The Health Benefits of Saunas and Thermal Medicine

Saunas and thermal medicine have many health applications. In this post, different fever therapies are outlined. (Section A) In a second section, the general health benefits of hyperthermia (heat therapy) is shown to be established by a decent preponderance of the evidence. (Section B). In a third and last section, I will discuss the benefits of saunas, in particular what appears to be the best portable sauna, the shielded full spectrum infrared gemstone sauna. (Section C)

INTRODUCTION

Since the early twentieth century, hyperthermia (also known as thermal therapy and thermal medicine), has been a safe, cost friendly and efficient holistic technique supported by thousands of articles published in peer reviewed journals, notably in European medical reviews.

Today, in Europe, thermal therapy is a major standard of care. Sauna therapy has been used for hundreds of years in the Scandinavian region as a medical standard. In Germany, just about all cancer clinics offer some form of cancer-defeating hyperthermia while in France, it has been characterized as an independent medical system, called “médecine thermale” or “médecine des thermes” or “cure thermale”, all covered by France’s medical social security system (since 1947). (1)

On the other hand, in the United States, hyperthermia is illegal to use as a stand alone procedure for serious diseases, in lieu of pharmaceutical drugs, radiation, surgery or the like. However, if used experimentally with chemotherapy and radiation for patients stricken with a cancer diagnosis, the treating physician will not get disciplined.

At the ACRI’s Pyrenean Center in South France, thermo-therapy is one of the key holistic life-style interventions. One of ACRI’s mission in the United States is to help promote this highly relevant medical procedure, both as a health maintenance procedure as well as a major tool to better control and reverse malignancies, cardio-vascular diseases and other pathologies. (See ACRI’s mission statement).

SECTION A
THERMAL MEDICINE MODALITIES

There are many heat modalities that can vary from micro wave, radio-frequency, magnetic nano-particle radiation via sophisticated technologies, to near infrared and far infra-red systems (e.g saunas, mats, hand devices and mineral lamps), hot packs, fever promotion via bacteria, viruses, hot sand burial techniques, heliotherapy, balneotherapy, bikram yoga, physical therapy and more. (See the Institute’s “Thermal and Acupuncture medicine as a cancer defeating tool” ebook)

At the Pyrenean Holistic wellness and medicine Center, we use a combination of hyperthermic techniques, from heliotherapy to balneotherapy, hot sand therapy exercises and both near and far infra-red heating tools with detox boosters, metabolic enhancers, photo-sensitizers, juicing, phytotherapy, aromatherapy, vino-therapy, moxibustion, acu-stimulation, essential oils, musico-therapy, meditation, massage, sophrology, exercises, thermal yoga, sleep medicine, clay therapy and ozone, all in synergistic combination with the Center’s other holistic interventions. (2).

SECTION B
GENERAL HYPERTHERMIA BENEFITS

The many benefits of heat therapy are based on the body’s natural fever and sweating mechanisms that are triggered when the immune surveillance system identifies threatening pathogenic microbes that have invaded the body (3). Subsidiarily, these two mechanisms, fever and sweating, are also activated with intense physical exertion. Below a selective list of these health benefits

1. Hyperthermia favors metabolic waste elimination, detoxification, insulin sensitivity, skin rejuvenation and weight regulation.

By raising the core temperature of the body multiple times a week as is done in ACRI’s Pyrenean center, in particular with the use of clinical nutrition in synergistic combination with heat, thermogenesis is efficiently activated, the metabolic rate increases and sweating occurs at a lower core temperature, thanks to which the sweat rate is maintained for a longer period, all of which favors metabolic waste elimination, detoxification, insulin sensitivity, weight regulation, skin rejuvenation and, inter alia, weight regulation. Among many pieces of evidence, consider the following peer reviewed study.

“…The physiological process of sweating has long been regarded as “cleansing” and of low risk. Reports of toxicant levels in sweat were sought in Medline, Embase, Toxline, Biosis, and AMED as well as reference lists and grey literature, from inception to March 22, 2011. Of 122 records identified, 24 were included in evidence synthesis. Populations, and sweat collection methods and concentrations varied widely. In individuals with higher exposure or body burden, sweat generally exceeded plasma or urine concentrations, and dermal could match or surpass urinary daily excretion. Arsenic dermal excretion was several fold higher in arsenic-exposed individuals than in unexposed controls. Cadmium was more concentrated in sweat than in blood plasma. Sweat lead was associated with high-molecular-weight molecules, and in an interventional study, levels were higher with endurance compared with intensive exercise. Mercury levels normalized with repeated saunas in a case report. Sweating deserves consideration for toxic element detoxification….” (4)

In yet another published study, scientists showed that whole body hyperthermia was useful with regards to obesity-related diseases as T2DM and insulin resistance.

“ Although the mechanisms have not yet been completely investigated, WBH may provide a new therapeutic or preventive modality against obesity-related diseases such as T2DM and metabolic or insulin resistance syndrome. (5)

2. Hyperthermia increases blood circulation, oxygenation, red blood cell production, nitric oxide release and nutrient uptake while decreasing nefarious cardio-vascular events.

Heat being expansive (vasodilatation in medical terms), fever therapy modulates blood circulation and composition, as a consequence, there are more nutrients, hormones, oxygen and red blood cells in heated bloodstream versus colder bloodstreams. In this perspective, studies document the effectiveness of sauna therapy for persons with hypertension, congestive heart failure, and for post-myocardial infarction care.

For example, in one of many published studies, as reported by Reuters News Agency, researchers found men who used heat therapy two to three times each week had a 27 percent lower risk of death from heart disease.

“During the study, men who spent time in a sauna seven times a week were less likely to die of heart problems or to die at all, compared to those who only visited the sauna once a week. Researchers followed more than 2,000 middle-aged men in eastern Finland for about 20 years. The more often the men went to the sauna, and the longer they stayed, the lower their risk for sudden cardiac death, fatal coronary heart disease and fatal cardiovascular disease over those 20 years. The association was strong even after many potentially interacting factors were taken into account, said senior author Dr. Jari Laukkanen, a cardiologist at the Institute of Public Health and Clinical Nutrition of the University of Eastern Finland in Kuopio.” (6)

Other studies have suggested that long-term heat therapy can also lower blood pressure in patients with hypertension and improve the left ventricular ejection fraction in patients with chronic congestive heart failure (See this Harvard Journal and the Institute’s ebook on Heat Medicine).

3. Hyperthermia boosts muscle regeneration, neurogenesis and new brain cells It thus can help to better treat many chronic diseases like Alzheimer’s Disease

Whether under a hot sun or within an infrared dome or a moderately hot old fashion bread oven, radiating heat promotes the release of nitric oxide. Nitric oxide stimulates vasodilatation of the microcirculatory system, bringing more blood and oxygen to the muscles. (Increased blood flow to skeletal muscle is known as muscle perfusion). With improved muscle perfusion, glycogen is better controlled and with stable glucose levels, the entire metabolic process functions better including, but not limited to muscle plasticity and growth.

“Heating resulted in approximately 25% elevation in heat shock protein expression (P < 0.05) and an approximately 30% greater soleus regrowth (P < 0.05) in RH compared with RC.” (Source)

Furthermore, if heat therapy is combined to exercise, acu-tonification, clinical nutrition and different “fasting” modalities as is done at ACRI’s Pyrenean Institute, nerve cells will release proteins known as neurotrophic factors. These brain-derived neurotrophic factor or BDNF will activate brain stem cells to produce new neurons. In this perspective, serum brain-derived neurotrophic factor is known to increase with exercise. This increase is believed to originate from the brain and it is suggested that monoamines are involved in BDNF regulation. In the published study below, it was shown that heat exposure influenced BDNF output from the brain.

“Exercise caused a rise in serum BDNF and cortisol. This increase was enhanced with exercise in the heat. Since permeability of the blood-brain barrier increases with exercise in the heat, the hypothesis was raised that this causes a higher cerebral output of BDNF”. (7)

Thus, like with bikram yoga, exercising in heat as is done in the Pyrenean Holistic Center increases BDNF compared to exercise done at lower temperatures. (Ibid).

Similarly to wine’s anti platelet aggregation effects, (ie wine’s anti-platelet activity of wine is by ethanol in combination with the polyphenolic components with which red wines are richly endowed), heat activation can also help cardio-vascular and brain cells thanks to nitric oxide release in synergistic combination with heat shock proteins inter alia. In effect, because Nitric oxide is anti-atherogenic through vasodilation, the inhibition of platelet aggregation and leukocyte adhesion to endothelial cells follows (Knowles & Moncada, 1994). Similar to exercise, passive heating increases heart rate and blood flow, ultimately exerting greater force on the vasculature (Tschakovsky, 2010). In support of this piece of allegation, 24 hours after bovine endothelial cells are exposed to 42°C heat shock, eNOS is significantly increased (Harris et al., 2003).

Inhibiting platelet aggregation for Alzheimer’s Disease via hyperthermia is relevant because platelets are generally considered a key element because they represent the link between amyloid-β (Aβ) deposition, peripheral inflammation and endothelial senescence. Both activated and senescent platelets are a source of Aβ, in addition activated platelets secrete many proinflammatory mediators that could contribute to increased peripheral inflammation and endothelial senescence. (8) (See the Institute’s ebook on thermal medicine for more references).

Bottom line: using heat activation on a regular basis can therefore help to slow or prevent brain aging and Alzheimer’s Disease.

4. Hyperthermia helps with respiratory diseases like asthma, autoimmune diseases, arthritis and chronic pain.

Heat therapy has demonstrable benefits for patients with asthma, bronchitis and chronic obstructive pulmonary disease

“Some individuals with chronic obstructive pulmonary disease (COPD), chronic fatigue, chronic pain, or addictions also find benefit. Existing evidence supports the use of saunas as a component of depuration (purification or cleansing) protocols for environmentally-induced illness.” (9)

In yet another published study, it was shown that Infrared sauna therapy has statistically significant short-term beneficial effects and clinically relevant period effects during treatment in RA and AS patients without adverse effects. After four weeks and eight treatments, pain and stiffness were significantly reduced.

“To study the effects of infrared (IR) Sauna, a form of total-body hyperthermia in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients were treated for a 4-week period with a series of eight IR treatments. Seventeen RA patients and 17 AS patients were studied. IR was well tolerated, and no adverse effects were reported, no exacerbation of disease. Pain and stiffness decreased clinically, and improvements were statistically significant (p < 0.05 and p < 0.001 in RA and AS patients, respectively) during an IR session.” (10)

Infrared, like hot baths, has also been shown to significantly increase the range of flexibility. (11)

Regarding the evidence on chronic pain mitigation, in 2005, a comparison study examining patients with chronic pain showed that those patients who used thermal therapy fared better.

“These results suggest that a combination of multidisciplinary treatment and repeated thermal therapy is an effective treatment of chronic pain”. (12)

The transient improvements in pulmonary function that occur in the sauna may provide pain relief to patients with asthma and chronic bronchitis. Sauna bathing may also alleviate pain and improve joint mobility in patients with rheumatic disease. (13)

5. Hyperthermia promotes the production of hormones and neurotransmitter (neuropeptides) while activating longevity genes

Research has shown heat therapy spurs multiple neurotransmitters and hormones, included but not limited to testosterone, one of the key longevity hormone. (14) In addition, norepinephrine, a hormone involved in the stress response that increases focus and attention, as well as prolactin, which promotes myelin growth, help the brain to function faster while better repairing nerve cell damage.

Concentrations of immunoreactiveβ-endorphin (irβ-E), corticotropin, cortisol, prolactin and catecholamines in plasma were followed in 11 healthy women during and after exposure to intense heat in a Finnish sauna bath, and compared to those in a similar control situation without exposure to heat. Heat stress significantly increased prolactin and norepinephrine secretion; the percentage increases from the initial plasma concentrations varied from 113 to 1280% (mean 510%) and from 18 to 150% (mean 86%), respectively. (15)

Hyperthermia also increases yet another longevity neuropeptide, human growth hormone. This hormone is a foundational anabolic molecule that can correct muscle loss, increase calcium retention, lipolysis (the breakdown of stored fat) and muscular atrophy that occurs with aging. (16)

At the ACRI Pyrenean center, we therefore promote the use of multiple modalities of heat for the benefit of advanced cancer patients who are cachexic (catabolic muscle wasting).

Growth hormone release is induced by an increase in body temperature (ie, not by the exercise itself), as a consequence, we put more emphasis in “feeling the heat” techniques rather than on exercises, in particular many holistic heat techniques designed to boost endorphin. (17) But we do not neglect the healing benefits of exercises and when indicated, we combine physical movement with thermo-regulation and homeostasis via many holistic modalities that have been lost and-or neglected over the last few centuries.

On the longevity front, (Optimal longevity is one the Pyrenean center’s specialities), hyperthermia is quite amazing because under particular conditions, heat shock proteins can repair misfolded and damaged proteins. This ability is beneficial for all ages, in particular for the elderly since the most common cause of death among those who have achieved 110 years old is amyloidosis.

This condition is characterized by the build-up of amyloid plaque, dysfunctional chaperones (18) and misfolded proteins that clog vital tissues like the brain (leading to inter alia Alzheimers Disease), the heart and kidneys. With age and lack of holistic knowledge, the body can no longer repair these damaged proteins. Thus, anyone interested in living in good shape for over 110 years needs to feel the deep heat (See Longevity workshop).

Among other pieces of supporting evidence, published research has shown that when rats were exposed to intermittent heat sessions, they had an expression of increased heat shock proteins that was associated with 30 percent more muscle regrowth compared to a control group. As a consequence thereto, misfolded proteins improved in both structure and function. (19)

Another study showed that a brief exposure of heat to flies and worms has been shown to increase their lifespan by up to 15% thanks to HSPs. (20)

“Heat-induced hormesis, i.e. the beneficial effect of mild heat-induced stress, increases the average lifespan of many organisms. This effect, which depends on the heat shock factor, decreases the log mortality rate weeks after the stress has ceased. To identify candidate genes that mediate this lifespan-prolonging effect late in life, we treated flies with mild heat stress (34 °C for 2 h) 3 times early in life and compared the transcriptomic response in these flies versus non-heat-treated controls 10–51 days after the last heat treatment. We found significant transcriptomic changes in the heat-treated flies. Several hsp70 probe sets were up-regulated 1.7–2-fold in the mildly stressed flies weeks after the last heat treatment (P < 0.01). This result was unexpected as the major Drosophila heat shock protein, Hsp70, is reported to return to normal levels of expression shortly after heat stress. We conclude that the heat shock response, and Hsp70 in particular, may be central to the heat-induced increase in the average lifespan in flies that are exposed to mild heat stress early in life.” (ibid)

Furthermore, heat shock proteins can help to better express longevity genes.

“We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat-shock protein) genes on 6p21 with human longevity. The availability of biological samples from various population cohorts in Denmark has given us the opportunity to try novel methods of gene association with human longevity. A significant association of one haplotype with male longevity was observed.” (21)

When hyperthermic conditioning is correctly accompanied with other modalities of holistic medicine, the longevity benefits also modulate telomere biology, which is the key age reversal pathway. (See Link).

6. Hyperthermia impacts the immune system, helps with infection reversal, Cancer re-differentiation and birth-pregnancy planning

Fever has been associated with shortened duration and improved survival in infectious disease. In this perspective, the heat-inducible 70-kDa heat shock protein (Hsp70) has been shown to be protective of peripheral leukocytes (especially monocytes) against the cytotoxicity of inflammatory mediators.

For example, research at the University of Vienna found a ten-fold increase in monocytes when blood was heated to 102.2°F (39°C).(22) The researchers confirmed that this increase was also associated with higher levels of heat shock proteins in the bloodstream.

As a consequence, there has been improved survival from severe infection.

“Heat treatment of whole blood in vitro for 2 hours at different temperatures revealed that Hsp70 expression depends on temperature and cell type; up to 41°C, Hsp70 increased only slightly in lymphocytes and polymorphonuclear leukocytes. However, in monocytes a strong induction was already seen at 39°C, and Hsp70 levels at 41°C were 10-fold higher than in the 37°C control ”. (23)

As for cancers, malignant tumors are weakened and die with high temperatures because their proliferative vasculature is so disorganized that there is no cooling system, different from healthy cells and mammalian testicles. Furthermore, increased core temperature enhances the immune system, which means that its surveillance system is more sensitive. The weight of the evidence that fever is a a cancer defeating immune booster established by many hundreds of medical journals including the well respected Nature journal which published many years ago some of the evidence that heat activates the T cells. Similarly, the preponderance of the evidence that heating tumors can elicit anti-tumour immune responses, including tumor cell damage, tumor surface molecule changes, heat shock proteins, exosomes, direct effects on immune cells and changes in the tumor vasculature and more is equally published (See the Institute’s cancer and heat article-post).

Heat also helps to remove accumulated toxins by improving lymph circulation and ATP production, thanks to which the cancer cell has more guidance to re-differentiate itself back into its origins as a healthy cell. Furthermore, there is an extensive body of research that suggests that many cancer patients have a lower core body temperature, typically 0.8°F (0.5°C) lower than the average person. (24) Thus, the automatic nervous system can only be imbalanced. Therefore, by heating the bio-milieu, metabolic homeostasis is promoted. Using antibiotics and antipyretics to bring down fever should be malpractice in most case. (25)

Still another benefit of heat medicine is that it can be used as a natural non toxic birth control procedure. When semen gets too hot, it is no longer fertile. But, once the testicles cool down, its semen returns to normal. We therefore have a natural non toxic holistic way to prepare and-or better control the timing of pregnancies, inter alia.

“Semen was collected at weekly intervals for 3 wk before and 10 wk after the sauna exposure at 85 degrees C for 20 minutes. The numbers, morphology, ultrastructure, motility, viability and metabolism of the sperm was assessed. Sperm numbers fell within one wk and slowly returned to normal in 5 wk.” (26)

SECTION C

FULL SPECTRUM INFRA-RED SAUNAS AND MEDICINE

Full spectrum infrared heat generates near, middle and far infrared radiation. One of the best and easiest way to get blasted with this radiation is via sauna sessions. Different saunas on the market do have full spectrum infrared capable of reaching high temperatures, but to my knowledge, these are not portable. Furthermore, I have not seen any full spectrum infrared sauna that eliminates EMF (a form of dirty electricity) (27) while generating negative ions, thanks to the fusion of gemstones like jade. (28)

In addition, this sauna made from satin, has earthing technology and is not heavy (28 pounds), so convenient in terms of travel. Therasage is also working on ozone and essential oils modules that will be able to be adapted onto these new generation portable saunas. To check out Therasage portable sauna, (which is distributed by Happiness Medicine Institute) click here.

DISCUSSION

In the United States, the allopathic chemical-based conventional sick-care system is too often based on flawed and outdated research. For example, in conventional oncology care, when a patient gets a 101 fever, he or she is told to go immediately to the emergency room where the E.R technicians will use antipyretics and antibiotics to reduce the fever. As a result, simple millennia old holistic therapies like fever turns out to be one of the most misunderstood physiological mechanisms. When cancer patients exceptionally have some fever, this means that their body is trying to fight off either some infection or even the cancer. Lowering that temperature artificially with antipyretics or antibiotics often harms the immune system’s integrity and all the more so that once the cancer process progresses, most cancer patients have a quasi-permanent lowering of their core temperature. As a result, they can no longer mount an effective fever or sweat. Furthermore, without an adequate fever, these cancer patients are unable to fully activate their immune system.

A contrario (legal latin for “on the other hand”), different forms of environmental stress like hyperthermia has been shown to extend healthy life (ie. studies were done on yeast, flies, worms, mice and humans). There are numerous overlapping mechanisms involved in this rejuvenation process, one of which is called hormesis.

Hormesis is the name given to circumstances whereby beneficial results occur as a result of mild levels of damage and stress. Some of the benefit of calorie restriction, exercise, and so forth, arises due to the triggering of hormetic processes: a little damage (like heat, caloric restriction, hydrotherapy or low toxin load) spurs all sorts of cellular maintenance for an extended time, resulting in a net gain in integrity and less damage than would otherwise exist. Extended healthy longevity is the observable result.

On the other hand, too much of what is good minimally can be deadly. Too much heat can indeed kill as can too much of anything, from onions, exercises to wine. For example, raw or mildly cooked onions are anti-platelet, but too cooked, they favor clot-forming platelet aggregation. Wine in small amounts can be life-saving and also anti-platelet, but too much can also be pro-platelet and destructive, etc. This boomerang-like effect is a rebound phenomenon of hyper-aggregability which  is observed after an acute alcohol consumption. This rebound phenomenon explains ischemic strokes or sudden deaths known to occur after episodes of drunkenness. But in small amounts or moderation, wine has a hormetic and inhibitory effect on platelet aggregation, among many other benefits. (For the details, see the Institute’s wine as medicine workshop).

CONCLUSION

As the notion “Médecine thermale” (thermal medicine) suggests, hyperthermia can be characterized as an independent scientific discipline equipped with an abundance of clinical ramifications, all of which are synergistically connected with Holistic Medicine’s fundamental multi-disciplinary core.

From the common cold, to immune disorders, heart issues, cancer, Alzheimer’s disease, arthritis, pain, metabolic detoxification, hormonal enhancer, skin rejuvenation, sleep therapy, inflammation inhibitor, oxidative stress protector, weight and birth controllers and more, (29) hyperthermia is generally safe, cost friendly and efficient.

Thermal medicine should therefore no longer be ignored by integrative-functional medicine experts nor boycotted by too many American government officials .who have willingly betrayed their constitutional mandate and sacrificed the People’s welfare on the altar of greed, dogma, incompetence and the pharmaceutical-based sick-care cartel. (*)

Christian Joubert: CSO &  Director  Happiness Medicine Institute. (About)

For the Pyrenean Holistic Center’s thermal techniques, click here.

To order the Institute’s ebook on “Thermal Medicine and Acupuncture as cancer defeating tools” , click here.

To check out Therasage portable sauna, (which is distributed by Happiness Medicine Institute), click here.

(*). Not all pharmaceutical companies are nefarious to Society. There is a place for pharmaceutical synthetic molecules (drugs), including, but not limited to emergency medicine. However, the use of pharmaceutical funds to buy off politicians who then accept company flawed studies and craft public policy based on these anti-scientific studies is constitutive of a cartel scheme.

 REFERENCE AND PRECISION NOTES

1. Four of many holistic healers of all time, Hippocrates, Parmenides, Avicennes and Kneipp used heat as a holistic technique to reverse many diseases, a tradition that has been retained in Europe, but disdained in corporate mainstream America. Paradoxically, hyperthermia has been used experimentally in the United States for many decades, including at the Anderson Cancer Center in Texas, but this approach is still considered an experimental therapy in the United States that can only be used exceptionally as an adjunct to chemo and radiation. Worse, in conventional oncology care, when a patient gets a 101 fever, he or she is told to go immediately to the emergency room where they will use antipyretics and antibiotics to reduce the fever. Over the last few years, there have been more holistic and functional medicine practitioners who use heat therapies. Among others European holistic health doctors, cancer specialist Dr Zabel, director of the cancer clinic Ringberg-Klinik, Dr. Josef Issels, Dr Herzog and Dr. Douwes have successfully used heat therapy to artificially induced fever against different cancer. In France “médecine thermale” heat systems including famous hot springs in large sections of the French South, reimbursed by the State since 1947. (Source) Among other European scientists and holistic scholars, Dr. A. Lwoff, a Nobel laureate French bacteriologist, has demonstrated in repeated scientific experiments that fever is indeed a “great medicine,” and that it can help to cure many “incurable diseases”. In biological and spa thermal clinics in France and Europe, artificially and holistically induced fever has been used successfully to treat such conditions as rheumatic diseases, skin disorders, insomnia, arthritis, cancer, thrombosis, fibromalgia, diabetes, obesity, Parkinson’s disease, urinary problems psoriasis and diseased automatic nervous systems. (Source)
2. Moxibustion is a traditional Chinese medicine technique that involves the burning of mugwort, a small, spongy herb, to facilitate healing. Moxibustion has been used throughout Asia for thousands of years; in fact, the actual Chinese character for acupuncture, translated literally, means “acupuncture-moxibustion.” The purpose of moxibustion, as with most forms of traditional Chinese medicine, is to strengthen the blood, stimulate the flow of qi, and maintain general health. For the Pyrenean Center’s other holistic techniques, see http://centredebienetreholistique.com
3. A healthy organism reacts to encroaching disorders with regulated increases in temperature, progressing in acute cases to high fever that initiates an enhanced immunogenic response. Accordingly, an artificially induced fever surge in body temperature can sustainably, as opposed to allopathically, help to dissipate blocked energy, even in cases of chronic and malignant processes .
4. www.ncbi.nlm.nih.gov/pmc/articles/PMC3312275/
5. Int J Hyperthermia. 2007 May;23(3):259-65.
6. To read, click this site: www.reuters.com/article/us-heart-health-saunas-idUSKBN0LR1LP20150223?feedType=RSS&feedName=healthNews
7. Neurosci Lett. 2011 Apr 25;494(2):150-4. Influence of citalopram and environmental temperature on exercise-induced changes in BDNF. By Roelands B, Heyman E, Njemini R, Meeusen R. et al. www.ncbi.nlm.nih.gov/pubmed/21385602
8. Curr Pharm Des. 2013;19(9):1727-38. Platelets in Alzheimer’s disease-associated cellular senescence and inflammation. Casoli T1, Balietti M, Giorgetti B, Solazzi M, Scarpino O, Fattoretti P.
https://www.ncbi.nlm.nih.gov/pubmed/23061730
9 Altern Med Rev. 2011 Sep;16(3):215-25. Sauna as a valuable clinical tool for cardiovascular, autoimmune, toxicant- induced and other chronic health problems by Crinnion WJ. www.ncbi.nlm.nih.gov/pubmed/21951023
10.  Infrared sauna in patients with rheumatoid arthritis and ankylosing spondylitis. Clinical Rheumatology, 28(1), 29. link.springer.com/article/10.1007/s10067-008-0977-y See also link.springer.com/journal/10067
11  Hot Baths for Pain. (2016). www.PainScience.com. https://www.painscience.com/articles/bathing.php See also Demura S., Noguchi T., and Matsuzawa J., Effect of Linear Polarized Near-infrared Irradiation on Flexibility of Shoulder and Ankle Joints
12 Psychother Psychosom. 2005;74(5):288-94. The effects of repeated thermal therapy for patients with chronic pain. Masuda A1, Koga Y, Hattanmaru M, Minagoe S, Tei C. https://www.ncbi.nlm.nih.gov/pubmed/16088266
13. American journal of medicine 110, 118-126 (2001).
14. Eur J Appl Physiol Occup Physiol. 1989;58(5):543-50. Haemodynamic and hormonal responses to heat exposure in a Finnish sauna bath. By Kukkonen-Harjula K1, Oja P, Laustiola K, Vuori I, Jolkkonen J, Siitonen S.
15. European Journal of Applied Physiology and Occupational Physiology 1988, Volume 57, Issue 1, pp 98-102 Response of plasma endorphins, prolactin and catecholamines in women to intense heat in a sauna T. LaatikainenK. SalminenA. KohvakkaJ. Pettersson et al link.springer.com/article/10.1007/BF00691246
16. Hannuksela, M. L. & Ellahham, S. Benefits and risks of sauna bathing. The American journal of medicine 110, 118-126 (2001).
17 Eur J Appl Physiol Occup Physiol. 1989;58(5):543-50. www.ncbi.nlm.nih.gov/pubmed/2759081
Endorphins are endogenous opioid neuropeptides or neurotransmitters, which function to transmit electrical signals within the nervous system. At least 20 types of endorphins have been demonstrated in humans. Endorphins can be found in the pituitary gland, in other parts of the brain, or distributed throughout the nervous system. Stress and pain are the two most common factors leading to the release of endorphins
18. In molecular biology, molecular chaperones are proteins that assist the covalent folding or unfolding and the assembly or disassembly of other macromolecular structures. Chaperones are present when the macromolecules perform their normal biological functions and have correctly completed the processes of folding and/or assembly. The chaperones are concerned primarily with protein folding. The first protein to be called a chaperone assists the assembly of nucleosomes from folded histones and DNA and such assembly chaperones, especially in the nucleus, are concerned with the assembly of folded subunits into oligomeric structures. Cf. Cell Stress Chaperones. 2001 Oct; 6(4): 306–315. (Source)
In this context, heat shock proteins (HSP) are molecular chaperones and have been implicated in longevity and aging in many species. Their major functions include, chaperoning misfolded or newly synthesized polypeptides, protecting cells from proteotoxic stress, and processing of immunogenic agents. These proteins are expressed constitutively and can be induced by stresses such as heat, oxidative stress and many more. The induction of HSP in aging could potentially maintain protein homeostasis and longevity by refolding the damaged proteins which accumulate during aging and are toxic to cells. HSP are shown to increase life span in model organisms such as C. elegans and decrease aging related proteotoxicity. Thus, decrease in HSP in aging is associated with disruption of cellular homeostasis which causes diseases such as cancer, cell senescence and neurodegeneration. HSP levels are decreased with aging in most organs including neurons. Aging also causes attenuation or alteration of many signaling pathways as well as the expression of transcription factors such as heat shock factor (HSF). The alteration in regulation and synthesis of Forkhead box O3a (FOXO3a) family of transcription factors as well as major antioxidant enzymes [manganese superoxide dismutase (MnSOD), catalase] are also seen in aging. Among many signaling mechanisms involved in altering longevity and aging, the insulin/IGF1 pathway and the Sir2 deacetylase are highly significant. This review inquires into the role of some of these pathways in longevity/aging along with HSP. (Source).
In this perspective, when heat stress or hyperthermia produces HSPs, these proteins help to prevent protein degradation. Whenever a cell is exposed to an unfriendly environment, the DNA separates in certain regions and begins to read the genetic code to produce these stress proteins. HSPs are actually beneficial, helping to both prevent and repair damaged proteins. When these heat shock proteins are induced by heat they therefore produce a hormetic response (a protective stress response), which promotes the expression of a gene called heat shock factor 1.  As a consequence, HSPs can prevent damage by directly scavenging free radicals and also by supporting cellular antioxidant capacity through its effects on maintaining glutathione. HSPs can also repair misfolded, damaged proteins thereby ensuring proteins have their proper structure and function. (Source)
21. Ann N Y Acad Sci. 2006 May;1067:301-8. Heat-shock protein 70 genes and human longevity: a view from Denmark. By Singh R1, Kølvraa S, Bross P, Christensen K, Gregersen N, Tan Q, Jensen UB, Eiberg H, Rattan SI. https://www.ncbi.nlm.nih.gov/pubmed/16804002
22. Cell type–specific variations in the induction of hsp70 in human leukocytes by feverlike whole body hyperthermia, by Rudolf Oehler,1 Erich Pusch,1 Maria Zellner,1 Peter Dungel,1 Nicole Hergovics,2 Monika Homoncik,2 Maja Munk Eliasen,1 Marianne Brabec,1 and Erich Roth1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC434413/
23 Zellner M, et al. Human monocyte stimulation by experimental whole body hyperthermia [in German]. Wien Klin Wochenschr. 2002 Feb 15;114(3):102–107.
24. When body temperature reaches 101.3°F (38.5°C), typically the immune system shifts into a state of intensive activity. At this temperature, immune factors in the bloodstream increase two-fold or more, and in some cases as high as ten-fold, triggering an activation of immune defenses throughout the body. Numerous studies have reported higher levels of messenger chemicals, white blood cells, and immune scavengers in response to fever, including, but not limited to heat shock proteins interleukins and other cytokines. Furthermore, there may also be an inconsistent pattern in the rhythm of their temperature over a 24-hour period. Cf. Gorter R, Peper E. Fighting Cancer: A Nontoxic Approach to Treatment. Berkeley: North Atlantic Books; 2011.
25. Cf. Schulman CI, Namias N, Doherty J, et al. The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study. Surg Infect. 2005;6(4):369–375. There are cases when antipyretics can be envisaged, notably for the elderly and babies who can not thrive holistically. Sometimes they are so damaged by allopathic medicine or their disease that fever therapy can be counter-indicated.
26 Arch Androl. 1984;12(1):9-15. The effect of a single sauna exposure on spermatozoa. Brown-Woodman PD, Post EJ, Gass GC, White IG www.ncbi.nlm.nih.gov/pubmed/6476971. The physiological reason why testicles are outside the body is for cooling effects.
27. Far infra red electronic saunas (especially the later generation carbon panels) which are not grounded emit high levels of electromagnetic radiation. This is significant because the entire human body is electric. When volts generate electric fields and when electric fields of charged particles generate a magnetic field we have EMFs.
Technological advances like those at Therasage have provided new techniques for delivering these healing radiations as well as near infra red waves while protecting the body from EMF’s Fibers impregnated with FIR emitting ceramic nanoparticles and woven into fabrics, are being used as garments and wraps to generate FIR radiation, and attain health benefits from its effects.
Far infrared (FIR) radiation (λ = 3–100 μm) is a subdivision of the electromagnetic spectrum that has been investigated for biological effects. In particular, microns 3 to 12 (ums) have been observed in both in vitro and in vivo studies, to stimulate cells and tissue.
28 The benefits of infrared heat may be further enhanced by different types of gem stones, including natural jade stone. Jade is the most efficient natural infrared heat absorber of all the semiprecious stones. When run through jade, far infrared passes its heat smoothly to the body. It also creates negative ions, which is a further benefit. Heating pads and saunas combining far infrared and or full spectrum infrared heat with jade stone are now available to provide convenient at-home relief for individuals seeking to increase flexibility, relieve discomfort, boost circulation, and relieve stress and fatigue”
29. Cardiovascular and All-Cause Mortality Events. JAMA Internal Medicine, 175(4), 542-548. jamanetwork.com/article.aspx?articleid=2130724

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Disclaimer and safety
Although heat medicine is generally safe, there are caveats, multiple biological parameters to monitor, from the proper management of cardio-vascular functions, the coagulation cascade, tumor lysis, to heat shock proteins, the tumor micro-environment, pregnancy status and more. Sweat can even increase itching in patients with atopic dermatitis. Contraindications to sauna bathing include unstable angina pectoris, recent myocardial infarction, and severe aortic stenosis. Sauna bathing is safe, however, for most people with coronary heart disease with stable angina pectoris or old myocardial infarction. Very few acute myocardial infarctions and sudden deaths occur in saunas, but certain drugs and hard alcohol consumption during sauna bathing can increase the risk of hypotension, arrhythmia, and sudden death. Therefore, a patient should always be guided by a competent health-care practitioner. Futhermore, nothing in this pedagogical website should be construed as medical advise. Due diligence is encouraged. Via this disclaimer and the website’s private use section, Happiness Institute as well as its agents are therefore immune from liability insofar as how blog viewers interpret and act upon said article and share information.
2016-8 Copyright (c). Happiness Medicine Institute and agents. All rights reserved

Professor Joubert teaches how to extend a healthy cancer-free Lifespan to 122 years thanks to safe, efficient and cost friendly breakthrough protocols. Working on a documentary and book that redefines Medicine in light of new discoveries, ancient wisdoms, innovative research and holistic science, he can be nonetheless available to coach patients back to homeostasis, wellbeing & Joie de Vivre. On occasion, Pr. Joubert can also coach health professionals to better protect their holistic practice when they must deviate from outdated and-or irrational mainstream “standards of care” in order to genuinely serve their patients, evidence-strong Science and internationally recognized human rights. For details, see the links called “Contact” and “Mission” (under the “About” link).

Posted in Neuro-science, Mental Disorders, Happiness & Joie de Vivre Medicine, Psycho-neuro-Immunology

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