Healthy Centenarians and Thirty years Old Healthy Individuals Share Similar diverse Microbiota

In a recent microbiota study conducted in humans, researchers have shown a significant correlation between healthy aging and a healthy gut as compared to younger microbiota. In this blog-article, i will first examine the substance of these findings  (Section A)  and then compare them with other former studies from which this one derived.(Section B). Thereafter, I will discuss a  few implications that this and other studies inspire. (Section C).

Section A

Microbiota & Gut Diversity

This microbiota longevity Study was published last  September 2017, in the journal mSphere (1). The Chinese researchers from this study found was a significant correlation between the gut microbiota of  healthy elderly up to 100 years old and the gut microbiota of healthy 30 year olds.

In conjunction with the China-Canada Institute, Western University, Lawson Health Research Institute and Tianyi Health Science Institute in Zhenjiang, Jiangsu, China,  the researchers studied the gut bacteria in a cohort of more than 1,000 Chinese individuals in a variety of age-ranges from 3 to over 100 years-old who were self-selected to be very healthy with no known health issues and no family history of disease. The results showed a direct correlation between health and the microbes in the intestine.

“Our analysis showed several surprising results compared to other cohorts. First, the overall microbiota composition of the healthy aged group was similar to that of people decades younger. Second, the major differences between groups in the gut microbiota profiles were found before age 20. Third, the gut microbiota differed little between individuals from the ages of 30 to >100. Fourth, the gut microbiota of males appeared to be more variable than that of females. Taken together, the present findings suggest that the microbiota of the healthy aged in this cross-sectional study differ little from that of the healthy young in the same population, although the minor variations that do exist depend upon the comparison cohort”. (2)

Section B

Microbiota and Longevity Studies in Perspective

Past studies have shown a contrario that the composition of the microbiota in elders is considerably different from that of younger adults. In this perspective, for example, a very low abundance of phylum Firmicutes and an overall low diversity were detected in elderly subjects. (3) Low diversity has been found to be associated with increased health risks. (4) Another study has reported significantly higher abundance of Bacteroidetes, and lower abundance of Clostridium cluster IV in elders compared to younger subjects.(5)

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Top: Lactobacillus (sp 01): Public Domain (CDC)

Section C

Discussion & Implications

Given the past studies between the elderly and younger microbiota, this new study that showed similarity between elderly and younger microbiota proves that an elder’s microbiota is controllable by lifestyle change. In other words, an imbalanced and frail microbiota is not necessarily part of the aging process (ie, today’s dogma).

Thus, from the viewpoint of holistic medicine, this is a great finding because we can use the. quality and the diversity of microbiota as a biomarker and a diagnostic tool to determine who is healthy and less healthy and then prescribe simple diverse cultured foods,  probiotics and prebiotics to improve this marker of health and longevity.

The major study’s limitation is based on the fact that its findings are not causative.  In other words, a healthy diverse microbiota leading  to healthy old age has not been proven, only associated. Common sense and past studies however allow us to infer that eating well and being deligent in feeding our microbiota are keys to the optimization of a healthy longevity process.  Because it has also been shown that diverse cultured foods and probiotics boosts longevity, it can thus be reasonably deduced that healthy microbiota is one of many other variables for the enhancement of optimal longevity. (6)

On the other hand, in some of these microbiota studies, there is the variable of antibiotics that may not have been taking into consideration with sufficient diligence. In a young group that takes antibiotics versus an elderly group that does not, one could assume that the elder’s microbiota would be in better  shape. (7) I have not as of yet seen any hard evidence of this assumption, but up to now, it is reasonable to make it, if only to better target our future microbiota Research work.

Conclusion

The Study’s results suggest that for people who live to be 100 and in perfect health in China,  their microbiota will likely appear to be relatively similar to a person in his-her mid-30s. This study has not proven whether this is cause or effect. But it does suggest that resetting an elderly microbiota to that of a 30-year-old individual would promote wellbeing and longevity.

For the elderly who do not adopt a holistic-happiness lifestyle, the process of immunosenescence accelerates to such a degree that chronic low-grade inflammatory in the gut is a quasi-permanent feature, because of which unfavorable changes in the composition and structure of the gut microbiota in older people quicken their ultimate demise. This Chinese study also strengthens the proof that in healthy nonagenarians and centenarians, the microbiota is a key player insofar as optimized longevity and wellbeing are concerned.

 Christian Joubert (HMI Director and CSO)

Reference Notes

(1). 1Gaorui Bian, Gregory B. Gloor, Aihua Gong, Changsheng Jia, Wei Zhang, Jun Hu, Hong Zhang, Yumei Zhang, Zhenqing Zhou, Jiangao Zhang, Jeremy P. Burton, Gregor Reid, Yongliang Xiao, Qiang Zeng, Kaiping Yang, Jiangang Li. The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young. mSphere, 2017; 2 (5): e00327-17 DOI: 10.1128/mSphere.00327-171Gaorui Bian, Gregory B. Gloor, Aihua Gong, Changsheng Jia, Wei Zhang, Jun Hu, Hong Zhang, Yumei Zhang, Zhenqing Zhou, Jiangao Zhang, Jeremy P. Burton, Gregor Reid, Yongliang Xiao, Qiang Zeng, Kaiping Yang, Jiangang Li. The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young. mSphere, 2017; 2 (5): e00327-17 DOI: 10.1128/mSphere.00327-17
(2). Ibid.
(3). Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, et al, Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A. (2008) ;105: (6):2117–2122. See also Duncan SH , Lobley GE , Holtrop G , Ince J , Johnstone AM , Louis P , et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond). (2008) ;32: (11):1720–4. See also, Andersson AF , Lindberg M , Jakobsson H , Bäckhed F , Nyräen P , Engstrand L . Comparative analysis of human gut microbiota by barcoded pyrosequencing. PLoS One [Internet]. (2008) ;3: (7):e2836. Available from: http://www.scopus.com/inward/record.url?eid=2-s2.0-523&partnerID=tZOtx3y1. And this one: Gill SR , Pop M , Deboy RT , Eckburg PB , Turnbaugh PJ , Samuel BS , et al. Metagenomic Analysis of the Human Distal Gut Microbiome (2006) ;312: (June):1355–1360. See also: Eckburg PB , Bik EM , Bernstein CN , Purdom E , Dethlefsen L , Sargent M , et al. Diversity of the human intestinal microbial flora. Science. (2006) ;308: (5728):1635–1638. .
(4). Shoaie S , Ghaffari P , Kovatcheva-Datchary P , Mardinoglu A , Sen P , Pujos-Guillot E , et al. Quantifying diet-induced metabolic changes of the human gut microbiome. Cell Metab [Internet]. (2006) ;22: (2):320–331. Available from:http://linkinghub.elsevier.com/retrieve/pii/S.
(5). Zwielehner J , Liszt K , Handschur M , Lassl C , Lapin A , Haslberger AG . Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly. Exp Gerontol [Internet]. Elsevier Inc. (2009) ;44: (6-7):440–446. Available from: http://linkinghub.elsevier.com/retrieve/pii/S.
(6). In actuality, we can even do better than this study in terms of optimizing diverse healthy microbiota. Instead of using a healthy population of 30 year old healthy individuals, we could use latest research on the microbiota that is looking at the best and most diverse forms of gut microbiota that promote health and longevity. There are thousands of different bacterial species in the gut, some are more important than others. Therefore, by selecting what recent Research has dermine to be the best longevity and health microbiota, we could foster the intestinal conditions to promote even more health and longevity.
(7). Bartosch S , Fite A , Macfarlane GT , Mcmurdo MET . Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota characterization of bacterial communities in feces from. Appl Environ Microbiol. (2004) ;70: (6):3575–81.

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Disclaimer: Nothing in this Education Blog should be construed as Medical advise.
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The Happiness Medicine Institute's central mission is centered on shouldering the masses (ie majority of People including, but not limited to the low and modest income categories) to meet their fundamental human birth-right of living a fulfilling, healthy and an evolutionarily designed Lifespan of 120 years and beyond. The only son of a Polish Jew mother and a Catholic Frenchmen father from Bordeaux, Christian and has come to the US, like Lafayette, to share the best of French and European experiences with Americans in order to beat the "enemy". In the 18th century, Lafayette, Rochambeau and France were the decisive forces that toppled those nasty British imperialists in Yorktown, thanks to which American sovereignty was made possible. In the 21st century, the "enemy" is chronic stress and an American food, medical and public health system that is un-necessarily maiming and killing Americans by the millions each year. Once (and if) the official standards of care become consistent with the People's basic needs and with the best Science, then Christian's mission will have been accomplished. In terms of bio, Christian was trained in French conventional medicine, Chinese acupuncture, European naturopathy, law, wine and a few other disciplines. He has partaken in thousands of seminars and conferences to corroborate what the safest, most efficient and cost friendly health restoration and lifespan techniques are. To this end, Christian established a research and education center called happiness medicine institute. A former law professor (Paris and Gonzaga School of Law), organic agriculture farmer (certified by Ecocert), professor of holistic oncology, naturopath and director of other health centers, Christian has been specializing for over twenty years in geroscience and biogerontology as both these "optimal longevity" fields of the Health Sciences are much more "holistic" and useful than conventional medicine insofar as slowing down and reversing age-related pathologies is concerned, including the aging process itself. As a result, by better tweaking the aging process and its concomitant longevity determinants, we can modulate and resolve most chronic diseases, including cancer, auto-immunity, diabetes, mental disorders, cardiovascular events and much more. The only rampant malady holistic medicine is powerless to act upon is arrogance (ie, hubris). Thus, not everyone can benefit from Joubert's expertise. If motivated people comply to a holistic lifestyle with specific longevity and happiness techniques, they can die after having peacefully reached 120 without any chronic diseases. Over 95 percent of chronic diseases are completely avoidable. This claim is not constitutive of what is called a "false promise". The evidence is overwhelmingly established, but most pharmaceutical firms and their medical and political allies ignore these claims and-or are not interested, if only because Joubert's proposed holistic techniques do not generate enough cash-flow for corporate appetite to be satieted. This extension of time to 120 years and beyond will give People more opportunities to better enjoy Life (Joie de vivre) and build the conditions that will lead to a new, lasting, healthier and happier civilization based on the exact opposite values and mechanisms of most of today's outdated and irrational standards and systems. Christian investigates Science, medicine and any other phenomena with medically and legally trained eyes. And digs deep, through multiple layers of knowledge and via multiple fields of science, thank to which he is able to identify the inter-connectiveness of relevant issues and determine the key root cause (or causes) upon which the consultee can act. Thus, over 95 percent of published material and common clinical practice is weeded out in order to get to the “crème”, the quintessence, the clinical pearl or what jurists call the “therapeutic relevance” for the benefit of whatever the health challenge may be….. So don't hesitate to schedule an appointment with Christian before he goes away. By doing so, the consultee will learn innovative, safe, efficient and cost-friendly techniques to achieve a healthy lifespan of over 120 years, as the French Mediterranean lady, Jeanne Calment has, (ie, the book of Guinness confirms she is the longest living human ever and most people don't even know why), as the most successful "bleu zone" does (i.e., the French-cultured Principality of Monaco in the Mediterranean South has the most centenarians, most bleu zoners don't know this) and as the French culture and lifestyle have abundantly shown over the last 1600 years, including, but not limited to its Mediterranean diet, Lourdes, its wine, its thermal medicine as well as to its many other health promoting techniques including France's health-vacation spas and other "joie de vivre" institutions that substantially slow down the rate at which telomeres shorten while significantly upregulating (activating) the other eleven hallmarks of Optimal Longevity. Thus, it's not for nothing that the World Health Organization ranked France as having the best health-care system in the world. To read more on France's health-vacation spas and dozens of validated longevity techniques as well as on Christian’s mission and background, click “about” and examine the website's other links. To benefit in vivo from Christian Joubert’s medical, legal, inter-disciplinary and trans-cultural training and experience, CLICK the Consult LINK in the top menu bar. Thank you.

Posted in Longevity Medicine, Anti-Aging, Gerontology, Telmomeres, Telomerase, Caloric Restriction, mTOR, Sirtuins, Protein Misfoldment, Microbiota, Microbiome, Intestinal Flora, Cultured Foods & Prebiotics

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