies, therapeutic dosage, epigenetics, anti-inflammatory pathways, neuro-psycho-immunologiy, restoration.neutraceuticals, combination therapies (and molecules), immunotherapeutic agents, hyperthermia, circulating stem cell targeting, metabolic and glycolysis inhibitors and clinical nutrition.
Christian Joubert (HM and ACR Institutes DIrector and CSO)
Referehce and Precision Notes
(1). One of the key proponents of the metabolic approach to cancer is Professor Seigfried. He has shown that the emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. Dr Gonzalez used another variant of the metabolic approach (See Video section).
(2). The goal of metabolic ketogenic-based cancer therapy is to restrict cancer cells of glucose, their main energy substrate. The ketogenic diet targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (β-hydroxybutyrate) via a fatty diet.
(3). That which usually includes red wine, in moderation or homeopathically, that which also benefits overall health. Cf. Pérez-Guisado J, Muñoz-Serrano A, Alonso-Moraga A. Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet for weight loss. Nutr J. 2008;7(1):30. doi:10.1186/1475-2891-7-30.
(4). Because wine in moderation can help to increase the good cholesterol, help with vascular health and lipid digestion, be an aromatase inhibitor and activate key pathways, we include red organic wine either in moderation and-or homeopathically within the ACR Institute’s clinical trial protocol. Cf. Corder R, Mullen W, Khan NQ, et al. Oenology: red wine procyanidins and vascular health. Nature. 2006;444(7119):566.
(5). Otto Warburg got two Nobel prizes for his cancer discovery.
(6). In 2010 researchers from the NCI showed that metformin, the diabetes drug which reduces blood sugar levels, was linked to lowered levels of lung cancer. Other synthetic drugs have been used with success, including synthetic vitamin C in IV infusion . Plant-derived chemo agents have also worked, but in combination with different integrative and holistic oncology techniques for optimal results and in order to minimize the toxic side effects. These chemo agents have been more successful with the liquid cancers since these cancers usually have fewer genetic mutations than the solid malignancies. Likewise with radiotherapy, provided hyperthermia and other techniques are also used.
( 7). Neuroblastoma is a malignant pediatric cancer derived from neural crest cells. It is characterized by a generalized reduction of mitochondrial oxidative phosphorylation. It is an aggressive and often fatal malignancy of the central nervous system. Despite extensive research and clinical trials over the past 50 years, very little progress has been made to significantly alter its lethal prognosis. See the ACR Institute’s cancer stem cells research findings.
(8). Nude mice is the official name.
(9) Morscher RJ1, Aminzadeh-Gohari S2, Feichtinger RG2, Mayr JA3, Lang R4, Neureiter D5, Sperl W3, Kofler B2.Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model. PLoS One. 2015 Jun 8;10(6).
(11). Our excuses, Facebook deleted all of our Facebook discussion groups and pages. We are leaving the link on nonetheless in hope that Facebook will restore this and many other links.
(12). For a more complete discussion on the long term failure of Dr Atkin’s case studies regarding the ketogenic diet and the absence of hard proof that the classical ketogenic diet works long term, please see the Institute’s publications and workshops.