Biophysics & Frequency Fields for Cancer Reversals: a Happy non-invasive Holistic Solution in the Making

There’s nothing like fields, resonance, waves and curves to heal, including via Nature, Art and now Medicine and Bio-Physics, a discipline which is missing from Conventional Allopathic Medical schools. In this blog-article i will first examine a recent anti-cancer wave-frequency technique which reversed one of the toughest cancers, glioblastoma. (Section A). Thereafter, I will look at mechanisms of action (Section B), speak about the supporting evidence on safety and efficiency regarding this Israeli machine (Section C) and conclude.

Section A

Tumor Treating Electro-Magnetic Fields

Tumor treating fields (TTFields) therapy for cancer treatment is a new, noninvasive, regional anti-mitotic intervention modality. (See Exhibit A, below). It has been approved for the treatment of recurrent glioblastoma by the U.S. FDA. (1) It also benefits from the CE European Seal. Given its non-invasiveness and interesting mechanisms of action that promotes cancer cell apoptosis, this therapy is part of the HMI’s and its sister ACR Institute’s scope of inquiry, notwithstanding its high costs. (2)

Section B

How do the Tumor Treating Fields work ?

TTFields therapy delivers via electrodes  low-intensity (1-3 V/cm), intermediate-frequency (100-300 kHz), alternating electric fields ( 3) to the tumor using transducer arrays ( 4) placed on the skin around the region of the body containing the tumor. (5)

TTFields therapy affects metaphase, by disrupting mitotic spindle formation, and anaphase, by dielectrophoretic dislocation of intracellular constituents, resulting in apoptosis. (See the ACR Institute’s Education Videos for pictorial details).

“Tumor Treating Fields, or TTFields, are low intensity, alternating electric fields within the intermediate frequency range. TTFields disrupt cell division through physical interactions with key molecules during mitosis. This non-invasive treatment targets solid tumors. There are two well established physical processes that TTFields use to disrupt dividing cells, dipole alignment and dielectrophoresis.” (6)

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Section C

Clinical Safety and Efficiency

The antimitotic effect of TTFields therapy has been demonstrated in multiple cell lines when the appropriate frequency was utilized.

In this perspective, a phase III trial of TTFields monotherapy compared to active chemotherapy in recurrent glioblastoma patients established that TTFields therapy is associated with minimal toxicity, better quality of life, and comparable efficacy to chemotherapy. (7)

The preliminary results of a Novocure-sponsored randomized clinical trial of TTF in patients with newly diagnosed glioblastoma were reported at a meeting of the Society for Neuro-Oncology in November, 2014 wherein it was shown that a statistically significant benefit in median survival for patients treated with TTF plus conventional therapy (temozolomide, radiation, and surgery) versus patients treated with conventional therapy alone, a result which led the trial’s independent data monitoring committee to recommended early study termination. (8) On the basis of these results, the FDA approved a modification of the trial protocol, allowing all patients on the trial to be offered TTF. (9) A recent peer reviewed study wrote:

“ Intra-rater reliability was very high, indicating reproducible performance”. (10)

Discussion

The only data that i have seen in terms of comparative studies suggest that TTFields versus chemotherapy are on the same efficiency level in stopping cancer growth. However, given chemotherapy’s impact on spurring metastatic cancer stem cells as well as it’s potential to create new malignant cells via the DNA damage it produces, one can reasonably conclude that low dose electro-magnetic fields are preferable. More data and clinical trials  of course are warranted.

Conclusion

TTFields therapy is presently a novel noninvasive low frequency therapeutic option for recurrent GBM, (glioblastoma), from which my French colleague, Dr. David Servan-Schreiber, died not too long ago, notwithstanding his meritorious integrative oncology efforts. Ongoing and future trials are set to evaluate TTFields beyond neuro-oncology, in particular with nonsmall cell lung cancer, ovarian and pancreatic cancers. (11 )

Even though “hard-evidence” via additional clinical trials are still ongoing and inconclusive, Happiness Medicine and Advanced Cancer Research Institutes recommend this new standard of care in conjunction, when necessary, with integrative and  holistic healing modalities, including techniques in energy & resonance medicine, (12)  electro-acupuncture, pmef, meditation and other frequency-based modalities that can positively impact the body-mind unity on the molecular  and cellular levels.

One of the important drawbacks of this technique however is its price, 20k per month. The sister ACR  Institute team will therefore be vigilant to see if there are other less costly integrative and holistic techniques that can also selectively disrupt cancer cells’ mitotic spindle formation, in particular the dipole alignment and dielectrophoresis processes. For more information about this field, see the Institute’s workshops and reports in energy medicine and the Institute’s education video section. See also our experience with the Antoine Prioré electro-magnetic machine (via the ACR website).

Christian Joubert, CSO and HMI director

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Alternating current (green curve). The horizontal axis measures time; the vertical, current or voltage.
PRECISION AND REFERENCE NOTES
(1). http://www.accessdata.fda.gov/cdrh_docs/pdf10/P100034b.pdf. See also http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm251669.htm.
(2) As of December 2014, treatment with the Optune device cost $21,000 per month. Kotz, Deborah (December 27, 2014). “Scalp device might help patients with brain tumors”. Boston Globe. Retrieved 30 November 2015 (Source)
( 3) Alternating current (AC), is an electric current in which the flow of electric charge periodically reverses direction, whereas in direct current (DC, also dc), the flow of electric charge is only in one direction.
(4) A transducer is a device that converts one form of energy to another. Usually a transducer converts a signal in one form of energy to a signal in another.
(5) Davies AM1, Weinberg U, Palti Y.Tumor treating fields: a new frontier in cancer therapy. Ann N Y Acad Sci. 2013 Jul;1291:86-95.
(6)  Source  http://www.novocure.com/our-therapy/mechanism-of-action.aspx
(7) Op cit.,  Davies
(8). Stupp, Roger; Wong, Eric; Scott, Charles; Taillibert, Sophie; Kanner, Andrew; Kesari, Santosh; Ram, Zvi. “Interim Analysis of the EF-14 Trial: A Prospective, Multi-center Trial of NovoTTF-100A Together With Temozolomide Compared to Temozolomide Alone in Patients with Newly Diagnosed GBM (Abstract)” (PDF). Neuro-Oncology 16 (suppl 5): v167.
(9). “Novocure Announces FDA Approval of an IDE Supplement Allowing All Control Patients in its Phase III Trial in Newly Diagnosed GBM to Cross Over to Receive Tumor Treating Fields” (PDF) (Source) Retrieved Nov 30, 2015.
(10). Chaudhry A1, Benson L2, Varshaver M3, Farber O4, Weinberg U5, Kirson E6, Palti Y7. NovoTTF(™)-100A System (Tumor Treating Fields) transducer array layout planning for glioblastoma: a NovoTAL(™) system user study. World J Surg Oncol. 2015 Nov 11;13(1):316.  (Source)
(11). Op cit., Davies.
(12). In physics, resonance is a phenomenon in which a vibrating system or external force drives another system to oscillate with greater amplitude at specific frequencies.
EXHIBIT A
World J Surg Oncol. 2015 Nov 11;13(1):316.
NovoTTF(™)-100A System (Tumor Treating Fields) transducer array layout planning for glioblastoma: a NovoTAL(™) system user study.
Chaudhry A1, Benson L2, Varshaver M3, Farber O4, Weinberg U5, Kirson E6, Palti Y7.
BACKGROUND:
Optune™, previously known as the NovoTTF-100A System™, generates Tumor Treating Fields (TTFields), an effective anti-mitotic therapy for glioblastoma. The system delivers intermediate frequency, alternating electric fields to the supratentorial brain. Patient therapy is personalized by configuring transducer array layout placement on the scalp to the tumor site using MRI measurements and the NovoTAL System. Transducer array layout mapping optimizes therapy by maximizing electric field intensity to the tumor site. This study evaluated physician performance in conducting transducer array layout mapping using the NovoTAL System compared with mapping performed by the Novocure in-house clinical team.
METHODS:
Fourteen physicians (7 neuro-oncologists, 4 medical oncologists, and 3 neurosurgeons) evaluated five blinded cases of recurrent glioblastoma and performed head size and tumor location measurements using a standard Digital Imaging and Communications in Medicine reader. Concordance with Novocure measurement and intra- and inter-rater reliability were assessed using relevant correlation coefficients. The study criterion for success was a concordance correlation coefficient (CCC) >0.80.
RESULTS:
CCC for each physician versus Novocure on 20 MRI measurements was 0.96 (standard deviation, SD ± 0.03, range 0.90-1.00), indicating very high agreement between the two groups. Intra- and inter-rater reliability correlation coefficients were similarly high: 0.83 (SD ±0.15, range 0.54-1.00) and 0.80 (SD ±0.18, range 0.48-1.00), respectively.
CONCLUSIONS:
This user study demonstrated an excellent level of concordance between prescribing physicians and Novocure in-house clinical teams in performing transducer array layout planning. Intra-rater reliability was very high, indicating reproducible performance. Physicians prescribing TTFields, when trained on the NovoTAL System, can independently perform transducer array layout mapping required for the initiation and maintenance of patients on TTFields therapy. (Source)
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The Happiness Medicine Institute's central mission is centered on shouldering the masses (ie majority of People including, but not limited to the low and modest income categories) to meet their fundamental human birth-right of living a fulfilling, healthy and an evolutionarily designed Lifespan of 120 years and beyond. The only son of a Polish Jew mother and a Catholic Frenchmen father from Bordeaux, Christian and has come to the US, like Lafayette, to share the best of French and European experiences with Americans in order to beat the "enemy". In the 18th century, Lafayette, Rochambeau and France were the decisive forces that toppled those nasty British imperialists in Yorktown, thanks to which American sovereignty was made possible. In the 21st century, the "enemy" is chronic stress and an American food, medical and public health system that is un-necessarily maiming and killing Americans by the millions each year. Once (and if) the official standards of care become consistent with the People's basic needs and with the best Science, then Christian's mission will have been accomplished. In terms of bio, Christian was trained in French conventional medicine, Chinese acupuncture, European naturopathy, law, wine and a few other disciplines. He has partaken in thousands of seminars and conferences to corroborate what the safest, most efficient and cost friendly health restoration and lifespan techniques are. To this end, Christian established a research and education center called happiness medicine institute. A former law professor (Paris and Gonzaga School of Law), organic agriculture farmer (certified by Ecocert), professor of holistic oncology, naturopath and director of other health centers, Christian has been specializing for over twenty years in geroscience and biogerontology as both these "optimal longevity" fields of the Health Sciences are much more "holistic" and useful than conventional medicine insofar as slowing down and reversing age-related pathologies is concerned, including the aging process itself. As a result, by better tweaking the aging process and its concomitant longevity determinants, we can modulate and resolve most chronic diseases, including cancer, auto-immunity, diabetes, mental disorders, cardiovascular events and much more. The only rampant malady holistic medicine is powerless to act upon is arrogance (ie, hubris). Thus, not everyone can benefit from Joubert's expertise. If motivated people comply to a holistic lifestyle with specific longevity and happiness techniques, they can die after having peacefully reached 120 without any chronic diseases. Over 95 percent of chronic diseases are completely avoidable. This claim is not constitutive of what is called a "false promise". The evidence is overwhelmingly established, but most pharmaceutical firms and their medical and political allies ignore these claims and-or are not interested, if only because Joubert's proposed holistic techniques do not generate enough cash-flow for corporate appetite to be satieted. This extension of time to 120 years and beyond will give People more opportunities to better enjoy Life (Joie de vivre) and build the conditions that will lead to a new, lasting, healthier and happier civilization based on the exact opposite values and mechanisms of most of today's outdated and irrational standards and systems. Christian investigates Science, medicine and any other phenomena with medically and legally trained eyes. And digs deep, through multiple layers of knowledge and via multiple fields of science, thank to which he is able to identify the inter-connectiveness of relevant issues and determine the key root cause (or causes) upon which the consultee can act. Thus, over 95 percent of published material and common clinical practice is weeded out in order to get to the “crème”, the quintessence, the clinical pearl or what jurists call the “therapeutic relevance” for the benefit of whatever the health challenge may be….. So don't hesitate to schedule an appointment with Christian before he goes away. By doing so, the consultee will learn innovative, safe, efficient and cost-friendly techniques to achieve a healthy lifespan of over 120 years, as the French Mediterranean lady, Jeanne Calment has, (ie, the book of Guinness confirms she is the longest living human ever and most people don't even know why), as the most successful "bleu zone" does (i.e., the French-cultured Principality of Monaco in the Mediterranean South has the most centenarians, most bleu zoners don't know this) and as the French culture and lifestyle have abundantly shown over the last 1600 years, including, but not limited to its Mediterranean diet, Lourdes, its wine, its thermal medicine as well as to its many other health promoting techniques including France's health-vacation spas and other "joie de vivre" institutions that substantially slow down the rate at which telomeres shorten while significantly upregulating (activating) the other eleven hallmarks of Optimal Longevity. Thus, it's not for nothing that the World Health Organization ranked France as having the best health-care system in the world. To read more on France's health-vacation spas and dozens of validated longevity techniques as well as on Christian’s mission and background, click “about” and examine the website's other links. To benefit in vivo from Christian Joubert’s medical, legal, inter-disciplinary and trans-cultural training and experience, CLICK the Consult LINK in the top menu bar. Thank you.

Posted in Biophysics, Ionic Channels, Fields, Resonance, Electro-Magnetism, Waves, Quantum Mechanics, Radiation, Wireless Technology & the Four Fundamentals Forces of Physics, Cancer & Auto-Immune Diseases

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